Mehmet Ali Eryilmaz

Konya Training and Research Hospital, Conia, Konya, Turkey

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Publications (16)10.34 Total impact

  • Serden Ay · Mehmet Ali Eryilmaz · Nergis Aksoy · Ahmet Okus · Yasar Unlu · Baris Sevinc
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    ABSTRACT: Red cell distribution width (RDW) is one of the standard parameters with blood cell counts. Much previous research has indicated that it increases in cases of systemic inflammation or cardiametabolic incident. However, information on the relation of RDW with solid tumors causing systemic inflammation is limited. In the present research, we examined the relation of RDW with malignant and benign lesions of the colon. 115 patients with colon polyps (group 1), and 30 with colon cancer (group 2) who were diagnosed histopathologically in our clinic between January 2010-January 2013 were scanned retrospectively. Patients with anemia, hematologic diseases and active inflammation were excluded. RDW, mean corpuscular volume (MCV), hemoglobin (Hgb) and platelet (Plt) measurements were recorded and their relations with the malignant and benign lesions of the colon were examined. Both groups were similar in age and gender distribution. RDW values of patients with colon cancer were significantly higher than the patients with colon polyp (p=0,01). No significant differences were detected between the two groups in terms of MCV and Plt values (p>0,05). RDW can be used as an early warning biomarker for solid colon tumors. Further prospective research is required on the relations of cheap and easily measured RDW parameters with colon malignancies.
    No preview · Article · Feb 2015 · Asian Pacific journal of cancer prevention: APJCP
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    B. Sevinç · Ö. Karahan · S. Bakdik · N. Aksoy · M.A. Eryilmaz
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    ABSTRACT: With the appropriate indications, puncture, aspiration, injection and reaspiration (PAIR) is the most effective minimal invasive method used in the treatment of hydatic cysts. Hemobilia is the hemorrhagia in bile ducts in consequence of any reason. In literature there is no case with hemobilia because of PAIR. This is the first case with recurrent hemobilia, infection in cyst cavity and pneumonia because of PAIR. A 66 years old female patient was admitted to hospital with complaints of abdominal pain, hematemesis and melaena. She gave the history of PAIR for two hydatic cysts. At physical examination, there were jaundice, tenderness at right subcostal area and melaena at rectal digital examination. Hemobilia was detected by abdominal ultrasonography and magnetic resonance cholangiopancreaticography (MRCP). An endoscopic retrograde cholangiopancreaticography (ERCP) and endoscopic sphincterotomy were performed. The patient was discharged after 6 days hospital stay. One day after the discharge the patient was admitted to hospital with the same complaints again. Performing ERCP and balloon extraction, the hematoma filling the common bile duct was removed. After the patient was hemodynamically stable for 3 days, she was discharged from the hospital. A week after that the patient was admitted to hospital with the clinical findings of infected hydatic cyst and pneumonia. The patient was treated medically with mechanical ventilation support for 8 days. It should not be underestimated that, there can be serious complications of PAIR like hemobilia. Therefore, PAIR should be performed only in centers having appropriate medical and surgical facilities. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
    Full-text · Article · Feb 2015 · International Journal of Surgery Case Reports
  • M.A. Eryilmaz · S. Ay · N. Aksoy · A. Okuş · B. Sevinç · R. Demirgül · Ö. Karahan
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    ABSTRACT: Aim: We aimed at evaluating the Histopathological examination results of biopsies obtained from the anastomosis line of patients with previous gastrectomy in terms of malignancy. Material and Method: The endoscopic findings and the biopsy records obtained from the anastomosis line of 23 patients with gastrectomy history for whom upper gastrointestinal system (GIS) endoscopy was performed at the General Surgery Clinic, Endoscopy Unit of Training & Research Hospital in Konya between Jan. 2009 and Dec. 2011 were retrospectively examined for the existence of Helicobacter pylori, intestinal metaplasia (IM), dysplasia and cancer. Results: The average age of patients was 63 (range 30-82), with 17 males (74%) and 6 females (26%). 15 (65%) of these patients had undergone a gastrectomy for a malignity, and 8 (35%) for a benign reason. The time elapsed after the surgical operation was 46 (range 12-144) months in average. 17 (74%) of these surgical operations were Billroth II, 3 (13%) gastroenterostomy without resection, 2 (9%) total gastrectomy, and 1 (4%) Billroth I. Upper GIS endoscopy revealed alkaline reflux gastritis at 14 (61%) patients, anastomosis ulcer at 6 (26%) patients, polyp at 2 (9%) patients, and cancer at 1 (4%) patient. Histopathological examination of the biopsy results displayed 5 (22%) reactive hyperplasic changes, 5 (22%) chronic active gastritis, 5 (22%) dysplasia, 3 (13%) IM, and 2 (9%) cancer. Discussion: Patients with gastrectomy history develop IM in the anastomosis line in parallel with the time elapsed after surgical operation, and subsequently develop dysplasia. Monitoring with endoscopy will make diagnosis and appropriate treatment possible in the stage of dysplasia.
