David J Goldberg

Icahn School of Medicine at Mount Sinai, Borough of Manhattan, New York, United States

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Publications (15)26.38 Total impact

  • No preview · Article · Jul 2015 · Journal of the American Academy of Dermatology

  • No preview · Article · Jul 2015 · Journal of the American Academy of Dermatology
  • David J Goldberg · Angela N Beckford · Andrea Mourin
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    ABSTRACT: Abstract Background: Verruca Vulgaris is common benign neoplasm. However, it can present a therapeutic challenge. Previous studies have suggested that the Nd-YAG laser may be beneficial in the management of warts. Objective: To determine the effectiveness and safety of a novel 100 microsecond pulsed 1064nm Nd:YAG laser for the treatment of Verruca Vulgaris Method: 25 adult subjects with a total of 63 hand verrucae were enrolled in the clinical trial to receive treatment with a low energy (200mjoule) 1064nm Nd:YAG laser (PinPointe, NuvoLase, Inc.). Each subject was eligible for 3 treatments administered at monthly intervals. All verrucae were measured before each treatment session and at 6 months after the final treatment. A complete response was seen in 19 subjects and in 41 verrucae. A complete response was defined as complete absence of verruca with the presence of normal skin dermatoglyphics. All other lesions showed at least partial response. A partial response was defined as a 50% or greater reduction in verruca size. No adverse events were noted. Low energy 1064nm Nd: YAG laser treatment may be a promising safe and effective therapeutic modality for the treatment of verruca vulgaris. However, more treatment sessions may be needed for complete clearance and increased efficacy in some subjects.
    No preview · Article · Jan 2015 · Journal of Cosmetic and Laser Therapy
  • Bradley S Bloom · Lea Payongayong · Andrea Mourin · David J Goldberg
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    ABSTRACT: MATERIALS AND METHODS: Twenty-five subjects aged 35 to 70 years with Fitzpatrick skin Types I to IV and facial erythema of erythematotelangiectatic rosacea were enrolled in the trial. Subjects received 15 to 45 units of intradermal injections of abobotulinumtoxinA to the nasal tip, nasal bridge, and nasal alae. A nontreating investigator assessed the facial erythema of rosacea using a standardized grading system (0 = absent, 1 = mild erythema, 2 = moderate erythema, and 3 = severe erythema) to evaluate digital photographs at baseline, 1, 2, and 3 months after treatment. Statistical analysis of erythema grade included one-way repeated-measures analysis of variance and pairwise comparisons using SPSS (IBM Corporation) software.
    No preview · Article · Jan 2015 · Dermatologic Surgery
  • Margarita S. Lolis · David J. Goldberg
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    ABSTRACT: The conduct of medical research that involves human subjects has many ethical and legal implications. Great strides in protecting the welfare and safety of research participants have been made in the past 40 years due to a series of unethical events. This chapter will focus on the history and evolution of the ethical and legal measures that have been implemented to safely conduct human research.
    No preview · Chapter · Jan 2015
  • Patricia Lucey · David J Goldberg
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    ABSTRACT: As the skin ages, a deficiency in collagen occurs, thus injectable collagen products have become a sensible and popular option for dermal filling and volume enhancement. Several types of collagen have been developed over the years, including animal sources such as bovine and porcine collagen, as well as human-based sources derived from pieces of the patient's own skin, cadaver skin, and later cultured from human dermal fibroblasts. While collagen overall has a relatively safe, side effect profile, there are several complications, both early and late onset, that practitioners and patients should be aware of. Early complications, occurring within days of the procedure, can be divided into non-hypersensitivity and hypersensitivity reactions. The non-hypersensitive reactions include injection site reactions, discoloration, maldistribution, infection, skin necrosis, and the very rare but dreaded risk of vision loss, whereas the hypersensitivity reactions present usually as delayed type IV reactions, but can also rarely present as an immediate type I reaction. Late complications, occurring within weeks to even years after injection, include granuloma formation, foreign body reactions, and infection secondary to atypical mycobacteria or biofilms. This review will give a detailed overview of the complications secondary to cutaneous collagen injections. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
