F Mauguière

French National Centre for Scientific Research, Lutetia Parisorum, Île-de-France, France

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Publications (436)1193.04 Total impact

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    ABSTRACT: The orbitofrontal cortex is known to carry information regarding expected reward, risk and experienced outcome. Yet, due to inherent limitations in lesion and neuroimaging methods, the neural dynamics of these computations has remained elusive in humans. Here, taking advantage of the high temporal definition of intracranial recordings, we characterize the neurophysiological signatures of the intact orbitofrontal cortex in processing information relevant for risky decisions. Local field potentials were recorded from the intact orbitofrontal cortex of patients suffering from drug-refractory partial epilepsy with implanted depth electrodes as they performed a probabilistic reward learning task that required them to associate visual cues with distinct reward probabilities. We observed three successive signals: (i) around 400 ms after cue presentation, the amplitudes of the local field potentials increased with reward probability; (ii) a risk signal emerged during the late phase of reward anticipation and during the outcome phase; and (iii) an experienced value signal appeared at the time of reward delivery. Both the medial and lateral orbitofrontal cortex encoded risk and reward probability while the lateral orbitofrontal cortex played a dominant role in coding experienced value. The present study provides the first evidence from intracranial recordings that the human orbitofrontal cortex codes reward risk both during late reward anticipation and during the outcome phase at a time scale of milliseconds. Our findings offer insights into the rapid mechanisms underlying the ability to learn structural relationships from the environment.
    Full-text · Article · Jan 2016 · Brain
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    ABSTRACT: We prospectively studied early bedside standard EEG characteristics in 61 acute postanoxic coma patients. Five simple EEG features, namely, isoelectric, discontinuous, nonreactive to intense auditory and nociceptive stimuli, dominant delta frequency, and occurrence of paroxysms were classified yes or no. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC) of each of these variables for predicting an unfavorable outcome, defined as death, persistent vegetative state, minimally conscious state, or severe neurological disability, as assessed 1 year after coma onset were computed as well as Synek's score. The outcome was unfavorable in 56 (91.8%) patients. Sensitivity, specificity, PPV, NPV, and AUC of nonreactive EEG for predicting an unfavorable outcome were 84%, 80%, 98%, 31%, and 0.82, respectively; and were all very close to the ones of Synek score >3, which were 82%, 80%, 98%, 29%, and 0.81, respectively. Specificities for predicting an unfavorable outcome were 100% for isoelectric, discontinuous, or dominant delta activity EEG. These 3 last features were constantly associated to unfavorable outcome. Absent EEG reactivity strongly predicted an unfavorable outcome in postanoxic coma, and performed as accurate as a Synek score >3. Analyzing characteristics of some simple EEG features may easily help nonneurophysiologist physicians to investigate prognostic issue of postanoxic coma patient. In this study (a) discontinuous, isoelectric, or delta-dominant EEG were constantly associated with unfavorable outcome and (b) nonreactive EEG performed prognostic as accurate as a Synek score >3.
    No preview · Article · Nov 2015 · Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS)

