M. Serban

Victor Babes University of Medicine and Pharmacy of Timisoara, Freidorf, Timiş, Romania

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Publications (72)169.85 Total impact


  • No preview · Article · Jun 2015 · Haemophilia
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    ABSTRACT: DCs are potent APCs and key regulators of innate and adaptive immunity. After allo-SCT, their reconstitution in the peripheral blood (PB) to levels similar to those in healthy individuals tends to be slow. We investigate the age- and sex-dependant immune reconstitution of myeloid (mDC) and plasmacytoid DC (pDC) in the PB of 45 children with leukaemia or myelodysplastic syndrome (aged 1-17 years, median 10) after allo-SCT with regard to relapse, acute GVHD (aGVHD) and relapse-free survival. Low pDC/μL PB up to day 60 post SCT are associated with higher incidence of moderate or severe aGVHD (P=0.035), whereas high pDC/μL PB up to day 60 are associated with higher risk of relapse (P<0.001). The time-trend of DCs/μL PB for days 0-200 is a significant predictor of relapse-free survival for both mDCs (P<0.001) and pDCs (P=0.020). Jointly modelling DC reconstitution and complications improves on these simple criteria. Compared with BM, PBSC transplants tend to show slower mDC/pDC reconstitution (P=0.001, 0.031, respectively), but have no direct effect on relapse-free survival. These results suggest an important role for both mDCs and pDCs in the reconstituting immune system. The inclusion of mDCs and pDCs may improve existing models for complication prediction following allo-SCT.Bone Marrow Transplantation advance online publication, 10 November 2014; doi:10.1038/bmt.2014.257.
    No preview · Article · Nov 2014 · Bone Marrow Transplantation
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    ABSTRACT: Unlabelled: Haemophilic arthropathy is a defining feature and a debilitating condition of persons with haemophilia (PwH) in low resource countries. Orthopaedic surgery is unavoidable for patients with high occurrence of joint damage. Aims: We aimed to evaluate the spectrum and outcome of invasive orthopaedic therapies in PwH and von Willebrand diseases (VWD). Patients and methods: Our descriptive observational retrospective study included 131 invasive surgical procedures, performed on 76 consecutive patients, most of them (93.4%) with severe disease, treated in Timisoara's Haemophilia Center over a period of 12 years; 17.1% had pre-operation anti-FVIII inhibitors. Invasive elective procedures were predominant (90.8%) as compared to emergency measures (9.2%); according to their invasiveness, 20.6% of interventions were major, 44.3% intermediate and 35.1% minor. Results were good in the majority of cases; significantly reduced joint bleed rate and pain score were the most consistent achievements. The greatest proportion of complications occurred after major (66.7%), compared to moderate (25.6%) and minor (7.7%) interventions. The main threatening complication was the development (3.8%) or increase (4.6%) of inhibitor titer. Local bacterial infections and wound dehiscence complicated the evolution in 4.6% and 0.8 % of cases, respectively; we noticed no blood-borne infections or thrombotic accidents. Low dosage (10.7%) and short duration of substitution (21.4%) led to increased post-surgical bleeding and post-haemorrhagic anaemia. Conclusions: Surgery is a highly demanding intervention in haemophilia, which cannot be ignored in a low resource country. It represents a life or limb-saving and quality of life-improving measure.
    Full-text · Article · Nov 2014 · Hamostaseologie
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    ABSTRACT: The ability to switch between coagulation factors safely is of common interest to haemophilia patients and treating physicians. This is the first formal prospective comparative evaluation of safety, efficacy and incremental recovery of a plasma-derived FIX (pdFIX) and a recombinant FIX (rFIX) in the same haemophilia B patients following a switch from pdFIX Immunine® to a recently developed rFIX Bax326 product. Patients (aged <65 years) who completed a pretreatment study which prospectively documented the exposure to Immunine® and monitored FIX inhibitors while receiving prophylactic treatment were transitioned into pivotal (patients aged 12–65 years) and paediatric (patients aged <12 years) clinical studies investigating prophylaxis and treatment of bleeding episodes with Bax326. None of the 44 patients developed inhibitory or specific binding anti-FIX antibodies during the course of the studies. A total of 38 unrelated adverse events (AEs) were occurred in 20/44 (45.5%) subjects during the Immunine® study. Following a switch to Bax326, 51 AEs were reported in 25/44 (56.8%) subjects. The incidence of AEs related to Bax326 treatment (two episodes of dysgeusia in one patient) was low (2.3%); there were no serious adverse reactions. The comparison between Immunine® and Bax326 demonstrated analogous haemostatic characteristics and annualized bleeding rates. Overall, there is direct evidence indicating a safe and clinically effective transition from a pdFIX (Immunine®) to a newly developed rFIX (Bax3261) for prophylaxis and treatment of bleeding in previously treated patients of all age cohorts with severe or moderately severe haemophilia B.
