Hao Zhang

Peking University, Peping, Beijing, China

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Publications (21)62.82 Total impact

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    ABSTRACT: TbMnO3 is an important multiferroic showing strong coupling between magnetic and ferroelectric orderings. Incommensurate magnetic ordering is suggested to be vital for this coupling in TbMnO3, which can be modified by doping at the site of Tb and/or Mn. Our study shows that a self-doped solid solution Tb1-xMnyMnO3 (yx) can be formed with Mn doped into the site of Tb of TbMnO3. When y is very small Tb1-xMnyMnO3 shows both ferroelectric and incommensurate magnetic orders at low temperature, which is similar to TbMnO3. However, if y is large enough, a commensurate antiferromagnetic ordering appears along with the incommensurate magnetic ordering to prevent the appearance of multiferroicity in Tb1-xMnyMnO3. That is to say, the magnetoeletric coupling can be broken by the co-existence of a commensurate antiferromagnetic ordering. This finding may be useful to the study of TbMnO3.
    No preview · Article · Feb 2016 · ChemPhysChem
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    ABSTRACT: A solid solution EuMn1-xCuxO3-δ(0≤x≤0.316) was synthesized by traditional solid state reaction under 1150 oC. They crystallize in the space group Pnma confirmed by the powder X-ray and selected area electron diffraction. Magnetic susceptibility measurements show that the two magnetic transitions for these materials occur from 52 to 22 K and 45 to 20 K, respectively.
    No preview · Article · Jan 2016 · RSC Advances
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    ABSTRACT: Two novel layered silicates, PKU-13 and PKU-13a, were hydrothermally synthesized by using trimethylpropylammonium hydroxide as the structure directing agent (SDA). Their structures were solved by powder X-ray diffraction data in combination with electron diffraction technique and NMR spectroscopy. These two silicates are built from the same r52 layer in different stacking modes: the adjacent r52 layers in PKU-13a take a 0.5b + 0.68c shift compared with those in PKU-13. The difference is due to the SDA cations located between the layers. The SDA cations exist as monolayer in the structure of PKU-13, and link the adjacent layers by coulomb actions in combination with strong hydrogen bonds. In PKU-13a, SDA cations present in bi-layer which expends the distance between layers and destroys the inter-layer hydrogen bonds. PKU-13a can transform to PKU-13 after the treatment by acetic acid solution. The co-existence of intra-layer hydrogen bonds in PKU-13 interfere in its condensation to ordered crystalline microporous framework. Both PKU-13 and PKU-13a exhibit good catalytic activities as base catalysts in Knoevenagel condensation reaction.
    No preview · Article · Jul 2015 · Dalton Transactions
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    ABSTRACT: A series of BaFe1-xBixO3- (0.09 ≤ x ≤ 0.35) has been synthesized by traditional solid state method. They all crystallize in space group P4/mmm (with a = 4.0759(1) Ǻ, c = 4.0782(1) Ǻ for x=0.15) confirmed by the combinational use of powder X-ray, synchrotron, neutron, and electron diffractions. The magnetic susceptibility measurements show that the antiferromagnetic transition for these materials occurs from 64 to 50 K.
    Full-text · Article · Jan 2015 · RSC Advances
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    ABSTRACT: Epigenetic silence in cancer frequently altered signal-transduction pathways during the early stages of tumor development. Recent progress in the field of cancer epigenetics has led to new opportunities for diagnosis and treatment of cancer. We previously demonstrated that novel identified nuclear factor MARVELD1 was widely expressed in human tissues, but down-regulated by promoter methylation in multiple cancers. This study was carried out to determine the biological and clinical significance of MARVELD1 gene silencing in lung cancer. Here, we found the reduced MARVELD1 expression significantly correlated with diagnostic histopathology and malignant degree of lung cancers. DNA hypermethylation and histone deacetylation synergistically inactivated MARVELD1 gene in lung cancer cells. Moreover, MARVELD1 modulated the efficiency of nonsense-mediated mRNA decay (NMD) through interaction with NMD core factor SMG1. The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the association between NMD complex component UPF1/SMG1 and premature termination codons containing mRNA (PTC-mRNA). The results suggested that MARVELD1 silencing is an appealing diagnostic biomarker for lung cancer and epigenetic silencing of MARVELD1 gene links with the regulatory mechanism of NMD pathway in lung cancer, which may be required for tumorigenesis.
