[Show abstract][Hide abstract] ABSTRACT: The article discusses various options of anticoagulant therapy for pulmonary thromboembolism and the main criteria of medication choice including the use of unfractionated heparin, low-molecular-weight heparins, and rivaroxaban. The data presented are based on the own experience and results of international clinical trials.
[Show abstract][Hide abstract] ABSTRACT: A relapse of lower-limb varicose disease (LLVD), despite the development of surgical achievements in surgical technologies is currently an important problem of present-day phlebology. A considerable factor of its pathogenesis is endothelial dysfunction (ED). The results of clinical studies of "false" relapses (n=32) and the control group were indicative of pronounced ED. Studying the level of leukocytes confirmed a hypothesis on a "leukocytic" trap at the level of the varicose veins of lower extremities. The authors analysed the dynamics of certain markers of ED (CECs, VCAM-1, P-selectin, E-selectin t-RA, endothelin-1), suggestive of the degree of ED severity, revealing a tendency towards normalization of the ED markers on the background of phlebotrophic therapy (Antistax). The carried out study also makes it possible to conclude that the level of endothelemia and biochemical indices of ED may serve as an evaluating marker of the activity of processes of varicose transformation of veins in patients with a relapse of the disease.
No preview · Article · Dec 2013 · Angiologii͡a i sosudistai͡a khirurgii͡a = Angiology and vascular surgery
[Show abstract][Hide abstract] ABSTRACT: Endothelium as the main structural unit of the vessel appears to exert a considerable influence on the processes of regulation of the cardiovascular system. The authors generalize herein and present the findings of the studies aimed at investigating endothelial dysfunction in varicose disease. Based on analysing the results of various methods of study they show importance of endothelial dysfunction, followed by discussing possibilities of medicamentous correction thereof, proceeding from pathogenetic mechanisms of its development.
No preview · Article · Jan 2010 · Angiologii͡a i sosudistai͡a khirurgii͡a = Angiology and vascular surgery
[Show abstract][Hide abstract] ABSTRACT: During the recent 6 years (2004-2010) tumors of the small intestine were diagnosed in 19 patients. Mean age of the patients with benign tumors was 63 years, with malignant tumors--57 years (age variations from 19 to 82 years). There were 16 (84%) men and 3 (16%) women. In 9 patients tumors were localized in the jejunum, in 10 patients--in the ileum. Complications appeared in 11 patients which was the cause of emergency operations. In 33.3% of the patients clinical manifestations of benign tumors of the small bowel were as episodes of intestinal bleedings which were not intensive as a rule, but were of recurrent character. Malignant tumors of the jejunum had clinical manifestations in 87% of patients. Most frequent symptoms were spastic or diffuse pains in the abdomen (63% of the patients), loss of the body mass (50%), intestinal obstruction (27.7%), intestinal bleedings (5.5%).
No preview · Article · Jan 2010 · Vestnik khirurgii imeni I. I. Grekova
[Show abstract][Hide abstract] ABSTRACT: The algorithm of the acute destructive pancreatitis' treatment is based on the analysis of 167 patients data. It includes medical activities on patient's admission, basic medication components and indications to the operative treatment. The application of the algorithm ensured satisfactory results of the treatment in 94% of patients with the destructive pancreatitis on early stages.
[Show abstract][Hide abstract] ABSTRACT: The article deals with the findings obtained by present-day studies in pathophysiology of venous outflow disorders. The authors highlight a considerable role of the endothelium of the vascular wall resulting from its lesion with metabolic products of activated leukocytes in the development of varicose transformation. Also studied was the dynamics of the endothelial dysfunction marker, i.e., the number of the circulating endothelial cells (CECs). In so doing, amongst the patients presenting with segmental subcutaneous varicosity with reflux along the superficial and perforating veins, endothelial dysfunction was revealed most frequently, i.e., in 91% of the cases. It was proved that the CEC index might be used as a marker of endothelial dysfunction in patients presenting with varicose disease. An increase in this parameter above 6 x 10(4) cells per 1 ml of blood should be considered as a reliable manifestation of an endothelial lesion in diseases of the peripheral veins. By the degree of severity of endotheliemia, one may judge of the activity of the process of varicose transformation of veins, which makes it possible to timely take appropriate corrective measures. A priority trend in medical treatment of venous transformation is assigned to diosmine-based phlebotonics.
No preview · Article · Feb 2008 · Angiologii͡a i sosudistai͡a khirurgii͡a = Angiology and vascular surgery
[Show abstract][Hide abstract] ABSTRACT: Results of diagnosis and treatment of 150 patients with thymoma and generalized myasthenia are analyzed. The results of examination were registered before surgery, and also in 1, 3, 5 and 10 years after one. It is demonstrated that thymoma is potentially malignant tumor with risk of recurrence and requires long follow-up of patient after operation. Morphologic type and stage of tumor, severity of myasthenia are the main predictors in the prognosis of surgical treatment. Thymomectomy with excision of fatty tissue of anterior mediastinum is absolutely indicated for this severe category of patients, and it decreases the risk of tumor progression. Mortality of patients depends not only on tumor growth or recurrence but also on concomitant myasthenic disorders.
