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Publications (5)6.39 Total impact

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    ABSTRACT: We measured bone texture parameters of excised human femurs with a new device (BMA™). We also measured bone mineral density by DXA and investigated the performance of these parameters in the prediction of failure load. Our results suggest that bone texture parameters improve failure load prediction when added to bone mineral density. Bone mineral density (BMD) is a strong determinant of bone strength. However, nearly half of the fractures occur in patients with BMD which does not reach the osteoporotic threshold. In order to assess fracture risk properly, other factors are important to be taken into account such as clinical risk factors as well as macro- and microarchitecture of bone. Bone microarchitecture is usually assessed by high-resolution QCT, but this cannot be applied in routine clinical settings due to irradiation, cost and availability concerns. Texture analysis of bone has shown to be correlated to bone strength. We used a new device to get digitized X-rays of 12 excised human femurs in order to measure bone texture parameters in three different regions of interest (ROIs). We investigated the performance of these parameters in the prediction of the failure load using biomechanical tests. Texture parameters measured were the fractal dimension (Hmean), the co-occurrence matrix, and the run length matrix. We also measured bone mineral density by DXA in the same ROIs as well as in standard DXA hip regions. The Spearman correlation coefficient between BMD and texture parameters measured in the same ROIs ranged from -0.05 (nonsignificant (NS)) to 0.57 (p = 0.003). There was no correlation between Hmean and co-occurrence matrix nor Hmean and run length matrix in the same ROI (r = -0.04 to 0.52, NS). Co-occurrence matrix and run length matrix in the same ROI were highly correlated (r = 0.90 to 0.99, p < 0.0001). Univariate analysis with the failure load revealed significant correlation only with BMD results, not texture parameters. Multiple regression analysis showed that the best predictors of failure load were BMD, Hmean, and run length matrix at the femoral neck, as well as age and sex, with an adjusted r (2) = 0.88. Added to femoral neck BMD, Hmean and run length matrix at the femoral neck (without the effect of age and sex) improved failure load prediction (compared to femoral neck BMD alone) from adjusted r (2) = 0.67 to adjusted r (2) = 0.84. Our results suggest that bone texture measurement improves failure load prediction when added to BMD.
    No preview · Article · Jun 2011 · Osteoporosis International
  • P. Massin · M. Bonnin · S. Paratte · R. Vargas · P. Piriou · G. Deschamps
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    ABSTRACT: L’objectif de ce travail était d’étudier les résultats de l’arthroplastie totale du genou dans les raideurs de la flexion dans les gonarthroses post-traumatiques et décrire les particularités techniques de leur prise en charge. Une série multicentrique de 40 patients, avec une flexion de genou inférieure ou égale à 90°, a été sélectionnée à partir de 152 gonarthroses post-traumatiques sur cal vicieux. L’hypothèse est que le taux de complications de l’arthroplastie est plus élevé que dans les autres étiologies de raideur et nécessite une prise en charge spécifique.
    No preview · Article · Feb 2011 · Revue de Chirurgie Orthopédique et Traumatologique
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    ABSTRACT: Mycetoma is a chronic granulomatous infection caused by environmental fungi or bacteria. It affects dermal and subcutaneous tissues, with putative contiguous extension to muscles or bones. While common in tropical and subtropical areas, mycetoma is rare in Europe. We describe a case of Actinomadura meyerae osteitis in a 49-year-old Caucasian woman who suffered a tibia open fracture contaminated with hay; to the best of our knowledge the first case of autochthonous A. meyerae infection reported in France. The bacterium was cultivated from a bone biopsy. Following surgical osteosynthesis and six months of treatment with cotrimoxazole, our patient made a full recovery. Our case report suggests that A. meyerae is a potential agent of wound infection in farm workers in contact with hay.
    Full-text · Article · Jan 2011 · Journal of Medical Case Reports
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    P Massin · M Bonnin · S Paratte · R Vargas · P Piriou · G Deschamps
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    ABSTRACT: The objective of this study is to investigate the results of total knee arthroplasty (TKA) in traumatic osteoarthritis cases with flexion restriction and to describe the technical details of their management. A multicentre series comprising 40 patients with limitation of flexion less than or equal to 90° was selected from 152 cases of post-traumatic knee arthritis with malunion. We hypothesized that the arthroplasty complication rate would be higher than in other etiologies of limitation of flexion and would require specific management strategies.
    Full-text · Article · Dec 2010 · Orthopaedics & Traumatology Surgery & Research

  • No preview · Article · Oct 2004 · Orthopedics