    No preview · Article · Jul 2014
  • O Karahan · M A Eryilmaz · A Okus · S Ay · Y Unlu · M Cayci · M Kaya
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    ABSTRACT: Background: Experimental research into the viability and functionality of splenic tissue placed in the liver and the omentum. Methods: There were 4 groups in this study. First group: sham laparotomy, 2nd group: splenectomy, 3rd group: splenectomy and splenic autotransplantation into the greater omentum and 4th group: splenectomy and splenic autotransplantation into the liver. Blood levels of haemoglobin, leukocytes, thrombocytes, immunoglobulin G (IgG), immunoglobulin M (IgM) and complement protein 3 (C3) were studied 1 day before and 6 weeks after the procedure. At the end of 6 weeks, scintigraphy was performed. Splenic tissue in the liver and the omentum were subjected to macroscopic and histopathologically. Results: Pre- and postoperatively, no significant differences were found in terms of haematological and immunological measurements of groups I, III and IV. An increase in the numbers of thrombocytes and leukocytes and a decrease in the levels of IgG, IgM and C3 were observed in the postoperatively in group II.When the postoperative hematological and immunological values of the second group are compared to those of groups III and IV, the difference was significant in terms of levels of thrombocyte, leukocyte and IgM; insignificant in terms of levels of IgG and C3. In the microscopic and scintigraphic analyses the spleen tissue was found to be viable in all of the six rabbits in groups III and IV. Conclusions: The liver is a suitable organ for splenic autotransplantation (Tab. 6, Fig. 2, Ref. 17).
    No preview · Article · Nov 2013 · Bratislavske lekarske listy
  • Ö Karahan · A Okus · B Sevinc · MA Eryilmaz · S Ay · M Cayci · C Duran
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    ABSTRACT: Background: More than 85% of primary hyperparathyroidism (PHPT) cases are due to solitary, benign parathyroid adenomas. Recently, the success rate of Tc99m sestamibi scintigraphy in localization has made minimally invasive parathyroidectomy (MIP) more prominent. MIP is as effective as conventional bilateral neck exploration. Moreover, it offers lower morbidity, cost effectiveness, and better cosmetics effects. Aim: We aimed to evaluate the success of MIP, which happens only under local anesthesia, in this study. Materials and Methods: Total of 63 patients were operated for PHPT, of which 54 had solitary adenoma. Five patients underwent bilateral neck exploration under general anesthesia for thyroid nodules or unlocalizated adenomas. A total of 49 patients underwent MIP under local anesthesia without any sedation. During MIP, gamma probe was used for all patients. The patients were followed for parathyroid functions. Results: The mean age of 49 patients with MIP (5 male, 44 female) was 59 years. The mean follow-up time was 16.4 (±10.1) months (range: 2-36 months). Of the 49 patients, 47 (96%) were totally cured. In 2 patients, the procedure was switched to conventional bilateral neck exploration. Temporary hypocalcaemia was noted in 4 patients. Conclusions: If the adenoma is localizated, MIP under only local anesthesia can be performed with a high success rate. Gamma probe-guided MIP under local anesthesia is an effective and safe method. It has the advantage of being minimally invasive and, therefore, it should be preferred over the conventional method.