    No preview · Article · Dec 2014 · Facial Plastic Surgery
  • Andrew S Dorizas · Amer H Nassar · David J Goldberg
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    ABSTRACT: We determine if the use of Multispectral Digital Skin Lesion Analysis for the evaluation of nevi in children and possible detection of malignancies. Evidence gathered from a pivotal study involving 1,383 patients with 1,831-pigmented lesions. The isolated use of the pediatric population within this study was used to determine the specificity and sensitivity of such a device with comparison to a dermatologists evaluation. For all lesions from the assessed pediatric population the biopsy ratio was equivalent for the Multispectral Digital Skin Lesion Analysis device as for the dermatologists when performing as independent reviewers. Furthermore analyzed data suggests that dermatologists who incorporate the Multispectral Digital Skin Lesion Analysis device perform better than they would independently or if they were to follow the device blindly without incorporating their own judgment. An approach that integrates automated imaging technology like the Multispectral Digital Skin Lesion Analysis device, along with another diagnostic aid, with the end result being cost-effective, easy to use by even non-experts and comforting for the pediatric patient is likely to compete to be the new gold standard in successful early diagnosis and management of melanoma. J Drugs Dermatol. 2014;13(10):1269-1273.
    No preview · Article · Oct 2014 · Journal of drugs in dermatology: JDD
  • David J Goldberg · Carl S Hornfeldt
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    ABSTRACT: BACKGROUND Microfocused ultrasound has been shown to lift and tighten lax eyebrows, submental, and neck skin. OBJECTIVE The aim of this study was to evaluate the safety and effectiveness of microfocused ultrasound to lift, tighten, and smooth the buttocks. MATERIALS AND METHODS Thirty-one subjects, with buttock skin laxity, were entered into the study. The right buttock was treated with microfocused ultrasound. Subjects were evaluated for up to 180 days for improvement in overall lifting and tightening of the buttock. RESULTS Among subjects evaluated at 180 days, 89.5% showed improvement. However, when asked, most subjects would not recommend treatment to family or friends. CONCLUSION Although microfocused ultrasound clearly can be used to safely lift, tighten, and smooth the buttocks, better subject selection and newer developed transducers may lead to greater overall acceptance of this technique.
    No preview · Article · Oct 2014 · Dermatologic Surgery
  • Margarita S. Lolis · David J. Goldberg
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    ABSTRACT: Bipolar radiofrequency (RF) has been used to treat photodamage. Periorbital rhytides are often difficult to treat. In this study bipolar RF was assessed in the 20 subjects, who are in treatment of periorbital rhytides and it was proved that it can successfully treat the periorbital rhytides.
    No preview · Article · Jul 2014 · Journal of Cosmetic and Laser Therapy
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    ABSTRACT: Abstract Background: Skin laxity and cellulite on the buttocks and thighs are two common cosmetic concerns. Skin tightening with radiofrequency (RF) devices has become increasingly popular. Objective: The purpose of this study is to evaluate the efficacy and safety of a topical skin laxity tightening agent when used in combination an RF device Methods: A double-blinded, randomized clinical trial enrolled twenty females with mild to moderate skin laxity on the posterior thighs/buttocks. Each subject underwent two monthly treatments with a radiofrequency source (Alma Accent) to both legs. Subjects were then randomized to apply a topical agent (Skinceuticals Body Tightening Concentrate) twice daily to only one designated thigh/buttock throughout the eight week duration of the study. All subjects were evaluated for improvement in lifting, skin tone, radiance, firmness/tightness, skin texture, and overall appearance based on photographic evaluation by blinded investigators at 12 weeks following the final RF treatment. Results: A statistically significant improvement was found in overall appearance on both sides treated with the RF device when compared to baseline. However, the area treated with the topical agent showed a statistically significantly greater degree of improvement compared to the side where no topical agent was applied. No adverse effects were reported. Conclusion: The use of a novel skin tightening agent used post RF procedures is both safe and effective for treatment of skin laxity on the buttocks and thighs. Combined therapy leads to a better result.
    Full-text · Article · Jun 2014 · Journal of Cosmetic and Laser Therapy

