Hong Jiang

China Academy of Chinese Medical Sciences, Peping, Beijing, China

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Publications (505)1555.03 Total impact

  • Limin Shi · Xixun Du · Hong Jiang · Junxia Xie
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    ABSTRACT: Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor 1a (GHS-R1a), is a gut-derived, orexigenic peptide hormone that primarily regulates growth hormone secretion, food intake, and energy homeostasis. With the wide expression of GHS-R1a in extra-hypothalamic regions, the physiological role of ghrelin is more extensive than solely its involvement in metabolic function. Ghrelin has been shown to be involved in numerous higher brain functions, such as memory, reward, mood, and sleep. Some of these functions are disrupted in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). This link between ghrelin and these neurodegenerative diseases is supported by numerous studies. This review aims to provide a comprehensive overview of the most recent evidence of the novel neuromodulatory role of ghrelin in PD, AD, and HD. Moreover, the changes in circulating and/or central ghrelin levels that are associated with disease progression are also postulated to be a biomarker for clinical diagnosis and therapy.
    No preview · Article · Jan 2016 · Molecular Neurobiology
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    Chuting Li · Yuan Liu · Dexiang Liu · Hong Jiang · Fang Pan
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    ABSTRACT: Several types of microRNA (miRNA) overexpression in the brain are associated with stress. One of the targets of miR-34c is the stress-related corticotrophin releasing factor receptor 1 mRNA (CRFR1 mRNA). Here we will probe into the short-term effect and long-term effect of early adolescent traumatic stress on the expression of miR-34c and CRFR1 mRNA. Traumatic stress was established by electric foot shock for six consecutive days using 28-day rats. The anxiety-like behaviors, memory damage, CRFR1 protein, CRFR1 mRNA, and miR-34c expression were detected in our study. The results of our study proved that exposure to acute traumatic stress in early adolescent can cause permanent changes in neural network, resulting in dysregulation of CRFR1 expression and CRFR1 mRNA and miR-34c expression in hypothalamus, anxiety-like behavior, and memory impairment, suggesting that the miR-34c expression in hypothalamus may be an important factor involved in susceptibility to PTSD.
    Preview · Article · Jan 2016
  • Li Zhao · Zhi-Gang Mao · Hong Jiang · Li Qin · Chun-Yan Huang · Bin Tan
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    ABSTRACT: Objective: To evaluate the value of mean corpuscular volume/RBC distribution width (MCV/RDW) combined with reticulocyte parameters in differential diagnosis of aplastic anemia (AA), myelodysplastic syndrome (MDS), megaloblastic anemia (MA) and hemolytic anemia (HA) in order to provide some laboratorial evidence for clinical doctors in first diagnosis of these diseases. Methods: The data of MCV/RDW and reticulocyte parameters of AA, MDS, MA and HA patients from January 1 of 2011 to August 31 of 2014 were retrospectively collected in West China Hospital of Sichuan University. And 158 healthy unrelated individuals with age-, sex-matched were collected as controls. The value of MCV/RDW and reticulocyte parameters in differentiating diagnosis of above mentioned 4 kinds of anemia diseases was assessed. ROC analysis was used to determine the cutoff value of MCV/RDW and the reticulocyte parameters were performed in differentiating diagnosis of AA and MDS. Results: The average values of MCV/RDW of 158 AA patients (79 acute AA patients and 79 chronic AA patients), 107 MDS patients, 13 MA patients and 81 HA patients increased in variable degrees as compared with the controls, and there was statistical difference between them, the MCV/RDW value of acute AA patients was obviously less than that of other patients. In the 4 kinds of anemia diseases, the reticulocyte absolute count in acute AA patients was the lowest, that of chronic AA, MA and MDS