    Full-text · Article · Apr 2014 · Haemophilia
  • M Iancu · C Copăescu · M Serban · C Ginghină
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    ABSTRACT: Background: Obesity is associated with high prevalence ofcoronary heart disease (CHD) and long term increasedcardiovascular morbi-mortality. There are no data regarding theeffect of laparoscopic sleeve gastrectomy (LSG) on long-termCHD - risk. It is known that “a man is as old as hisarteries” and this concept is illustrated by Framinghamcoronary risk score, which can predict vascular age.Purpose: To assess the 10-year CHD risk in patients withobesity, preoperatively, and 6 and 12 months after LSG.Methods: 47 consecutive obese subjects (44.7% males, mean age 39.8 years) scheduled for LSG were prospectively studiedbefore and 6 and 12 months after surgery. The 10 years CHDrisk and corresponding vascular age were calculated usingFramingham risk score.Results: The body mass index (BMI) decreased from 44.6 Â+-10.6 kg m2 preoperatively to 32.2Â+-6.9 kg m2 and to 29.4 Â+- 5.4kg m2 at 6 and 12 months follow-up (both p 0.05). Meanexcessive weight loss (EWL) was 67.3Â+-23.7% and 78.3 Â+-23.4% at 6 and 12 months postoperatively. At 6 and 12 monthsafter LSG, there was a marked improvment of lipid profile(decrease of total cholesterol, LDL-cholesterol, triglycerides andincrease of HDL-cholesterol) and a significant decrease inprevalence of diabetes mellitus, systemic hypertension andsmoking. The 10-year CHD risk reduced from 10.1% preoperativelyto 3.5% and to 2.2% at 6 and 12 months aftersurgery (both p 0.05). Patients' mean vascular age was 65.6years preoperatively and decreased to 45.8 years 6 monthspostoperatively (p 0.05) and to 40.7 years one year afterLSG (p 0.05 vs. 6 months postoperatively, p=NS vs.chronological age).Conclusions: In obese subjects, CHD risk is significantlyreduced early, beginning with 6 months after LSG and isdiminished with 80% one year postoperatively. Despite thefact that not all patients had achieved the ideal weight yet,mean vascular age is similar to their chronological age one yearafter surgery.
    No preview · Article · Oct 2013 · Chirurgia (Bucharest, Romania: 1990)
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    ABSTRACT: To date, few publications report on dendritic cells values in healthy children and mostly are found as control groups in studies focused on either allergic and autoimmune diseases or malignancies. This report provides an overview of 8 publications regarding absolute dendritic cells quantification in the peripheral blood of healthy children by using minimum manipulated samples processed within 24 hours.
    No preview · Article · Oct 2013 · Klinische Pädiatrie
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    ABSTRACT: Obesity is accompanied by increased arterial stiffness, left ventricular (LV) hypertrophy, and diastolic dysfunction, all associated with a negative prognosis. The evolution of LV mass, function, and arterial elasticity after laparoscopic sleeve gastrectomy (LSG) was unknown, and this is what we have investigated. Thirty-four consecutive obese subjects (mean age, 39 ± 11 years; 35.2 % men), scheduled for LSG, were studied before, at 6 and 12 months after surgery. The body mass index (BMI) decreased from 43.6 ± 11.9 to 32.1 ± 7.4 and to 28.9 ± 5.8 kg/m(2) at 6 and 12 months after surgery (all p < 0.05). The baseline LV mass index was correlated with age, BMI, waist circumference, blood glucose level, systemic hypertension stage, and with aortic distensibility, strain, and stiffness index (all p < 0.05). Aortic distensibility increased by 110 %, aortic strain by 58 %, and aortic stiffness index decreased by 88 % at 6 months after LSG (all p 6 months-baseline < 0.05) and all the parameters had similar values at 12 months postoperatively (all p 12-6 months = NS). LV hypertrophy prevalence decreased from 61.8 to 47.1 % and to 32.3 % at 6 and 12 months after surgery (all p < 0.05). The proportion of patients with LV diastolic dysfunction decreased from 52.9 to 23.5 % at 6 months (p 6 months-baseline < 0.01) and to 20.6 % at 12 months postoperatively (p 12 -6 months = 0.7). Significant improvements of aortic elasticity and of LV diastolic function were recorded at 6 months, and they were maintained at 12 months after LSG. The LV hypertrophy showed also a favorable evolution: it has been slightly improved 6 months after surgery and further ameliorated 1 year postoperatively.
