Wanying Xie

Singapore General Hospital, Tumasik, Singapore

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Publications (5)6.83 Total impact

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    ABSTRACT: We present a case of a 63-year-old gentleman, who had an initial negative prostate needle biopsy, but persistently elevated prostate-specific antigen levels. An magnetic resonance imaging study of the prostate failed to demonstrate the presence of malignancy. 18F-fluorocholine positron emission tomography/computed tomography (PET/CT) was then acquired which revealed suspicious prostate lesions. These were confirmed by subsequent surgery and histology to represent prostatic carcinoma.
    No preview · Article · Sep 2014
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    ABSTRACT: Rationale and Objectives Diffusion-weighted imaging (DWI) of the pelvis at 3T is prone to artifacts that diminish the image quality. Readout-segmented echo-planar imaging (RS-EPI) is a new DWI technique that can reduce the artifacts associated with standard single-shot echo-planar imaging (SS-EPI) DWI. The purpose of this study was to evaluate the feasibility and image quality of RS-EPI in pelvic DWI compared to SS-EPI on a 3T imaging system. Materials and Methods Thirty patients underwent pelvic DWI on a 3T scanner with SS-EPI and RS-EPI techniques. Two blinded readers independently assessed each set of images for geometric distortion, image blurring, ghosting artifacts, lesion conspicuity, and overall image quality on a 7-point scale. Qualitative image scores were compared using paired Wilcoxon signed rank test. Interreader correlation was assessed by Spearman rank correlation. Results Geometric distortion, imaging blurring, ghosting artifacts, lesion conspicuity, and overall image quality were rated significantly better by both readers for RS-EPI technique (P < .01 for all parameters). There was moderate–high correlation between the readers (r = 0.649–0.752) for all parameters apart from lesion conspicuity (r = 0.351). Both readers preferred the RS-EPI set of DWI images in most of the cases (reader 1: 0.87, 95% CI 0.74–0.99; reader 2: 0.77, 95% CI 0.61–0.93). Mean difference and limits of agreement between apparent diffusion coefficient (ADC) values obtained from the two methods were 0.01 (−0.08, 0.10) × 10−3 mm2/s. Conclusions RS-EPI DWI images showed improved image quality compared to SS-EPI technique at 3T. RS-EPI is a feasible technique in the pelvis for producing high-resolution DWI.
    No preview · Article · Apr 2014 · Academic radiology
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    ABSTRACT: Locoregional treatment of hepatocellular carcinomas using yttrium-90 (Y-90) microspheres is an emerging modality, and involves the administration of such radioactive particles directly into the hepatic arterial vasculature. We present the case of a 58-year-old gentleman undergoing evaluation for Y-90 microsphere therapy for hepatocellular carcinoma, in which our findings suggest that significant hepatic arterial portal venous shunting detected during the angiogram maybe a predictor of poor localization of microspheres in the turmor, and that centers that utilize body surface area (BSA) approaches for dosimetry should take note of such findings.
    No preview · Article · Apr 2013
  • Wanying Xie · Ajit Kumar Padhy · Wai Yin Wong
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    ABSTRACT: Osteosarcoma metastases frequently occur in the lungs or the skeleton. Bone scans play an important role in disease staging by identifying other skip areas of skeletal involvement as well as extraosseous metastases. We report a case of aggressive osteosarcoma, with bone metastases and extraosseous areas of involvement in the lungs, distant lymph nodes, and peritoneal and subcutaneous metastasis seen in a preoperative Tc-99m methylene diphosphonate bone scan. These findings were confirmed with histology and correlative cross-sectional imaging.
    No preview · Article · Aug 2012 · Clinical nuclear medicine
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    ABSTRACT: The 2005 American Association for Study of Liver Diseases (AASLD) diagnostic criteria allow non-invasive diagnosis of hepatocellular carcinoma (HCC) based on their enhancement pattern but we have observed a high incidence of atypical enhancement characteristics in HCC associated with portal vein thrombosis. This study seeks to examine the radiological features of this particular subgroup. Patients with HCC and portal vein thrombosis who underwent pre-treatment multiphasic CT imaging were drawn from a surgical database. The arterial, portal venous and delayed phase images were assessed qualitatively and quantitatively (with region of interest [ROI] analysis) for lesion hypervascularity and washout. The background enhancement of the left and right lobes of the liver was also quantifi ed by ROI analysis. Twenty-fi ve lesions in 25 patients were selected for analysis. Qualitative analysis showed that 10/25 (40%) lesions demonstrated arterial hypervascularity while 16/25 (64%) lesions showed washout. Ten out of 25 (40%) lesions demonstrated both arterial hypervascularity and washout. Quantitative analysis showed that the average absolute lesion enhancement from precontrast to arterial phases was 49.1 (± 17.1) HU for hypervascular lesions compared to 23.8 (± 16.6) HU for non-hypervascular lesions (P <0.01). The mean absolute enhancement of the background liver parenchyma in the arterial phase was 13.79 (± 7.9) HU for hypervascular lesions compared to 36.6 (± 30.6) HU for non-hypervascular lesions (P = 0.03). A large proportion of HCC with portal vein thrombosis lack characteristic arterial hypervascularity, which may be secondary to compensatory increased arterial supply to the background liver. This is a potential pitfall when applying imaging criteria for diagnosis of HCC.
    Full-text · Article · Oct 2011 · Annals of the Academy of Medicine, Singapore