C C Wang

Chang Gung University, Hsin-chu-hsien, Taiwan, Taiwan

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Publications (72)117.71 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Fingerprint identification system has caught people's eyes because personal mobile device is getting development rapidly recent years. Similar to the principle of touch screen panel device, but a fingerprint identification IC needs the design with higher sensitivity and more accurate design to sense the tiny variations on a fingerprint. So that it could be qualified and adopted at verifications of identifications, even for mobile payment in the future. The first section of this paper simply introduces to the principle of capacitive fingerprint sensor chip and the relation with its package design. The second part shows the package structure and each factor of package design which effects capacitive fingerprint sensor performance. Then, the simulation results are summarized and concluded all design factors to the performance. Of course, the best design rule is able to be found out. Later, JMP is participated in order to analyze more factors and advanced improve the sensitivity of package design. Final is the conclusion.
    No preview · Article · Jan 2015
  • S.-H. Huang · C.-W. Kuo · C.-C. Wang · T. Kitazawa
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    ABSTRACT: In this paper, we propose an open-stub compensation technique for passive equalizers used in high-speed digital communication systems. By simply lumping an open-stub to the conventional RL-type passive equalizer, the frequency-dependent channel loss from the long transmission path can be compensated, the frequency response of the channel becomes more flat and the bandwidth is wider. Compared proposed passive equalizer with typical RL passive equalizers, the simulation result shows this technique can improve 1 GHz in the flat region of S21 on a 60cmlong differential pair. This technique is successfully demonstrated the improvement of electrical performance about 57.4% on time domain. © 2014 The Institute of Electronics, Information and Communication Engineer.
    No preview · Article · Dec 2014
  • M.-H. Lu · C.-C. Wang · C.-W. Kuo · T. Kitazawa
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    ABSTRACT: In this paper, a novel power plane is proposed using the novel S-shaped bridge electromagnetic bandgap (EBG) structure to isolate the ground bounce noise (GBN) and ultrawideband suppression of simultaneous switching noise (SSN) in high-speed circuit. The S-shaped bridge effectively increases the inductance between two adjacent unit cells. And the ripples are held down by open stub to get higher attenuation level. The stop-band of -30 dB suppression bandwidth of the design |S31| is from 114 MHz to 8.5 GHz, The results of simulation and experiment will be presented to verify the good performance, and that it covers the entire noise band. © 2014 The Institute of Electronics, Information and Communication Engineer.
    No preview · Article · Dec 2014 · IEEE International Symposium on Electromagnetic Compatibility
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    ABSTRACT: Adipose-derived mesenchymal stem cells (ASCs) have been considered to be attractive and readily available adult mesenchymal stem cells (MSCs) and are becoming increasingly popular for use in regenerating cell therapy. However, recent evidence attributed a fibrotic potential to MSCs which differentiated into myofibroblasts with highly increased α-smooth muscle actin (α-SMA) expression while transplanted into an injured/regenerating liver in mice. In this study, we studied the role of miR-27b in ASCs and their regenerative potential after partial liver resection in rats. ASCs transfected with control siRNA or miR-27b were intravenously injected into autologous rats undergoing 70% partial hepatectomy (PH). Our data showed that the regenerative capacities of ASCs with overexpressed miR-27b were significantly higher compared with control ASCs. However, the enhanced regeneration, hepatic differentiation, and suppressed liver inflammation, as well as fibrotic activity, were significantly reverted by ZnPP coadministration (heme oxygenase-1 [HO-1] inhibitor) indicating an important role of HO-1 in the regenerating and cytoprotective activities of miR-27b–transfected ASCs. We demonstrated that administration of autologous ASCs overexpressed with miR-27b enhances rapid and early liver regeneration and, importantly, preserves function after PH. The ASCs with miR-27b overexpression might offer a viable therapeutic option to facilitate rapid recovery after liver resection.
    No preview · Article · May 2014 · Transplantation Proceedings
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    ABSTRACT: An open-stub compensation technique is proposed for passive equalisers used in high-speed digital communication systems. By simply lumping an open stub to the conventional RL-type passive equaliser, the frequency-dependent channel loss from the long transmission path can be compensated, the frequency response of the channel becomes more flat and the bandwidth is wider. On comparing the proposed passive equaliser with typical RL passive equalisers, the simulation results show that the proposed technique can achieve an improvement by 1 GHz in the flat region of S21 on a 60 cm-long differential pair. Thus, the proposed technique successfully demonstrates an improvement in electrical performance of about 57.4% in the time domain.
