Mohammadreza Shams-Ardakani

Tehran University of Medical Sciences, Teheran, Tehrān, Iran

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Publications (13)13.92 Total impact

  • Maliheh Safavi · Mohammadreza Shams-Ardakani · Alireza Foroumadi
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    ABSTRACT: Abstract Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants. Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words "medicinal plants" and "Helicobacter pylori" or "anti-Helicobacter pylori". Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae, Anacardiaceae, Apiaceae, Apocynaceae, Asclepiadoideae, Asteraceae, Bignoniaceae, Clusiaceae, Chancapiedra, Combretaceae, Cyperaceae, Euphorbiaceae, Fabaceae, Geraniaceae, Lamiaceae, Lauraceae, Lythraceae, Menispermaceae, Myristicaceae, Myrtaceae, Oleaceae, Papaveraceae, Plumbaginaceae, Poaceae, Ranunculaceae, Rosaceae, and Theaceae were studied as herbs with potent anti-H. pylori effects. Conclusion: Traditional folk medicinal use of some of these plants to treat gastric infections is substantiated by the antibacterial activity of their extracts against H. pylori.
    No preview · Article · Nov 2014 · Pharmaceutical Biology
  • Parmis Badr · Ghazaleh Mosleh · Mohammadreza Shams-Ardakani · Abdolali Mohagheghzadeh

    No preview · Article · Jun 2014 · Pharmaceutical historian
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    ABSTRACT: Helicobacter pylori infection causes lifelong chronic gastritis, which can lead to peptic ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. The growing problem of antibiotic resistance by the organism demands the search for novel candidates from plant-based sources. In the present study, we evaluated the in vitro anti-H. pylori activity of some selected medicinal plants on clinical isolates of H. pylori. Gastric biopsy samples were obtained from patients presenting with gastroduodenal complications. Helicobacter pylori was isolated from the specimens following standard microbiology procedures. The disc-diffusion method was used to determine the susceptibility of three H. pylori isolates to methanol extracts of 23 Iranian plants. All tests were performed in triplicate. Among them, the extracts of Punica granatum and Juglans regia had remarkable anti-H. pylori activity with mean of inhibition zone diameter of 39 and 16 mm at 100 µg disc⁻¹, respectively. In view of the results obtained with P. granatum (pomegranate), the peel extracts of nine cultivars of pomegranate (Shirin-e-Pust Sefid, Agha Mohammad Ali-e-Shirin, Sefid-e-Shomal, Sefid-e-Torsh, Shirin-e-Malase, Tabestani-e-Torsh, Shirin-e-Saveh Malase, Alak-e-Shirin, Pust Siyah) were further assayed against the clinical isolates of H. pylori. The results revealed that all Iranian pomegranate cultivars, except for Alak-e-Shirin, showed significant in vitro anti-H. pylori activity against the clinical isolates of H. pylori (mean of inhibition zone diameter ranging from 16 to 40 mm at 50 µg disc⁻¹).
    Full-text · Article · Jul 2011 · Natural product research
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    M. Shams-Ardakani · A. Mohagheghzadeh · A. Ghannadi · A. Barati