  • No preview · Article · Sep 2015 · Neurology
  • Geneviève Demarquay · François Mauguière
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    ABSTRACT: Whereas considerable data have been generated about the pathophysiology of pain processing during migraine attacks, relatively little is known about the neural basis of sensory hypersensitivity. In migraine, the term "hypersensitivity" encompasses different and probably distinct pathophysiological aspects of sensory sensitivity. During attacks, many patients have enhanced sensitivity to visual, auditory and/or olfactory stimuli, which can enhance headache while interictally, migraineurs often report abnormal sensitivity to environmental stimuli that can cause nonpainful discomfort. In addition, sensorial stimuli can influence and trigger the onset of migraine attacks. The pathophysiological mechanisms and the origin of such sensitivity (individual predisposition to develop migraine disease or consequence of repeated migraine attacks) are ill understood. Functional neuroimaging and electrophysiological studies allow for noninvasive measures of neuronal responses to external stimuli and have contributed to our understanding of mechanisms underlying sensory hypersensitivity in migraine. The purpose of this review is to present pivotal neuroimaging and neurophysiological studies that explored the basal state of brain responsiveness to sensory stimuli in migraineurs, the alterations in habituation and attention to sensory inputs, the fluctuations of responsiveness to sensory stimuli before and during migraine attacks, and the relations between sensory hypersensitivity and clinical sensory complaints.
    No preview · Article · Sep 2015 · Headache The Journal of Head and Face Pain
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    Claire Czekala · François Mauguière · Stéphanie Mazza · Philip L. Jackson · Maud Frot
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    ABSTRACT: Humans are expert at recognizing facial features whether they are variable (emotions) or unchangeable (gender). Because of its huge communicative value, pain might be detected faster in faces than unchangeable features. Based on this assumption, we aimed to find a presentation time that enables subliminal discrimination of pain facial expression without permitting gender discrimination. For 80 individuals, we compared the time needed (50, 100, 150, or 200 milliseconds) to discriminate masked static pain faces among anger and neutral faces with the time needed to discriminate male from female faces. Whether these discriminations were associated with conscious reportability was tested with confidence measures on 40 other individuals. The results showed that, at 100 milliseconds, 75% of participants discriminated pain above chance level, whereas only 20% of participants discriminated the gender. Moreover, this pain discrimination appeared to be subliminal. This priority of pain over gender might exist because, even if pain faces are complex stimuli encoding both the sensory and the affective component of pain, they signal a danger. This supports the evolution theory relating to the necessity of quickly reading aversive emotions to ensure survival but might also be at the basis of altruistic behavior such as help and compassion.
    Full-text · Article · Sep 2015 · The journal of pain: official journal of the American Pain Society
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    Full-text · Dataset · Jun 2015
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    Full-text · Dataset · Jun 2015
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    Irene Cristofori · Sylvain Harquel · Jean Isnard · François Mauguière · Angela Sirigu
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    ABSTRACT: Social pain after exclusion by others activates brain regions also involved in physical pain. Here we evaluated whether monetary reward could compensate for the negative feeling of social pain in the brain. To address this question we used the unique technique of intracranial electroencephalography in subjects with drug resistant epilepsy. Specifically, we recorded theta activity from intracranial electrodes implanted in the insular cortex while subjects experienced conditions of social inclusion and exclusion associated with monetary gain and loss. Our study confirmed that theta rhythm in the insular cortex is the neural signature of social exclusion. We found that while a monetary gain suppresses the effect of social pain in the anterior insula, there is no such effect in the posterior insula. These results imply that the anterior insula can use secondary reward signals to compensate for the negative feeling of social pain. HENCE, HERE WE PROPOSE THAT THE ANTERIOR INSULA PLAYS A PIVOTAL ROLE IN INTEGRATING CONTINGENCIES TO UPDATE SOCIAL PAIN FEELINGS: Finally, the possibility to modulate the theta rhythm through the reward system might open new avenues of research for treating pathologies related to social exclusion. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.
    Full-text · Article · May 2015 · Social Cognitive and Affective Neuroscience
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    F Mauguière · I Merlet · N Forss · S Vanni · V Jousmäki · P Adeleine · R Hari

    Full-text · Dataset · Apr 2015
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    F Mauguière · I Merlet · N Forss · S Vanni · V Jousmäki · P Adeleine · R Hari