patients was higher, and that of HA patients was highest. The ratio of low fluorescent reticulocyte decreased, and the ratio of moderate and high fluorescent reticulocytes increased in the 4 kinds of anemia diseases, as compared to controls. The difference was statistically significant. The analysis of differential diagnosis of chronic AA and MDS showed that RDW-SD could differentiate the chronic AA from MDS. The area under the curve (AUC) of RDW-SD was 0.76 (P < 0.01). The cutoff value of RDW-SD was 22.75fl. The sensitivity and specificity of RDW-SD for differential of chronic AA and MDS was 49.5% and 98.7%, respectively. Conclusion: MCV/RDW and reticulocyte parameters can be used as the laboratorial differential diagnostic indicators for AA, MDS, MA and HA diseases.
    No preview · Article · Dec 2015 · Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
  • Jue Jiang · Zhifeng Chen · Bing Liang · Jia Yan · Ying Zhang · Hong Jiang
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    ABSTRACT: Insulin-like growth factor (IGF)-1 is implicated in learning and memory. Experimental studies have suggested that the IGF-1 system is beneficial in cognition, especially in Alzheimer's disease (AD), by opposing Aβ amyloid processing and hyperphosphorylated tau toxicity. Low IGF-I and insulin-like growth factor binding protein (IGFBP)-3 serum levels are significantly associated with AD. To assess the relationship between circulating IGF-I and IGFBP3 levels and change of postoperative cognition. The study was performed in patients scheduled for elective head and neck carcinoma surgery under general anesthesia. On the day before the operation and postoperative days 1, 3 and 7, mini-mental state examination (MMSE) was performed by the same doctor, and blood samples were collected at 08:00 h after overnight fasting. The circulating levels of IGF-1 and IGFBP3 were measured by enzyme-linked immunosorbent assay. One hundred and two patients completed all four MMSE tests and forty-four of them completed all the four blood samples collection. Postoperative circulating IGF-1 level, ratio of IGF-1/IGFBP3 and MMSE score significantly decreased, whereas IGFBP3 level significantly increased compared with preoperative values in total patients. The change trends of circulating IGF-1 level and MMSE score were similar. Preoperative circulating IGF-1 level, ratio and MMSE score were significantly lower in POCD group compared to non-POCD group. There was no significant difference in preoperative level of circulating IGFBP3 between the two groups. Preoperative circulating IGF-1 level was negatively correlated with age and positively with MMSE. Logistic regression analysis revealed that lower preoperative IGF-1 level and elderly patients increased the odds of POCD. Down-regulation of circulating IGF-1 level may be involved in the mechanism of postoperative cognitive dysfunction. Older patients had lower circulating IGF-1 levels and were more susceptible to POCD.
    No preview · Article · Dec 2015 · SpringerPlus
  • Xiaolin Wu · Wenwei Liu · Hong Jiang · Jing Chen · Jichun Wang · Rui Zhu · Bin Li
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    ABSTRACT: It is known that vascular smooth muscle cell (VSMC) proliferation and migration leads to intimal hyperplasia in cases of atherosclerosis and restenosis. In the present study, we investigated the effects of kindlin-2 on VSMC proliferation, migration and intimal hyperplasia, and the underlying mechanisms. The left common carotid artery of Sprague‑Dawley rats were subjected to balloon injury in order to induce intimal hyperplasia, and then transfected with kindlin-2 small interfering RNA (siRNA) lentivirus or negative control siRNA lentivirus. We noted that the degree of intimal hyperplasia 4 weeks after balloon injury was significantly reduced in arteries transfected with kindlin-2 siRNA lentivirus (P<0.05). In vitro, kindlin-2 siRNA suppressed VSMC proliferation and migration induced by Wnt3a (100 ng/ml). Western blot analyses and RT-qPCR revealed that kindlin-2 regulated Wnt/β-catenin signaling and thereby modulated the expression of β-catenin target genes, including c-myc and cyclin D1. This study demonstrated that kindlin-2 plays a critical role in VSMC proliferation, migration and intimal hyperplasia via Wnt signaling. Therefore, blocking the activity of kindlin-2 represents a novel therapeutic strategy for vascular injury.
