J J Lu

Huazhong University of Science and Technology, Wu-han-shih, Hubei, China

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Publications (1)1.09 Total impact

  • F Tian · J J Lu · L Wang · L Li · J Yang · Y Li · Y Q Liu · G X Shen · Y T Tu · J Tao
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    ABSTRACT: Numerous molecular events have been associated with the development of malignant melanoma (MM). The cellular FLICE-like inhibitory protein (c-FLIP) was originally identified as an inhibitor of death-receptor signalling through competition with FADD-like interleukin-1β-converting enzyme (FLICE; also known as caspase-8) for recruitment to the FAS-associated death domain (FADD), and it has been suggested recently that c-FLIP is required for the survival and proliferation of various cell types. Aim.  To investigate the relationship of c-FLIP expression with the clinicopathological features of MM. Immunohistochemical staining with anti-c-FLIP antibody was performed on tissue samples taken from 77 MMs and 20 naevi. The proliferative cells were visualized by staining with Ki-67 antibody. Annexin V-propidium iodide labelling, a marker for chromatin condensation, was performed to observe the rate of cell apoptosis by flow cytometry. Expression of c-FLIP was increased in MM tissue compared with the matched pigmented naevi. The c-FLIP expression was significantly associated with the histological type and Clark level of MM, and correlated strongly with the Ki-67 labelling index. Downregulation of c-FLIP might increase apoptosis in MM cell lines. c-FLIP might play an important role in the obtaining of aggressive biological behaviours and be useful in predicting prognosis of patients with MM.
    No preview · Article · Nov 2011 · Clinical and Experimental Dermatology

Publication Stats

10 Citations
1.09 Total Impact Points


  • 2011
    • Huazhong University of Science and Technology
      • Department of Dermatology
      Wu-han-shih, Hubei, China