  • No preview · Article · May 2014 · JAMA Dermatology
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    Full-text · Article · May 2014 · JAMA Dermatology

  • No preview · Conference Paper · May 2014
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    ABSTRACT: Importance Excisional skin cancer surgery is a common procedure, with no formal consensus for mitigating the risk of wrong-site cutaneous surgery.Objective To systematically consider the usefulness and feasibility of proposed methods for correct biopsy site identification in dermatology.Evidence Review Survey study with a formal consensus process. Item development was via a literature review and expert interviews, followed by 2 stages of a Delphi process to develop consensus recommendations.Findings In total, 2323 articles were reviewed in the literature search, with data extraction from 14. Twenty-five experts underwent 30-minute structured interviews, which were transcribed and coded. The resulting survey was composed of 42 proposed interventions by multiple stakeholders (biopsying physicians, operating physicians, nurses, ancillary staff, patients, caregivers, and family members) at 3 time points (day of biopsy, delay and consultation period, and day of definitive surgery). Two rounds of a Delphi process with 59 experts (25 academic and 34 private practice) scored the survey. Strong consensus was obtained on 14 behaviors, and moderate consensus was obtained on 21 other behaviors. In addition, a 2-state simultaneous algorithm was developed to model surgeon behavior on the day of definitive surgery based on surgeon and patient perceptions.Conclusions and Relevance When definitive surgery is performed after the initial biopsy and by a different surgeon, procedures can be implemented at several time points to increase the likelihood of correct site identification. The specific circumstances of a case suggest which methods may be most appropriate and feasible, and some may be implemented. The risk of wrong-site cutaneous surgery can be reduced but not eliminated.
    No preview · Article · Mar 2014
  • Amy E Rose · David J Goldberg
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    ABSTRACT: Objectives: To evaluate the safety and efficacy of a microsecond 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser for the treatment of facial telangiectasias. Methods: Subjects ages 35-70 with Fitzpatrick skin types I to III and facial telangiectasias underwent two treatments with a micropulse (0.65 ms) 1,064-nm Nd:YAG laser. Treatments were spaced 30 days apart, with a final evaluation 60 days after the second treatment. Evaluation included digital photography and an assessment of the degree of improvement on a scale from 1 to 5 by the subject and a nontreating investigator. Results: Twenty subjects (18 women, two men) with Fitzpatrick skin type II and III completed the study. The nontreating investigator rated the objective clinical response as total clearance (100% clear) in 10% (n = 2) of subjects, significant clearance (≥50% clear) in 75% (n = 15), and some clearance (0-49% clear) in 15% (n = 3). None of the subjects was rated as having no clearance or worsening. In terms of subjective clearance reported by subjects, 80% (n = 16) reported significant clearance, with the remainder reporting some clearance. No adverse events were reported. Conclusion: The micropulse 1,064-nm Nd:YAG successfully treated facial telangiectasias with a high degree of patient satisfaction, minimal discomfort, and no adverse events.
    No preview · Article · Mar 2013 · Dermatologic Surgery
  • Amy E Rose · David J Goldberg
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    ABSTRACT: Objective: To evaluate the safety and efficacy of intradermal injection of abobotulinumtoxinA for the treatment of oily skin. Methods and materials: Twenty-five patients with oily skin were treated in the forehead region with intradermal injections of botulinum toxin. Baseline and post-treatment sebum production was measured using a sebometer. Photographs were taken. Patients were also asked to rate their satisfaction with the treatment in terms of improvement in their oily skin. Results: Treatment with botulinum toxin resulted in significantly lower sebum production at 1 week and 1, 2, and 3 months after injection (p < .001, t-test). Twenty-one patients (91%) reported that they were satisfied (50-75% improvement) with intradermal botulinum toxin as a treatment for oily skin. [Correction added after online publication 7-Jan-2013: the number of satisfied patients has been updated] Conclusion: Intradermal injection of botulinum toxin significantly reduced sebum production in the forehead region, with a high degree of patient satisfaction. Intradermal botulinum toxin may be an effective treatment to reduce sebum production in patients with oily skin. Larger, randomized, blinded, placebo-controlled studies are warranted.
    No preview · Article · Jan 2013 · Dermatologic Surgery