    No preview · Article · Oct 2013 · Obesity Surgery
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    ABSTRACT: Children with haemophilia often experience limitations in activities of daily life. Recently the Paediatric Haemophilia Activities List (PedHAL) has been developed and tested in Dutch children with intensive replacement therapy. The psychometric properties of the PedHAL in children not receiving intensive replacement therapy are not known. The objective was to gain further insight into the psychometric properties of the PedHAL and to study the functional health status of Romanian children and adolescents with haemophilia. Children attending to the rehabilitation centre of Buzias in Romania were sampled consecutively. Construct validity of the PedHAL was evaluated by concurrent testing with objective and subjective measures of physical function and functional ability. Reproducibility was tested by a 3-day test-retest by intraclass correlation coefficient (ICC) and limits of agreement (LOA). Responsiveness to rehabilitation was assessed by Haemophilia Joint Health Score (HJHS) and PedHAL. Twenty-nine children with severe (n = 25) or moderate (n = 4) haemophilia participated. Mean age was 13.2 years (SD 4.0). Median score of the PedHAL was 83.5 (IQR 47.9-90.5). The PedHAL correlated moderately with HJHS (rho = -0.59), Functional Independence Score in& Haemophilia (rho = 0.65) and Child Health Questionnaire-physical function (rho = 0.40) and not with Child Health Questionnaire-mental health, Child Health Questionnaire-behaviour and 6MWT. Test-retest reliability was good (ICC = 0.95). LOA was 17.4 points for the sum score. HJHS scores improved slightly after rehabilitation, whereas PedHAL scores did not change. In general, construct validity and test-retest reliability were good, test-retest agreement showed some variability. Therefore, currently the PedHAL may be more appropriate for research purposes than for individual patient monitoring in clinical practice.
    No preview · Article · Feb 2013 · Haemophilia
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    ABSTRACT: Haemophilia, a lifelong congenital bleeding disease, is a highly demanding disorder, due to the costs of its replacement therapy. In the absence of this pivotal treatment, life expectancy and quality of life are deleteriously affected. As illustration, we present a 14 years long follow-up of a patient with severe haemophilia A, treated sporadically with fresh plasma, cryoprecipitate and factor concentrates, who developed a giant iliopsoas pseudotumor. Since he was an infant, under on demand therapy with fresh frozen plasma, cryoprecipitate and low doses of factor concentrates he presented many spontaneous bleedings, developing multiple disabling arthropathies. At the age of 14 years, an iliopsoas hematoma occurred, which relapsed several times, developing an iliopsoas pseudotumour. After 5 years, sepsis with Klebsiella was diagnosed. A CT scan revealed fistula between the pseudotumor and the gut. Under antibiotics, the evolution of sepsis improved, but over a period of 10 months 5 episodes of haematemesis and melena, followed by one episode of macroscopic haematuria occurred; two months later he developed an inguino-crural mass, which fistulized through the abdominal wall. A mixt german-romanian team solved the clinical concern. After 108 hospitalization days and consumption of 104840 IU factor VIII he left the clinic in good condition. One year later, the temporary colostomy with anus praeter was closed. The follow-up reveals now, after almost 10 years with favourable outcome, that the patient is well, active within his family and profession.