    No preview · Article · Nov 2013 · Electronics Letters
  • S.W. Guan · C.W. Kuo · H.Y. Wang · C.S. Hsu · S.M. Wu · C.C. Wang
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    ABSTRACT: A new type of differential transmission line with a bend is proposed to reduce differential-to-common-mode conversion noise for high-speed digital circuits. The hybrid structure consists of alternating edge-coupled and broadside-coupled transmission line sections which has the effect of reducing the mode conversion noise by at least 20 dB up to 10 GHz, whereas the differential insertion loss remains low. In addition, in the time domain, the common-mode noise is lower than the conventional edge-coupled differential transmission line bend. The performance of the proposed structure with a bend is demonstrated both numerically and experimentally. The measurement results agree very well with the simulation results from the three-dimensional full-wave solver.
    No preview · Article · Aug 2013 · Electronics Letters
  • S.-W. Guan · C.-W. Kuo · C.-C. Wang · T. Kitazawa
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    ABSTRACT: The co-design of power and signal integrity issues on a quad flat non-lead (QFN) package is described. A novel decoupling capacitor is achieved by separating the die pad and footprint, coating a solder mask on the footprint and connecting the footprint to the printed circuit board power plane through a via. Large capacitance between power (footprint) and ground (die pad) resulted from the thin mask and large die pad lowering the input impedance of the power delivery network without parasitic effects at low frequency. A power bridge and a ground bridge are introduced to substitute the wire bond to decrease the inductance and hence the impedance magnitude up to 30%, thus enhancing the power integrity at high frequency. A modified design called hybrid power/ground exhibits great signal integrity by providing good reference for signals. The thermal dissipation is also better than the first design through direct contact of the die pad and the footprint ground regions. The overall design demonstrates excellent broadband performance for signal and power integrity.
    No preview · Article · Jul 2012 · Electronics Letters
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    ABSTRACT: The aim of this study was to evaluate portal vein stenosis (PVS) in pediatric liver transplantation (PLT) using Doppler ultrasound (DUS) before and after interventional management for hemodynamic changes. From 2000 to 2010, we encountered 11 PVS cases among 180 PLT that were evaluated using DUS and computed tomography (CT) angiography (CTA); all underwent portal stenting. DUS was used to monitor portal hemodynamics. For the diagnosis of PVS, we investigated multiple parameters including stenotic size (SS), stenotic ratio (SR) (SR [%]=PRE-SS/PRE [PRE=stenotic size]), portal flow velocity ratio (VR) (VR=VS/PRE [PRE=velocity at prestenotic site; VS=peak velocity at stenotic site]), spleen size, and platelet count. The incidence of PVS was 5.6% (11/180). The PV was 2.5 mm using DUS and 2.7 mm using CTA. The average SR was 65% fitting the criterion. Low prestenotic portal flow<12 cm/sec and high peak velocity in the stenotic segment (up to 147 cm/sec) were observed in 6 cases. The VR value was high at 7.5:1 and there was splenomegaly with thrombocytopenia. After portal vein stenting, hyperperfusion occurred might after reopening the stenosis: the flow increased to an average of 34 cm/sec and then flow decreased slowly to a stable level 2 weeks later. The size of the spleen decreased from 17 to 12 cm and the thrombocytopenia also improved with platelet counts increasing from 67×10(3) to 178×10(3)/μl at 2 months follow-up. The changes in portal flow, portal vein size, spleen size, and platelet count were significant (P<.05). PVS is diagnosed using DUS by increased intrahepatic PV dilatation, peak flow at the stenotic site, discrepant VR. Early portal stenting showed a better prognosis. DUS is essential and effective for hemodynamic monitoring and management of PVS.
    Full-text · Article · Mar 2012 · Transplantation Proceedings
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    ABSTRACT: Recent proteomic approach allows us to target on specific molecules underlying the common mechanism between experimental and clinical liver allograft tolerance. Especially, new insight has been gained from our studies since we found that post-transplant autoimmune responses with high titer of anti-nuclear antibodies against histone H1 and high mobility group box 1 (HMGB1) play an important role in the induction of liver allograft tolerance in OLT rats and clinical drug-free OLT patients. Our previous studies showed that either treatment of recipient rats with commercially available histone H1 polyclonal Ab or immunization with calf thymus histone H1 could prolong allograft survival in heterotopic heart transplantation. We have also reported that the blockade of histone H1 modulated dendritic cells toward tolerogenic status, decreased the cytotoxicity of lymphokine activated killer and natural killer cells, and induced CD4+CD25+ T-cells. For further analysis of this mechanism, we generated an immunosuppressive histone H1 monoclonal Ab (16G9 mAb) and determined one peptide (designated SSV) that binds directly to 16G9 mAb. The binding of SSV to 16G9 mAb or serum of both tolerogeneic OLT rats and clinical drug-free OLT patients, was inhibited by histone H1. Furthermore, immunization of mice with SSV induced immunosuppression in serum, suggesting that SSV was an epitope responsible for the immunosuppressive activity of 16G9 mAb. 16G9 mAb and peptide SSV will allow us to establish a novel diagnostic and therapeutic strategy in transplantation. This article reviews our work exploring how the autoimmune response against nuclear proteins is involved in liver transplantation immunology.