    No preview · Article · Dec 2015 · International Journal of Molecular Medicine
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    ABSTRACT: Inflammation plays a key role in pressure overload-induced cardiac hypertrophy and heart failure, but the mechanisms have not been fully elucidated. High-mobility group box 1 (HMGB1), which is increased in myocardium under pressure overload, may be involved in pressure overload-induced cardiac injury. The objectives of this study are to determine the role of HMGB1 in cardiac hypertrophy and cardiac dysfunction under pressure overload. Pressure overload was imposed on the heart of male wild-type mice by transverse aortic constriction (TAC), while recombinant HMGB1, HMGB1 box A (a competitive antagonist of HMGB1) or PBS was injected into the LV wall. Moreover, cardiac myocytes were cultured and given sustained mechanical stress. Transthoracic echocardiography was performed after the operation and sections for histological analyses were generated from paraffin-embedded hearts. Relevant proteins and genes were detected. Cardiac HMGB1 expression was increased after TAC, which was accompanied by its translocation from nucleus to both cytoplasm and intercellular space. Exogenous HMGB1 aggravated TAC-induced cardiac hypertrophy and cardiac dysfunction, as demonstrated by echocardiographic analyses, histological analyses and foetal cardiac genes detection. Nevertheless, the aforementioned pathological change induced by TAC could partially be reversed by HMGB1 inhibition. Consistent with the in vivo observations, mechanical stress evoked the release and synthesis of HMGB1 in cultured cardiac myocytes. This study indicates that the activated and up-regulated HMGB1 in myocardium, which might partially be derived from cardiac myocytes under pressure overload, may be of crucial importance in pressure overload-induced cardiac hypertrophy and cardiac dysfunction.
    No preview · Article · Dec 2015 · Journal of Cellular and Molecular Medicine
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    ABSTRACT: Low-level vagal stimulation has been shown to suppress cardiac sympathetic activity, which plays an important role in ventricular arrhythmia after myocardial infarction (MI). Our previous studies reported a noninvasive approach to deliver vagal stimulation by transcutaneous stimulation at the tragus, where the auricular branch of the vagus nerve is located.
    No preview · Article · Dec 2015 · JACC Clinical Electrophysiology
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    ABSTRACT: A simple, rapid and general method of self-initiated photografting and photopolymerization (SIPGP) was first introduced to fabricate dual-responsive nanochannel with a solid-state conical nanopore for the first time. The high density of carboxyl and hydroxyl groups on the internal surface of the etched poly(ethylene terephthalate) (PET) nanochannel acted as photo-active sites to provide further growth and amplification of polymer brushes via SIPGP. Poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) was chosen as a prototypical polymer which can be grafted on the surface of the nanochannel with high efficiency. SIPGP provided a smart and simple strategy to graft polymer brush on the surface of the nanochannel without the need of a surface bonded initiator. Series of characterizations including current-voltage curves, scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) indicated the successful construction of the polymer. The functionalized nanochannel was finally used for the construction of smart gate with perfect responsibility, reversibility and stability towards CO2 and temperature. This modification strategy combined with unique character of the polymer may hold a great potential in building various smart responsive systems.
    Full-text · Article · Dec 2015 · Talanta
