P. Lachake

Manipal University, Udupi, Karnataka, India

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Publications (3)0.32 Total impact

  • H N Aswatha Ram · Prachiti Lachake · Ujjwal Kaushik · C S Shreedhara
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    ABSTRACT: Floating tablets prolong the gastric residence time of drugs, improve bioavailability, and facilitate local drug delivery to the stomach. With this objective, floating tablets containing aqueous extract of liquorice as drug was prepared for the treatment of Helicobacter pylori and gastric ulcers. The aqueous extract of liquorice was standardized by HPTLC. Tablets containing HPMC K100M (hydrophilic polymer), liquorice extract, sodium bicarbonate (gas generating agent), talc, and magnesium stearate were prepared using direct compression method. The formulations were evaluated for physical parameters like diameter, thickness, hardness, friability, uniformity of weight, drug content, buoyancy time, dissolution, and drug release mechanism. The formulations were optimized on the basis of buoyancy time and in vitro drug release. The diameter of all formulations was in the range 11.166-11.933 mm; thickness was in the range 4.02-4.086 mm. The hardness ranged from 3.1 to 3.5 kg/cm(2). All formulations passed the USP requirements for friability and uniformity of weight. The buoyancy time of all tablet formulations was less than 5 min and tablet remained in floating condition throughout the study. All the tablet formulations followed zero-order kinetics and Korsemeyer-Peppas model in drug release. The optimized formulation was found to be F6 which released 98.3% of drug in 8 h in vitro, while the buoyancy time was 3.5 min. Formulations containing psyllium husk, sodium bicarbonate and HPMC K100M in combination can be a promising for gastroretentive drug delivery systems.
    No preview · Article · Sep 2010 · Pharmacognosy Research
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    ABSTRACT: Free radicals are highly reactive chemical species indicated in various diseases and ailments. In order to study the antioxidant ability of Avipattikar churna, the aqueous and methanolic extracts of Avipattikar churna was evaluated for in vitro antioxidant potential. The free radical scavenging activity was carried out using the reactivity of extracts towards different radicals such as 2,2 - Azino bis (3-ethyl Benzo Thiazole - 6 - Sulphonic acid (ABTS), 1,1-Diphenyl-2- Picryl Hydrazine (DPPH) and 1:10- Phenanthroline hydrate (O-phenenthroline). The superoxide scavenging activity was measured by spectrophotometric method using (Nitroblue tetrazolium) NBT. The total antioxidant potential of aqueous and methanolic extracts of Avipattikar churna was also evaluated.
    No preview · Article · Sep 2009 · Pharmacologyonline
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    ABSTRACT: The aqueous extract of Avipattikar churna was evaluated for gastroprotection in rats using the ibuprofen, ethanol and pylorus ligation induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and gastric irritancy index (GII). Oral administration of aqueous extract (500mg/kg) of Avipattikar churna significantly protected against gastric lesions as compared to ranitidine in ibuprofen, ethanol and pylorus ligation induced ulcer models. Histopathological examination of stomach mucosa showed the protective action of aqueous extract of Avipattikar churna against mucosal epithelial damage caused by ibuprofen, ethanol and pylorus ligation. The present study provides a strong evidence of antiulcer activity of aqueous extract of Avipattikar churna against gastric lesions. The antiulcer activity is recognised by a reduction in acid secretory parameters (i.e. total and free acid), gastric volume and gastric irritancy index (GII).
    No preview · Article · Jan 2009 · Pharmacologyonline

Publication Stats

3 Citations
0.32 Total Impact Points

Institutions

  • 2010
    • Manipal University
      • Department of Pharmacognosy
      Udupi, Karnataka, India