G Madhumitha

VIT University, Velluru, Tamil Nadu, India

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Publications (19)19.86 Total impact


  • No preview · Chapter · Sep 2015
  • K. Hemalatha · G. Madhumitha

    No preview · Article · Jan 2015 · Research Journal of Pharmacy and Technology
  • Selvaraj Mohana Roopan · Gunabalan Madhumitha
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    ABSTRACT: Vegetable triglycerides are among the first renewable resources exploited by man primarily in coating applications because their unsaturated varieties polymerize as thin films in the presence of atmospheric oxygen. Nowadays, use of the vegetable oils is spotlight of the chemical industries and as they are using these as a renewable platform for further ability. In order to overcome disadvantages such as poor mechanical properties of polymers from renewable resources, or to offset the high price of synthetic biodegradable polymers, various blends and composites have been developed over the last decade. The progress of blends from three kinds of polymers from renewable resources (1) natural polymers, such as starch, protein, and cellulose; (2) synthetic polymers from natural monomers, such as polylactic acid; and (3) polymers from microbial fermentation. In this chapter we have discussed about the different types of polymer composites obtained from the vegetable oil and applications of the polymer composites.
    No preview · Article · Jan 2015
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    Gunabalan Madhumitha · Ganesh Elango · Selvaraj Mohana Roopan
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    ABSTRACT: In recent era researchers are mainly focused on silver (Ag) and silver doped nanoparticles due to its vast area of applications which are effectively acts against the microbial activity. Silver nanoparticles (AgNP’s) were one of the metal nanoparticles which have high activity against various diseases causing pathogens to safeguard the environment. However, there is increasing concern related to biological impacts by the use of silver doped nanoparticles on a large scale. The synthesized silver nanoparticles were doped with other chemical reagents by using various physio-chemical methods. The stability of silver nanoparticles was governed by morphological features, capping agents and organic molecules. This review article briefs about the synthesis of silver doped nanoparticles using different methods and their antimicrobial activity.
    Full-text · Article · Dec 2014 · Journal of Sol-Gel Science and Technology
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    ABSTRACT: In this paper, we have established for the first time, the terrific efficiency of aqueous extract of agricultural waste dried peel of sugar apple (Annona squamosa) in the rapid synthesis of stable SnO2 nanoparticles. In topical years, the deployment of secondary metabolites from plant extract has emerged as a novel technology for the synthesis of various nanoparticles. In this paper, we have studied the potential of SnO2 nanoparticles assembly using agricultural waste source for the first time. The synthesized nanoparticles were characterized and confirmed as SnO2 nanoparticles by using UV-visible spectroscopy, XRD, and TEM analysis. The motivation of this study was to examine cytotoxicity study of SnO2 nanoparticles against hepatocellular carcinoma cell line (HepG2). SnO2 nanoparticles inhibited the cell proliferation in a dose- and time-dependent manner with an IC50 value of 148 μg/mL. The treated cells showed an altered morphology with increasing concentrations of SnO2 nanoparticles. Our result shows that the SnO2 nanoparticles exhibit moderate cytotoxicity towards the hepatocellular carcinoma (HepG2) at tested concentrations.
    No preview · Article · Nov 2014 · Applied Biochemistry and Biotechnology
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    ABSTRACT: We want to express our sincere appreciation to all the authors for their contribution. Moreover, our thanks are extended to all the reviewers for their time and for enhancing the quality of these articles. S. Mohana Roopan and Amir Kajbafvala contributed equally to this special issue.
    Preview · Article · Aug 2014 · Journal of Nanomaterials
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    ABSTRACT: Heterocyclic motif is an important scaffold which has both industrial and pharmaceutical applications. These motifs can be prepared using wide variety of reaction conditions such as the use of expensive catalyst, toxic solvent, harsh reaction condition like the use of base, high temperature, and multistep reaction. Although various methods are involved, the chemistry arena is now shifted towards the greener way of synthesis. Nanocatalyst constitutes an important role in the green synthesis. This is because the activity of the catalyst resides in the exposed portion of the particles. By decreasing the size of the catalyst, advantages such as more surface area would be exposed to the reactant, only negligible amount would be required to give the significant result and selectivity could be achieved, thereby, eliminating the undesired products. The current review enlists the various types of nanocatalyst involved in the heterocyclic ring formation and also some other important functionalization over the ring.
