A. F. Borkenstein

Medical University of Graz, Gratz, Styria, Austria

Are you A. F. Borkenstein?

Claim your profile

Publications (3)1.19 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND: Retinal artery occlusion (RAO) is a common vision-threatening disease. Several risk factors including arterial hypertension, diabetes mellitus and atherosclerosis have been identified. Atherosclerosis itself is a chronic low-grade inflammatory disease with a distinct proinflammatory cytokine profile. Among others, tumor necrosis factor alpha (TNF-α), a proinflammatory cytokine, contributes to atherogenesis and two TNF-α gene polymorphisms (TNF-α -308G>A and -238G>A) have previously been shown to modulate TNF-α expression. Consequently, the present study was set to investigate a hypothesized association between the TNF-α -308G>A and -238G>A polymorphisms and the presence of RAO. MATERIAL AND METHODS: Genotypes of the TNF-α -308G>A and -238G>A polymorphisms were determined in 240 patients with RAO and 335 control subjects. Determination of genotypes was done using 5′ exonuclease assays (TaqMan). Results: Genotype distributions and allele frequencies of both TNF-α polymorphisms did not significantly differ between patients with RAO and control subjects (p>0.05). Prevalences of arterial hypertension, diabetes mellitus and ever-smoking status were significantly higher in patients than among controls (arterial hypertension: 77.1% vs. 52.2%, p<0.001; diabetes mellitus: 13.8% vs. 6.3%, p=0.002; ever-smoking status: 55.0% vs. 23.6%, p<0.001). CONCLUSIONS: Our data suggest that both investigated TNF-α polymorphisms are not associated with increased risk for RAO in a Central European population.
    No preview · Article · Sep 2011 · Spektrum der Augenheilkunde
  • A.F. Borkenstein · S. Hausberger · C. Mayer · C. Faschinger
    [Show abstract] [Hide abstract]
    ABSTRACT: Obwohl die transiente Myopie ein recht seltenes Symptom ist, sollte man bei Auftreten einer plötzlichen Sehverschlechterung an systemische Erkrankungen denken, die zu einem lebensbedrohlichen Zustand führen können. Daher spielt die Erstdiagnose in der ophthalmologischen Klinik/Praxis eine entscheidende Rolle. Although transient myopia is an extremely rare symptom, systemic diseases which can also lead to a life-threatening condition should also be considered in cases of sudden deterioration of vision. Therefore, the initial diagnosis in an ophthalmological clinic or practice plays a decisive role. SchlüsselwörterTransiente Myopie–Hantavirus–Puumulavirus–Sehverschlechterung–Systemische Erkrankungen KeywordsTransient myopia–Hantavirus–Puumula virus–Visual deterioration–Systemic disease
    No preview · Article · Jul 2011 · Der Ophthalmologe
  • A F Borkenstein · S Hausberger · C Mayer · C Faschinger
    [Show abstract] [Hide abstract]
    ABSTRACT: Although transient myopia is an extremely rare symptom, systemic diseases which can also lead to a life-threatening condition should also be considered in cases of sudden deterioration of vision. Therefore, the initial diagnosis in an ophthalmological clinic or practice plays a decisive role.
    No preview · Article · May 2011 · Der Ophthalmologe