K S Nagarsekar

Bombay College of Pharmacy, Mumbai, Maharashtra, India

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Publications (2)0.96 Total impact

  • K S Nagarsekar · M S Nagarsenker · S R Kulkarni
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    ABSTRACT: Supercritical fluid extract and ethanol extract of Vitex negundo Linn. were subjected to the chromatographic evaluation for identification of their constituents. Free radical scavenging activity of both extracts was studied by subjecting them to DPPH assay. IC(50) values of ethanol and supercritical fluid extract of Vitex negundo indicate that ethanol extract has stronger reducing potential and ability to scavenge free radicals as compared to the supercritical fluid extract. The in vivo effect of extracts on lipid peroxidation was studied using ethanol induced oxidative stress model in rat. Ingestion of extracts for 14 days exhibited significant reduction in plasma MDA level of stressed animals. Ethanol extract exhibited higher in vivo antilipid peroxidation potential as compared to supercritical fluid extract which correlated well with radical scavenging potential of extract.
    No preview · Article · Jul 2011 · Indian Journal of Pharmaceutical Sciences
  • K S Nagarsekar · M S Nagarsenker · S R Kulkarni
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    ABSTRACT: Supercritical fluid extract of leaves of Vitex negundo was tested for its antimicrobial potential and was compared with that of ethanol extract, ether extract and hydrodistilled oil of leaves. The chemical constituents of extracts were studied by chromatographic techniques. Extracts were evaluated for antimicrobial potential against bacterial strains like Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and yeast Candida albicans. Extracts showed prominent antibacterial activity against Bacillus subtilis and Staphylococcus aureus. Supercritical fluid extract exhibited good antibacterial potential.
    No preview · Article · Sep 2010 · Indian Journal of Pharmaceutical Sciences

Publication Stats

15 Citations
0.96 Total Impact Points


  • 2010-2011
    • Bombay College of Pharmacy
      • Department of Pharmacognosy
      Mumbai, Maharashtra, India