Mehmet Bulent Vatan

Sakarya University, Ada Bazar, Sakarya, Turkey

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Publications (39)52.63 Total impact

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    ABSTRACT: Aorto femoral bypass is usually the recommended therapy for diffuse disease involving the aorta and iliac arteries. In this case report, a case involving a chronic endovascular abdominal aortic stent graft occlusion in which percutaneous angioplasty was performed via a transbrachial and transfemoral approach is presented. This case emphasized that occlusion of an endovascular abdominal aortic stent graft can also be treated, primarily, with an endovascular technique.
    No preview · Article · Jan 2016 · Perfusion
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    ABSTRACT: Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis. The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR). Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study. Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP). The frequencies of the heterozygote genotype (Lys/Gln-AC) and homozygote genotype (Gln/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%, p = 0.049 ; 38.15% versus 16.2%, p = 0.018 ). Homozygote variant (Gln/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097–3.863; p = 0.018 ). Heterozygote variant (Lys/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041–2.129; p = 0.049 ). The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101–1.992; p = 0.011 ). This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.
    Full-text · Article · Oct 2015 · Disease markers

  • No preview · Article · Jul 2015 · Atherosclerosis

  • No preview · Article · Jul 2015 · Atherosclerosis
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    ABSTRACT: Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-α, IL-1β, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
    Full-text · Article · Mar 2015 · Biological trace element research

  • No preview · Article · Mar 2015 · The American Journal of Cardiology
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    ABSTRACT: Objectives: Patients with carotid disease are frequently referred for carotid artery stenting based on the results of carotid duplex studies. During carotid artery stenting, the stent is usually extended into the common carotid artery, thereby crossing the external carotid artery. Previous studies have shown conflicting results regarding internal carotid stenting and external carotid artery flow velocities, but the effect of stenting on ipsilateral superior thyroid artery velocities has not been defined. This study examined the effect of internal carotid angioplasty and stenting on the ipsilateral superior thyroid artery Doppler-derived flow parameters. Methods: We prospectively studied preinterventional and postinterventional duplex scans obtained from 41 patients (mean age ± SD, 64 ± 10 years) who underwent carotid artery stenting. The Doppler-defined preprocedural peak systolic velocity (PSV) end-diastolic velocity (EDV), resistive index (RI), and pulsatility index (PI) in the ipsilateral external carotid and superior thyroid arteries were compared with postprocedural values. Results: Among patients with stenting, the preprocedural PSV, EDV, RI, and PI in the ipsilateral superior thyroid artery were 30 ± 11 cm/s, 13 ± 6 cm/s, 0.62 ± 0.11, and 1.04 ± 0.28,respectively; after stenting, they were 36 ± 8 cm/s, 14 ± 9 cm/s, 0.71 ± 0.07, and 1.11 ± 0.19. The preprocedural PSV, EDV, RI, and PI in the ipsilateral external carotid artery were 79 ± 24 cm/s, 17 ± 7 cm/s, 0.77 ± 0.26, and 1.27 ± 0.22; after stenting, they were 94 ± 31 cm/s, 20 ± 6 cm/s, 0.80 ± 0.4, and 1.25 ± 0.31. Despite a slight increase in superior thyroid and external carotid artery flow, there was no statistically significant change from before to after stenting. Conclusions: This study showed no differences in blood velocity profiles in the ipsilateral superior thyroid and external carotid arteries after stenting.
    Preview · Article · Oct 2014 · Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine
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    ABSTRACT: Rivaroxaban is an oral anticoagulant agent that directly inhibits Factor Xa and interrupts both the intrinsic and extrinsic pathway of the coagulation cascade and is currently indicated for use in patients for atrial fibrillation and prophylaxis of deep venous thrombosis. The present case reports of spontaneous rectus sheath hematoma during rivaroxaban therapy for atrial fibrillation in a 75-year-old woman.
    Full-text · Article · May 2014 · Indian Journal of Pharmacology
  • Hasan Ergenc · Yasemin Gunduz · Mehmet Bulent Vatan · Ali Tamer

