Jung Eun Lee

Korea Hydro and Nuclear Power - Central Research Institute, Sŏul, Seoul, South Korea

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Publications (360)1034.68 Total impact

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    ABSTRACT: To determine how low-dose ionizing radiation (LDIR) regulates B lympho-proliferation and its molecular mechanism related with Ikaros, transcription factor.
    No preview · Article · Jan 2016 · International journal of radiation oncology, biology, physics
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    ABSTRACT: Renal functional decline that is frequently seen during chronic hepatitis B (CHB) treatment can exert adverse effects on overall prognosis. It, however, is difficult to distinguish vulnerable patients who may experience renal dysfunction because most previous CHB studies were conducted in relatively healthy individuals. In this retrospective observational study, renal functional decline in CHB patients receiving oral antiviral agents for more than 6 months was analyzed and risk factors of chronic kidney disease (CKD) progression were determined.Renal functional decline was defined when the estimated glomerular filtration rate (eGFR) decreased by more than 25% from baseline and rapid CKD progression was defined as eGFR decreased by more than 5 mL/min/1.73 m/y among patients who experienced renal functional decline.A total of 4178 patients were followed up for a median 23 months. Antiviral agents included lamivudine (17.0%), adefovir (3.7%), entecavir (70.4%), telbivudine (0.6%), tenofovir (4.0%), or clevudine (4.3%). Renal functional decline occurred in 706 (16.9%) patients. Based on multivariate Cox regression analysis, age, hypertension, diabetes, history of liver or kidney transplantation, underlying underlying CKD, and simultaneous administration of diuretics increased the hazard ratio for renal functional decline; however, clevudine reduced risk. The eGFR significantly increased over time in patients receiving telbivudine or clevudine compared with lamivudine. Among the 3175 patients followed up for more than 1 year, 407 (12.8%) patients experienced rapid CKD progression. Patients with rapid CKD progression showed lower serum albumin, higher total bilirubin, and prolonged prothrombin time compared with patients with stable renal function, but hepatitis B envelope antigen positivity and hepatitis B virus deoxyribonucleic acid level did not differ between the control and rapid CKD progression groups. Age, diabetes, kidney transplantation, underlying CKD, and simultaneous administration of diuretics were identified as risk factors for rapid CKD progression, and clevudine showed a beneficial effect.Age, hypertension, diabetes, liver or kidney transplantation, underlying CKD, and diuretics were identified as risk factors for renal functional decline. This study suggests that close monitoring of renal function and adequate management are required for CHB patients receiving antiviral agents with these risk factors.
    No preview · Article · Jan 2016 · Medicine
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    ABSTRACT: Inflammatory process mediated by innate and adaptive immune systems is a major pathogenic mechanism of renal ischemia-reperfusion injury (IRI). There are concerns that organ recipients may be at increased risk of developing IRI after receiving kidneys from elder donors. To reveal the effects of aging on the development of renal IRI, we compared the immunologic micromilieu of normal and postischemic kidneys from mice of three different ages (9 weeks, 6 months, and 12 months). There was a higher number of total T cells, especially effector memory CD4/CD8 T cells, and regulatory T cells in the normal kidneys of old mice. On day 2 after IRI, the proportion of necrotic tubules and renal functional changes were comparable between groups although old mice had a higher proportion of damaged tubule compared to young mice. More T cells, but less B cells trafficked into the postischemic kidneys of old mice. The infiltration of NK T cells was similar across the groups. Macrophages and neutrophils were comparable between groups in both normal kidneys and postischemic kidneys. The intrarenal expressions of TNF-α and VEGF were decreased in normal and postischemic kidneys of aged mice. These mixed effects of aging on lymphocytes and cytokines/chemokines were not different between the two groups of old mice. Our study demonstrates that aging alters the intrarenal micromilieu but has small effects on the development of initial renal injury after IRI. Further study investigating aging dependent differences in the repair process of renal IRI may be required.
    No preview · Article · Dec 2015 · American journal of physiology. Renal physiology
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    ABSTRACT: Purpose: Slow graft function (SGF) can influence overall prognosis in patients receiving deceased donor kidney transplantation (DKT). However, the impact of SGF on renal function remains uncertain. We investigated retrospectively renal function in cases with SGF compared with early graft function (EGF) and delayed graft function (DGF). Methods: Renal function after transplantation was analyzed in 199 patients who underwent DKT. Patients were classified into 130 (65.3 %) cases with EGF, 27 (13.6 %) cases with SGF, 6 (3.0 %) cases with DGF and one dialysis (DGF1), and 36 (18.1 %) cases with DGF and two or more dialyses (DGF2). Results: The 1-year estimated glomerular filtration rate (eGFR) in the SGF group was lower than that in the EGF group (P = 0.027), but the rate of eGFR decline did not differ between the groups. The risk factors for renal function were evaluated using the area under the eGFR curve over 3 years (AUCeGFR). Donor age was negatively, and recipient age and the number of HLA matches were positively correlated with the AUCeGFR (all P < 0.05). A multivariate analysis revealed that the AUCeGFR was lower in cases of younger recipient age, older donor age, and acute rejection (all P < 0.05). The AUCeGFR was significantly lower in the SGF and DGF2 groups compared with the EGF group (P = 0.031 and 0.006, respectively). Conclusions: SGF may be an independent risk factor for poor renal function after DKT. Moreover, it was comparable to DGF. Efforts should be dedicated to minimizing the development of SGF and DGF.
    No preview · Article · Nov 2015 · International Urology and Nephrology

