Mete Akin

State Hospital of Ercis, Turkey, Arcis, Van, Turkey

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Publications (11)4.3 Total impact

  • [Show abstract] [Hide abstract] ABSTRACT: Aims: Aspirin has a side effect of mucosal damage even at low doses. The aim of the present study was to investigate the efficacy of kefir in the prevention of gastric damage produced by aspirin. Materials and methods: In the present study, 32 male Wistar-Albino rats were divided into four equal groups. First group (Control) and 2nd group (Aspirin) were administered 2 ml serum physiologic for seven days. Third group (Kefir) and 4th group (Kefir + Aspirin) were administered 2 ml kefir solution instead of serum physiologic. On the eight day, aspirin and Kefir + Aspirin groups were administered 200 mg/kg aspirin, three hours before being sacrificed. All stomach mucosa was examined and mucosal damage scores were evaluated. Results: In Kefir + Aspirin group, macroscopic damage score was higher than Control (P=0.002) and Kefir (P=0.028) groups, and lower than Aspirin group (P=0.005). Histological damage scores in Kefir + Aspirin group were similar to those in control and kefir groups and significantly lower than Aspirin group (P<0.001). Conclusion: It was established that kefir prevents aspirin-induced gastric damage in experimental model.
    No preview · Article · Jan 2014 · Acta Medica Mediterranea
  • [Show abstract] [Hide abstract] ABSTRACT: Objective: The significance of gastrointestinal xanthelasmas (GX) is unclear, although sometimes lesions they may be confused with malignant lesions. The aim of this study is to investigate the relationship between GX, atrophic gastritis, Helicobacter pylori (HP), and dyslipidemia. Material and Method: Upper gastrointestinal endoscopy reports of 8040 patients were evaluated retrospectively. Among them, 20 patients with GX were included into the study and evaluated for endoscopic characteristics, atrophic gastritis, HP infection and serum lipid profiles. The findings were compared with 20 age- and gender-matched control subjects. Results: The prevalence of GX was 0.24% with no gender difference. As compared with the control group, lipid profiles of GX group showed significantly lower HDL-cholesterol (38.50±9.59 vs 48.80±14.80, p=0.01) and total serum-cholesterol levels (mg/dL) (171.70±26.21 vs 194.25±34.84, p=0.032). LDL- cholesterol and triglyceride levels were not related to the presence of GX. GX showed a close relationship with endoscopically determined atrophic gastritis (30.0% vs 5.0%, p=0.03). HP infection and intestinal metaplasia were not significantly related with GX. Conclusion: In our serial endoscopy, the prevalence of GX was 0.24% and it showed an increase with age. Dyslipidemia and atrophic gastritis were found to be related to GX. This relation was not observed with HP infection.
    No preview · Article · Jan 2014 · Nobel medicus
  • No preview · Article · Oct 2012 · The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology
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    [Show abstract] [Hide abstract] ABSTRACT: Acute pancreatitis is the rapid onset inflammation of the pancreas. Medications are rare but important and rising cause of acute pancreatitis and account for approximately 2% of all cases. Sitagliptin is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of patients with type 2 diabetes mellitus and acts by increasing active incretin hormone concentrations. Adverse effects including constipation, nausea, nasopharyngitis, urinary tract infection and dizziness were reported. We reported a case with acute pancreatitis that seems to be induced by sitagliptin.
    Preview · Article · Jun 2012 · Turkiye Klinikleri Journal of Medical Sciences
  • [Show abstract] [Hide abstract] ABSTRACT: Wilson disease is an autosomal recessive disorder characterized by copper accumulation in the liver, brain, kidneys, and cornea due to inadequate biliary copper excretion. It should be considered especially in young patients who have findings of liver disease with unexplained etiology. Clinical presentation of the disease can be variable, and different types of parenchymal changes of the liver can be seen on imaging modalities. Multiple nodular lesions mimicking metastases can be detected. This condition can obligate physicians to screen for a malignant disease. Moreover, it may cause misdiagnosis as advanced stage of disease when coexistent with a malignancy. The coexistence of Wilson disease with some malignant diseases has been reported; however, coexistence with seminoma was not reported before. Approximately 40% of testicular cancers are pure seminoma. Liver metastases are rare in seminoma. In this article, a case of Wilson cirrhosis is reported. The patient was first followed with diagnosis of seminoma with suspicion of liver metastases.
    No preview · Article · Apr 2012 · The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology
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    [Show abstract] [Hide abstract] ABSTRACT: Paroxetine is an antidepressant agent, which affects via selective inhibition of serotonin reuptake. It is widely used for the treatment of depression, obsessive compulsive disorder, pa-nic disorder and anxiety disorder. Although it has low side effects and a high safety profile, some cases of severe toxic hepatitis associated with paroxetine have been reported. Hepatotoxicity can be hepatocellular, cholestatic or mixed type. It is generally idiosyncratic and unpredictable, however patients with high risk such as coexisting liver disease and use of other potential hepatotoxic drugs, should be monitored carefully for hepatotoxicity while using this drug. Here we report a case of severe toxic hepatitis related to use of paroxetine. The patient recoverd completely after the the drug was stopped.
    Preview · Article · Feb 2012 · Turkiye Klinikleri Journal of Medical Sciences
  • No preview · Article · Jun 2011 · The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology
  • No preview · Article · Jun 2011 · The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology

Publication Stats

8 Citations
4.30 Total Impact Points


  • 2014
    • State Hospital of Ercis, Turkey
      Arcis, Van, Turkey
    • T.C. Süleyman Demirel Üniversitesi
      Hamitabat, Isparta, Turkey
  • 2010
    • Akdeniz University
      • Section for Internal Medicine
      Satalia, Antalya, Turkey