    Full-text · Article · Dec 2014 · Scientific Reports
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    ABSTRACT: The aims of this study were to investigate the regulation of TrkA protein by micro (mi)RNA‑92a and its effect on the proliferation and migration of human neuroblastoma cells. The BE(2)‑M17 human neuroblastoma cell line was cultured and transfected with either miRNA‑92a mimics or miRNA‑92a inhibitors. The expression levels of miRNA‑92a and TrkA mRNA were detected by quantitative polymerase chain reaction prior and subsequent to transfection. TrkA protein was quantitatively detected by flow cytometry. The proliferation and migration of neuroblastoma cells were examined in vitro by Cell Counting Kit‑8 and Transwell assays. Transfection of BE(2)‑M17 cells with miRNA‑92a mimics produced significantly higher expression levels of miRNA‑92a compared with those in the same cells transfected with negative controls (NCs). Increased proliferation and migration of the cells was also observed. Transfection of BE(2)‑M17 cells with miRNA‑92a inhibitors resulted in significantly lower expression levels of miRNA‑92a when compared with those of the same cells transfected with NCs (P<0.01). This reduction in the miRNA‑92a expression levels was accompanied by reduced proliferation and migration of the cells. The expression levels of TrkA mRNA and protein after 24 h transfection with the miRNA‑92a mimics were significantly reduced when compared with the control (P<0.01). However, the expression levels of TrkA were significantly higher (P<0.01) after 48 h transfection with miRNA‑92a inhibitors when compared with the control. In conclusion, miRNA‑92a promoted the proliferation and migration of human neuroblastoma cells through downregulation of TrkA, which suggested that miRNA‑92a may be a potential target for human neuroblastoma treatment in the future.
    Preview · Article · May 2014 · Molecular Medicine Reports
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    ABSTRACT: Two compounds (Tb1-xMny)MnO3-δ (W1, x = 0.089, y = 0.063; W2, x = 0.122, y = 0.102) have been synthesized by solid-state method and characterized using neutron diffraction and magnetic measurements. They crystallize in space group Pnma at room temperature and Pna21 at low temperature. W1 shows a sinusoidal antiferromagnetic order, and W2 shows both sinusoidal and canted commensurate antiferromagnetic orders. The magnetic moments of the commensurate antiferromagnetic order for W2 are antiferromagnetically coupled along the a- and c-axes, and ferromagnetically coupled along the b-axis in the Pna21 setting. Strong ferromagnetic response is induced by doping more Mn into the Tb site of (Tb1-xMny)MnO3-δ.
    No preview · Article · Apr 2014 · Inorganic Chemistry
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    ABSTRACT: Green BaIn0.80Mn0.20O2.70 (S1) has been synthesized by solid-state reaction under high temperature, and black BaIn0.80Mn0.20O2.60 (RS1) is obtained by treating S1 under vacuum at 500 °C. They were characterized by powder X-ray and neutron diffraction, selected area electron diffraction, magnetic measurement, and impedance spectrum. S1 and RS1 crystallize in Cmcm (a = 5.9722(3), b = 5.9664(3), c = 8.4511(4) Å) and P21/c (a = 5.9328(7), b = 5.9445(11), c = 16.8154(14) Å, β = 90.02(2)°), respectively. Oxide ion vacancies are confirmed to exist in S1 and RS1 by the neutron diffraction data.
    No preview · Article · Apr 2014 · Solid State Ionics
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    ABSTRACT: The series of BaBi 1−y Pb y O 3(0 ≤y≤1) has been synthesized by high-temperature solid-state reaction. X-ray and selected area electron diffraction data indicate that BaBi 1−y Pb y O 3(0 ≤y≤ 0.88) crystallizes in space group P1 and BaBi 1−y Pb y O 3 (0.93 ≤y≤1) crystallizes in space group Imma. The samples with the nominal formula BaBi 1−y Pb y O 3(y = 0.70, 0.80, 0.90) shows superconductivity with transition temperature (T c) around 11 K. When BaBi 1−y Pb y O 3 (0 ≤ y≤0.80) was treated with KOH and KF at 450 ∘C, the corresponding samples with the nominal formula Ba 1−x K z Bi 1−y Pb y O 3 (0 ≤y≤ 0.80) were obtained, which shows superconductivity with T c changing from 30 to 11 K.
