[Show abstract][Hide abstract]ABSTRACT: Fish oils have shown beneficial effects on various parameters in patients with coronary artery disease (CAD). The purpose of this study was to investigate whether the same effects can be demonstrated with a low dose of fish oil concentrate (FOC). Thirty-nine patients were studied and divided into two groups. Twenty were given 10 g fish oil (group A) and 19 were given 10 g placebo Italian olive oil (group B). Weekly anginal attacks (AA), weekly glyceryl trinitrate consumption (GTN), exercise tolerance time (ETT), serum triglycerides (ST), platelet aggregation ratio (PAR), and beta-thromboglobulin were measured at eight and twelve weeks after start of treatment. 1. The number of anginal attacks recorded by both groups decreased by 41% in group A reaching statistical significance (P < 0.05). No change was observed in group B. 2. GTN consumption decreased in group A (P < 0.05) with no significant change in group B (P:ns). 3. ETT increased significantly in group A eight and twelve weeks after start of treatment (20.6% P < 0.01, 22.6% P < 0.01). A smaller but insignificant increase was observed in group B (P: ns). 4. ST decreased significantly in group A by 22% eight weeks after start of treatment (P < 0.01) and to a lesser degree (11%) twelve weeks after start of treatment (P: ns). In group B, ST slightly increased (P: ns). 5. No statistically significant change was observed in either group in regard to PAR and beta-thromboglobulin (P: ns). These observations suggest that dietary supplementation with a low dose of FOC may have beneficial effects on the clinical status of patients with CAD.(ABSTRACT TRUNCATED AT 250 WORDS)
[Show abstract][Hide abstract]ABSTRACT: In a double blind study thirty nine patients with coronary heart disease were studied (mean age 54 range 30-79); twenty of them were treated with fish oil Maxepa 10 g daily and 19 with simiiar capsules of olive oil in the same dose (placebo group). Lipid analysis was performed before, at the 3 week and at the 12 week of the study. From the results of this study the following were observed: 1) The serum triglycerides decreased significantly in group A by 22% 8 weeks after starting treatment (p < 0.01) and to a lesser degree 11% after 12 weeks of treatment (p:NS). In group S triglycerides slightly increased after 12 weeks of treatment. 2) No statistically significant changes were observed as regards total cholesterol, and HDL-cholesterol. 3) None of the patients complained of any side effects. It is concluded that Maxepa fish oil is a safe lipid lowering agent that has a favourable effect especially on the reduction of the triglycerides levels.