  • No preview · Article · Nov 2015 · Critical care medicine
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    ABSTRACT: Objective: The purpose of this study is to evaluate the diagnostic usefulness of the reverse attenuation gradient sign in occlusive lower extremity arterial disease through CT angiography (CTA). Materials and methods: This study sample enrolled 45 men and eight women in the chronic total occlusion group and 30 men and seven women in the subtotal occlusion group. Luminal CT attenuation (in Hounsfield units) was measured at three points from the end of the occlusion site to the first collateral vessel's insertion point. We also used Hounsfield units to measure the CT attenuation of the opposite side artery at the same level in a similar manner. We compared each value using the Mann-Whitney U test. Results: The absolute value of the mean differences in the Hounsfield units among the proximal, middle, and distal portion of chronic total occlusions were higher than those of subtotal occlusions, and this result was statistically significant (p < 0.001). The mean ratios of the Hounsfield units (Hounsfield units of the stenosed lumen divided by Hounsfield units of the opposite normal lumen) of the proximal portion of chronic total occlusions were statistically significantly lower than those of subtotal occlusions. Conclusion: The reverse attenuation gradient sign can be applied to the lower extremity arteries and can be helpful for differential diagnosis of chronic total occlusions from subtotal occlusions using CTA.
    No preview · Article · Oct 2015 · American Journal of Roentgenology