    No preview · Article · Feb 2014 · Journal of Superconductivity and Novel Magnetism
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    ABSTRACT: Cell adhesion on an extracellular matrix (ECM) participates in cell motility, invasion, cell signal transduction and gene expression. Many nuclear proteins regulate cell-ECM adhesion through managing the transcription of cell adhesion-related genes. Here, we identified MARVEL [MAL (The myelin and lymphocyte protein) and related proteins for vesicle trafficking and membrane link] domain containing 1 (MARVELD1) that could suppress cell spreading and complicate actin organization. Over-expression of MARVELD1 in NIH3T3 cells decreased the expression level of integrin β1 and vinculin, and further led to dephosphorylation of focal adhesion kinase (FAK) at Tyr 397. We also found that MARVELD1 partially colocalized with serine/arginine-rich splicing factor 2 (SC35) and interacted with nuclear cap binding protein subunit 2 (CBP20). Finally, we demonstrated that pre-mRNA processing of integrin β1 was affected by MARVELD1. Taken together, our studies demonstrate that MARVELD1 plays a role in pre-mRNA processing of integrin β1, and thereby regulates cell adhesion and cell motility. These studies provide a novel regulatory mechanism of cell-ECM adhesion by nuclear protein in cells.
    Full-text · Article · Sep 2013 · The international journal of biochemistry & cell biology
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    ABSTRACT: A new organic-inorganic hybrid pentaborate [C6H14N][B5O6(OH)(4)] (1) has been synthesised hydrothermally in aqueous solution and characterised by single-crystal X-ray diffraction, FT-IR, DTA-TG and photoluminescence spectroscopy. It crystallizes in the monoclinic system, space group P2(1)/c, with the lattice constants of a = 9.463 (2) angstrom, b = 14.005 (3) angstrom, c = 10.642 (2) angstrom, and beta = 93.82(3)degrees. The structure consists of isolated [B5O6(OH)(4)](-) groups interlinked by protonated cyclohexylamine via hydrogen bonding. Blue photoluminescence of 1 is observed upon UV excitation, which can be further enhanced and modified to near-white emission by thermal treatment. The maximum emissions and peak shapes of 1-250 degrees C are also tunable with various excitation wavelengths in the region of 350-470 nm. This compound provides a novel example of organically templated borate materials potential for display and lighting applications. (c) 2013 Elsevier B.V. All rights reserved.
    Full-text · Article · Sep 2013 · Journal of Molecular Structure
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    ABSTRACT: Bulk crystals of α- and β-PbO have been grown selectively by using transition metal ions as additives. The role of orientated pressure in the unexpected β to α phase transition related to the layered structure has been proposed for the first time.
    Full-text · Article · Apr 2013 · CrystEngComm
  • Hao Zhang · Chen Feng · Suo-Qin Tang

    No preview · Article · Dec 2012 · Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
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    ABSTRACT: In the present study, we demonstrated the cell cycle periodicity of Erbin expression with the maximal expression of Erbin in G2/M phase. A significant increase in Erbin promoter activity was observed in G2/M phase-synchronized cells. Sequence analysis revealed a c-Myb site in the core promoter region of Erbin. Mutagenesis of c-Myb consensus sequences abrogated the increased Erbin promoter activity in G2/M phase. ChIP and oligonucleotide pull-down assays validated that the recruitment of c-Myb to the consensus sequences was specific. The interaction of c-Myb with c-Myb site in the Erbin promoter was significantly enhanced in G2/M phase. Ectopic overexpression of c-Myb led to the up-regulation of Erbin promoter activity and c-Myb silencing by small interfering RNA significantly decreased Erbin protein level. Transfection of c-Myb rescued Erbin expression that was impaired by c-Myb knockdown. It proves that c-Myb and the c-Myb response element mediate the cell cycle-dependent expression of Erbin. Inactivation of Erbin causes an acceleration of the G1/S transition, the formation of multipolar spindles and abnormal chromosome congression. These results unravel a critical role of c-Myb in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression.
