[Show abstract][Hide abstract]ABSTRACT: OBJECTIVE. Much attention has recently been focused on the underlying role of circulating inflammatory biomarkers such as high-sensitivity C-reactive protein for predicting cardiovascular disease progression. We therefore set out to assess the relationship between the value of high-sensitivity C-reactive protein and (i) coronary artery disease severity, and (ii) left ventricular end diastolic pressure. DESIGN. A cross-sectional study. SETTING. The Shafa hospital in Kerman, Iran. PATIENTS. A total of 107 consecutive patients referred for coronary angiography from January 2008 to January 2009 were prospectively studied. INTERVENTION AND MAIN OUTCOME MEASURES. All patients underwent coronary angiography. They all had undergone left ventricular end diastolic pressure measurement, involving a 6-Fr pigtail catheter and a properly zeroed fluid-filled pressure transducer. For each patient, the level of high-sensitivity C-reactive protein was also determined using enzyme-linked immunosorbent assay kits. RESULTS. The high-sensitivity C-reactive protein levels could strongly predict increased left ventricular end diastolic pressure (standardised beta=1.010; P=0.008), with other patient variables being confounders, but there was no significant association between these levels and Gensini scores. Multiple linear regression analysis showed that among the study parameters, systolic hypertension (standardised beta=1.611; P=0.047) and a family history of coronary artery disease (standardised beta=1.911; P=0.005) were the main predictors of high Gensini scores in study patients. CONCLUSION. High-sensitivity C-reactive protein level is a clinical parameter that could predict left ventricular end diastolic pressure and left ventricular dysfunction, but was not associated with the severity of coronary artery disease.
Preview · Article · Jun 2013 · Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine
[Show abstract][Hide abstract]ABSTRACT: This article was to present the sampling and measurements methods and the main preliminary findings of the KERCADR cohort study (first round) in an urban and peri-urban setting, Kerman, southeastern Iran 2009-11.
5900 (3238 female) people aged between 15 to 75 years were recruited in the household survey by non-proportional to size one-stage cluster sampling. Trained internal specialists, general practitioners, clinical psychologists and dentists have assessed the study subjects by person-assisted questionnaires regarding different NCD risk factors including cigarette and opium smoking, physical activity, nutrition habits, anxiety, depression, obesity, hypertension and oral health. Blood samples were also collected for determining FBS, HbA1c, cholesterol and triglyceride. Weighted standardized prevalence estimates were calculated by STATA 10 survey analysis package.
The participation rate was more than 95% in all subgroups. Cigarette smoking (18.4% vs. 1.2%), opium use (17.8% vs. 3.0%) and triglyceridemia (16.1% vs. 12.0%) were significantly higher among men than women. In contrast, women were presented with higher level of sever anxiety (29.1% vs. 16.7%), obesity (16.8% vs. 9.2%), low-physical activity (45.1% vs. 39.2%) and uncontrolled diabetes (60.2% vs. 31.0%). More than 68% of all subjects have presented with moderate to severe gingival index scores.
The first round of the KERCADR cohort with sufficient sample size and response rate provided precise estimates for the main clinical and para-clinical NCD risk factors. These evidences need to be translated into public health interventions and monitored in the next rounds of the cohort.
Full-text · Article · Sep 2012 · Iranian Journal of Public Health
[Show abstract][Hide abstract]ABSTRACT: The high-sensitive C-reactive protein (HS-CRP) assay is being increasingly used as a marker for cardiac risk assessment and as a prognostic tool in heart disease. In current study, we assessed the relationship between serum level of HS-CRP and extension of myocardial involvement in acute myocardial infarction.
In a Cross-Sectional study, 50 patients with the final diagnosis of acute myocardial infarction and admitted for the first time in CCU wards of the Kerman University in 2010 were studied. Serum HS-CRP and Troponin I level was measured using commercial ELISA kits, 24 hours after the appearance of first manifestations. All patients underwent 2-dimensional echocardiography for assessing the number and severity of involved segments as well as wall motion abnormality.
There was a strong positive correlation between the serum level of HS-CRP and serum Troponin I level (beta = 0.509, p < 0.001). Multivariable linear regression showed that the level of HS-CRP could strongly predict serum level of Troponin I within the first 24 hours of MI appearance (Beta = 0.308, Standard Error = 0.080, p < 0.001). But, no significant relationships were revealed between the mean serum HS-CRP level and the location of myocardial infarction, the number of involved segments, left ventricular ejection fraction, and ST-segment elevation score.
For a strong correlation between HS-CRP and Troponin I, HS-CRP can be a useful biomarker for predicting extended myocardial involvement in patients with acute myocardial infarction.
No preview · Article · Nov 2011 · Romanian journal of internal medicine = Revue roumaine de médecine interne
[Show abstract][Hide abstract]ABSTRACT: Therapeutic effect of Hypericum perforatum L. has been well known. The aim of this study is to investigate the anticonvulsant effects of Hypericum methanolic extract against seizure induced by picrotoxin in mice. The study were performed on four groups of animals. They received percolated extract of Hypericum perforatum at the doses of 25, 50, 100 & 200 mg/kg intra peritoneally. After 20 minutes animals received picrotoxin 10 mg/kg for induction of seizure. Latency of seizure, duration of seizure, death latency and percent of mortality were determined. The results indicated that latency of seizure increased in pretreated group with the dose of 50 mg/kg (p<0.01). The higher dose of extract 200 mg/kg significantly decrease duration of seizure and death latency. It maybe due to unknown ingredients in this plant or producing concentrations higher than the therapeutic level. The results showed that Hypericum perforatum L. at the dose of 50 mg/kg maybe have some beneficial effect in seizure induced by picrotoxin and this plant is suitable for continuing search in this field.