    Full-text · Article · Apr 2013 · Journal of Nanomaterials
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    G. Madhumitha · Selvaraj Mohana Roopan
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    ABSTRACT: Integration of green chemistry principles to nanotechnology is one of the key issues in nanoscience research. Biological methods were used to synthesize metal and metal oxide nanoparticles of specific shape and size since they enhance the properties of nanoparticles in greener route. Plant-mediated methods devoid the use of toxic chemicals in the synthetic protocols which has adverse effects on the environment. Owing to the rich biodiversity of plants and their potential secondary constituents, plants and plant parts have gained attention in recent years as medium for nanoparticles’ synthesis. In this review, we present the current status of nanoparticles synthesis using devastated crops.
    Full-text · Article · Mar 2013 · Journal of Nanomaterials
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    ABSTRACT: a b s t r a c t Phyto-synthesis of transition metal nanoparticles is gaining importance due to their biocompatibility, low toxicity, green approach and environmental friendly nature. We used mesocarp layer extract of Cocos nucifera and was assessed for the synthesis of silver nanoparticles. The reduction of silver ions occurred when silver nitrate solution was treated with aqueous extract of C. nucifera coir at 60 • C. Synthesized silver nanoparticles (AgNPs) particles were confirmed by analysing the excitation of surface plasmon resonance (SPR) using UV–vis spectrophotometer at 433 nm. Further TEM analysis confirmed the range of particle size as 23 ± 2 nm. The XRD spectrum showed the characteristic Bragg peaks of 1 1 1, 2 0 0, 2 2 0 and 3 1 1 facets of the face centered cubic silver nanoparticles and confirms that these nanoparticles are crystalline in nature. Gas chromatography–mass spectrometry (GCMS) of coir extract confirms the pres-ence of hydrocarbon such as nonacosane and heptacosane which may possibly influence the reduction process and stabilization of silver nanoparticles. This is the first account of C. nucifera coir assisted syn-thesis of biogenic Ag nanoparticles; the nanoparticles are notably smaller and better faceted compared with those synthesized by A. squamosa extracts previously reported. Synthesized Ag nanoparticles were effective anti-larvicidal agent's against Anopheles stephensi and C. quinquefasciatus.
    Full-text · Article · Mar 2013 · Industrial Crops and Products
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    Full-text · Dataset · Mar 2013
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    ABSTRACT: a b s t r a c t Phyto-synthesis of transition metal nanoparticles is gaining importance due to their biocompatibility, low toxicity, green approach and environmental friendly nature. We used mesocarp layer extract of Cocos nucifera and was assessed for the synthesis of silver nanoparticles. The reduction of silver ions occurred when silver nitrate solution was treated with aqueous extract of C. nucifera coir at 60 • C. Synthesized silver nanoparticles (AgNPs) particles were confirmed by analysing the excitation of surface plasmon resonance (SPR) using UV–vis spectrophotometer at 433 nm. Further TEM analysis confirmed the range of particle size as 23 ± 2 nm. The XRD spectrum showed the characteristic Bragg peaks of 1 1 1, 2 0 0, 2 2 0 and 3 1 1 facets of the face centered cubic silver nanoparticles and confirms that these nanoparticles are crystalline in nature. Gas chromatography–mass spectrometry (GCMS) of coir extract confirms the pres-ence of hydrocarbon such as nonacosane and heptacosane which may possibly influence the reduction process and stabilization of silver nanoparticles. This is the first account of C. nucifera coir assisted syn-thesis of biogenic Ag nanoparticles; the nanoparticles are notably smaller and better faceted compared with those synthesized by A. squamosa extracts previously reported. Synthesized Ag nanoparticles were effective anti-larvicidal agent's against Anopheles stephensi and C. quinquefasciatus.
    Full-text · Dataset · Mar 2013
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    ABSTRACT: In the present study, the biosynthesis of rutile TiO(2) nanoparticles (TiO(2) NPs) was achieved by a novel, biodegradable and convenient procedure using fruit peel Annona squamosa aqueous extract. This is the first report on the new, simple, rapid, eco-friendly and cheaper methods for the synthesis of rutile TiO(2) NPs at lower temperature using agricultural waste. Rutile TiO(2) NPs were characterized by UV, XRD, SEM, TEM and EDS studies. The UV-Vis spectrophotometer results were promising and showed a rapid production of TiO(2) NPs with a surface plasmon resonance occurring at 284nm. The formation of the TiO(2) NPs as observed from the XRD spectrum is confirmed to be TiO(2) particles in the rutile form as evidenced by the peaks at 2θ=27.42°, 36.10°, 41.30° and 54.33° when compared with the literature. The TEM images showed polydisperse nanoparticles with spherical shapes and size 23±2nm ranges.
