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ABSTRACT: The Life Skills Profile (LSP) is an assessment instrument of general function in activities of daily life, especially developed for people diagnosed of a severe mental illness. There are different versions of the LSP. The aim of this paper is to validate and adapt the brief form of the LSP (LSP-20) to the Spanish population. Two different samples have been recruited for this study. The first sample was made up of 231 outpatients with a clinical diagnosis of schizophrenia who were randomly selected. The following analyses were performed: principal axis factoring analysis, internal consistency and convergent and discriminant validity between the LSP-20 and the Positive and Negative Symptoms Scale (PANSS). The second sample was recruited in order to assess interrater reliability and was composed of 30 long-stay inpatients with a diagnosis of chronic schizophrenia. Factor analysis produced four factors accounting for 41.22 % of the total variance. The following labels were suggested for the factors: compliance, social initiative, self-care and antisocial behavior. Internal consistency ranged from 0.69 (antisocial behavior) to 0.79 (social initiative). Correlations between the LSP-20 and the PANSS were moderate and clinically significant. Interrater reliability ranged from 0.58 (to have defined interests) to 0.89 (to wear clean clothes usually). The brief form of LSP can be useful in real clinical settings to help to personalize the aims of the rehabilitation interventions and to evaluate the health care model.