    No preview · Article · Mar 2013 · Journal of Postgraduate Medicine
  • A Okus · O Karahan · S Ay · M A Eryilmaz · Y Unlu · N Aksoy · B Sevinc
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    ABSTRACT: Purpose: This experimental study aimed at comparing the cyanoacrylate abdomen closure to the effectiveness of triclosan coated polidioxanone abdomen closure. Methods: The abdomen layers were closed with 3/0 polidioxanone suture in the first group. In the second group, the layers were closed with triclosan coated polidioxanone suture in a single layer. The abdomen layers of rats in the third group were attached with cyanoacrylates without sutures. The rats were sacrificed on the 14th day and the adhesive level was recorded. The incision resistance strength was measured. The tissue was examined blindly in the terms of inflammatory cell infiltration, capillary proliferation, fibrosis and micro-abscess by the pathologist. Results: No significant difference was determined between the 1st and 2nd groups in the terms of inflammatory cell infiltration, capillary proliferation, collagen deposition, fibroblast activity, adhesive and tissue distension strength. The fibrosis and adhesive rate of the 3rd group was significantly higher than the 1st and 2nd groups statistically. The tissue distension strength was lower than in the other groups and the differences between the groups were found to be significant (p < 0.05). No significant difference was determined between the groups in the term of micro-abscess. Conclusions: Antibacterial suture is not superior to the conventional suture. It is concluded that cyanoacrylate is not an appropriate molecule for abdomen closure (Tab. 1, Fig. 3, Ref. 17).
    No preview · Article · Feb 2013 · Bratislavske lekarske listy
  • O Karahan · A Okus · M A Eryilmaz · S Ay · S Kilic · B Sevinc
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    ABSTRACT: Purpose: While LigaSure is commonly used for blood vessel closure, our aim was to research the effectiveness of using the latter tool for the purpose of closing intestines in rats. Methods: Twenty Wistar albino rats were divided into two groups per 10 each. In Group 1, the sigmoid colon was cut from its middle and its distal was closed with 4/0 silk. In Group 2, on the other hand, the sigmoid colon was divided from the middle with LigaSure LS1200 probe and its distal was closed with LigaSure. In both groups, the proximal sigmoid colon was entered by means of colostomy with 4/0 silk to the left part of the abdomen. Operation durations, adhesion levels and explosion pressures were recorded. Tissue samples were taken for tissue hydroxyproline level. Results: While the average duration of the operation was 25.7 minutes in Group 1, it was 18.8 minutes in Group 2 and the difference between them was significant in favour of LigaSure. (p<0.001). Stump explosion pressure was 181.4 (160-190) mmHg in average in the suture group (Group 1), and 173.3 (150-190) mmHg in the LigaSure group (Group 2) and the difference between them was not statistically significant. Tissue hydroxyproline level was 123.6 (13-232) in Group 1, and 123.3 (32-216) in Group 2 and no significant difference was determined between the groups. Adhesion level between the groups was also similar. Conclusions: This study experimentally shows that the duration of effective stump closure as part of Hartman colonostomy can be shortened with LigaSure (Tab. 1, Fig. 4, Ref. 12).
    No preview · Article · Jan 2013 · Bratislavske lekarske listy
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    ABSTRACT: Purpose: To compare the healing properties of lateral internal sphincterotomy (LIS) and isosorbide dinitrate (ISDN) ointment for chronic anal fissure. Methods: Patients with a chronic anal fissure were randomly assigned to a group treated with ISDN ointment (n = 105) or a group treated with LIS (n = 102). The same investigators examined the patients in a blinded manner, 1, 2, 3, 6, and 12 months after the treatments. Results: The anal fissure had healed completely by 4 weeks in 64.7 versus 92.2 %, and by 6 months in 77.1 versus 97.1 % of the ISDN and LIS group patients, respectively. At 12 months, the recurrence rates were 4.8 versus 1 % for the ISDN and LIS groups, respectively, and the success rates of the treatments were 72.4 versus 96.1 %, respectively. Six patients in the LIS group experienced minor fecal incontinence, and seven (6.7 %) patients in the ISDN group experienced headaches that responded well to paracetamol. Conclusion: ISDN ointment was reported by all patients to be easy to use. Although its success rate was lower than that of surgery, ISDN can be offered to selected patients with a chronic anal fissure, as it has a low recurrence rate and rare side effects are rare.