    Full-text · Article · Sep 2012 · Hamostaseologie
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    ABSTRACT: The aim of this study was to determine the clinical conditions of patients with haemophilia within Europe as recommended by the European Commission. In this multicentre, cross-sectional, ambispective study, conducted within 21 European countries patients' clinical data were collected, amongst others haemophilia type, severity, treatment pattern, use of factor products, bleeding, orthopaedic joint scores and infections. A total of 1400 patients, 84.3% with haemophilia A and 15.7% with haemophilia B were enrolled by 42 centres between 2004 and 2006. Thereof, 417 were children (30.0%) and 983 were adults (70.0%). About 70% of patients had severe factor deficiency (<1%). More than half of the adults were carriers of chronic infections (12.6% HIV, 55.8% HCV), compared to only 3.8% children (no HIV, 2.9% HCV). Patients were grouped according to per capita amount of clotting factor used in patients' region of residence in 2005: region 1: >5 IU; region 2: 2-5 IU; region 3: <2 IU. Paediatric and adult patients in region 3 had median numbers of three and eight joint bleeds, respectively, with worse joint scores compared to region 1 with zero and one bleed. Prophylactic therapy was used in only 31.3% children and 8.9% adults with severe haemophilia in region 3 compared to 93.7% and 54.1%, respectively, in region 1. Statistical analysis revealed that residence in areas with low factor consumption/availability is the most prominent risk factor for joint disease. Access of European patients with haemophilia to optimal care with safe factor VIII concentrates is limited and depends on the region of residence.
    No preview · Article · May 2012 · Haemophilia
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    Preview · Article · Jan 2012 · Archives of Cardiovascular Diseases Supplements
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    ABSTRACT: A number of 513 consecutive patients (494-haemophilia A and 19-haemophilia B) from eight haemophilia treatment centers have been investigated with Bethesda assay for the presence of factor VIII or IX inhibitors. The overall prevalence of inhibitors was 15.20%, 18.48% in severe, 5.60% in moderate and 12.24% in mild forms. The prevalence was higher than reported in most of the western countries. The age at start of substitution (p = 0.9775), the frequent switching of factor concentrates (p = 0.8931) were not relevant factors for the development of inhibitors. It is worth to be mentioned the unexpectedly occurrence of inhibitors in prior inhibitor negative (6/72) patients (during surgical interventions) probably due to their previous scarce substitution, occurrence which seems not being connected with the continuous infusion modality of factor VIII administration (p = 0.8341). In controversial situations, in the field of low titer (≤ 1 BU/ml) inhibitors for a reliable interpretation of the results the performance of recovery index and half-life time assessment of FVIII/IX was undertaken.
    Full-text · Article · Nov 2011 · Hamostaseologie
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    ABSTRACT: Portopulmonary hypertension is a form of pulmonary arterial hypertension that has gained interest in recent years with the development of liver transplantation techniques and new pulmonary vasodilator therapies. Portopulmonary hypertension is defined as pulmonary artery hypertension associated with portal hypertension with or without advanced hepatic disease. Echocardiography plays a major role in screening for portopulmonary hypertension but right heart catheterization remains the gold standard for diagnosis. The treatment of patients with portopulmonary hypertension consists of general measures that apply to all patients that carry the diagnosis of pulmonary hypertension and specific vasodilator therapies. These new therapies showed encouraging results in patients who would otherwise have a contraindication for liver transplantation. The review presents a summary of the current knowledge on the epidemiology, diagnosis, treatment and prognosis of patients with portopulmonary hypertension.
    No preview · Article · Oct 2011 · European Journal of Internal Medicine
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    ABSTRACT: Plasma-derived factor IX (FIX) concentrate remains an important choice for replacement therapy in haemophilia B patients. Haemonine is a high purity double-virus inactivated human plasma-derived coagulation FIX concentrate (pdFIX). Aim was to evaluate the clinical efficacy, safety and pharmacokinetic properties of Haemonine in three prospective, open-label uncontrolled studies and a compassionate use program in previously treated patients with severe haemophilia B. Long-term efficacy and safety were investigated in 29 patients treated prophylactically and, in addition, treatment on-demand (TOD) in the case of acute haemorrhage. Pharmacokinetic properties were assessed in 14 patients at baseline and after 3 months of regular treatment. Pharmacokinetic parameters were in accordance with published data and remained nearly unchanged over time, notably recovery and half-life. Mean terminal elimination half-life was 27.6 h and 25.0 h, mean incremental recovery (IU dL(-1) /IU kg(-1)) was 1.55 and 1.60, at baseline and 3 months, respectively. Haemonine was shown to be effective in preventing and controlling bleeds. 55.2% (16/29) of patients were free of bleeds under prophylaxis. 38 haemorrhages occurred, 42% (16/38) required treatment and 87.5% (14/16) resolved after a single infusion, 12.5% after 2 infusions. All responses reported on haemorrhages were rated as 'excellent' or 'good'. Moreover, 'excellent' haemostatic efficacy was demonstrated in 12 surgeries with no complications. Few adverse events (AEs) and no thrombogenic complication, nor induction of FIX inhibitory antibodies were observed. Haemonine is effective, safe and well tolerated in long-term prophylaxis, TOD and when applied after minor and major surgeries.
