N Kundakçi

Ankara University, Engüri, Ankara, Turkey

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Publications (8)11.93 Total impact

  • A Akyol · A Boyvat · N Kundakçi
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    ABSTRACT: To report two cases of aluminum contact dermatitis caused by different sources. Two patients were patch-tested for suspected contact sensitivities. The results of patch testing revealed aluminum contact dermatitis reactions in both patients. Aluminum contact dermatitis is a rare finding with many possible etiologies. One should consider aluminum sensitivity when all patch test sites are positive when using aluminum Finn Chambers.
    No preview · Article · Jan 2005 · International Journal of Dermatology
  • Prof. A. Akyol MD · A. Boyvat · N. Kundakçi

    No preview · Article · Mar 2004 · International journal of dermatology
  • N Kundakçi · T Oskay · U Olmez · H Tutkak · E Gürgey
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    ABSTRACT: Association of psoriasis vulgaris with HLA antigens reference to age at onset has been reported in different racial or ethnic populations. Our purpose was to determine the distribution of HLA markers in the Turkish population according to the age at onset of the psoriasis vulgaris. HLA class I and class II antigens were performed by serologic methods in a group of 100 Turkish patients with psoriasis and 201 control subjects. Patients with psoriasis were subdivided into two groups based on age at onset (below or above 40 years of age) and family history. The frequency of HLA A30, Cw3, Cw6, DR7, DR14, DQ8, and DQ9 antigens were significantly increased in the Turkish psoriatic patients whereas HLA A66, Cw2, Cw4 and DR11 were found to be negatively associated with psoriasis. However, there were striking differences in HLA antigens according to the age at onset of the disease. Type I, early onset was associated with a high frequency of A30, B50, Cw6 and DR7 antigens whereas patients with type II, late onset had an increased frequency of Cw7. We conclude that psoriasis is probably a genetically determined disease and suggest that HLA-Cw6 antigen seems to associate commonly with early onset of psoriasis in Turkish patients.
    No preview · Article · Jul 2002 · International Journal of Dermatology
  • M Koçak · M Balci · B Pençe · N Kundakçi
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    ABSTRACT: Leprosy is a chronic infection caused by an intracellular microorganism. Genetic predisposition to both disease susceptibility and to host immunological response has been postulated for many years. The aim of this study was to determine whether there is HLA-linked susceptibility to leprosy and its different types. HLA-class I (A, B, C) and II (DR, DQ) antigen frequencies in 80 patients with leprosy (35 borderline lepromatous, 25 lepromatous, 15 borderline tuberculoid, five tuberculoid) were compared with those in 120 healthy individuals. HLA-class I antigens A9, A10, A32, B5, B21, Bw4, Bw6, Cw1, Cw2 and HLA-class II antigens DR9, DR10, DRw52, DQ1, DQ3 were found to be significantly more frequent in patients with leprosy, whereas HLA-class I antigens A3, B44, B49 and HLA-class II antigen DQ5 were so in controls. However, there was no significant difference in HLA-class I and II antigen frequencies between subtypes of leprosy. HLA-A null antigen was found to have weak expression in patients with leprosy. In conclusion, factors other than HLA-class I and class II antigens may have a more critical role in the pathophysiology of leprosy infection in man.
    No preview · Article · Jun 2002 · Clinical and Experimental Dermatology
  • N. Kundakçi · T. Oskay MD · Ü. Ölmez · H. Tutkak · E. Gürgey · T. Oskay
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    ABSTRACT: Background Association of psoriasis vulgaris with HLA antigens reference to age at onset has been reported in different racial or ethnic populations. Objective Our purpose was to determine the distribution of HLA markers in the Turkish population according to the age at onset of the psoriasis vulgaris. Methods HLA class I and class II antigens were performed by serologic methods in a group of 100 Turkish patients with psoriasis and 201 control subjects. Patients with psoriasis were subdivided into two groups based on age at onset (below or above 40 years of age) and family history. Results The frequency of HLA A30, Cw3, Cw6, DR7, DR14, DQ8, and DQ9 antigens were significantly increased in the Turkish psoriatic patients whereas HLA A66, Cw2, Cw4 and DR11 were found to be negatively associated with psoriasis. However, there were striking differences in HLA antigens according to the age at onset of the disease. Type I, early onset was associated with a high frequency of A30, B50, Cw6 and DR7 antigens whereas patients with type II, late onset had an increased frequency of Cw7. Conclusions We conclude that psoriasis is probably a genetically determined disease and suggest that HLA-Cw6 antigen seems to associate commonly with early onset of psoriasis in Turkish patients.