    No preview · Article · Jan 2014
  • Sabiye Yilmaz · Mehmet Akif Cakar · Mehmet Bulent Vatan · Harun Kilic · Nurgul Keser
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    ABSTRACT: Drowning is one of the fatal accidents frequently encountered during the summer and is the most common cause of accidental death in the world. Anoxia, hypothermia, and metabolic acidosis are mainly responsible for morbidty. Cardiovascular effects may occur secondary to hypoxia and hypothermia. Atrial fibrillation, sinus dysrhythmias (rarely requiring treatment), and, in serious cases, ventricular fibrillation or asystole may develop, showing as rhythm problems on electrocardiogram and Osborn wave can be seen, especially during hypothermia. A 16-year-old male patient who was admitted to our hospital's emergency service with drowning is presented in this article. In our case, ventricular fibrillation and giant J wave (Osborn wave) associated with hypothermia developed after drowning was seen. We present this case as a reminder of ECG changes due to hypothermia that develop after drowning. Response to cardiopulmonary resuscitation after drowning and hypothermia is not very good. Mortality is very high, so early resuscitation and aggressive treatment of cardiovascular and respiratory problems are important for life.
    No preview · Article · Jan 2014
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    ABSTRACT: Patients with non-ST-elevation acute coronary syndrome are heterogeneous in terms of clinical presentation and immediate- and long-term risk of death or non-fatal ischemic events. The aim of the present study was to evaluate the relationship between the Global Registry of Acute Coronary Events (GRACE) score and severity of coronary artery disease angiographically evaluated by Gensini score in patients with non-ST-elevation acute coronary syndrome. A total of 245 patients with non-ST-elevation acute coronary syndrome were enrolled to the study. Based on the GRACE risk score classification system, the patients were divided into low- (n=97, 39.6%), intermediate- (n=84, 34.3%), and high- (n=64, 26.1%) risk groups. All patients underwent coronary angiography within five days after admission. The Gensini scores were 26±29 in the low-risk group, 29±19 in the intermediate-risk group, and 38±23 in the high-risk group (p=0.016). The low-risk group was significantly different from the high-risk group (p=0.013), and the difference from the intermediate-risk group almost reached significance. Normal, noncritical, one and two, or multivessel disease were identified in 15 (6.1%), 31 (12.7%), 75 (30.6%), and 124 (50.6%) patients, respectively. The prevalence of multivessel disease was 28% in the low-risk group, 30% in the intermediate-risk group, and 42% in the high-risk group. The high-risk group was significantly different from the low-risk group (p<0.01). Our study demonstrates that the GRACE score has significant value for assessing the severity and extent of coronary artery stenosis in patients with non-ST-elevation acute coronary syndrome.
    Full-text · Article · Sep 2013 · Journal of Cardiology
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    ABSTRACT: The correlation between plasma D-dimer level and reperfusion has not been clarified yet in thrombolytic therapy applied for acute myocardial infarction patients. The aim of this study was to investigate whether there is a relationship between reperfusion and fibrinolytic activity in acute myocardial infarction patients treated with thrombolytic therapy. Fibrinolytic activity was reflected by plasma D-dimer levels. During the study period, 186 patients were initially analyzed. But 18 of these patients were excluded from the study because they were not suitable for study criteria. Blood was collected from 168 acute myocardial infarction patients within first 6 h. Intravenous tissue plasminogen activator (100 mg) or streptokinase (1 500 000 U) was applied to patients. Mean age of the patients was 58 (28-86) years and majority was men (86%). The number of anterior, inferior, and lateral myocardial infarction patients were 76 (45.2%), 85 (50.6%), and seven (4.2%), respectively. The mean time from symptom onset to thrombolytic application was 134 (95-212) min. Reperfusion occurred in 115 (68.5%) patients. D-dimer levels were markedly high after thrombolytic therapy versus before (155 mg/dl, 362 mg/dl, P <0.005). We compared the D-dimer values before and after thrombolytic therapy between reperfused group and the nonreperfused group (189-409 mg/l in reperfused group, P = 0.086; 82-258 mg/l in the nonreperfused group, P = 0.173). In conclusion, in this study, D-dimer levels were elevated markedly in patients with ST elevation myocardial infarction after thrombolytic therapy, but no significant difference was seen in D-dimer levels between the reperfused and nonreperfused groups.
    No preview · Article · Sep 2013 · Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis
  • Yasemin Gunduz · Ramazan Akdemir · Salih Sahinkus · Mehmet Bulent Vatan
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    ABSTRACT: Renal artery stenosis (RAS) is the most common cause of secondary hypertension and accounts for approximately 1-3% of all causes of hypertension. Over 90% of RASs are caused by atherosclerosis; atherosclerotic RAS is increasingly common in aging populations, particularly elderly people with diabetes, hyperlipidaemia, aortoiliac occlusive disease, coronary artery disease or hypertension. Three therapeutic options are currently available for patients with renovascular hypertension: medical antihypertensive therapy, surgical revascularisation and transluminal angioplasty including stent implantation. We present in this report a male patient with bilateral severe ostial stenosis and coronary artery disease, and who was successfully treated with renal stent implantation in one session.
    No preview · Article · Jun 2013 · Case Reports