    Full-text · Article · Aug 2012 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
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    ABSTRACT: a b s t r a c t Phyto-synthesis of transition metal nanoparticles is gaining importance due to their biocompatibility, low toxicity, green approach and environmental friendly nature. We used mesocarp layer extract of Cocos nucifera and was assessed for the synthesis of silver nanoparticles. The reduction of silver ions occurred when silver nitrate solution was treated with aqueous extract of C. nucifera coir at 60 • C. Synthesized silver nanoparticles (AgNPs) particles were confirmed by analysing the excitation of surface plasmon resonance (SPR) using UV–vis spectrophotometer at 433 nm. Further TEM analysis confirmed the range of particle size as 23 ± 2 nm. The XRD spectrum showed the characteristic Bragg peaks of 1 1 1, 2 0 0, 2 2 0 and 3 1 1 facets of the face centered cubic silver nanoparticles and confirms that these nanoparticles are crystalline in nature. Gas chromatography–mass spectrometry (GCMS) of coir extract confirms the pres-ence of hydrocarbon such as nonacosane and heptacosane which may possibly influence the reduction process and stabilization of silver nanoparticles. This is the first account of C. nucifera coir assisted syn-thesis of biogenic Ag nanoparticles; the nanoparticles are notably smaller and better faceted compared with those synthesized by A. squamosa extracts previously reported. Synthesized Ag nanoparticles were effective anti-larvicidal agent's against Anopheles stephensi and C. quinquefasciatus.
    Full-text · Dataset · Aug 2012
  • G. Madhumitha · A. Mary Saral
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    ABSTRACT: The aim of this study is to investigate the larvicidal activity of crude extracts obtained from petroleum ether (A), ethyl acetate (B) and methanol (C) of C. infundibuliformis against Anopheles Stephensi, Aedes aegypti and Culex quinquefasciatus. Six fourth-instar mosquito larvae were used for the study. The experimental results demonstrated that, petroleum ether extract (A) have significantly reduced the mortality of the larvae when compared with other two extracts. The results showed that the extracts of C. infundibuliformis may be considered as a potent source for new drug. The bioactivity-guided fractionation, isolation and identification will bring out potential drug to mankind, especially with anti-infective properties.
    No preview · Article · Jan 2012 · International Journal of Pharmacy and Pharmaceutical Sciences
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    ABSTRACT: Plant products may be alternative sources of parasitic control agents, since they constitute a rich source of bioactive compounds that are eco-friendly and nontoxic products. The plant extracts are good and safe alternatives due to their low toxicity to mammals and easy biodegradability. In the present study, fruit peel aqueous extract of Annona squamosa (Annonaceae) extracted by immersion method exhibited adulticidal activity against Haemaphysalis bispinosa (Acarina: Ixodidae) and the hematophagous fly, Hippobosca maculata (Diptera: Hippoboscidae), and larvicidal activity against the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae), Anopheles subpictus, and Culex quinquefasciatus (Diptera: Culicidae). The chemical composition of A. squamosa fruit peel aqueous extract was analyzed by gas chromatography-mass spectrometry. The major chemical constituent of peel aqueous extract of A. squamosa was identified as 1H- cycloprop[e]azulen-7-ol decahydro-1,1,7-trimethyl-4-methylene-[1ar-(1aα,4aα, 7β, 7 a, β, 7bα)] (28.55%) by comparison of mass spectral data and retention times. The other major constituents present in the aqueous extract were retinal 9-cis- (12.61%), 3,17-dioxo-4-androsten-11alpha-yl hydrogen succinate (6.86%), 1-naphthalenepentanol decahydro-5-(hydroxymethyl)-5,8a-dimethyl-y,2-bis(methylene)-(1α,4aβ,5α,8aα) (14.83%), 1-naphthalenemethanol decahydro -5-(5-hydroxy-3-methyl-3-pentenyl)- 1,4a-di methyl - 6-methylene -(1S-[1α, 4aα, 5α(E), 8aβ] (4.44%), (-)-spathulenol (20.75%), podocarp-7-en-3-one13β-methyl-13-vinyl- (5.98%), and 1-phenanthrene carboxaldehyde 7-ethenyl-1,2,3,4,4a,4,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-[1R-(1α,4aβ.4bα,7β, 10aα)]-(5.98%). The adult and larval parasitic mortalities observed in fruit peel aqueous extract of A. squamosa were 31, 59, 80, 91, and100%; 27, 42, 66, 87, and 100%; and 33, 45, 68, 92, and 100% at the concentrations of 250, 500, 1,000, 1,500, and 2,000 ppm, respectively, against Haemaphysalis bispinosa, Hippobosca maculata, and R. microplus. The observed larvicidal