[Show abstract][Hide abstract] ABSTRACT: The authors demonstrate the results of many years of observing patients with hormone-inactive adrenal gland adenomas. The subjects were 80 patients observed during 8 months to 12 years. The study shows that slow growth is generally typical of these adenomas. In 15% of patients an average growth of 1 mm/year was noted; this growth did not exceed 10 mm throughout the whole period of observation. The researchers also observed changes in the clinical symptoms and hormonal parameters over time. The study demonstrates that long existence of adenomas do not aggravate the clinical course of arterial hypertension and diabetes mellitus, and do not express any hormonal activity. The study established more precise indications to dynamic observation and its algorithm.
No preview · Article · Feb 2006 · Klinicheskaia meditsina
[Show abstract][Hide abstract] ABSTRACT: Results of treatment of 827 patients with bleedings from chronic gastric and duodenal ulcers are analyzed. Potentialities of various methods of endoscopic hemostasis were studied. Diathermocoagulation was the least effective method of hemostasis (59%). Irrigation of the bleeding source provided hemostasis in 88.7% patients, combined methods - in 94.1%. Methods of irrigation are appropriate in diffuse bleeding from ulcer (Forrest 1B). Stream bleeding (Forrest 1A) is indication for combined methods of hemostasis. It is demonstrated that type of endoscopic procedure does not influence rate of bleeding recurrences. The main element of conservative treatment of gastroduodenal ulcerous bleedings is antisecretory therapy. Proton pump blockers are more effective than H2-blockers; the rate of recurrences was 5.0 and 28.9%, respectively. Prediction of bleeding recurrences and preventive operations are the main way to treatment results improvement.
[Show abstract][Hide abstract] ABSTRACT: Experience of endovenous laser coagulation in the treatment of the varicose disease of the lower extremities is presented. This method was used in 107 patients. Surgical technique of isolated endovenous laser coagulation and combined phlebectomy was described in detail. Morphologic data on laser injury of a venous wall are presented. Short- and long-term results were evaluated with clinical and ultrasonic methods. It is demonstrated that endovenous laser coagulation may be regarded as alternative to traditional saphenectomy. This method decreases surgical trauma, number of complications and hospital stay.
[Show abstract][Hide abstract] ABSTRACT: Forty-year experience with surgical treatment of generalized myasthenia (GM) based on 2977 cases is analyzed. Role of special methods of mediastinum examination (CT, MRT) is demonstrated, indications to thymectomy are validated. It is noted that developed diagnostic algorithm, surgical technique, management before and after surgery improved significantly immediate and long-term results. Development of clinical, immunological and morphologic criteria of thymectomy effect permitted to predict course of GM and to optimize complex therapy after surgical treatment.
[Show abstract][Hide abstract] ABSTRACT: To analyse the experience in diagnosis and treatment of arterial hypertension (AH) of adrenal genesis.
A total of 243 patients with adrenal AH (mean age 46.3 +/- 3.2 years) were examined. 134 of them had endogenic adrenohypercorticism (EAH), 62--primary hyperaldosteronism (PHA), 47--chromaffin tissue tumors (CTT). Diurnal urinary excretion of adrenal hormones (epinephrine, norepinephrine, aldosteron, hydrocortisone) and peripheral blood hormones (aldosteron, renin, hydrocortisone, ACTH) were measured. Topic diagnosis was made with ultrasound, computed tomography, MR-imaging, angiography, adrenal venous sampling and 123I-MIBG scintigraphy.
Adrenalectomy was made in 224 patients (predominantly with tumor lesions). 19 patients (idiopathic hyperaldosteronism, advanced adrenocortical carcinoma) were treated conservatively (calcium antagonists, ACE inhibitors, AT1-receptor blockers, spironolacton). Good results of the surgical treatment were achieved in 60% patients with aldosterone-producing adenoma and adrenal Cushing's syndrome as well as in 80.5% patients with pheochromocytoma. Long-term outcomes depend on hypertension duration, histologic type of the tumor, age and family hypertension history (risk of essential hypertension).
Hypertension of adrenal origin occurs more frequently than it was supposed previously. Its late diagnosis may be due to lack of typical signs and symptoms, insufficient application of novel diagnostic techniques and poor alertness of physicians. It is recommended to include tests for adrenal hormones in urine and blood and ultrasound investigation of the adrenals in a complex of primary examination of patients with severe refractory hypertension.
No preview · Article · Feb 2003 · Terapevticheskii arkhiv
[Show abstract][Hide abstract] ABSTRACT: The urgent need to discuss with military surgeons the problem of improvement of educational process in the faculty of managerial medical staff of the Military-and-Medical Academy under the new social-and-economic conditions against the background of the RF Armed Forces reformation has prompted the authors to write this article. The first report deals with the problems of general organization of educational process taking into account the needs for surgeons with higher military education and creation of certified specialized surgical care in the Troops. The authors suggest that all people with interests at stake should express their opinion concerning this problem.
No preview · Article · Aug 2000 · Voenno-medit͡sinskiĭ zhurnal