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    ABSTRACT: Interleukin (IL)-17A has an important role in myocardial ischemia/reperfusion (I/R) injury, and vagal stimulation (VS) has been demonstrated to exert cardioprotective effects. The present study aimed to investigate the effects of VS on a rat model of myocardial I/R injury, and detected an association between VS and IL‑17A. Anesthetized rats underwent VS (2 msec; 10 Hz) or were treated with anti‑IL‑17A neutralized monoclonal antibodies (mAbs) (200 μg; iv), and subjected to ischemia for 30 min prior to 4 h reperfusion. The following parameters were measured: Infarct size; lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase (SOD) and caspase‑3 activity levels; tumor necrosis factor (TNF)‑α and IL‑6 expression levels; and the percentage of terminal deoxynucleotidyl‑transferase mediated dUTP nick‑end labeling (TUNEL) positive cells. High mobility group box 1 protein (HMGB1) and IL‑17A expression levels were assessed by immunoblotting. Following 4 h reperfusion, VS was able to significantly decrease the infarct size and the activity levels of LDH and CK (P<0.05). Furthermore, VS administration significantly suppressed the increased MDA and decreased SOD activity levels, and significantly reduced caspase‑3 activity and the percentage of TUNEL‑positive cells (P<0.05). Treatment with anti‑IL‑17A mAbs demonstrated the same effects as VS. Furthermore, VS was able to significantly inhibit the increased expression levels of TNF‑α, IL‑6, HMGB1 and IL‑17A induced by I/R (P<0.05). The results of the present study suggested that VS may attenuate myocardial I/R injury by xidative stress and the apoptosis of inflammatory cytokines, oxidative stress and the apoptosis of cardiomyocytes. Furthermore, VS may induce cardioprotective effects, which may be associated with the inhibition of IL‑17A expression.
    Preview · Article · Nov 2015 · Experimental and therapeutic medicine
  • Qi Hu · Jing Chen · Jing Zhang · Changwu Xu · Shuo Yang · Hong Jiang
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    ABSTRACT: The epigenetic modification of vascular smooth muscle cell (VSMC) phenotypic switching, proliferation, migration, apoptosis and extracellular matrix synthesis is known to occur in atherosclerosis. The aim of the present study was to investigate the effects of IOX1, a Jumonji domain-containing 2A (JMJD2A) inhibitor, on regulation of the cell cycle in angiotensin II (Ang II)-stimulated VSMCs and to elucidate the possible mechanisms involved. The proliferation and migration of the Ang II-stimulated VSMCs in the presence or absence of IOX1 were evaluated in vitro. Flow cytometric analysis was used to determine the effects of IOX1 on cell cycle progression. RT-qPCR and western blot analysis were carried out to measure the expression levels of cell cycle-related genes. The trimethylation of histone H3 lysine 9 (H3K9me3) at the promoters of these genes was detected by chromatin immunoprecipitation (ChIP) assay. We confirmed that the JMJD2A levels were increased, whereas the H3K9me3 levels were decreased in the Ang II-stimulated VSMCs. The inhibition of JMJD2A by IOX1 suppressed the Ang II-induced cell proliferation, migration and cell cycle progression by inhibiting cyclin D1 expression and increasing p21 expression. The underlying mechanisms were related to the restoration of the H3K9me3 levels at the promoters of these genes. In conclusion, the findings of our study indicate that IOX1 exerts its anti-proliferative and anti-migratory effects by regulating the expression of the cell cycle-related proteins, cyclin D1 and p21.
    No preview · Article · Nov 2015 · International Journal of Molecular Medicine
  • Songyun Wang · Zhibing Lu · Wenbo He · Bo He · Jing Xie · Xiaomei Yu · Hong Jiang
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    ABSTRACT: The goal of this study was to investigate the effect of selective ablation of the ligament of Marshall (LOM) on ventricular arrhythmias (VAs).
    No preview · Article · Nov 2015 · JACC Clinical Electrophysiology
  • Bo He · Bing Huang · Zhibing Lu · Wenbo He · Hong Jiang

