Jonathan Davis

McGill University, Montréal, Quebec, Canada

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Publications (2)6.1 Total impact

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    ABSTRACT: Abnormalities in control of breathing have been associated with near-miss sudden infant death syndrome. Because caffeine is a respiratory stimulant, its effect on breathing pattern was evaluated in 12 infants with infantile apnea. Caffeine induced a significant increase in ventilation, tidal volume, and mean inspiratory flow. In contrast, no changes were noted in inspiratory time, expiratory time, or total cycle duration. These effects were observed with plasma concentrations of caffeine ranging from 8 to 20 mg/L. Caffeine increases ventilation mainly by increasing central inspiratory drive, and not be effective timing (T1/TTOT). This drug may be of value in near-miss SIDS.
    No preview · Article · Jan 1984 · Journal of Pediatrics
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    ABSTRACT: Abnormalities in control of breathing have been associated with near-miss SIDS. Since caffeine (C) is a respiratory stimulant, its effect on breathing pattern was evaluated in 12 infants with near-miss SIDS. Mean birth weights (±SE), gestational and postnatal age were 3.1±3.0 kg, 37.0±1.1 wks, and 7.9±1.7 wks, respectively. Ventilatory responses were measured with a face mask attached to a pneumotachometer to measure flow and integrated to yield volume before and 1 hour after caffeine citrate (20 mg/kg IV). Analysis of data before and after caffeine shows a significant increase in ventilation (Mean ±SE = 350.1±42.7 to 444.2±39.3 ml/kg/min, p<0.005); tidal volume (6.8±0.6 to 8.4±0.8 ml/kg, p<0.005) and mean inspiratory flow (VT/TI = 12.2 ± 1.2 to 15.9±1.2 ml/kg/sec, p = 0.001). In contrast, no changes were noted in inspiratory time (TI), expiratory time or total cycle curation. These effects were observed with plasma concentrations of (C) (measured by HPLC) ranging from 8 to 20 mg/1. Data suggest that caffeine increases ventilation mainly by increasing central inspiratory drive and not by effective timing (TI/TTOT) and suggest possible efficacy of caffeine in near-miss SIDS.
    Full-text · Article · Apr 1981 · Pediatric Research