  • No preview · Article · Oct 2015 · Clinical Interventions in Aging
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    ABSTRACT: We report that combining diagnostic bioimaging fluorescence and photothermal therapeutic (PTT) within a single nano-platform can be used to simultaneously and accurately diagnose and ablate tumors. The integrated pH with thermo-responsive poly(dimethylaminoethyl methacrylate-co-N-isopropylacylamide) sulfobetaine (PDNS) backbone carrier retained optical bioimaging from boron dipyrromethane (BODIPY) and sufficient photothermal generation is ensured by integrating IR825 within this same theranostic system. BODIPY (fluorescence dye) with IR825 (NIR dye) quaternized zwitterionic PDNS (IR825/BOD-PDNS) showed pH and temperature-dependent fluorescence emissions and NIR irradiated in vitro photothermal toxicity to cancer cells. This fluorescence platform maximizes the antitumor response, monitors treatment condition, and successfully ablates tumors with thermal energy.
    No preview · Article · Oct 2015 · Journal of Industrial and Engineering Chemistry
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    ABSTRACT: We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cells, however was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of ~10 nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time dependent tumor target accumulation. This long term in vivo survival study of WO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.
    No preview · Article · Sep 2015 · Journal of Controlled Release
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    ABSTRACT: The association of egg consumption with subclinical coronary atherosclerosis remains unknown. Our aim was to examine the association between egg consumption and prevalence of coronary artery calcium (CAC). Cross-sectional study of 23,417 asymptomatic adult men and women without a history of cardiovascular disease (CVD) or hypercholesterolemia, who underwent a health screening examination including cardiac computed tomography for CAC scoring and completed a validated food frequency questionnaire at the Kangbuk Samsung Hospital Total Healthcare Centers, South Korea (March 2011-April 2013). The prevalence of detectable CAC (CAC score > 0) was 11.2%. In multivariable-adjusted models, CAC score ratio (95% confidence interval [CI]) comparing participants eating ≥ 7 eggs/wk to those eating < 1 egg/wk was 1.80 (1.14-2.83; P for trend = 0.003). The multivariable CAC score ratio (95% CI) associated with an increase in consumption of 1 egg/day was 1.54 (1.11-2.14). The positive association seemed to be more pronounced among participants with low vegetable intake (P for interaction = 0.02) and those with high BMI (P for interaction = 0.05). The association was attenuated and no longer significant after further adjustment for dietary cholesterol. Egg consumption was associated with an increased prevalence of subclinical coronary atherosclerosis and with a greater degree of coronary calcification in asymptomatic Korean adults, which may be mediated by dietary cholesterol. The association was particularly pronounced among individuals with low vegetable intake and those with high BMI. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    No preview · Article · Aug 2015 · Atherosclerosis
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    ABSTRACT: The number of elderly people on dialysis is increasing rapidly. Fluid overload and malnutrition status are serious problems in elderly dialysis patients. We aimed to compare the hydration and nutritional status through bioimpedance analysis (BIA) between young and elderly hemodialysis (HD) patients and to analyze risk factors related to fluid overload and malnutrition status in these patients. We conducted a cross-sectional study, in which 82 HD (males 42, mean age 58.7±12.9 years) patients were enrolled. We collected different types of data: laboratory data, such as serum creatinine, albumin, total iron-binding capacity, hemoglobin, total cholesterol; anthropometric data, such as hand grip strength (HGS); BIA data, such as intracellular water, skeletal muscle mass, body cell mass, bone mineral content, phase angle (PhA), extra cellular water (ECW)/total body water (TBW) ratio; and malnutrition-inflammation score (MIS), which is a traditional nutritional parameter for dialysis patients. All patients were stratified into two groups according to their age: young (<65 years [n=54]) and elderly (≥65 years [n=28]). Total iron-binding capacity and HGS were significantly lower in elderly HD patients than in young HD patients (198.9±35.6 vs 221.4±52.1 mcg/dL; and 22.4±10.3 vs 36.4±23.2 kg, respectively) (P<0.05). Also, intracellular water and PhA measured by BIA were significantly lower (18.3±4.0 vs 20.3±4.2 L [P=0.043]; and 4.0±1.0 vs 4.9±1.2° [P=0.002], respectively), and ECW/TBW were higher in elderly HD patients (0.40±0.01 vs 0.39±0.01 [P=0.001]). ECW/TBW was positively associated with age (P<0.001) and the presence of diabetes (P<0.001) and was negatively associated with sex (P=0.001), albumin (P<0.001), urine volume (P=0.042), HGS (P<0.001), and PhA by BIA (P<0.001). MIS was negatively related to sex (P=0.001), albumin (P<0.001), HGS (P=0.001), and PhA (P<0.001) in HD patients. On multivariate analysis, older age (P=0.031), the presence of diabetes (P=0.035), and decreased PhA (P<0.001) were independent risk factors for increased ECW/TBW, representative of fluid overload status, whereas only decreased PhA (P=0.008) was a significant factor for MIS, representative of malnutrition status in these HD patients. We found that fluid overload and malnutrition status were more common in elderly HD patients compared with young HD patients. PhA was a significant independent factor in fluid overload status and malnutrition in these HD patients. Thus, our results indicated that PhA assessed by BIA might be a clinically useful method for assessing nutritional and hydration status in elderly HD patients.
    Preview · Article · Aug 2015 · Clinical Interventions in Aging