    No preview · Article · Nov 2015 · International journal of cardiology
  • Jichun Wang · Xiaorong Hu · Hong Jiang

    No preview · Article · Nov 2015 · International journal of cardiology
  • Bo He · Zhibing Lu · Wenbo He · Bing Huang · Hong Jiang

    No preview · Article · Nov 2015 · International journal of cardiology
  • Zhibing Lu · Bo He · Wenbo He · Jing Xie · Xiaomei Yu · Hong Jiang
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    ABSTRACT: Aims: The right ventricular outflow tract (RVOT) and tricuspid annulus (TA) are common origins for idiopathic PVCs from the right ventricle. We sought to clarify the characteristics of a subgroup of idiopathic PVCs originating from the RVOT-TA junction. Methods and results: Surface ECG and intra-cardiac electrophysiological characteristics were analyzed in 101 patients with frequent PVCs who underwent successful RFCA in the right ventricle. Pacing was performed in the right ventricle in another 5 control subjects. The origin of PVCs determined by the successful ablation site was at the RVOT, the TA and the RVOT-TA junction in 78, 11 and 12 patients, respectively. The PVCs originating from RVOT-TA junction showed a monophasic R wave in leads I, II, III and aVF and a flat QRS complex in lead aVL. A flat QRS complex (rsr', qs, qr, rs or r pattern, mean r or qs amplitude, 0.3±0.1mV) in lead aVL distinguished the RVOT-TA junction origin from the RVOT (deep negative, -0.7±0.4mV) and the TA (tall positive, 0.8±0.3mV) origins. Activation mapping and pace mapping strategies were successfully applied to localize this specific origin of the PVCs. Pacing at the RVOT-TA junction in the control subjects validated a flat QRS complex in lead aVL. Conclusion: We report for the first time that the RVOT-TA junction is a non-rare but distinct origin of right ventricular PVCs. The flat QRS complex in lead aVL distinguishes this origin from RVOT and TA. RFCA is highly effective for eliminating PVCs in this origin.
    No preview · Article · Oct 2015 · International journal of cardiology
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    ABSTRACT: Diverse clinical factors, including intestinal ischemia, contribute to acute lung injury (ALI), which has up to a 40% mortality rate. During the development of lung injury an immune response is elicited that exacerbates the lung insult. Neutrophils have been well studied in mediating the pulmonary insults through an assortment of mechanisms, such as release of granule contents and production of proinflammatory cytokines due to the overactivation of complement and cytokines. In this study, we found that enhanced endoplasmic reticulum (ER) stress was observed in infiltrated neutrophils in the early stage of an ALI mice model. In neutrophils, complement 5a (C5a) inspires strong ER stress through inositol-requiring kinase 1a and, to a less extent, the protein kinase R -: like ER kinase signaling pathway. The granule release induced by C5a was ER stress mediated. Knowkdown of X-box -: binding protein 1, a downstream signaling molecule of inositol-requiring kinase 1a, impaired granule release, based on myeloperoxidase production. Further analysis revealed that C5a induced ER stress by binding to C5a receptor in neutrophils. Using xbp(f/f) MRP8-cre mice in which X-box-binding protein 1 is deficient specifically in neutrophils and ER stress is deprived, we confirmed that ER stress in neutrophils was required for granule release in vivo and led to ALI, whereas dampening ER stress in neutrophils substantially alleviated ALI. Taken together, our results demonstrated that C5a receptor -: mediated ER stress induced granule release in neutrophils, contributing to the development of ALI. This novel mechanism suggests a new potential therapeutic target in autophagy regulation for ALI.
    No preview · Article · Oct 2015 · The Journal of Immunology
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    ABSTRACT: Background: Hyperactivity of the cardiac sympathetic nervous system may underlie the pathogenesis of inappropriate sinus tachycardia (IST). Studies have proven that cervical vagal stimulation could inhibit stellate ganglion neural activity. Subjects: To investigate whether noninvasive vagal nerve stimulation (NVNS) could inhibit sympathetically induced sinus node acceleration by reducing right stellate ganglion (RSG) neural activity. Methods: Sixteen anesthetized dogs were randomly divided into NVNS group (with NVNS, n = 8) and Control group (with sham NVNS, n = 8). NVNS was delivered to the vagus nerve innervating at the right tragus with a voltage of 80% below the threshold, the minimal voltage to slow the sinus rate or atrioventricular conduction. The maximal sinus rate acceleration induced by high frequency stimulation (HFS) of RSG and RSG neural activity were measured at baseline and 3 hours after NVNS. At the end, SK2, c-fos and NGF protein expression in RSG were examined in both groups. Results: Compared to group baseline, the maximal sinus node acceleration induced by RSG stimulation and RSG neural activity at 3 hours later were significantly attenuated in the NVNS group, whereas kept at a no significant changes of these indices were observed in the control group (P>0.05). SK2 expression in RSG was significantly higher and c-fos and NGF expressions were significantly lower in the NVNS group than in the control group (P<0.05). Conclusion: Noninvasive vagal nerve stimulation may suppress RSG activity possibly by modulating SK2, c-fos and NGF expressions in RSG, thus inhibiting sympathetically induced sinus node acceleration. This article is protected by copyright. All rights reserved.
    No preview · Article · Oct 2015 · Journal of Cardiovascular Electrophysiology
  • Bo He · Zhibing Lu · Wenbo He · Hong Jiang

