Unité Inserm U1077, Caen, Lower Normandy, France
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Available from: Gwenvael Le Dréau
Temporal and spatial expression of CCN3 during retina development
Le Dréau Gwenvaël
Lelièvre Elise Cécile
· Slembrouck Amélie ·
NOV/CCN3 is one of the founding members of the CCN (Cyr61 CTGF NOV) family. In the avian retina, CCN3 expression is mostly located within the central region of the inner nuclear layer. As retinal development progresses and this retinal layer differentiates and matures, CCN3 expression forms a dorsal-ventral and a central-peripheral gradient. CCN3 is produced by two glial cell types, peripapillary cells and Müller cells, as well as by horizontal, amacrine, and bipolar interneurons. In retinal neurons and Müller cell cultures, CCN3 expression is induced by activated BMP signaling, whereas Notch signaling decreases CCN3 mRNA and protein levels in Müller cells and has no effect in retinal neurons. In Müller cells, the CCN3 expression detected may thus result from a balance between the Notch and BMP signaling pathways. © 2011 Wiley Periodicals, Inc. Develop Neurobiol, 2012.
Full-text · Article · Nov 2012 · Developmental Neurobiology
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Gwenvael Le Dréau
Spanish National Research Council
Unité Inserm U1077
Caen, Lower Normandy, France
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