    No preview · Article · Jan 2011 · Current Trends in Immunology
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    ABSTRACT: To evaluate the postoperative portal vein stenosis (PVS) and the diagnostic efficiency of Doppler ultrasound (DUS) in adult living donor liver transplantation (ALDLT). From January 2007 to December 2008, 103 ALDLTs were performed and postoperatively followed by routine DUS. The morphologic narrowing at the anastomotic site (AS) of the PVS was analyzed. We calculated the PV stenotic ratio (SR) using the following formula: SR (%)=PRE-AS/PRE (PRE=pre-stenotic caliber). An SR>50% was defined as the critical point for PVS. We also calculated the velocity ratio (VR) between the AS and PRE, and set the significant VR as >3:1. Statistical analyses were carried out to determine clinical significance. Using the definition of morphologic PVS by DUS, there were total 20 cases (19.4%) in this series with SR>50%, which included 17 cases with VR>3:1. Eight cases of severe PVS had a stenotic AS>5 mm and subsequently underwent interventional management. Doppler criteria of SR and VR values were elevated up to 75.8% and 7.5:1, respectively, in these treated cases. Two cases of severe PVS subsequently developed PV thrombosis. Intervention by balloon dilation and/or stenting was performed successfully in this PVS case. DUS is the most convenient and efficient imaging modality to detect and follow postoperative PVS in ALDLT. The Doppler criteria of SR and VR are both sensitive but less specific. Cases of AS<5 mm require interventional management for good long-term graft survival.
    No preview · Article · Apr 2010 · Transplantation Proceedings
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    ABSTRACT: This paper formulates generalized transformer efficiency associated with the applications of Above-IC multifilar transformers to multiport integrated passive devices (IPDs). The formulation derives the power loss ratio for a multifilar transformer in multiport configuration based on a terminated microwave network and then leads to the expression of passive efficiency using the concept of power conservation. For demonstration, the S-parameters for several different types of three-port transformers have been measured to compute their passive efficiency and further predict the minimum available insertion loss of the three-port IPDs such as baluns and combiners that use these three-port transformers.
    No preview · Article · Jan 2010 · Proceedings - Electronic Components and Technology Conference
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    ABSTRACT: The impact of strain induced oxide trap charge on the performance and reliability of contact etch stop SiN layer capped, fully silicided metal gate, fully depleted SOI (FDSOI) CMOSFET is investigated. For an ultra thin nitride oxide, the position of these oxide trap charge can be evaluated by variable frequency noise spectrum and variable frequency charge pumping technique. Gate oxide film bending caused by net stress from these strain technologies was considered as the main reason for bulk oxide trap charge formation. We find that a strained SOI MOSFET with a thinner SOI is more subjective to the stress than the thicker one, and the thinner SOI device possesses a higher oxide/Si interface trap charge density which will degrade the channel mobility. On the other hand, more bulk oxide trap, which existed in the strained device having a thicker SOI, was the dominate factor on current/voltage stress induced device degradation.
    Full-text · Article · Dec 2009
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    ABSTRACT: This paper presents design and modeling techniques of integrated passive devices (IPDs) that can be stacked with RF chips in a highly integrated and miniaturized 3D system-in-package (SiP) for wireless applications. The research starts to study winding and modeling techniques for high efficiency planar transformers. Based upon the proposed and modeled planar transformers, the research explores novel planar transformer-based structures for various kinds of wireless passive components including baluns, bandpass filters and power combiners to achieve miniature size as well as high performance. The IPDs presented in this study are manufactured in an Above-IC (AIC) process that is ready for mass production in semiconductor industry.