    Full-text · Dataset · Apr 2015
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    DESCRIPTION: accepté pour publication (NCCN) Summary Somatosensory evoked potentials (SSEPs) are increasingly performed for the assessment of peripheral neuropathies, but no practical guidelines have been established in this specific application. For this purpose, a survey was conducted among the French-speaking practitioners having an experience of SSEP recording in the context of peripheral neuropathies. The objectives were to determine the relevant indication criteria and technical settings for SSEP recording in this condition. From this survey, SSEPs appeared to be a second-line test when electroneuromyographic investigation was not enough conclusive, providing complementary and valuable information on peripheral proximal conduction and central conduction in the somatosensory pathways. Guidelines for a standardized recording protocol, including the various variables to measure, are proposed. This consensus statement is an important step in the process to recognize the value of this technique in assessing peripheral neuropathies in clinical practice. Keywords: diagnosis; evoked potentials; indication; parameters; peripheral neuropathies; technique.
    Full-text · Research · Apr 2015
  • Perrine Devic · Philippe Petiot · François Mauguière
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    ABSTRACT: Diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) remains uncertain when nerve conduction studies (NCS) fail to show demyelination. We conducted a retrospective study of patients who presented with clinical criteria of CIDP in whom electrodiagnostic (EDX) criteria of definite or probable CIDP were missing [axonal sensory-motor neuropathy (n=23), normal EDX with pure sensory presentation (n=3)]. All patients received immunomodulatory treatment. Twenty-six patients were evaluated with somatosensory evoked potentials (SSEPs), MRI of spinal roots, CSF analysis, and/or nerve biopsy. Diagnosis of CIDP was considered to be confirmed in patients who responded to immunotherapy. 22 of 26 patients (85%) had SSEPs reflecting abnormal proximal conduction in sensory fibers, including 14 who had only clinical and SSEP data in favor of CIDP. SSEPs were abnormal in 16 of 20 responders (80%) to immunotherapy. SSEP recording contributes to diagnosis of CIDP when NCS fail to detect peripheral demyelination. This article is protected by copyright. All rights reserved. © 2015 Wiley Periodicals, Inc.
    No preview · Article · Apr 2015 · Muscle & Nerve
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    ABSTRACT: Radiofrequency thermocoagulation (RFTC) guided by stereoelectroencephalography (SEEG) has proved to be a safe palliative method to reduce seizure frequency in patients with drug-resistant partial epilepsy. In malformation of cortical development (MCD), increasing the number of implanted electrodes over that needed for mapping of the epileptogenic zone could help to maximize RFTC efficiency. To evaluate the benefit of SEEG-guided RFTC in 14 patients suffering from drug-resistant epilepsy related to MCD located in functional cortical areas or in regions poorly accessible to surgery. Ten men and 4 women were treated by RFTC. Thermolesions were produced by applying a 50-V, 120-mA current for 10 to 30 seconds within the epileptogenic zone as identified by the SEEG investigation. An average of 25.8 ± 17.5 thermolesions were made per procedure. The median follow-up after the procedure was 41.7 months. Sixty-four percent of the patients experienced a long-term decrease in seizure frequency of >50%, of whom 6 (43%) presented long-lasting freedom from seizure. When a focal low-voltage fast activity was present at seizure onset on SEEG recordings, 87.5% of patients were responders or seizure free. All of the patients in whom electric stimulation reproduced spontaneous seizures were responders. Our results show the good benefit-risk ratio of the SEEG-guided procedure for patients suffering from MCD in whom surgery is risky. This study identifies 2 factors, focal low-voltage, high-frequency activity at seizure onset and lowered epileptogenic threshold in the coagulated area, that could be predictive of a favorable seizure outcome after RFTC. LVFA, low-voltage fast activityMCD, malformation of cortical developmentRFTC, radiofrequency thermocoagulationSEEG, stereoelectroencephalography.
    Full-text · Article · Mar 2015 · Neurosurgery
  • F. Mauguière · S. Corkin
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    ABSTRACT: On August 25, 1953, the patient H.M., aged 27, underwent a bilateral surgical destruction of the inner aspect of his temporal lobes performed by William Beecher Scoville with the aim to control H.M.'s drug refractory epileptic seizures and alleviate their impact on his quality of life. Postoperatively, H.M. presented for 55 years a "striking and totally unexpected grave loss of recent memories". This paper reports what we know about H.M.'s epilepsy before and after surgery and puts forward arguments supporting the syndromic classification of his epilepsy. We attempted to elucidate what could have been the rationale, in 1953, of Scoville's decision to carry out a bilateral ablation of H.M.'s medial temporal lobe structures, and we examined whether there was any convincing argument published before 1953 suggesting that bilateral hippocampal ablation could result in a permanent and severe amnesia. Our a posteriori analysis of H.M.'s medical history suggested that he was most probably suffering from idiopathic generalized epilepsy with absences and generalized convulsive seizures worsened by high dosage phenytoin treatment, or less probably from cryptogenic frontal lobe epilepsy. Importantly, he did not have temporal lobe epilepsy. Scoville based his proposal of bilateral mesial temporal lobe ablation on his experience as a psychosurgeon and on the assumption that the threshold of generalized epileptic activity could be lowered by some kind of hippocampal dysfunction potentially epileptic in nature. Given the scanty information on the link between amnesia and medial temporal lobe lesions that was available in humans in 1953, one can understand why Scoville was so surprised by the "striking and totally unexpected" memory loss he observed in H.M. after the bilateral ablation of his mesial temporal lobe structures. Copyright © 2015. Published by Elsevier Masson SAS.
    No preview · Article · Feb 2015 · Revue Neurologique
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    ABSTRACT: To explore whether painful somatosensory seizures (PSS) are generated in the primary somatosensory cortex (SI area) or in the operculo-insular cortex. We analyzed ictal recordings and data from stimulation using intracerebral electrodes exploring the operculo-insular cortex (including secondary somatosensory [SII] region), SI area, and other areas of the pain matrix (cingulate gyrus and supplementary motor area) in a case series study of 5 patients with PSS. Clinical features of PSS were different from those of seizures arising from the SI area: (1) pain intensity was higher; (2) pain spreading was not from one somatotopic territory to adjacent ones; and (3) the spatial extent of pain was large, fitting better with the size of somatosensory receptive fields of the insula and SII region than of the SI area. The insula and SII region were systematically involved at the onset of seizures, rapidly followed by the opercular portion of SI area. The upper part of SI cortex was involved at a lesser degree, with some delay, and pain duration did not correlate in time with that of the discharge in SI. Ictal pain was consistently reproduced by stimulation of the insula or SII region but never by stimulating the SI area. These data strongly suggest that PSS originate in the operculo-insular cortex and not in the SI area and corroborate the concept that this region is involved in the sensory-discriminative processing of pain inputs. Pain at the onset of PSS has a high value for localizing the epileptogenic area. © 2015 American Academy of Neurology.
    Full-text · Article · Jan 2015 · Neurology
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    F Mauguière · I Merlet · N Forss · S Vanni · V Jousmäki · P Adeleine · R Hari