    Preview · Article · Aug 2012 · PLoS ONE
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    ABSTRACT: We have previously found that expression of MARVELD1 was remarkably downregulated in multiple tumor tissues, but unclear in hepatocellular carcinoma (HCC) and its function has not been explored yet. In the present study, to uncover the underlying mechanism of MARVELD1 in the pathogenesis and development of HCC, we investigated the expression pattern of MARVELD1 and its effect on tumor proliferation in HCC. The results indicated the frequent downregulation of MARVELD1 in clinic samples and cell lines of HCC resulted from promoter methylation, as well as genetic deletion. Furthermore, treatment of MARVELD1 unexpressing Hep3B2.1-7 and PLC/PRF/5 cells with the demethylating agent 5-aza-2' deoxycytidine restored its expression. Overexpression of MARVELD1 suppressed the proliferation of HCC cells in vitro and in vivo, whereas downregulation of endogenous MARVELD1 by shRNAs significantly enhanced these characters. MARVELD1 overexpression could enhance chemosensitivity of HCC cells to epirubicin and 10-hydroxycamptothecin. Corresponding to these results, the expression of p-ERK1/2 and cyclin D1 were decreased, whereas p16 and p53 were increased in MARVELD1-transfected cells. We also demonstrated that knockdown of MARVELD1 resulted in upregulation of p-ERK1/2 and cyclin D1, and downregulation of p16 and p53. Moreover, the effect of the decreased cell growth rate was significantly reversed when MARVELD1-overexpressing cells were trasfected with p53 or p16 siRNA. Our findings suggest that MARVELD1 is a tumor suppressor by negatively regulating proliferation, tumor growth and chemosensitivity of HCC cells via increasing p53 and p16 in vitro and in vivo. MARVELD1 may be a potential target for HCC therapy.
    Full-text · Article · Feb 2012 · Cancer Science
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    ABSTRACT: Highly crystalline single crystals of sillenite-type Bi10Cd3O20 and Bi12(BixM1−x)O20 (M = B, Si, P, V, Mn, Fe, Ga, Ge) were successfully grown under mild hydrothermal conditions. Bulk crystals with smallest average size of 100 μm and preferable shapes can be obtained by optimizing respective growth conditions. The morphologies for Bi25FeO40 show regular evolutions along with different synthesis routes. Characterizations were performed by means of powder X-ray diffraction analyses, chemical analyses, optical spectra and first-principles calculations. It is found that all of the crystals possess certain transparency along with distinct absorptions in the visible region, corresponding to the discrete MO4 tetrahedra in the crystal lattices. Band gap energies of the fabricated sillenite crystals vary from approximately 1.66 eV for Bi12(Bi0.375Mn0.625)O20 to 2.85 eV for Bi12GeO20, as estimated from the absorption data. The impacts of tetrahedrally coordinated transition-metal cations on their electronic structures were investigated by first-principles computational approaches.
    Full-text · Article · Jan 2012 · CrystEngComm
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    ABSTRACT: To study the antifungal treatment and intensive chemotherapy in children with acute leukemia and invasive aspergillosis. The diagnosis and treatment of 4 cases of childhood acute leukemia complicated by invasive aspergillosis between July 2007 and July 2008 were studied retrospectively. Three children who underwent remission induction chemotherapy for ALL and one who underwent consolidation chemotherapy for AML developed invasive aspergillosis. One child with proven aspergillosis and 3 with possible aspergillosis all had halo sign on CT at diagnosis. Voriconazole or amphotericin B was given as primary therapy. Improvements of fungal lesions were shown by CT after two to four weeks of antifungal therapy. Complete radiologic remissions were achieved between 4 months and one year. The intensive chemotherapy schedule was continued in all of 4 cases. The median time from fungal infection to the continuation of chemotherapy was 35 days. None showed recurrence of fungal infection. The halo sign on CT may be a reliable indicator for the early diagnosis of invasive aspergillosis. The preemptive antifungal therapy on the basis of the identification of a halo sign and the reversal of immunosuppression may improve the outcome of invasive aspergillosis. Prolonged antifungal treatment during subsequent cycles of chemotherapy permits completion of scheduled intensive chemotherapy without fungal recurrence.