    No preview · Article · Oct 2015 · International journal of cardiology

  • No preview · Article · Oct 2015 · International journal of cardiology
  • Jing Chen · Lin Xu · Qi Hu · Shuo Yang · Bofang Zhang · Hong Jiang

    No preview · Article · Oct 2015 · International journal of cardiology

Publication Stats

5k Citations
1,555.03 Total Impact Points

Institutions

  • 2015
    • China Academy of Chinese Medical Sciences
      Peping, Beijing, China
  • 2013-2015
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Hainan University
      Heilongjiang Sheng, China
  • 2008-2015
    • Qingdao University
      • Department of Physiology
      Tsingtao, Shandong Sheng, China
  • 2007-2015
    • Shanghai Jiao Tong University
      • • Department of Anesthesiology
      • • School of Medicine
      Shanghai, Shanghai Shi, China
    • Xi'an Jiaotong University
      • The Institute of Biomedical Engineering
      Ch’ang-an, Shaanxi, China
  • 2006-2015
    • Shandong University
      • • Key Laboratory for Cardiovascular Remodelling and Function Research
      • • Department of Physiology
      • • Institute of Psychology
      • • School of Medicine
      Chi-nan-shih, Shandong Sheng, China
    • The Hong Kong Polytechnic University
      • Department of Applied Biology and Chemical Technology
      Hong Kong, Hong Kong
    • Ruijin Hospital North
      Shanghai, Shanghai Shi, China
    • Nanjing University
      • International Institute for Earth System Science
      Nan-ching, Jiangsu Sheng, China
  • 2004-2015
    • Sichuan University
      • • Department of Laboratory Medicine
      • • Analytical Center
      • • College of Chemistry
      Hua-yang, Sichuan, China
  • 2003-2015
    • Renmin University of China
      Peping, Beijing, China
  • 2002-2015
    • Wuhan University
      • • Department of Cardiology
      • • State Key Laboratory of Virology
      Wu-han-shih, Hubei, China
  • 2014
    • Hangzhou First People's Hospital
      Hang-hsien, Zhejiang Sheng, China
    • Huazhong University of Science and Technology
      Wu-han-shih, Hubei, China
  • 2013-2014
    • Third Military Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 2010-2014
    • Fudan University
      • Institutes of Biomedical Sciences
      Shanghai, Shanghai Shi, China
    • University of Jinan (Jinan, China)
      Chi-nan-shih, Shandong Sheng, China
  • 2007-2014
    • Chinese Academy of Sciences
      • State Key Laboratory of Electroanalytical Chemistry
      Peping, Beijing, China
  • 2012-2013
    • Zhejiang Cancer Hospital
      Hang-hsien, Zhejiang Sheng, China
    • Central South University
      • Department of Chemistry Engineering
      Ch’ang-sha-shih, Hunan, China
  • 2011-2012
    • Banner Sun Health Research Institute
      Sun City, Arizona, United States
    • Zhongshan University
      Shanghai, Shanghai Shi, China
    • Lanzhou University
      Kao-lan-hsien, Gansu Sheng, China
  • 2003-2004
    • Second Military Medical University, Shanghai
      • Department of Anesthesiology
      Shanghai, Shanghai Shi, China