    No preview · Article · Sep 2012 · Surgery Today
  • M A Eryilmaz · A Igci · M Muslumanoglu · V Ozmen · M Koc
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    ABSTRACT: To retrospectively evaluate the 15-year experience with breast cancer in males at a single institution. The data from 25 male patients who had undergone surgery for breast cancer at a single center were retrospectively analysed. Their medical records were studied for clinical characteristics, therapeutic modalities used and factors associated with disease free (DFS) and overall survival (OS), like local recurrence/distant metastasis. The median patient age was 67 years (range 38-83). The most frequent presenting symptom was a palpable lump. Eighteen (72%) patients underwent modified radical mastectomy (MRM), while sentinel lymph node biopsy (SLNB) was performed in 14 (56%) cases. Of 25 patients, 21 (84%) underwent axillary lymph node dissection (ALND) and 15 (71.4%) of them had pathological axillary lymph node involvement. Two of 25 (8%) patients with bone and liver metastases underwent toilet mastectomy due to breast ulceration. Estrogen receptor (ER) was positive in 15 (60%) patients, while progesterone receptor (PR) and C-erbB2 (HER-2) were positive in 10 (40%) and 2 (8%) patients, respectively. Ten patients (40%) had both ER(+) and PR(+). The median follow-up period was 19 months (range 3-102). Local recurrence developed in one (4%) patient and distant metastasis in 4 (16%). Five-year OS and DFS were 53 and 49%, respectively. In univariate and multivariate analysis, pathological tumor size (<2 vs. >2 cm), pathological lymph node involvement and preoperative skin involvement over the breast were not associated with breast recurrence. Only in univariate analysis local recurrence/distant metastasis were associated with poor OS. Large cooperative studies are needed using strict clinical and laboratory criteria to advance the understanding of this disease and to identify the most effective treatment approaches.
    No preview · Article · Jan 2012 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • A. Okuş · S. Ay · C. Karakaş · M. Çarpraz · M.A. Eryilmaz
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    ABSTRACT: Hydatid cyst of liver is a disease usually seen in endemic regions. While it is very small at the beginning, cyst diameter increases approximately 1-3 cm per year. Among known complications of hydatid disease, pressure to the adjacent organs due to the cyst growth, perforation into peritoneal cavity or bile truct are most noteable. However, its fistulization into gastrointestinal tract is very rare. A 80-year-old male patient presented with the complaints of abdominal pain, fever and deterioration in general physical condition. It was determined that the patient was diagnosed with hydatid cyst of liver about 15 years ago but refused treatment. Imaging revealed a 20x15 cm multiseptal cystic lesion filled with air in the right lobe of liver. Patient was admitted to OR and exploration revealed that cyst had fistulized into the duodenum. The fistulization of liver hydatid cyst into the duodenum is very rare. We believe that the size of cyst and the delay in treatment caused the cystoduodenal fistula.