    No preview · Article · Nov 2009 · Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
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    ABSTRACT: Fra-1 is overexpressed in a variety of human tumors. Whether MMP-9 expression is regulated by Fra-1 has been contradictory. To clarify the capability of Fra-1 in activating transcription of MMP-9 gene, we analyzed the transcriptional activity of the MMP-9 promoter through the measure of luciferase activities in the MCF-7 cells transiently transfected with Fra-1. The positive regulation of Fra-1 on MMP-9 promoter was not detectable. By the analysis of MMP-9 promoter, a potential Stat3 binding site, just juxtaposed AP-1 consensus sequence, was noticed. The reporter assay showed that MMP-9 promoter was activated remarkably by cotransfection with Fra-1 and Stat3C. DNA affinity precipitation assay confirmed the binding of Stat3 and Fra-1 to the elements of MMP-9 promoter and also revealed c-Jun recruited to Stat3-Fra-1 complex. By immunoprecipitation assay, the Stat3/Fra-1, Stat3/c-Jun and Fra-1/c-Jun complexes were identified in vivo. Our study demonstrated that the activation of MMP-9 promoter is dependent upon interactions of Fra-1/c-Jun with Stat3. A juxtaposed Stat3/AP-1 element plays a crucial role in the manner of enhancersome in the activation of MMP-9 gene. The functional cooperation of the Stat3 and AP-1 transcription factors is required for the transcription of MMP-9 gene.
    No preview · Article · Feb 2008 · Molecular Immunology
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    ABSTRACT: Human breast cancer cell line SKBR3 expresses high level of the ErbB2 molecule, which has been associated with poor prognosis of breast cancer. Elevated ErbB2 functions as a transactivating co-receptor and promotes the formation of ErbB2 containing heterodimers, which are more mitogenic and transforming, and have a higher ligand affinity and signaling potency by virtue of the potent latent kinase activity of ErbB2. Interestingly, SKBR3 cells are non-tumorigenic in nude mice. By ectopic overexpression of c-Jun in SKBR3 cells, involvement of c-Jun in invasiveness and metastasis in vivo was investigated in this study. The critical role of c-Jun in the tumorigenesis and metastasis is demonstrated in nude mice.
    Preview · Article · Dec 2007 · Oncology Reports
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    ABSTRACT: In the present study, the sub-cellular localization of ErbB2 and its mutants expressed as GFP-tagged proteins in MCF-7 cells or endogenous ErbB2 in SKBR3 cells was examined. The data presented here demonstrate that the full-length ErbB2 was localized at the cytoplasmic membrane and ErbB2 ICD localized in the nucleus predominantly. The sequence of ErbB2 ICD contains the information supporting its nuclear translocation and cytoplasmic retention. A region (residues 721-970) harboring an arginine triplet is essential for the cytoplasmic trafficking of ErbB2. The results indicate that differential sub-cellular localization of ErbB2 ICD and the full-length ErbB2 is dependent on their structural determinants. The present results give initial clues for further analysis of the mechanism of ErbB2 intracellular localization.
    No preview · Article · Dec 2007 · Histochemie

Publication Stats

101 Citations
62.82 Total Impact Points

Institutions

  • 2012-2015
    • Peking University
      • • Beijing National Laboratory for Molecular Science
      • • National Laboratory of Rare Earth Material Chemistry and Application
      • • College of Chemistry and Molecular Engineering
      Peping, Beijing, China
    • Government of the People's Republic of China
      Peping, Beijing, China
  • 2012-2014
    • Harbin Institute of Technology
      • School of Life Science and Technollogy
      Charbin, Heilongjiang Sheng, China
  • 2009
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China