    No preview · Article · Aug 2011 · Haemophilia
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    ABSTRACT: Purpose To describe the enzymatic profile of plasma matrix metalloproteinases (MMP7 and MMP9) and their tissue inhibitors (TIMP1 and TIMP2) in different categories of patients (pts.) with coronary artery disease (CAD), and their relationship with clinical status, left ventricular (LV) function and remodelling. Methods Total MMP7, active fraction of MMP9, TIMP1 and TIMP2 were determined in 68 consecutive pts with confirmed CAD (Group A, 56.6 ± 9.9 years, 75% men) and compared with a control group of 23 pts. with normal coronary arteries (Group B, 58.1 ± 10.7 years, 56.5% men). LVEF was calculated by Simpson's method. We calculated global longitudinal (L), circumferential (C) and radial (R) strain (S) and strain rate (SR) values as the average of segmental values by 2D strain analyses. Results The active form of MMP9 differed significantly between group A and B, as did the MMP9/TIMP1 and MMP9/TIMP2 ratios (8.78 ± 10.0 ng/ml vs 3.33 ± 4.0 ng/ml p = 0.016; 5.43 ± 3.4 v 0.85 ± 0.9, p = 0.039 and 11.60 ± 5.2 v 3.71 ± 1.0, p = 0.022, respectively). Group A included 35 pts. with acute coronary syndromes (ACS) and 33 pts. with stable angina (SA), with similar profile of LVEF and number of coronary arteries involved. The were no significant differences in MMP9, MMP9/TIMP1 and MMP/TIMP2 ratio between normal and SA group, but only between normal and ACS group (p = 0.02 for MMP9). In group A, only MMP7, TIMP1/MMP7 and TIMP2/MMP7 ratio corellated with markers of systolic function: LVEF (p<0.05 for all), and global LS (r = 0.31, r = 0.40, r = 0.23, p = 0.023, respectively, p<0.05 for all). There were no significant correlations between MMP or TIMP and global C and R-S or SR. Conclusion There were no significant changes in extracellular matrix markers in pts. with chronic stable ischemia vs normals. Only active form of MMP9 and its ratio with TIMP differed significantly in ACS. Total MMP7 and its ratio with TIMP correlated with parameters of LV systolic function even in pts. with normal LVEF.
    Full-text · Article · Jan 2011 · Archives of Cardiovascular Diseases Supplements
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    ABSTRACT: Thyroid dysfunction after hematopoietic stem cell transplantation (HCST) is recognized as a late complication following HSCT. It has been established that both imaging and serological investigation are required in order to monitor the thyroid function of patients after HSCT. The aim of this study is to present the experience of a single Stem Cell Transplantation (SCT) Centre in endocrinological follow up focusing on thyroid dysfunction in order to emphasize the impact of late complications in long term prognosis and quality of life (QoL) of patients with HSCT. The studied group was of 146 patients admitted in the SCT Centre from Timisoara during 2005-2010. We used clinical, imagistic and biochemistry parameters. In our study thyroid dysfunction was observed in 31 patients (21.2%) and the most prevalent type of thyroid dysfunction was hypothyroidism found in 19 (13%) cases. The results of our study demonstrate the importance of a long term follow-up of the patients following HSCT and the importance of having an educated patient regarding HSCT. We conclude that these patients need a life-long follow-up and in particularly thyroid function studies should be performed annually and thyroid ultrasound should be included in the follow-up protocols with annual ultrasound evaluation.
    No preview · Article · Jan 2011 · Annals of the Romanian Society for Cell Biology
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    ABSTRACT: It is frequently recognized in medical literature as well as in daily clinical practice that right ventricular myocardial infarction and pulmonary embolism are two of the most challenging clinical pictures to differentiate in cardiology and the treatment, often chosen upon a mixture of clinical suspicion criteria subsequently confirmed by other diagnostic methods, can lead to therapeutic success. Differential diagnosis is often difficult due to similar clinical picture, unspecific electrocardiographic changes and unspecific biological markers. It is very important to know the risk factors and the associated comorbidities for these two clinical entities in order to be able to interpret them contextually. In most cases the diagnosis key is the clinical suspicion. Usually in evaluating these cases we are in the position of choosing more complex diagnostic procedures, most likely not available in Emergency Department. In conclusion it is expected from the clinician to use the available methods with a thorough approach to details but in the same time considering the whole clinical picture.