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    ABSTRACT: Gastric cancer is the second most common cause of cancer-related death worldwide. Although brain metastasis is a rare complication of gastric cancer, no standard therapy for gastric cancer brain metastasis has been established. We attempted to identify biological markers that predict brain metastasis, and investigated how to modulate such markers. A case-control study of patients newly diagnosed with gastric cancer who had developed brain metastasis during follow-up, was conducted. These patients were compared with patients who had advanced gastric cancer but no evidence of brain metastasis. Immunohistochemistry was used to analyze the expression of E-cadherin, N-cadherin, MSS1, claudin-3, claudin-4, Glut1, clusterin, ITGB4, vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR) and p53. The expression of VEGF tended to be higher in the case group (33.3 vs. 0%, p=0.055). Median survival was significantly correlated with vascular invasion (12 vs. 33 months, p=0.008) and N-cadherin expression (36 vs. 12 months, p=0.027). We also investigated the effects of metformin in tumor-bearing mouse models. VEGF expression was decreased and E-cadherin increased in the metformin‑treated group when compared with the control group. The expression of the mesenchymal marker MMP9 was decreased in the metformin-treated group. Brain metastasis of advanced gastric cancer was associated with the expression of VEGF. Metformin treatment may be useful for modulating the metastatic capacity by reducing VEGF expression and blocking epithelial-to-mesenchymal transition.
    No preview · Article · Aug 2015 · Oncology Reports
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    ABSTRACT: To examine the association between circulating 25-hydroxyvitamin D [25(OH)D] levels and colorectal adenoma in a case-control study and a meta-analysis. We conducted a matched case-control study (112 cases and 112 matched controls) and combined 15 studies, including our study, in a meta-analysis. The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using a random-effects model. In total, 5454 colorectal adenomas and 6656 controls were included in the meta-analysis. In a meta-analysis including 14 previous studies and our study, we observed a significant inverse association between circulating 25(OH)D levels and colorectal adenoma (OR = 0.68; 95%CI: 0.54-0.82) when comparing the highest category with the lowest category. Stratification by adenoma location (proximal or distal adenoma) showed similar estimates. When we stratified by study region, the ORs (95%CIs) were 0.70 (0.52-0.88) in the US and 0.66 (0.34-0.97) in Asia. These data suggest an inverse association between circulating 25(OH)D levels and colorectal adenoma in both Western and Asian populations.
    Preview · Article · Aug 2015
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    ABSTRACT: Many potentially modifiable risk factors for prostate cancer are also associated with prostate cancer screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)(2)), smoking, and alcohol consumption with risk of fatal prostate cancer in Asian countries where prostate cancer screening is not widely utilized. Analysis included 18 prospective cohort studies conducted during 1963-2006 across 6 countries in southern and eastern Asia that are part of the Asia Cohort Consortium. Body mass index, smoking, and alcohol intake were determined by questionnaire at baseline, and cause of death was ascertained through death certificates. Analysis included 522,736 men aged 54 years, on average, at baseline. During 4.8 million person-years of follow-up, there were 634 prostate cancer deaths (367 prostate cancer deaths across the 11 cohorts with alcohol data). In Cox proportional hazards analyses of all cohorts in the Asia Cohort Consortium, prostate cancer mortality was not significantly associated with obesity (body mass index >25: hazard ratio (HR) = 1.08, 95% confidence interval (CI): 0.85, 1.36), ever smoking (HR = 1.00, 95% CI: 0.84, 1.21), or heavy alcohol intake (HR = 1.00, 95% CI: 0.74, 1.35). Differences in prostate cancer screening and detection probably contribute to differences in the association of obesity, smoking, or alcohol intake with prostate cancer risk and mortality between Asian and Western populations and thus require further investigation. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
    Full-text · Article · Aug 2015 · American journal of epidemiology
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    ABSTRACT: Warfarin skin necrosis is an infrequent complication of warfarin treatment, and is characterized by painful ulcerative skin lesions that appear a few days after the start of warfarin treatment. Calciphylaxis also appears as painful skin lesions caused by tissue injury resulting from localized ischemia caused by calcification of small- to medium-sized vessels in patients with end-stage renal disease. We report on a patient who presented with painful skin ulcers on the lower extremities after administration of warfarin following a valve operation. Calciphylaxis was considered first because of the host factors; eventually, the skin lesions were diagnosed as warfarin skin necrosis by biopsy. The skin lesions improved after warfarin discontinuation and short-term steroid therapy. Most patients with end-stage renal disease have some form of cardiovascular disease, and some require temporary or continual warfarin treatment. It is important to differentiate between warfarin skin necrosis and calciphylaxis in patients with painful skin lesions.
    Preview · Article · Aug 2015
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    ABSTRACT: We have synthesized a pH-dependent, NIR-sensitive, reduced graphene oxide (rGO) hybrid nano-composite via electrostatic interaction with indocyanine green (ICG) which is designed not only to destroy localized cancer cells but also be minimally invasive to surrounding normal cells. The near-infrared (NIR) irradiated hybrid nano-composites showed pH dependent photo-thermal heat generation capability from pH 5.0 to 7.4 due to the pH response relief and quenching effects of poly(2-dimethyl amino ethyl methacrylate) [poly(PDMAEMA)] with ICG on a single rGO sheet. This pH-triggered relief and quenching mechanism regulated in vitro photo-thermolysis as the pH changed from 5.0 to 7.4. The in vitro cellular uptake and confocal laser scan microscopic (CLSM) images at different pH values show promise for environment sensitive bio-imaging. The NIR-absorbing hybrid nanomaterials showed a remarkably improved in vitro cancer cell targeted photothermal destruction compared to free ICG. Upon local NIR irradiation, these hybrid nano-composites-treated tumors showed necrotic, shrunken, ablation of malignant cells and totally healed after 18 days treatment. Our finding regarding the acidic pH stimulus of cancer cellular environment has proven to be a wining platform for the fight against cancer. Copyright © 2015. Published by Elsevier Ltd.
    No preview · Article · Aug 2015 · Biomaterials
  • Jung Eun Lee · Nayeon Kim · Hans-Olov Adami · Per Lindblad