[Show abstract][Hide abstract]ABSTRACT: Rapid measuring of B-type natriuretic peptide (BNP) in the emergency departments effectively results in evaluating patients with acute cardiac attacks and has appeared to be a useful prognostic marker of cardiovascular risk. A current study came to address the association between plasma N-terminal pro BNP level and severity of coronary vessels' defects based on Gensini score in patients with stable angina pectoris candidate for coronary angiography.
The study population consisted of 92 consecutive patients with appearance of stable angina and candidate for coronary angiography. All participants underwent selective left and right coronary angiography. For BNP measurement and just before the catheterization of left coronary, 5cc blood samples were drawn from coronary.
With respect to the role of N terminal pro BNP for predicting severity of CAD based on Gensini scoring, linear regression analysis confirmed that plasma BNP level was a strong predictor for CAD severity (p = 0.009) in the presence of study cofounders. A significant correlation was also observed between N terminal pro BNP and left ventricular ejection fraction, so that all patients with left ventricular dysfunction (EF < 40%) had plasma N terminal pro BNP level higher than 100 pg/ml.
NT-pro BNP can be a good parameter for predicting the severity of coronary vessels' involvement besides other diagnostic tools. In all patients with left ventricular ejection fraction less than 40%, plasma NT-pro BNP level was higher than 100 pg/ml.
Full-text · Article · Feb 2011 · Journal of research in medical sciences
[Show abstract][Hide abstract]ABSTRACT: Objective: Systolic blood pressure recovery (rSBP) immediately after exercise effectively predicts survival and co-morbidity in those with atherosclerotic heart disease. The aim of this study was to evaluate the diagnostic value of the rSBP index for detecting coronary artery disease (CAD) severity. Design: Prospective cross-sectional study. Setting: Shafa Hospital, Kerman Province, Iran between March and August 2009. Subjects: Ninety-four consecutive adult patients who were candidates for evaluation of CAD. Interventions: Exercise stress testing and initial coronary angiography. Main Outcome Measures: The rSBP was calculated by dividing the SBP three minutes after exercise by the SBP at peak exercise. Results: Subjects with a high ratio of SBPs at 3 min of recovery to peak exercise were more likely to have severe CAD, adjusting for age, gender and body mass index using multivariate logistic regression analysis. The sensitivity, specificity, positive predictive value and negative predictive value of abnormal rSBP for predicting severe CAD were 42.6%, 81.8%, 50.0% and 77.1%, respectively. According to the ROC curve analysis, the rSBP measurement was a good indicator of severe CAD with areas under the ROC curves 0.652 (95% CI: 0.524 - 0.780). The optimal cut-off value for rSBP for predicting severe CAD was identifiedat0.78yielding a sensitivity of 60.7% and a specificityof65.2%. Conclusion: Systolic blood pressure ratio at three minutes post-exercise is a good diagnostic marker for predicting severe CAD with a high specificity and a good discriminative power.
No preview · Article · Sep 2010 · The Journal of the Kuwait Medical Association
[Show abstract][Hide abstract]ABSTRACT: It is reported that dihydroxy chalcones have analgesic and anti-inflammatory effects. Study of the structure activity relationship (SAR) shows that benzofuran-3-one derivatives may be more effective in this respect. In this study, a new (Z)-2-(3,4-dihydroxybenzylidene)-5-methoxybenzofuran-3(2H)-one (compound 5) was synthesized and its analgesic and anti-inflammatory effects were evaluated by formalin, carrageenan and hot-Plate methods in mice. The results showed that, compound 5 induced significant antinociceptive and anti-inflammatory effect (P<0.01). Maximum analgesia (42.6%) was obtained at dose of 25 mg/kg in the first phase of formalin test. The effect of compound 5 was higher (87.7%) in chronic phase of inflammation induced by formalin (P<0.01). Administration of 25 mg/kg of compound 5 inhibited the inflammation induced by carrageenan, 32.8% and 41.7%, 1 and 3 hour after carrageenan injection, respectively. In addition, this dose of compound 5, induces significant analgesia (20.2%) in hot plate test 45 minutes after injection (P<0.01). Therefore it seems that compound 5 has potential for discovery of a compound with potent anti-inflammatory and analgesic effects and its scaffold could be use for further structural modifications.
Full-text · Article · Oct 2009 · Pakistan journal of pharmaceutical sciences
[Show abstract][Hide abstract]ABSTRACT: There have been many reports indicating the analgesic and anti-inflammatory effects of 3,4-dihydroxychalcones. We have designed and synthesized a rigid 3,4-dihydroxychalcone (RDHC) as a possible drug effecting inflammation and nociception. The analgesic and anti-inflammatory effects were evaluated by formalin and hot-plate tests, respectively. The results showed that RDHC induced significant antinociceptive and anti-inflammatory effects (P < 0.01). Maximum analgesia (63.7%) was observed at 37.5 mg/kg in the first phase of the formalin test. The effect of RDHC was higher in the chronic phase (inflammation phase) of the formalin test (86.4%, P < 0.01). In addition, a significant analgesia (maximum possible effect; MPE = 30.1%) was observed in the hot plate test 45 min after injection of 37.5 mg/kg RDHC (P < 0.01). As a result of our findings, this new RDHC could be suggested for further pharmacological studies.
No preview · Article · Aug 2009 · Annals of the New York Academy of Sciences