YL Jin

Guangzhou First People's Hospital, Shengcheng, Guangdong, China

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Publications (5)4.4 Total impact

  • [Show abstract] [Hide abstract] ABSTRACT: Objectives: The causal role of some cardiovascular risk factors, such as HDL cholesterol, has been increasingly challenged and attention is returning to all elements of Virchow's triad, i.e., hypercoagulability (including viscosity) as well as endothelial function and blood flow. We examined the life course origins of coagulability. Methods: We used multivariable linear regression to assess whether childhood influences, proxied by height and its components, were associated with hematocrit (Hct), hemoglobin (HGB), and other hematological parameters in 28,595 older Chinese adults (mean age = 61.8 years) from the Guangzhou Biobank Cohort Study. Results: Adjusted for age, sex, and recruitment phase, leg length was negatively associated with platelets (PLT) (-0.83 × 10(9) /l per centimeter (cm), 95% confidence interval (CI) -1.01 to -0.65). Sitting height and height were positively associated with Hct (0.05% per cm, 95% CI 0.04-0.07 for sitting height; 0.02% per cm, 95% CI 0.01-0.02 for height), HGB (0.21 g/l per cm, 95% CI 0.17-0.25; 0.07 g/l per cm, 95% CI 0.04-0.09) and negatively associated with PLT (-1.2 × 10(9) /l per cm, 95% CI -1.4 to -1.0; -0.83 × 10(9) /l per cm, 95% CI -0.95 to -0.70). Further adjustment for potential confounders did little to change the estimates. Conclusions: For the first time we provide anthropometric evidence for the different roles of prepubertal and pubertal influences in relation to Hct and HGB. Whether factors that promote leg growth but reduce growth of sitting height may help to prevent cardiovascular events, via effects on hypercoagulability or viscosity, overall or in specific subgroups, remains to be determined.
    No preview · Article · Sep 2014 · American Journal of Human Biology
  • CQ Jiang · TH Lam · KK Cheng · B Liu · WS Zhang · YL Jin · L Xu · KHB Lam · GN Thomas · P Adab · T Zhu · G Leung
    No preview · Article · Jan 2013 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
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    [Show abstract] [Hide abstract] ABSTRACT: Cross-sectional associations between white blood cell (WBC) count, lymphocyte and granulocyte numbers, and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) were examined in a novel older Chinese community sample. A total of 817 men and 760 women from a sub-study of the Guangzhou Biobank Cohort Study had a full blood count measured by an automated hematology analyzer, carotid IMT by B-mode ultrasonography and brachial-ankle PWV by a non-invasive automatic waveform analyzer. Following adjustment for confounders, WBC count (β=0.07, P<0.001) and granulocyte (β=0.07, P<0.001) number were significantly positively related to PWV, but not lymphocyte number. Similarly, WBC count (β=0.08, P=0.03), lymphocyte (β=0.08, P=0.002) and granulocyte (β=0.03, P=0.04) number were significantly positively associated with carotid IMT, but only the association with lymphocyte count survived correction for other cardiovascular risk factors. In conclusion, higher WBC, particularly lymphocyte and granulocyte, count could be used, respectively, as markers of cardiovascular disease risk, measured through indicators of atherosclerosis and arterial stiffness. The associations for WBC count previously observed by others were likely driven by higher granulocytes; an index of systemic inflammation.
    Full-text · Article · Jun 2011 · Journal of human hypertension
  • [Show abstract] [Hide abstract] ABSTRACT: Objective: To examine the effect of carotid atherosclerosis on mild cognitive impairment (MCI). Methods: 1886 relatively healthy Guangzhou residents without history of stroke, myocardial infarction, pulmonary heart disease and malignant tumor were recruited in this study by simple random selection. MCI and carotid color ultrasound were measured in these subjects by using the Mini Mental State Examination (MMSE), the 10-word list learning task (CWL) and common carotid artery intima-medial thickness (IMT) as indicators. Results: (1) The 300 (15.9%) subjects with MCI were identified. No significant difference in MCI prevalence between the sexes was identified. (2) Significant associations between CWL and traditional cardiovascular risk factors, such as older age, smoking and increased waist circumference, blood pressure and lipids were found. (3) After adjusting for multiple potential confounders, increasing IMT was significantly associated with both decreased CWL (β=-1.05, 95% CI: -1.73 - -0.36) and MMSE score (β=-0.95, 95% CI: -1.67--0.23). (4) After adjusting for age, sex, education, physical activity, smoking, waist circumference and high- and low-density lipoprotein cholesterol, IMT was significantly thicker in the MCI group than the normal (0.76 mm vs 0.74 mm, F=6.9, P < 0.01). Conclusions: The severity of MCI was significantly and linearly associated with increased IMT, suggesting that preventing atherosclerosis may help to reduce the incidence and development of dementia.
    No preview · Article · Sep 2010
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    CQ Jiang · L Xu · TH Lam · JM Lin · B Liu · YL Jin · WS Zhang · XJ Yue · KK Cheng · GN Thomas
    Full-text · Article · Jan 2010 · Zhonghua shen jing ke za zhi = Chinese journal of neurology