E King's scientific contributionswhile working at University of Western Australia (Perth, Australia) and other institutions
- Abstract: Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the apoptotic index of cells implanted into patients. Using electron microscopy, immunohistochemistry, RT-PCR and flow cytometry analyses, we have investigated protein and gene... Show More
Publications citing this author (21)
[Show abstract] [Hide abstract] ABSTRACT: Full thickness articular cartilage defects have limited regenerative potential and are a significant source of pain and loss of knee function. Numerous treatment options exist, each with their own advantages and drawbacks. The goal of this review is to provide an overview of the problem of cartilage injury, a brief description of current treatment options and outcomes, and a discussion of the current principles and technique of Matrix-induced Autologous Chondrocyte Implantation (MACI). While early results of MACI have been promising, there is currently insufficient comparative and long-term outcome data to demonstrate superiority of this technique over other methods for cartilage repair.
- The techniques can be grouped as bone marrow stimulation techniques such as drilling , abrasion , microfracture  and autologous matrix induced chondrogenesis (AMIC)  ; direct chondral replacement techniques such as mosaicplasty  , fresh osteochondral allograft transplantation , and periosteal transplantation ; and culture-based techniques such as Autologous Chondrocyte Implantation (ACI)  and Matrix-induced Autologous Chondrocyte Implantation (MACI)  . Each of these procedures can be performed in association with new techniques, materials, or growth factors, leading to the description of a huge number of treatment options that have been used in experimental and clinical settings . This review will provide an overview on the historical development of cartilage repair.