    Preview · Article · Aug 2010
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    Preview · Article · Jan 2010 · Archives of Cardiovascular Diseases Supplements
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    ABSTRACT: Background: Chronic haemophilic arthropathies, especially those affecting the knee, uni-or bilateral, generate severe mobility loss with flexum immobilisation. Regardless of the type of haemophilia, the degree of severity, the arthrotic modifications and the degree of musculo-tendinous retraction there are patients which can be selected for orthopaedic-non-surgical treatment. Material and methods: We present a group of 11 patients with haemophilia type A, with a mean age of 18 years, treated in our Clinic between 2000 and 2009. All patients had a severe form of haemophilia type A, 2 patients presenting high level of inhibitors. The degree of flexum was between 30-90°, and the arthropathy affected one knee in 5 patients and both knees in 6 patients. The paper presents in detail the methods and secventiality of therapeutic orthopedic procedures performed under specific substitutive therapy. Results and discussions: The objective of treatment was repositioning of the knee in extension or flexum of maximum 10°, which was done by repeated reduction and splinting, usually in 2-3 sessions. The results were consolidated by special orthosis and physiokinetotherapy. We did not encounter any local or general complications. We appreciate the results as being very good in 3 cases, good in 7 cases and satisfactory in 1 case. Conclusions: The orthopaedic non-surgical treatment is a valuable alternative in the management of chronic haemophilic arthropathy. The treatment is usually well tolerated, without major complications, has a great functional benefit and has a very good cost/efficiency rate compared to the surgical treatment.
    No preview · Article · Jan 2010 · Timisoara Medical Journal
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    ABSTRACT: To describe the enzymatic profile of plasma matrix metalloproteinases (MMP-7 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in different categories of patients (pts.) with coronary artery disease (CAD), and their relationship with clinical status, left ventricular (LV) function and remodelling. Total plasma MMP7, active fraction of MMP9, TIMP1 and TIMP2 were determined in 68 consecutive pts with confirmed CAD (Group A, 56.6 +/- 9 y, 75% men, LVEF 56.4 +/- 11%) and compared with a control group of 23 pts. without cardiovascular disease and normal coronary arteries (Group B, 58.1 +/- 10 y, 56.5% men, LVEF 58.7 +/- 5%). LVEF and wall motion index (WMI) were computed. Diastolic function parameters were evaluated: mitral E/A ratio, E/E'septal ratio. We calculated global longitudinal (L), circumferential (C) and radial (R) strain (S) and strain rate (SR) values as the average of segmental values, by 2D strain analysis. The active form of MMP9 differed significantly between group A and B, as did the MMP9/TIMP1 and MMP9/TIMP2 ratios (8.78 +/- 10.0 ng/ml vs 3.33 +/- 4.0 ng/ml; 5.43 +/- 3.4 vs 0.85 +/- 0.9, and 11.60 +/- 5.2 vs 3.71 +/- 1.0, respectively, p < 0.04 for all). Group A included 35 pts. with acute coronary syndromes (ACS) and 33 pts. with stable angina (SA), with similar profile of LVEF and number of coronary arteries involved. There were no significant differences in plasma MMP9, MMP9/TIMP1 and MMP/TIMP2 ratio between normal and SA group, but only between normal and ACS group (p = 0.02 for MMP9). In group A, only MMP7, TIMP1/MMP7 and TIMP2/MMP7 ratio correlated with markers of systolic function: LVEF, WMI and global LS. There were no significant changes in extracellular matrix markers in pts. with chronic stable ischemia vs normals. Only active form of MMP9 and its ratio with TIMP differed significantly in ACS. Total MMP7 and its ratio with TIMP correlated with parameters of LV systolic function even in pts. with normal LVEF.
    Full-text · Article · Jan 2010 · Romanian journal of internal medicine = Revue roumaine de médecine interne

Publication Stats

87 Citations
169.85 Total Impact Points

Institutions

  • 2004-2014
    • Victor Babes University of Medicine and Pharmacy of Timisoara
      • Department of Pediatrics
      Freidorf, Timiş, Romania
  • 2004-2013
    • Prof. Dr. C.C. Iliescu Institute for Emergency Cardiovascular Diseases
      București, Bucureşti, Romania
  • 2007
    • Carol Davila University of Medicine and Pharmacy
      Bucureşti, Bucureşti, Romania