    No preview · Conference Paper · Jun 2009
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    ABSTRACT: The purpose of this study was to assess factors influencing the end-tidal concentrations of isoflurane within a bispectral index (BIS) range of 45–55 among healthy live liver donors (n = 11), chronic hepatitis B patients undergoing hepatectomy hepatocellular carcinoma (n = 10), and end-stage liver disease patients undergoing liver transplantation (n = 7). Patients data collected prospectively were compared among the groups using one-way analysis of variance as well as univariate and multivariate techniques. The results showed that end-stage liver disease patients required the least end-tidal isoflurane concentration. Patients with hepatocellular carcinoma with cirrhosis required intermediate end-tidal isoflurane concentrations; healthy live liver donors required the highest end-tidal isoflurane concentrations to provide sufficient anesthetic depth, as monitored by a target BIS (range, 45–55). Upon multivariate analysis, liver function was the only significant factor influencing the likelihood of lowering the end-tidal isoflurane concentration by 4 hours after anesthesia induction (P = .026). In conclusion, we recommend a preset target BIS within the range of 45–55 to monitor the depth of anesthesia during partial hepatectomy and liver transplantation because end-tidal isoflurane concentration requirements are different for patients with various liver status. This strategy may protect the patients from intraoperative recall or anesthesia over-depth as a consequence of insufficient or overdose of anesthesia, respectively.
    No preview · Article · Nov 2008 · Transplantation Proceedings
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    ABSTRACT: We sought to compare the effects of operation room temperature (ORT) at typical ambient environment (19-21 degrees C) and ORT at 24 degrees C on the core temperature of patients undergoing living donor hepatectomy. Sixty-two patients undergoing living donor hepatectomy were divided into 2 groups. In group I (n = 31), surgery was performed at typical ambient ORT, and in group II (n = 31) in ORT at 24 degrees C. Anesthesia and measures to prevent heat loss, except ORT, were all the same. Nasopharyngeal temperature (NT) was recorded after anesthesia induction, then hourly until completion of the operation. Changes in NTs were analyzed as well as patient age, weight, anesthetic duration, blood loss, intravenous fluids, total urine output, and pre- and postoperative hemoglobin and hematocrit values. The Mann-Whitney U test was used for comparisons between groups. The patient's characteristics between groups were not statistically different. However, a significantly higher core temperature was noted in group II compared with group I. Increased ORT from 19 to 21 degrees C to 24 degrees C resulted in an increased core temperature of at least 0.5 degrees C during living donor hepatectomy.
    No preview · Article · Nov 2008 · Transplantation Proceedings
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    ABSTRACT: ObjectiveEarly diagnosis and appropriate management of vascular and biliary complications after living donor liver transplantation (LDLT) result in longer survival. We report our institutional experience regarding radiological management of these complications among patients with biliary atresia (BA) who underwent LDLT.MethodsWe analyzed the records of 116 children. All patients underwent Doppler ultrasound (US) at operation, daily for the first 2 postoperative weeks, and when necessary thereafter. After primary evaluation using US, the definite diagnosis of postoperative complication was confirmed using computed tomography, magnetic resonance imaging, and/or operation.ResultsThere were 61 boys and 55 girls. The overall mean age was 2.69 years. The overall mean preoperative weight and height were 13.06 kg and 83.79 cm, respectively. There were 28 (24.13%) biliary and vascular complications. These were cases of biliary stricture (n = 5), bile leakage (n = 3), hepatic artery stenosis (n = 6), hepatic vein stenosis (n = 4), and portal vein thrombosis (n = 17). The diagnostic accuracy of US in detecting biliary complication, hepatic artery stenosis, hepatic venous stenosis, and portal vein thrombosis was 95.69%, 97.41%, 100%, and 100%, respectively. US in combination with multiple imaging modalities and clinical suspicion resulted in 100% diagnostic accuracy. Percutaneous transhepatic cholangiography, thrombolysis, balloon angioplasty, and stent placement were performed for the complications noted. There was an early mortality due to multiple-organ failure after failed radiological invention and subsequent surgical management.ConclusionsDoppler US is accurate in detecting postoperative complications after pediatric LDLT for BA. Radiological interventions for vascular and biliary complications are effective and safe alternatives to reconstructive surgery.
    No preview · Article · Nov 2008 · Transplantation Proceedings
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    ABSTRACT: Portal hyperperfusion in a small-size liver graft is one cause of posttransplant graft dysfunction. We retrospectively analyzed the potential risk factors predicting the development of portal hyperperfusion in 43 adult living donor liver transplantation recipients. The following were evaluated: age, body weight, native liver disease, spleen size, graft size, graft-to-recipient weight ratio (GRWR), total portal flow, recipient portal venous flow per 100 g graft weight (RPVF), graft-to-recipient spleen size ratio (GRSSR) and portosystemic shunting. Spleen size was directly proportional to the total portal flow (p = 0.001) and RPVF (p = 0.014). Graft hyperperfusion (RPVF flow > 250 mL/min/100 g graft) was seen in eight recipients. If the GRSSR was < 0.6, 5 of 11 cases were found to have graft hyperperfusion (p = 0.017). The presence of portosystemic shunting was significant in decreasing excessive RPVF (p = 0.059). A decrease in portal flow in the hyperperfused grafts was achieved by intraoperative splenic artery ligation or splenectomy. Spleen size is a major factor contributing to portal flow after transplant. The GRSSR is associated with posttransplant graft hyperperfusion at a ratio of < 0.6.