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    ABSTRACT: BACKGROUND: A minimally invasive fractional bipolar radiofrequency (FRF) was developed. OBJECTIVE: To evaluate safety and efficacy of FRF in reducing face and neck rhytides and laxity. MATERIALS AND METHODS: This prospective, open-label, multicenter clinical trial enrolled 100 subjects with mild to severe facial and neck rhytides and laxity at seven centers in a per-protocol analysis. One single-pass FRF treatment was administered through five 32 g-needle electrode pairs at a preselected real-time fixed temperature of 62 to 78°C, energy duration for 3 to 5 seconds, and impedance restrictions of 200 to 3,000 Ohms, ensuring intradermal delivery. Five blinded dermatologists and plastic surgeons graded randomized standardized baseline and follow-up photographs of 53 and 42 subjects at 3- and 6-month follow-up intervals, respectively, using the Fitzpatrick wrinkle and Alexiades-Armenakas laxity scales. Subject assessments and adverse events were recorded in 100 subjects. RESULTS: Blinded evaluations revealed correct pre- and post-treatment identification in 100% of scored cases, mean improvement of 25.6% on the Fitzpatrick Wrinkle Scale and 24.1% on the Alexiades-Armenakas laxity scale at 6 months, and 100% response rate for rhytides and 95% for laxity. Subgroup analysis revealed maximal rhytid reduction in the mean target temperature of 66.7, energy duration of 4.2 seconds, and volume of denatured collagen of mm(3) denatured collagen group. Adverse events included transient erythema, edema, and ecchymoses, resolving within 1 to 5 days, and two incidents of temporary pinpoint depressions. More than 90% of subjects were satisfied or very satisfied. CONCLUSION: Real-time temperature-controlled FRF is a highly reproducible, safe, effective nonsurgical treatment of face and neck rhytides and laxity and provides important insights into neocollagenesis, neoelastogenesis, and clinical outcomes.
    No preview · Article · Dec 2012 · Dermatologic Surgery
  • Margarita S Lolis · David J Goldberg
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    ABSTRACT: Background: Fine lines and rhytides are clinically evident signs of photodamage. Traditionally, ablative and nonablative lasers have been used for nonsurgical facial rejuvenation, but their side effects and downtime have limited their use. Objective: Radiofrequency (RF) is novel nonablative technology originally used to target photodamage. It differs from lasers in that it uses an electric current rather than a light source. It is frequently used in dermatology to treat skin laxity, rhytides, acne vulgaris and scarring, and cellulite. The goal of this review is to summarize the various types of RF devices and their uses and to determine the evidence-based efficacy of these devices. Materials and methods: This article reviews the current literature on RF, its uses and clinical effectiveness, and a practical guide for application of the assorted RF devices. Results and conclusion: Results have been favorable for the different clinical uses of RF, but many studies are nonrandomized, noncomparative trials that use subjective means of evaluation. Overall, nonablative RF is a safe, tolerable, and effective tool for skin rejuvenation and cellulite treatment that produces modest results. RF should serve as an alternative but not as an equivalent substitute to surgery.
    No preview · Article · Aug 2012 · Dermatologic Surgery
  • David J. Goldberg
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    ABSTRACT: Although legal considerations can arise in the performance of any aspect of a dermatology practice, they are more likely to occur in the areas of diagnosis and treatment of skin cancers. Although there is no substantiated data about dermatologic skin cancer litigation, and specifically Mohs surgery, there are anecdotal suggestions that such malpractice claims have increased. Mohs surgeons, often performing some of the most complex skin cancer treatments, are clearly at risk for both ethical and legal issues related to their treatment. This chapter will look at the interplay between legal and ethical issues with an emphasis on those issues that specifically can arise in the practice of Mohs surgery.
    No preview · Chapter · Jun 2012
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    ABSTRACT: Part I of this two-part supplement brings together experts from the U.S., Europe, Canada, and Israel to discuss the state-of-the-art in soft tissue fillers in a fair-balanced, CME-accredited format. It includes a roundtable discussion on hyaluronic acid (HA) fillers that charts the clinical and scientific path that has led dermatologists from wrinkle-chasing to true volumetry. International case vignettes with commentary highlight a variety of applications for fillers'some currently available in the U.S., and some available elsewhere and on the American horizon. Topics covered include single-product and multi-product volumetry, anatomic and safety considerations, and the use of blunt injection microcannulas. Quick poll surveys provide an engaging snapshot of the faculty's personal approaches, with the first three surveys focusing on the palette of HA fillers. This is a CME supplement; visit the JDD Medical Education Library to participate in this activity and earn 2 AMA PRA Category 1 Credits.
    No preview · Article · Mar 2012 · Journal of drugs in dermatology: JDD

Publication Stats

150 Citations
26.38 Total Impact Points


  • 2009-2012
    • Icahn School of Medicine at Mount Sinai
      • Department of Dermatology
      Borough of Manhattan, New York, United States
  • 2006
    • University of British Columbia - Vancouver
      Vancouver, British Columbia, Canada