    No preview · Article · Aug 2015 · Cancer Research

  • No preview · Article · Aug 2015 · Cancer Research
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    ABSTRACT: Doxorubicin (Dox) is an effective anti-cancer drug, but its use is limited due to the adverse effect by inducing the irreversible dilated cardiomyopathy. Cilostazol (Cilo), a potent phosphodiesterase III inhibitor, has been reported to have an anti-inflammatory effect. Here, we investigated whether Cilo has a protective effect on Dox-induced cardiomyopathy (DIC). The mice were randomly divided into four groups: saline-control, Dox (15mg/kg), Dox (15mg/kg) plus Cilo (50mg/kg), and Cilo (50mg/kg). As results, the co-administration of Dox and Cilo significantly enhanced the left ventricular systolic function compared with Dox alone. In addition, Cilo treatment significantly reduced the Dox-induced perivascular fibrosis, collagen concentration, and connective growth factor expression in the hearts. Also, Cilo administration markedly reduced Dox-induced levels of serum B-type natriuretic peptide, dysferlin, high-mobility group protein B1 (HMGB1), toll-like receptor 4 (TLR4), nuclear factor-κB p65, and cyclooxygenase-2 (COX-2). Furthermore, Cilo treatment significantly reduced the Dox-induced oxidative stress by lowering the translocation of Nrf2 into the nucleus and the expression of NQO1, heme oxygenase (HO-1) and superoxide dismutase-1 (SOD-1). Our results suggest that Cilo may be the potential anti-fibrotic, anti-oxidative and anti-inflammatory drug for DIC. Copyright © 2015. Published by Elsevier Inc.
    No preview · Article · Jul 2015 · Free Radical Biology and Medicine
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    ABSTRACT: Successful cellular delivery of synthetic siRNA depends mainly on the capability of a carrier to form a stable complex with siRNA, which can provide efficient protection of the siRNA from enzyme-mediated degradation and improved cellular uptake. However, due to its short length and rigid structure, cellular delivery of siRNA is often not as efficient as that of plasmid DNA using conventional cationic polymer- and lipid-based carriers. Herein, we synthesized a dendritic gold nanoparticle (Au@MC)-based siRNA delivery system, which provides efficient protection of siRNA and improved cellular uptake. The Au@MC can be readily synthesized from a block copolymer micelle template with a dendritic structure. Au@MC can efficiently form a stable complex with the short and rigid siRNA by localizing it in the space between the branches of the Au@MC. The stability and cellular uptake efficiency were significantly influenced by the structural features of Au@MC, such as size, surface charge, and gap width between the branches. A selected Au@MC/siRNA formulation could successfully achieve highly efficient siRNA transfection in the absence and presence of serum proteins without significant cell toxicity, suggesting the formulation as a potential candidate for siRNA-based clinical gene therapy. [Figure not available: see fulltext.] © 2015, The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht.
    No preview · Article · Jul 2015 · Macromolecular Research

