Bawani Sivagurunathan

Imperial College London, Londinium, England, United Kingdom

Are you Bawani Sivagurunathan?

Claim your profile

Publications (1)2.82 Total impact

  • Anusha N Seneviratne · Bawani Sivagurunathan · Claudia Monaco
    [Show abstract] [Hide abstract]
    ABSTRACT: Atherosclerosis is a multi-factorial inflammatory disease and is the primary initiator of coronary artery and cerebrovascular disease. Initially believed to be exclusively lipid-driven, recent evidence demonstrates that inflammation is a significant driving force of the disease. Cellular components of innate immunity, for example monocytes and macrophages, play a predominant role in atherosclerosis. Toll-like receptors (TLRs) are the most characterised innate immune receptors and recent evidence demonstrates an important role in atherogenesis. Engagement of TLRs results in the transcription of pro-inflammatory cytokines, foam cell formation and activation of adaptive immunity. Recently they have also been implicated in protection from vascular disease. In this review, we detail the role of the innate immune system, specifically macrophages and TLR signalling, in atherosclerosis and acute cardiovascular complications, and thereby identify the potential of TLRs to act as therapeutic targets.
    No preview · Article · Aug 2011 · Clinica chimica acta; international journal of clinical chemistry

Publication Stats

50 Citations
2.82 Total Impact Points


  • 2011
    • Imperial College London
      • Faculty of Medicine
      Londinium, England, United Kingdom