  • No preview · Article · Apr 2013 · Angiology

  • No preview · Article · Mar 2013 · International Journal of Cardiology
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    ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with acute coronary syndrome (ACS). We assessed the association between NAFLD and SYNTAX Score (SS) in patients with ACS. Eighty consecutive patients with ACS were enrolled. Patients were evaluated using ultrasound to detect NAFLD and hepatosteatosis stage. The prevalence of NAFLD was 81.2%; median SS was 15. The SS was significantly higher in patients with NAFLD (18 ± 8 vs. 11 ± 5, P = .001). Univariate analysis showed that the stage of NAFLD correlated with SS (r = .6, P < .001). In multivariate binary logistic analysis, increased age (odds ratio [OR], 1.05; 95% confidence interval [CI],1.00-1.10) and presence of NAFLD (OR, 13.20; 95% CI, 2.52-69.15) were independent factors associated with supramedian SS. In conclusion, among patients with ACS, those with NAFLD have more complex CAD as assessed by SS.
    No preview · Article · Feb 2013 · Angiology
  • Yasemin Gunduz · Aysenur Ucar · Mehmet Bulent Vatan · Nurgul Keser
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    ABSTRACT: The development of thrombus on the tricuspid valve is very rare in adulthood and it needs special attention in clinical practice as it can be confused with vegetation or a tumour. Embolisation due to thrombus may have an acute and unexpected course with a detrimental prognosis and a high death rate during the first 24 h after diagnosis. In this report, we presented a case of mobile tricuspid valve thrombus detected by transthoracic echocardiography that led to recurrent pulmonary embolism.
    No preview · Article · Jan 2013 · Case Reports
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    Devrim Cabuk · Mustafa Volkan Demir · Selcuk Yaylaci · Mehmet Bulent Vatan · Ali Tamer

    Full-text · Article · Jan 2013
  • M.B. Vatan · H. Gündüz · R. Akdemir
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    ABSTRACT: Coronary arteries originating from a single coronary ostium is a rare condition. The incidence is 0.03% of patient undergoing diagnostic coronary angiography. Approximately 20 possible variations of single coronary artery have been described. Of these, single coronary artery arising from the right sinus of valsalva are extremely rare. Some of the patients are clinically silent, except for cases in which a coronary artery passes between the pulmonary artery and aorta, which can present with sudden death expecially in the athletes. Yet, most of the patient can present with recurrent ischemia or heart failure at younger age. Treatment is still controversial and no guidelines for treatment of this condition exist. We report the case of an octogenarean patient with acute inferior myocardial infarction who was managed by primary percutaneous coronary intervention (PCI) to the single coronary ostium.
    No preview · Article · Jan 2013 · Turk Geriatri Dergisi
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    ABSTRACT: Abstract The aim of this study is to investigate the blood characteristics in patients with severe mitral regurgitation due to idiopathic rupture of chordae tendinea. 26 patients who diagnosed severe mitral regurgitation due to idiopathic chordae tendineae (group 1) and 40 healthy age-sex matched subjects (group 2) were chosen as control group. All the echocardiography and clinical data were evaluated retrospectively between 2007 and 2012. There was not statistically significant difference in age, height, hypertension, diabetes and medications being used between the two groups. But, patients with idiopathic chordae tendineae rupture had more overweight than the controls (74.9±7.4 kg versus 70.7±7.5, and P=0.031). Also platelets, mean platelet volume, hemoglobin, hematocrit, lymphocytes, monocytes, eosinophil leucocytes, mean corpuscular hemoglobin concentration, red blood cell distribution width, mean corpuscular volume, plateletcrit, and platelet distribution width did not differ between the two groups. Red blood cell, neutrophil and basophil counts were significantly higher in patients with idiopathic chordae tendineae rupture (rbc, 42.8±5.05 versus 42.8±5.05, p=0.022; neu, 45.8±14.99 versus 38.3±11.70, p=0,026 and baso, 0.5±0.50 versus 0.8±0.33, p=0.002) This study showed that, patients with idiopathic chorda tendinea rupture is more overweight and their red blood cell, neutrophil and basophil counts are higher than controls. Those results suggest inflammation in the etiology of idiopathic chorda tendinea rupture. Key words: Idiopathic chorda tendinea rupture, blood characteristics, neutrophil, basophil, platelets.
    No preview · Article · Jan 2013