    Full-text · Dataset · Dec 2014
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    ABSTRACT: We have previously shown that an imaging marker, increased periventricular [11C]flumazenil ([11C]FMZ) binding, is associated with failure to become seizure free (SF) after surgery for temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS). Here, we investigated whether increased preoperative periventricular white matter (WM) signal can be detected on clinical [18F]FDG-PET images. We then explored the potential of periventricular FDG WM increases, as well as whole-brain [11C]FMZ and [18F]FDG images analysed with random forest classifiers, for predicting surgery outcome.
    Full-text · Article · Nov 2014 · Clinical neuroimaging
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    Maud Frot · Isabelle Faillenot · François Mauguière
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    ABSTRACT: Previous brain imaging studies have shown robust activations in the insula during nociceptive stimulation. Most activations involve the posterior insular cortex but they can cover all insular gyri in some fMRI studies. However, little is known about the timing of activations across the different insular sub-regions. We report on the distribution of intracerebrally recorded nociceptive laser evoked potentials (LEPs) acquired from the full extent of the insula in 44 epileptic patients. Our study shows that both posterior and anterior subdivisions of the insular cortex respond to a nociceptive heat stimulus within a 200-400 ms latency range. This nociceptive cortical potential occurs firstly, and is larger, in the posterior granular insular cortex. The presence of phase reversals in LEP components in both posterior and anterior insular regions suggests activation of distinct, presumably functionally separate, sources in the posterior and anterior parts of the insula. Our results suggest that nociceptive input is first processed in the posterior insula, where it is known to be coded in terms of intensity and anatomical location, and then conveyed to the anterior insula, where the emotional reaction to pain is elaborated. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc.
    Full-text · Article · Nov 2014 · Human Brain Mapping
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    ABSTRACT: Objective: The present study provides a functional mapping of vestibular responses in the human insular cortex. Methods: A total of 642 electrical stimulations of the insula were performed in 219 patients, using stereotactically implanted depth electrodes, during the presurgical evaluation of drug-refractory partial epilepsy. We retrospectively identified 41 contacts where stimulation elicited vestibular sensations (VSs) and analyzed their location with respect to (1) their stereotactic coordinates (for all contacts), (2) the anatomy of insula gyri (for 20 vestibular sites), and (3) the probabilistic cytoarchitectonic maps of the insula (for 9 vestibular sites). Results: VSs occurred in 7.6% of the 541 evoked sensations after electrical stimulations of the insula. VSs were mostly obtained after stimulation of the posterior insula, that is, in the granular insular cortex and the postcentral insular gyrus. The data also suggest a spatial segregation of the responses in the insula, with the rotatory and translational VSs being evoked at more posterior stimulation sites than other less definable VSs. No left-right differences were observed. Interpretation: These results demonstrate vestibular sensory processing in the insula that is centered on its posterior part. The present data add to the understanding of the multiple sensory functions of the insular cortex and of the cortical processing of vestibular signals. The data also indicate that lesion or dysfunction in the posterior insula should be considered during the evaluation of vestibular epileptic seizures.
    Full-text · Article · Oct 2014 · Annals of Neurology
  • M. Frot · C. Perchet · F. Mauguière