Publication Stats

4k Citations
1,034.68 Total Impact Points

Institutions

  • 2016
    • Korea Hydro and Nuclear Power - Central Research Institute
      Sŏul, Seoul, South Korea
  • 2015
    • Brown University
      Providence, Rhode Island, United States
  • 2014-2015
    • Konkuk University
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
    • University of Washington Seattle
      Seattle, Washington, United States
    • Dong-A University
      Busan, Busan, South Korea
    • Gwangju Institute of Science and Technology
      Gwangju, Gwangju, South Korea
  • 2012-2015
    • National Institute of Environmental Research
      Sŏul, Seoul, South Korea
    • National Institute of Food and Drug Safety Evaluation
      Sŏul, Seoul, South Korea
    • Ewha Womans University
      • Department of Chemistry Nano Science
      Sŏul, Seoul, South Korea
  • 2011-2015
    • Chung-Ang University
      • College of Pharmacy
      Sŏul, Seoul, South Korea
    • Gyeongsang National University
      • College of Veterinary Medicine
      Shinshū, Gyeongsangnam-do, South Korea
    • Boston University
      Boston, Massachusetts, United States
  • 2010-2015
    • Kyung Hee University
      • • College of Medicine
      • • Department of Applied Physics
      Sŏul, Seoul, South Korea
    • Sookmyung Women's University
      • Department of Food and Nutrition
      Sŏul, Seoul, South Korea
    • University of Chicago
      Chicago, Illinois, United States
  • 2008-2015
    • Catholic University of Korea
      • • College of Medicine
      • • Department of Neurosurgery
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Yonsei University
      • • Department of Internal Medicine
      • • College of Medicine
      • • College of Nursing
      Sŏul, Seoul, South Korea
  • 2007-2015
    • Samsung Medical Center
      Sŏul, Seoul, South Korea
  • 2005-2015
    • Sungkyunkwan University
      • • School of Pharmacy
      • • School of Medicine
      • • Department of Radiation Oncology
      Sŏul, Seoul, South Korea
  • 2011-2014
    • Chonbuk National University
      Tsiuentcheou, Jeollabuk-do, South Korea
    • Seoul National University Hospital
      • Department of Orthopedic Surgery
      Sŏul, Seoul, South Korea
  • 2007-2014
    • Korea University
      • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2004-2014
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2001-2014
    • Pusan National University
      • Department of Mechanical Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2013
    • University of Seoul
      Sŏul, Seoul, South Korea
  • 2012-2013
    • Seoul National University Bundang Hospital
      • • Department of Neurosurgery
      • • Department of Orthopaedic Surgery
      Sŏul, Seoul, South Korea
  • 2009-2013
    • Harvard University
      Cambridge, Massachusetts, United States
    • National Institutes of Health
      • Division of Clinical and Epidimiological Research
      베서스다, Maryland, United States
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
    • Brigham and Women's Hospital
      Boston, Massachusetts, United States
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2000-2013
    • Seoul National University
      • • Department of Orthopaedic Surgery
      • • Institute of Health and Environment
      • • Department of Public Health
      • • Department of Biological Sciences
      Sŏul, Seoul, South Korea
  • 2011-2012
    • Chungnam National University
      • Graduate School of Analytical Science and Technology
      Daiden, Daejeon, South Korea
  • 1999-2012
    • Inha University
      • • Department of Nursing
      • • College of Natural Sciences
      Sŏul, Seoul, South Korea
  • 2009-2011
    • Sejong University
      • Faculty of Food Science and Technology
      Sŏul, Seoul, South Korea
  • 1991-2011
    • Yeungnam University
      • • School of Chemical Engineering
      • • Department of Chemistry
      Gyeongsan, Gyeongsangbuk-do, South Korea
  • 2006-2009
    • University of Ulsan
      • Asan Medical Center
      Ulsan, Ulsan, South Korea
    • Inje University
      Kŭmhae, Gyeongsangnam-do, South Korea
    • Keimyung University
      • Dongsan Medical Center
      Sŏul, Seoul, South Korea
  • 2007-2008
    • Harvard Medical School
      • Department of Medicine
      Boston, MA, United States
  • 2005-2007
    • Korea Institute of Science and Technology
      • Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2004-2005
    • Hongik University
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2002-2005
    • Pohang University of Science and Technology
      • • Department of Chemistry
      • • School of Environmental Science and Engineering
      Antō, North Gyeongsang, South Korea
  • 2003
    • Hong-ik university
      Missouri, United States