efficacies were 36, 55, 72, 92, 100% and 14, 34, 68, 89, and 100% at 200, 400, 600, 800, and 1,000 ppm, respectively, against A. subpictus and C. quinquefasciatus. The highest parasite mortality was found after 24 h of exposure against Haemaphysalis bispinosa (LC(50) = 404.51 ppm, r (2) = 0.890), Hippobosca maculata (LC(50) = 600.75 ppm, r (2) = 0.983), the larvae of R. microplus (LC(50) = 548.28 ppm, r (2) = 0.975), fourth-instar larvae of A. subpictus (LC(50) = 327.27 pm, r (2) = 0.970), and C. quinquefasciatus (LC(50) = 456.29 ppm, r (2) = 0.974), respectively. The control (distilled water) showed nil mortality in the concurrent assay. The χ (2) values were significant at p < 0.05 level. Therefore, the eco-friendly and biodegradable compounds from fruit peel aqueous extract of A. squamosa may be an alternative to conventional synthetic chemicals, particularly in integrated approach for the control of Haemaphysalis bispinosa, Hippobosca maculata, R. microplus, and the medically important vectors A. subpictus and C. quinquefasciatus.
    No preview · Article · Oct 2011 · Parasitology Research
  • P Philip Jacob · G Madhumitha · A Mary Saral
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    ABSTRACT: To determine the antioxidant activity, total phenolic and flavonoid content of Petroleum ether extract (PE), Dichloromethane extract (DCM), Ethanol extract (ET) and aqueous extract (AQ) of henna seeds. Total antioxidant assay (phosphomolybenum method), DPPH radical scavenging assay, reducing power assay and lipid peroxidation inhibition assay were used to ascertain the potential of seeds as an antioxidant. In all the assays carried out ET showed a greater potential to scavenge DPPH radical, reduce MO (VI) to MO (V) complex and Fe (III) to Fe (II) and to inhibit lipid peroxidation. The IC(50) of ET was far greater than that of the standard, ascorbic acid (AS) in the lipid peroxidation assay. The activity of AQ was lesser when compared with that of ET but greater than PE and DCM. The amount of phenolics and flavonoids were present in higher amounts in ET followed by AQ. Trace amounts of phenolics were detected in PE and DCM, but the amount of flavonoids were below the detection level. The study showed that the antioxidant activity and the concentrations of phenolics and flavonoids are proportionate to each other. Ethanolic extract of henna seeds are efficient antioxidants, which can be utilized for further isolation of active compounds and pharmaceutical applications.
    No preview · Article · Jun 2011 · Asian Pacific Journal of Tropical Medicine
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    G Madhumitha · A Mary Saral
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    ABSTRACT: To investigate the phytochemical, antibacterial, antifungal and anticandidal activity of successive extracts of Crossandra infundibuliformis (Acanthaceae) leaves. Preliminary screening on the presence of alkaloids, saponins, phytosterols, phenolic compounds, flavanoids, tannins, carbohydrates, terpenoids, oils and fats were carried out by phytochemical analysis. The antibacterial, antifungal and anticandidal activities were done by agar well diffusion technique. The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0 μg/mL. In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250 μg/mL. These findings demonstrate that the leaf extracts of C. infundibuliformis presents excellent antimicrobial activities and thus have great potential as a source for natural health care products.
    Full-text · Article · Mar 2011 · Asian Pacific Journal of Tropical Medicine
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    G Madhumitha · A Mary Saral · B Senthilkumar · A Sivaraj
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    ABSTRACT: Objective: To analyze the hepatoprotective effect of the Crossandra infundibuliformis. Methods: Hepatotoxicity was induced by carbon tetrachloride. Petroleum ether extract of dried leaves was administrated to mice for 7 days. The hepatoprotective effect of petroleum ether extract was evaluated by the assay of liver function biochemical parameters. Results: The result clearly indicates that petroleum ether extract showed significant hepatoprotection when compared with standard Silumarin. Conclusions: The petroleum ether extract of the leaves of Crossandra infundibuliformis possess significant acute hepatoprotective activity. Thus further investigation on this species would bring a promising drug for liver disorders.
    Full-text · Article · Oct 2010 · Asian Pacific Journal of Tropical Medicine
  • K. Hemalatha · G. Madhumitha · S.M. Roopan

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