J.-J. Li

Sun Yat-Sen University, Shengcheng, Guangdong, China

Are you J.-J. Li?

Claim your profile

Publications (2)0 Total impact

  • M.-F. Gu · J.-J. Li · L.-Z. Liu · W.-J. Ye · R. Zhang
    [Show abstract] [Hide abstract]
    ABSTRACT: OBJECTIVE: To evaluate the efficacy and toxicity of chemotherapy regimen of Gemcitabine plus Cisplatin sequently combining radiotherapy (GP + RT) for advanced nasopharyngeal carcinoma. METHODS: Totally 240 patients were enrolled in this study of chemo-radiotherapy and divided into 3 groups randomizedly. 80 patients of experience group accepted regimens of GP chemotherapy sequently combining with regular radiotherapy (GP+RT): Gemcitabine 800 mg/m2, d1, d8; Cisplatin 20 mg/m2, d 1-d5, every 4 weeks, 4 cycles. Patients of contrast NO. 1 group accepted Concurrent Chemoradiotherapy(CT): DDP 20 mg/m2, d 1, every 1 week, 6 cycles within regular radiotherapy; and adjuvant chemotherapy (DDP 20 mg/m2, 5-FU 500 mg/m2, d 1-d5, every 4 weeks). The patients of contrast NO. 2 group accepted 5-FU plus Cisplatin sequently combining with radiotherapy (GP+RT): 5-FU 500 mg/m2, DDP 20 mg/m2, d1-d5, every 4 weeks, 4 cycles. Early response, long-term effects and side effects of 3 groups of patients were got in follow-up of 3 years. RESULTS: In recent effects, CR were found in 98.8% (79/80) GP+RT group, 91.3% (73/80) con-RT group and 93.8% (75/80) PF+RT group respectively. The main side-effects of GP regimen chemotherapy were neutropenia and thrombocytopenia. In follow-up of 3 years, the patients of GP+RT group got better overall survival rate (OS), disease free from local failure survival rate (DFS) and free from distant metastasis survival rate (FDM) over the other contrast groups. The GP+RT group had less recurrence rate and distant metastasis. CONCLUSION: Gemcitabine plus Cisplatin sequently combining with radiotherapy for advanced nasopharyngeal carcinoma has positive early and long-term effects, and it is recommended to be fist line chemo-radiotherapy regimen.
    No preview · Article · Feb 2011 · Chinese Journal of Cancer Prevention and Treatment
  • X.-L. Chen · M.-F. Gu · Y.-Z. Du · J.-J. Li · H.-M. Zhang
    [Show abstract] [Hide abstract]
    ABSTRACT: OBJECTIVE: To evaluate the validity and reliability of quality of life among nasopharyngeal carcinoma patients (QOL-NPC). METHODS: From 21 January to 7 February 2007, 433 NPC patients who were being or had been treated by radiation were face-to-face interviewed with QOL-NPC by the well-trained investigators in Cancer Centre of Sun Yat-sen University. And then correlation analysis, reliability analysis, factor analysis and Structural equation model (SEM) were used to evaluate the scale. RESULTS: QOL-NPC had good split-half reliability and internal consistency. All the internal consistency Cronbach's coefficients were above 0.8, except for the domain of social function (its Cronbach's coefficient is 0.628). The correlation between each item and its domain were more than 0.547, and they were statistically significant. What was more, they were greater than the correlation between the item and other domains. These demonstrated the QOL-NPC had good content validity and discriminatory validity. Six principal components extracted from all the items represented all domains of the scale and the cumulative variance was 57.04%. SEM showed that the constructs of the scale (the correlation between item and domain) obtained were consistent with the conceived concept in essence. It had good construct validity. The PS score of NPC patients among different gender and different radiation stage were statistically different (t = 2.10, P = 0.037; F=3.34, P = 0.019). The PH, PS and SE score of NPC patients among different income were statistically different (P<0.05). CONCLUSION: QOL-NPC has good reliability and validity, and it is available for the evaluation of quality of life among NPC patients who are being or has been treated by radiation.
    No preview · Article · Jul 2010 · Chinese Journal of Cancer Prevention and Treatment