Zun Zhang

Shanghai Jiao Tong University, Shanghai, Shanghai Shi, China

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Publications (3)0 Total impact

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    ABSTRACT: To investigate the relationship between diabetes mellitus and pulposis and the pathogenesis of diabetes mellitus pulposis, via comparing the pulp tissue conditions and ultramicrostructures of capillary vessels in pulp tissues of diabetes mellitus patients and normal control. Pulp tissues were obtained from clinically extracted human third molars with impaction (control group, 30 cases) and intact third molars with impaction (non-insulin dependent diabetes patients) whilst without pulposis symptom (diabetic group, 30 cases). The pathological changes of two groups' pulp tissues were evaluated under light microscope and electron microscopy. The thickness of pulp capillary basement membrane and their anionic sites were quantitatively analyzed by electron microscopy and special staining. Statistical analysis was performed using SAS6.12 software package. The tricked blood capillary wall was observed in diabetic pulp under light microscope. The thickened blood capillary wall and constrictive lumen were observed in diabetic pulp under electron microscope, accompanied with vascular endothelial cell swelling and structural destruction and thickened basement membrane (P<0.01). The decrease of anionic sites of capillary basement membrane was observed in diabetic pulp under specially stained electron microscope (P<0.01). Inflammatory reaction existed in the pulp of intact teeth of DM patients without symptoms. The changes observed in diabetic vessels may occur in the dental pulp. Diabetes mellitus is closely related to pulposis. Supported by Projects of Shanghai Municipal Health Bureau (2008156).
    No preview · Article · Oct 2012 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • Xiao-li Wang · Yi Xu · Qing Sun · Zun Zhang
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    ABSTRACT: To investigate the detected rate and modality of multiple canals in mandibular central incisor by 5 different methods and to compare the results and differences among the methods, in order to provide give theoretical evidence of choosing right method and treatment in clinic. 176 mandibular central incisors were examined by 5 different methods,including radiograph at a horizontal angle of 0, macrography 15#K- file, dental operative microscope, spiral CT scanning, and dental cross section. All statistical analysis was performed using SAS6.12 software package. Data of detected rate of these 5 methods were compared using McNemar exact probability test. The result of dental cross section was the key standard, the rate in 176 mandibular central incisor was 9.66% with two canals, of which 4.55% were type II, 5.11% were type v. The detected rate of two-canal teeth was 0.00% by radiograph at a horizontal angle of 0, 2.84% by macroscopy15# K- file, 4.76% by dental operative microscope, and 9.09% by spiral CT scanning,respectively. The results from 5 methods were compared with each other by McNemar test to find out the difference. Validity of these 5 methods according to γ was dental cross section > spiral CT scanning > dental operative microscope > macroscopy 15#K- file > radiograph at a horizontal angle of 0. Some mandibular central incisors have two canals, the clinicians should pay more attention to avoid missing canals. When radiograph at a horizontal angle of 0 and macroscopy 15#K- file can't effectively find two canals, we suggest using the other methods such as radiograph with an excursion angle, dental operative microscope and spiral CT scanning to make clear diagnosis.
    No preview · Article · Apr 2012 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • Zun Zhang · Qing Sun · Xiao-li Wang
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    ABSTRACT: To evaluate the concentration of monocyte chemoattractant protein-1 (MCP-1) in the gingival crevicular fluid from patients with chronic periodontitis and its correlation with clinic periodontal parameters as well as alkaline phosphates secretions. Gingival crevicular fluid (GCF) was collected with standardized filter strips from healthy control sites as well as periodontitis sites from chronic periodontitis patients before and after initial therapy, and the levels of MCP-1 and alkaline phosphatase were detected by ELISA. The data was analyzed with SPSS 11.0 software package. Concentration of MCP-1 in GCF was significantly higher in chronic periodontitis patients, and decreased significantly after initial therapy, the variation of MCP-1 correlated positively with clinical parameters like plaque index(PLI), probing depth (PD), gingival index (GI), clinic attachment lost (CAL) as well as alkaline phosphatase secretion. As an inflammatory chemotatic factor, MCP-1 in GCF may play an important role in occurrence and development of chronic periodontitis, and could be considered as a potential target for prevention and treatment of chronic periodontitis.
    No preview · Article · Apr 2011 · Shanghai kou qiang yi xue = Shanghai journal of stomatology