    No preview · Article · Jan 2012 · European Journal of General Medicine
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    Eryilmaz MA · Igci A · Muslumanoglu M · Ozmen V · Koc M
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    ABSTRACT: Purpose: To retrospectively evaluate the 15-year experience with breast cancer in males at a single institution. Methods: The data from 25 male patients who had undergone surgery for breast cancer at a single center were retrospectively analysed. Their medical records were studied for clinical characteristics, therapeutic modalities used and factors associated with disease free (DFS) and overall survival (OS), like local recurrence/distant metastasis. Results: The median patient age was 67 years (range 38-83). The most frequent presenting symptom was a palpable lump. Eighteen (72%) patients underwent modified radical mastectomy (MRM), while sentinel lymph node biopsy (SLNB) was performed in 14 (56%) cases. Of 25 patients, 21 (84%) underwent axillary lymph node dissection (ALND) and 15 (71.4%) of them had pathological axillary lymph node involvement. Two of 25 (8%) patients with bone and liver metastases underwent toilet mastectomy due to breast ulceration. Estrogen receptor (ER) was positive in 15 (60%) patients, while progesterone receptor (PR) and C-erbB2 (HER-2) were positive in 10 (40%) and 2 (8%) patients, respectively. Ten patients (40%) had both ER(+) and PR(+). The median follow-up period was 19 months (range 3-102). Local recurrence developed in one (4%) patient and distant metastasis in 4 (16%). Five-year OS and DFS were 53 and 49%, respectively. In univariate and multivariate analysis, pathological tumor size (<2 vs. >2 cm), pathological lymph node involvement and preoperative skin involvement over the breast were not associated with breast recurrence. Only in univariate analysis local recurrence/distant metastasis were associated with poor OS. Conclusion: Large cooperative studies are needed using strict clinical and laboratory criteria to advance the understanding of this disease and to identify the most effective treatment approaches.
    Full-text · Article · Jan 2012
  • Ahmet Okuş · Bariş Sevinç · Omer Karahan · Mehmet A Eryilmaz
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    ABSTRACT: Pilonidal disease is an inflammatory disease seen in the intergluteal region. In this study, our aim was to compare the efficacy of the Limberg flap versus a tension-free primary closure. A total of 93 patients were included in this study. The patients were assigned consecutively by the closed-envelope technique to one of two groups: 49 patients in group 1 (excision and Limberg flap) and 44 patients in group 2 (tension-free primary closure). Excision and reconstruction with the Limberg flap was performed in its classic form. For tension-free primary closure after excision of the sinus tract with an elliptical incision, the skin and subcutaneous tissue were released 2-3 cm away from the incision line. The subcutaneous tissue was closed twofold with 2/0 polyglactin sutures. The skin underwent 3/0 polypropylene mattress suturing. The median age was 25 years (17-43 years). The median follow-up period was 29.5 months (8-43 months). There was no significant difference between the groups in terms of age, sex, follow-up time, or anesthesia method. One patient in each group experienced wound infection. During the first 6 months of follow-up there was no recurrence. However, at later visits recurrences were seen in two patients in each group (4.1% in group 1, 4.5% in group 2). The lower rates of wound infection and recurrence associated with the Limberg flap reported elsewhere may be associated with healing of the tension-free procedure. In this study, tension-free primary closure was found to be as effective as the Limberg flap reconstruction.
    No preview · Article · Nov 2011 · World Journal of Surgery
  • M A Eryilmaz · M Muslumanoglu · V Ozmen · A Igci · M Koc
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    ABSTRACT: To retrospectively evaluate the outcome of patients with multifocal (MF) and multicentric (MC) breast cancer treated with conservative surgery. We evaluated 59 patients who had undergone breast conserving surgery (BCS) for MF/MC cancer between 1998-2008. We used sentinel lymph node (SLN) biopsy for all 59 patients and we performed axillary lymph node dissection in those with positive SLN. Local control, overall survival (OS), disease-free survival (DFS) and identification of predictive factors for recurrence were evaluated. Twenty patients with modified radical mastectomy because of persistent positive margins were excluded from the study. Evaluated were 55 patients with MF (93.2%) and 4 (6.8%) with MC disease. Thirty-four patients (57.6%) had 2, 20 patients (33.9%) had 3 and 5 (8.5%) had 4 or more tumor foci. Median follow up time was 20 months (range 2- 97). The projected 5- and 8-year OS were 95% and 89% respectively, and DFS 92.3%. At multivariate analysis, overexpression of human epidermal growth factor receptor 2 (HER-2) was associated with a higher ipsilateral breast cancer recurrence. Menopausal status, MF/MC disease, number of tumor foci (2 vs. ≥3), histological grade, extracapsular extension (ECE), lymphovascular invasion (LVI), and hormone receptor status were not associated with ipsilateral breast cancer recurrence. Our study demonstrates that in selected patients with MF/MC breast cancer, wide conservative surgery is a safe therapy.
