[Show abstract][Hide abstract] ABSTRACT: This prospective study aims to investigate the levels of bone turnover markers in pregnancy and correlate it with the assessment of preeclampsia.
A total of 140 women were followed up during their pregnancy. The women who developed preeclampsia (n=22), were compared with age-matched women (controls) who did not develop preeclampsia and had an uncomplicated pregnancy (n=22). Maternal serum levels of serum bone-specific alkaline phosphatase (sBAP), a marker of bone formation, and N-telopeptide of type 1 collagen (NTx), a marker of bone resorption, were estimated at recruitment (in the second trimester) and at delivery. sBAP and NTx levels were measured by enzyme immunoassay (EIA) and enzyme linked immunosorbent assay (ELISA), respectively. Serum and urinary calcium titers were compared by using a commercially-available calcium assay kit.
Serum NTx levels increased significantly during pregnancy (P<0.02) and were significantly higher at delivery (P<0.01) in women with preeclampsia compared with controls. The levels of sBAP and serum calcium did not change significantly in both groups during pregnancy. There was no significant correlation between sBAP and NTx with maternal factors. A negative correlation was observed between sBAP and NTx levels in the preeclamptic group.
Biochemical markers of bone turnover are greater in preeclampsia compared with normal pregnancy only when the disease is clinically evident (at delivery).
No preview · Article · Jan 2012 · Journal of Obstetrics and Gynaecology Research
[Show abstract][Hide abstract] ABSTRACT: Objectives
To compare the bone mineral density (BMD) and its variables in premenopausal and postmenopausal women.
In this cross sectional study, 62 premenopausal and 62 postmenopausal apparently healthy women were evaluated by a questionnaire. The dietary intake of calcium was evaluated by 24 hours recall method and using table for proximate principle of common Indian food by Indian Council of Medical Research (ICMR). BMD at lumbar spine, femoral neck and Ward’s triangle were measured by dual energy X-ray absorptiometry (DXA). A correlation between BMD and various variables were calculated for each of the two groups.
The mean age of premenopausal and postmenopausal women was 32.46±7.8 and 51.74±7.1 years respectively. The body mass index (BMI), height and weight were comparable in both the groups. The daily intake of calcium was significantly higher in premenopausal women (p<0.01). Approximately, 17% of the postmenopausal women and 9.6% of the premenopausal women were having osteoporosis; 28.56% of the postmenopausal women and 43.54% of the premenopausal women were having osteopenia at the lumbar spine. The BMD at lumber spine was found to be statistically significantly higher in premenopausal women than that in postmenopausal women (p=0.03). BMD at lumbar spine, femoral neck and Ward’s triangle were positively correlated with height, weight, BMI in premenopausal as well in postmenopausal women.
A significant number of women had osteopenia during premenopausal period and osteoporosis in postmenopausal phase. By increasing awareness towards bone health in second and third decade, morbidity of osteoporosis can be reduced.
No preview · Article · Apr 2011 · Journal of Obstetrics and Gynecology of India