    Full-text · Article · Apr 2007 · Chemistry of Natural Compounds
  • Abdolali Mohagheghzadeh · Pouya Faridi · Mohammadreza Shams-Ardakani · Younes Ghasemi
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    ABSTRACT: All through time, humans have used smoke of medicinal plants to cure illness. To the best of our knowledge, the ethnopharmacological aspects of natural products' smoke for therapy and health care have not been studied. Mono- and multi-ingredient herbal and non-herbal remedies administered as smoke from 50 countries across the 5 continents are reviewed. Most of the 265 plant species of mono-ingredient remedies studied belong to Asteraceae (10.6%), followed by Solanaceae (10.2%), Fabaceae (9.8%) and Apiaceae (5.3%). The most frequent medical indications for medicinal smoke are pulmonary (23.5%), neurological (21.8%) and dermatological (8.1%). Other uses of smoke are not exactly medical but beneficial to health, and include smoke as a preservative or a repellent and the social use of smoke. The three main methods for administering smoke are inhalation, which accounts for 71.5% of the indications; smoke directed at a specific organ or body part, which accounts for 24.5%; ambient smoke (passive smoking), which makes up the remaining 4.0%. Whereas inhalation is typically used in the treatment of pulmonary and neurological disorders and directed smoke in localized situations, such as dermatological and genito-urinary disorders, ambient smoke is not directed at the body at all but used as an air purifier. The advantages of smoke-based remedies are rapid delivery to the brain, more efficient absorption by the body and lower costs of production. This review highlights the fact that not enough is known about medicinal smoke and that a lot of natural products have potential for use as medicine in the smoke form. Furthermore, this review argues in favor of medicinal smoke extended use in modern medicine as a form of drug delivery and as a promising source of new active natural ingredients.
    No preview · Article · Dec 2006 · Journal of Ethnopharmacology
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    M. Mehrabani · A. Ghannadi · E. Sajjadi · N. Ghassemi · M. Shams-Ardakani
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    ABSTRACT: Toxic pyrrolizidine alkaloids are present in some species of Echium (Boraginaceae). In this study petals of Echium amoenum Fisch. & Mey. (Gol-e-Gavzaban) as a popular herbal medicine in Iran, were investigated for pyrrolizidine alkaloids (PAs). The alkaloids were separated and purified by preparative TLC and characterized by IR, one and two dimensional 1H and 13C-NMR and Mass spectroscopy. Four toxic alkaloids namely: echimidine I, echimidine isomer II, 7-angeloyl retronecine III and 7-tigloyl retronecine IV were identified.
    Full-text · Article · Jan 2006
  • Mohammadreza Shams-Ardakani · Alireza Ghannadi · Parmis Badr · Abdolali Mohagheghzadeh
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    ABSTRACT: Biotransformation of monoterpene aldehydes and related compounds, carvone and bornyl acetate was carried out by cell suspension culture of Glycyrrhiza glabra L. Cells reduced most saturated and unsaturated terpene aldehydes, aromatic and related aldehydes to corresponding primary alcohols. Furthermore, the C=C bonds in the side chain of cinnamaldehyde and in the cyclohexene ring of carvone were converted into corresponding saturated compounds, hydrocinnamylalcohol, cis- and trans-dihydrocarvone. Bornyl acetate hydrolyzed to two isomers, isoborneol and endo-borneol. Copyright © 2004 John Wiley & Sons, Ltd.
    No preview · Article · Mar 2005 · Flavour and Fragrance Journal
  • M. Shams-Ardakani · S. Hemmati · A. Mohagheghzadeh
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    ABSTRACT: The possibility of enhancment accumulation of podophyllotoxin (PTOX) has been studied in cultures of cell suspension of Linum album Kotschy ex Boiss. (Linaceae) producing PTOX was studied. Attempts were made to manipulate the biosynthetic pathway of PTOX by some biotic (yeast extract) and abiotic (Ag +, Pb2+ and Cd2+) elicitors for 24 or 48 hr in Murashige and Skoog (MS) medium. Silver significantly enhanced PTOX production up to 0.24 % (mg/g cell dry wt.) in cultures. This effect could be attributed to the inhibitory role of silver on production of ethylene.
    No preview · Article · Jan 2005