    No preview · Article · Jul 2011 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Ahmet Okus · Baris Sevinc · Abdulhalim Serden Ay · Omer Karahan · Mehmet Ali Eryilmaz

    No preview · Article · Jan 2011
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    ABSTRACT: Aim: The purpose of this study is to determine the factors affecting the development of parathyroid surgery in our hospital. Material and Method: We investigated the age, sex, laboratory, imaging and histopathologic data about the patients who had undergone parathyroid surgery between 2000 and 2010. We evaluated the methods used in diagnosis, determination of surgical indications, surgical and anesthesia techniques and the follow up period. We determined the data that can play a role in the process of diagnosis and treatment of this disease. Results: Until 2005 there were important deficienciesabout laboratory investigations and specialists for parathyroid surgery. These were resolved in 2006,except an experienced surgeon. There had been only 2 parathyroid operations until February 2010 (one in 2002 and the other in 2007). In 2008 there was a case with incidental parathyroid adenoma excisionduring a thyroidectomy. In 2009, with the inauguration of an experienced surgeon, the parathyroidsurgeries gained momentum. After this date, there were 28 parathyroid surgeries in 22 months. Twenty two of the cases had primary hiperparathyroidism and 6 had secondary hiperparathyroidism. Twenty one (95,5%) of the 22 parathyroid adenomas underwent MIP. Six patients with secondary hyperparathyroidismunderwent total parathyroidectomy and parathyroid autotransplantation. The success rate of the treatment was 100%. Conclusion: Parathyroid surgery is a team work. With an appropriate team, more than 90%of parathyroid adenomas can be treated by MIP.
    No preview · Article · Jan 2011 · Turkish Journal of Surgery
  • Omer Karahan · Mehmet Ali Eryilmaz · Veli Torun · Baris Sevinc · Hande Koksal · Faruk Aksoy · Serdan Ay
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    ABSTRACT: Purpose: We have noticed the increase in pilonidal sinus operations (PSO) and performed this study to determine the extent of this change and if there is a difference between the number of pilonidal sinus surgery and outpatient and inpatient numbers. Material and Method: We scanned PSO, which was performed in three hospitals [medical faculty hospital (MFH), education and research hospital (ERH) and state hospital (SH)] in the same city, in the last 10 years between 1999 and 2008. We have determined the yearly distribution of cases, total number of operations performed, number of general surgery operations (GSO) at the same period and changes in staff of general surgery clinics. We reviewed the number of outpatients, inpatients and the middle group surgical procedures containing PSO as well, performed at the whole city and the country in the last 10 years. Results: The number of PSO was 234 and the number of GSO was 7.728 at MFHs in the first 5 years. These numbers were 259 and 10.384 in the second period, respectively. The increase was 11% for PSO and 72% for GSO. The increase in PSO was lower than GSO. In ERH there were 506 PSOs in the first 5 years and 760 PSOs in the second 5 years. The number of GSO had increased from 11.563 to 11.452 in the second 5 years. There was a 1% decrease in the number of GSOs, whereas the number of PSOs increased by 50% (p<0.001). The number of PSOs performed in SHs increased from 353 to 1.224, by 247%. Also, the number of GSO increased from 10.215 to 15.595, by 53%. The increase in the number of PSOs in two hospitals (ERH and SH) was statistically significant (p<0.001). The number of PSOs was 246 in 2005 and it became 1.341 in 2008, with an increase of 439% at the whole city. Considering Turkey, the number of PSOs performed was 12.415 in 2005 and it increased to 54.633 (340%) in 2008. Conclusion: There is a rapid increase in the number of PSOs performed at the state hospitals in Konya and all around Turkey. Absolute reasons for this increase should be investigated and preventive measures should be taken.
    No preview · Article · Jan 2010 · Turkish Journal of Surgery

Publication Stats

35 Citations
10.34 Total Impact Points

Institutions

  • 2011-2015
    • Konya Training and Research Hospital
      Conia, Konya, Turkey
  • 2013
    • Bursa Yuksek Ihtisas Egitim Ve Arastirma Hastanesi
      Boursa, Bursa, Turkey