Yunpeng Chen

Jilin University, Yung-chi, Jilin Sheng, China

Are you Yunpeng Chen?

Claim your profile

Publications (2)5.52 Total impact

  • Yuanxin Zhang · Quanshun Li · Yakun Ge · Yunpeng Chen · Jun Chen · Ying Dong · Wei Shi
    [Show abstract] [Hide abstract]
    ABSTRACT: Silibinin, a flavonoid compound, has shown to be of chemopreventive potential against many cancers. However, its efficacy against gastric cancer has not been well elucidated. Here, we assessed the activity of Silibinin on apoptosis and cell-cycle arrest in human gastric cells culture system using SGC-7901 as the model. Silibinin treatment could inhibit the cell growth and cause a prominent G(2) phase arrest and apoptosis in dose- and time-dependent manner. In mechanistic studies, Silibinin decreased the protein level of p34cdc2, which might be the possible molecular mechanism of Silibinin efficacy on the growth inhibition in SGC-7901 cells. In addition, Silibinin caused an increase in p53 and p21 protein level as well as mRNA levels. Interestingly, Silibinin-induced apoptosis in SGC-7901 cells was independent of caspases activation. These results indicated that Silibinin is a cell-cycle regulator and apoptosis inducer in human gastric carcinoma SGC-7901 cells and might be used as a candidate chemopreventive agent for gastric carcinoma prevention and intervention. Copyright © 2012 John Wiley & Sons, Ltd.
    No preview · Article · Mar 2013 · Phytotherapy Research
  • Source
    Yakun Ge · Yuanxin Zhang · Yunpeng Chen · Quanshun Li · Jun Chen · Ying Dong · Wei Shi
    [Show abstract] [Hide abstract]
    ABSTRACT: Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells' proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy.
    Full-text · Article · Dec 2011 · International Journal of Molecular Sciences

Publication Stats

17 Citations
5.52 Total Impact Points


  • 2011-2013
    • Jilin University
      • Key Laboratory for Molecular Enzymology and Engineering
      Yung-chi, Jilin Sheng, China