    No preview · Article · May 2002 · International journal of dermatology
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    ABSTRACT: Psoriasis is a common, chronic and recurrent, inflammatory disease of the skin. With no sociodemographic psoriasis data available in Turkey, we decided to investigate the clinical features and distribution of this disease in our country. The records of 329 patients with psoriasis were retrospectively reviewed. Psoriasis constituted 1.3% of the total dermatological disorders. Sixty-one per cent of the patients were female, and 39% were male. The mean age at onset of disease was 25 +/- 16 years in females, and 28 +/- 15 years in males. Family history was positive 30% of the patients. A positive family history was observed in 25% of the females and 37% of the males. 312 cases (95%) had psoriasis vulgaris, 17 cases (5%) had pustular psoriasis. Of the patients with psoriasis vulgaris, 212 (68%) had plaque, 73 (23%) guttate, 18 (6%) palmoplantar, 9 (3%) inverse type. The mean and median PASI score were 3.7 +/- 3.8 & 2.7 for females, 5.4 +/- 6.1 & 3.5 for males, respectively. 1.5% of patients had psoriatic arthropathy. Nail changes were seen in 54 (16%) of the cases. The various nail involvement types observed in descending frequency were: pitting (13%), subungual hyperkeratoses (7%), onycholysis (2%), discoloration (1.5%), oily spot (1%) and splinter hemorrhages (0.3%). The prevalence of psoriasis in Turkey is similar to numbers reported in South America and Germany. Females were predominant, and the mean age of onset was lower in women. Positive family history was more frequent in males. Plaque type psoriasis was the most common presentation. The difference between mean PASI scores of female and male patients was not statistically significant. Psoriatic arthritis was extremely rare in Turkish psoriasis patients. Pitting was the most common abnormality of the nails.
    No preview · Article · Apr 2002 · International Journal of Dermatology
  • A Boyvat · N Kundakçi · M.O.A. Babikir · E Gürgey
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    ABSTRACT: Livedoid vasculopathy is characterized by recurrent painful ulceration of the feet, ankles and legs that heals with residual white atrophic scars. For many years, livedoid vasculopathy has been considered to be a primary vasculitic process. Recently, however, there has been a trend towards considering livedoid vasculopathy as an occlusive vasculopathy due to a hypercoagulable state. Livedoid vasculopathy (under the designation livedo vasculitis) was first reported to be associated with protein C deficiency in 1992. We describe an additional patient with livedoid vasculopathy associated with heterozygous protein C deficiency. This second reported case suggests that protein C deficiency may be one cause of the hypercoagulable condition in these patients and demonstrates the necessity for further investigation of thrombogenic factors underlying the disease.
    No preview · Article · Nov 2000 · British Journal of Dermatology
  • E. Altiparmak · M. Kocak · N. Kundakci · Y. Kosar · B. Pence · B. Sahin · G. Temucin
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    ABSTRACT: The aim of this study was to investigate the prevalance of hepatitis-B and hepatitis-C infection in leprosy patients. Fourty-six patients comprising 15 (32.6%) women and 31 (67.3%) men with an age range of 20-75 years (mean of 53.8 years) were investigated. The average period of disease was 33.5±11.2 years. Hepatitis-B markers and anti-HCV antibodies were tested by Elisa method. We found anti-HCV positivity in 15.2%, HBsAg positivity in 10.8% and anti-Hbs positivity in 50% of patients. The 15.2% seropositivity of anti-HCV found in Leprosy patients was higher and seropositivities of anti-HBS and HBsAg, 50% and 10.8% were in accordance with the data in the literature. Whilst anti-HBs and HBsAg positivity levels were concurrent with available data, anti-HCV seropositivity at 15.2% was found to be higher than current data in the literature.
    No preview · Article · Jan 1999