[Show abstract][Hide abstract] ABSTRACT: Individuals infected with human immunodeficiency virus type 1 (HIV-1) are frequently coinfected with hepatitis C virus (HCV).
Acute HCV infection is often asymptomatic and poorly understood. We conducted a historical prospective study of HCV antibody
and viremia in plasma samples obtained during 1994–1999 from a cohort of initially HIV-1–infected, HCV-uninfected women and
from HIV-1–HCV–uninfected women. Twenty-two (1.5%) of 1517 experienced seroconversion. Of these, 14 (64%) truly acquired a
new infection as assessed by enzyme immunoassay response and new-onset viremia. The incidence rate in HIV-1–infected women
was 2.7 cases per 1000 person-years; it was 3.3 cases per 1000 person-years in HIV-1–seronegative women (relative risk, 1.21;
P = .75). Acquisition of HCV was associated with any history of drug use (P < .01). Five of 12 viremic, seroconverting individuals cleared viremia. Incident HCV infection among HIV-1–infected and HIV-1–uninfected
women was low. It was linked to drug use and commonly resolved.
Preview · Article · Dec 2003 · Clinical Infectious Diseases