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    M. Mehrabani · N. Ghassemi · E. Sajjadi · A. Ghannadi · M. Shams-Ardakani
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    ABSTRACT: Echium amoenum Fisch, and C.A. Mey. (Boraginaceae) is an indigenous Iranian plant, that its dry violet-blue petals (Gol-e-Gavzaban) have long been used in traditional medicine of Iran. In this study concentrated metanolic extract of the grounded dried petals of E. amoenum was fractionated by column chromatography and the fractions were purified by preparative HPLC. The structure of main pure component which was characterized by UV, IR, one and two dimensional 1H and 13C-NMR and Mass spectroscopy was found to be rosmarinic acid which is widespread in the plants of the Lamiaceae and Boraginaceae families in insignificant quantities and has antimicrobial, antiviral, and anti-inflammatory effects.
    Full-text · Article · Jan 2005
  • A Mohagheghzadeh · M Shams-Ardakani · A Ghannadi · M Minaeian
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    ABSTRACT: Rosmarinic acid (RA) was obtained from Zataria multiflora tops' extract and its structure was confirmed by spectroscopic methods. Various in vitro cultures were established on Murashige and Skoog (MS) or Modified Tobacco (MT) medium containing growth hormones. The results indicated that cultures of Z. multiflora biosynthesize RA (55-355 mg/100 g dry wt.) and the highest accumulation were reached on MT media containing NAA 2 mg/l.
    No preview · Article · Jul 2004 · Fitoterapia
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    N. Ghassemi · S.E. Sajjadi · A. Ghannadi · M. Shams-Ardakani · M. Mehrabani
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    ABSTRACT: Echium amoenum Fisch. & C.A. Mey. (Boraginaceae) is an endemic Iranian plant, that its dry violet-blue petals has long been used in traditional medicine of Iran. The chemical composition of the volatile fraction of the dried petals of this plant which was isolated by steam distillation extraction with pentane (in yield of 0.05%) was examined by GC-MS. The constituents were identified by their mass spectra and Kovats' indices. The major components except aliphatic alkanes which belong to sesquiterpenes were: δ-cadinene (24.25%), viridiflorol (4.9%), α-muurolene (4.52%), ledene (3.8%), α-calacorene (3.04%), and y-cadinene (2.9%).
    Full-text · Article · Jan 2003
  • Abdolali Mohagheghzadeh · Mohammadreza Shams-Ardakani · Alireza Ghannadi
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    ABSTRACT: Green callus of Zataria multiflora Boiss. (Lamiaceae) was induced from seedlings. The detailed volatile composition of callus and of flower-bearing tops used in the callus induction was investigated by GC and GC – MS spectrometry. Callus volatile constituents consisted of monoterpenoids (25.59% monoterpene hydrocarbons and 70.99% oxygenated monoterpenes), while volatile oil of the flowering tops consisted mainly of monoterpenoids (20.95% monoterpene hydrocarbons and 73.07% oxygenated monoterpenes) and 4.62% sesquiterpene hydrocarbons. The typical components for the two volatile oils were p-cymene (4.85% and 5.43%), γ-terpinene (19.95% and 7.74%), thymol (34.91% and 32.35%) and carvacrol (5.06% and 25.95%). Furthermore, thymol acetate (22.60%) and carvacrol acetate (5.95%) were found mainly in the former and linalol (6.77%) was found merely in the latter. Copyright © 2000 John Wiley & Sons, Ltd.
    No preview · Article · Nov 2000 · Flavour and Fragrance Journal
  • Abdolali Mohagheghzadeh · Mohammadreza Shams-Ardakani · Alireza Ghannadi
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    ABSTRACT: The detailed composition of distilled bud- and flower-bearing tops of Zataria multiflora was investigated by several analytical techniques (GC, GC–MS, FT-IR, 1H- and 13C-NMR). The volatile oil of the former consisted mainly of oxygen-containing monoterpenes (84.81%) and sesquiterpene hyrocarbons (11.88%), whilst the volatile oil of the latter consisted mainly of oxygen-containing monoterpenes (81.78%), monoterpene hydrocarbons (7.33%) and sesquiterpene hydrocarbons (6.96%). The major components for the two volatileyoils were linalol (62.22% and 60.39%), linalyl acetate (11.52% and 8.55%), β-caryophyllene (7.34% and 4.53%). Copyright © 2000 John Wiley & Sons, Ltd.
    No preview · Article · Mar 2000 · Flavour and Fragrance Journal