    No preview · Article · Jun 2014

Publication Stats

13k Citations
1,193.04 Total Impact Points


  • 2012-2015
    • French National Centre for Scientific Research
      Lutetia Parisorum, Île-de-France, France
  • 2006-2015
    • Hospices Civils de Lyon
      Lyons, Rhône-Alpes, France
    • Centre Hospitalier Le Vinatier
      Брон, Rhône-Alpes, France
  • 1995-2015
    • Claude Bernard University Lyon 1
      Villeurbanne, Rhône-Alpes, France
  • 1990-2015
    • University of Lyon
      Lyons, Rhône-Alpes, France
    • Centre Hospitalier Universitaire de Saint-Étienne
      • Department of Neurology
      Saint-Étienne, Rhône-Alpes, France
  • 1989-2011
    • CHU de Lyon - Hôpital Neurologique et Neurochirurgical Pierre Wertheimer
      Lyons, Rhône-Alpes, France
  • 2010
    • Université Jean Monnet
      Saint-Étienne, Rhône-Alpes, France
    • Lyon Neuroscience Research Center
      Lyons, Rhône-Alpes, France
    • French Institute of Health and Medical Research
      Lutetia Parisorum, Île-de-France, France
  • 2009
    • Unité Inserm U1077
      Caen, Lower Normandy, France
  • 2008
    • HCL
      Noida, Uttar Pradesh, India
  • 2005
    • The Neurosciences Institute
      لا هویا, California, United States
    • University of Malaga
      • Area of Physiology
      Málaga, Andalusia, Spain
  • 1992-2000
    • CERMEP
      Rhône-Alpes, France
  • 1999
    • The Catholic University of America
      Washington, Washington, D.C., United States
  • 1996
    • Faculté des Sciences Ain Chock - Casablanca
      Anfa, Grand Casablanca, Morocco
  • 1994
    • Catholic University of the Sacred Heart
      • Institute of Neurology
      Roma, Latium, Italy
  • 1983
    • University Hospital Brussels
      Bruxelles, Brussels Capital, Belgium