Olivia Boccara

Université de Versailles Saint-Quentin, Versailles, Île-de-France, France

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Publications (5)6.01 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin. The epidemiological factors strongly associated with this tumor are: age over 65 years, fair skin, chronic sun exposure and immune suppression. Data are sparse in the literature and many questions remain unanswered regarding the diagnosis and treatment of this tumor. To provide clinical practice guidelines for the diagnosis and treatment of MCC. The literature data were analyzed and the current American and German practice guidelines were compared. Consensus items between these two guidelines were adopted as recommendations. Regarding discordant points, a formalized expert consensus process was devised. The guidelines were then written up by an editorial panel and validated by the Cutaneous Oncology Group of the French Society of Dermatology. The guidelines were drawn up according to three levels of scientific evidence: (a) complete agreement between the American and German guidelines; (b) the results of the formalized expert consensus process; and (c) the expert opinion of the steering group, based on analysis of the available evidence. The guidelines presented here are up-to-date recommendations on the clinical and pathological procedures for MCC diagnosis, staging, surgical treatment, sentinel node biopsy, radiotherapy and follow-up. These guidelines for diagnosis and treatment of MCC should standardize MCC management, which may not be optimal in France today.
    No preview · Article · Apr 2012 · European journal of dermatology: EJD
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    ABSTRACT: Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is an effective treatment for several conditions such as Bowen's disease, subsets of basal cell carcinomas and actinic keratosis. Surgical resection is the first-choice therapy for extramammary Paget's disease (EMPD), but extensive resection is highly invasive and recurrences are frequent. We report two cases of genital EMPD treated by PDT with partial efficacy. The first patient, a 78-year-old male, suffered from pubic and scrotal Paget's disease for 6 years despite numerous treatments. The second patient, a 78-year-old female, had vulvar involvement for 2 years that was resistant to multiple treatments. The disease was recurrent and chronic with important pruritus and significant impact on the quality of life. Methyl 5-aminolevulinate was applied for 3 h, and irradiation was applied with red light (630 nm) using a total light dose of 37 J/cm(2) for a period of 10 min. The patients were treated every 2 to 4 weeks for a total of at least three treatments. Both patients experienced a partial transient reduction in their symptoms. One patient had a partial transient remission (< 50% reduction of the involved surface), whereas in the other patient, PDT failed to reduce the surface area of the lesions.
    Full-text · Article · Feb 2012 · Photodermatology Photoimmunology and Photomedicine
  • O Boccara · C Girard · L Mortier · G Bens · P Saiag · B Guillot
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    ABSTRACT: Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma that originates in the skin. Epidemiological factors strongly associated with MCC are: age over 65 years, fair skin, history of extensive sun exposure and chronic immune suppression. The literature is sparse and many questions currently remain unanswered regarding optimal treatment of MCC. To provide clinical practice guidelines for the diagnosis and treatment of MCC. Literature data were analysed and the existing German and American practice guidelines were compared. Where German and US guidelines were identical, the recommendations in question were adopted. Regarding discordant points, a formalized consensus process was devised. The guidelines were then written by an editorial group and validated by the cutaneous oncology group of the French Society of Dermatology. The guidelines were drawn up according to three levels of scientific evidence: a: complete agreement between the German and American guidelines; b: results of the formalized consensus process; c: expert opinion of the steering group based on available evidence. Our guidelines present up-to-date recommendations on clinical and pathological procedures for diagnosis, staging, surgical treatment, sentinel lymph node biopsy, radiotherapy and follow-up. We created a set of diagnostic and treatment guidelines in order to standardize management of MCC, which may be not optimal throughout France.
    No preview · Article · Jan 2012 · Annales de Dermatologie et de Vénéréologie
  • O. Boccara · C. Girard · L. Mortier · G. Bens · P. Saiag · B. Guillot
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    ABSTRACT: Le carcinome à cellules de Merkel est une tumeur neuroendocrine cutanée rare et agressive du sujet âgé, favorisée par le soleil et l’immunodépression. La littérature étant pauvre, la prise en charge diagnostique et thérapeutique est controversée et donc hétérogène.
    No preview · Article · Jun 2011 · Annales de Dermatologie et de Vénéréologie
  • B Guillot · O Boccara · L Mortier · G Bens · C Girard · P Saiag
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    ABSTRACT: Le carcinome à cellules de Merkel (CCM) est une tumeur rare développée à partir des cellules neuroendocrines de la peau. Sa prise en charge diagnostique et thérapeutique n’est pas consensuelle. Dans le but de rédiger des recommandations, le groupe de cancérologie cutanée de la Société française de dermatologie s’est appuyé sur les recommandations existant aux États-Unis et en Allemagne. Les accords entre les deux recommandations ont été validés par le groupe et, devant le nombre important de discordances, le recours à la méthode du consensus formalisé d’experts a été retenu.
    No preview · Article · Jun 2011 · Annales de Dermatologie et de Vénéréologie

Publication Stats

40 Citations
6.01 Total Impact Points

Institutions

  • 2012
    • Université de Versailles Saint-Quentin
      Versailles, Île-de-France, France
  • 2011-2012
    • Hôpital Ambroise Paré – Hôpitaux universitaires Paris Ile-de-France Ouest
      Billancourt, Île-de-France, France
    • Hôpital Ambroise Paré Paul Desbief
      Marsiglia, Provence-Alpes-Côte d'Azur, France

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