    Full-text · Article · Dec 2006 · American Journal of Transplantation
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    C L Hsueh · YH Huang · C C Wang · CY Chen
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    ABSTRACT: Photooxidation of azo dye Reactive Black 5 (RB5) by H202 was performed with a novel supported iron oxide in a batch reactor in the range of pH 2.5-6.0. The iron oxide was prepared through a fluidized-bed reactor (FBR) and much cheaper than the Nafion-based catalysts. Experimental results indicate that the iron oxide can significantly accelerate the degradation of RB5 under the irradiation of UVA light (wavelength = 365 nm). An advantage of the catalyst is its long-term stability, which was confirmed through using the catalyst for multiple runs in the degradation of RB5. In addition, this study focused mainly on determining the proportions of homogeneous catalysis and heterogeneous catalysis in the batch reactor. Conclusively, although heterogeneous catalysis contributes primarily to the oxidation of RB5 during pH 4.5-6.0, the homogeneous catalysis is of increasing importance below pH 4.0 because of the Fe ions leaching from the catalyst to solution.
    Preview · Article · Feb 2006 · Water Science & Technology
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    ABSTRACT: The color Doppler ultrasound has been used to evaluate hepatic vein (HV) outflow insufficiency based on flow velocity and waveforms. In our experience, some cases with flat waveforms are clinically asymptomatic. The parameters of HV flow velocity and waveforms are not always correlated with clinical problems. So, we proposed that total HV flow volume (HVFV) may be a more reliable index. From August 2001 to July 2003, 31 cases among 48 adult-to-adult living related transplants of a right liver graft had one HV anastomosis. HV velocity, waveforms, and HVFV were compared both before and after transplantation. We set the minimal HVFV ratio at 80% based on the original HVFV before graft retrieval. There was no significant difference in HVFV before liver graft retrieval between the 2 groups, but there was a significant change after transplantation. There were no cases of HV insufficiency among group A patients (>80%), whose HVFV ranged from 397 to 1181 mL/min with ratios from 75% to 180% (mean 115%). In group B, there were 4 complicated cases with prolonged severe ascites (<80%) with HVFV ratios from 56% to 76% (mean 66%). Fisher exact test showed a great significance (P < .001). Thus the preliminary criteria of 80% minimal HVFV ratio allows detection of HV insufficiency for further interventional management.
    Full-text · Article · Mar 2005 · Transplantation Proceedings
  • H.Z. Liu · H.K. Huang · C C Wang · Y H Wang · C H Chang · W Wu · C L Wu · C S Chang
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    ABSTRACT: A high linearity, high efficiency 1.9 GHz power amplifier sub-system using a 50 mm AIGaAs/InGaAs/GaAs PHEMT for PHS 500 mW base station is demonstrated. Under 10 V and 3.8 A bias condition, the output stage amplifier has achieved 12.5 dB small-signal gain, 43.7 dBm PldB with 43% PAE and 44 dBm saturated output power with 41% PAE. For the amplifier sub-system, the ACPR at 600 KHz and 900 KHz offset from 1.906 GHz when operating at 38.5 dBm output power with Π/4-DQPSK signal are better than 75 dBc and 79 dBc, respectively.
    No preview · Conference Paper · Jan 2005

Publication Stats

662 Citations
117.71 Total Impact Points

Institutions

  • 1998-2014
    • Chang Gung University
      • Division of Physiology and Pharmacology
      Hsin-chu-hsien, Taiwan, Taiwan
  • 2013
    • National Kaohsiung University of Applied Science
      • Department of Electronic Engineering
      Kao-hsiung-shih, Kaohsiung, Taiwan
  • 1997-2010
    • Chang Gung Memorial Hospital
      • • Department of Diagnostic Radiology
      • • Department of Surgery
      • • Department of Pathology
      T’ai-pei, Taipei, Taiwan
  • 2009
    • National University of Kaohsiung
      Kao-hsiung-shih, Kaohsiung, Taiwan
  • 2002-2005
    • National Cheng Kung University
      • Institute of Microelectronics
      Tainan, Taiwan, Taiwan