Rui-Tao Wang

Harbin Medical University, Charbin, Heilongjiang Sheng, China

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Publications (22)65.43 Total impact

  • Ji-Bin Yin · Ying Li · Tiemin Liu · Rui-Tao Wang
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    ABSTRACT: BACKGROUND Gallstones are associated with dyslipidemia, metabolic syndrome, hyperinsulinemia, and carotid intima-media thickness, which all are related to hyperviscosity. Therefore, this study aimed to examine the associations between blood viscosity and gallstones. MATERIAL AND METHODS We investigated the associations between blood viscosity and gallstones in a study conducted in middle-aged subjects. RESULTS Among 849 enrolled patients, 421 (49.6%) had gallstone disease. Compared with control subjects, whole-blood viscosity (WBV) levels were increased in patients with gallstones. The prevalence of gallstones increased as WBV (3 s-1) quartiles increased. Furthermore, logistic regression analysis showed that WBV (3 s-1) was associated with gallstone disease. CONCLUSIONS We found that whole-blood viscosity at low shear rate was independently associated with gallstones. Whether control of hyperviscosity would reduce the risk of developing gallstones deserves further investigation.
    No preview · Article · Dec 2015 · Medical science monitor: international medical journal of experimental and clinical research
  • Xue-Song Li · Su-Jun Cheng · Zhi-Gang Cao · Ying Li · Rui-Tao Wang
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    ABSTRACT: Background: Various vascular risk factors such as smoking, obesity, and diabetes mellitus are associated with hyperviscosity and lumbar disc herniation (LDH). However, the changes of viscosity in LDH have not been examined. Aims: The present study was to elucidate 1) the rheological parameter levels in patients with LDH, 2) the risk factors that were related to rheological parameters. Methods: Our study evaluated the rheological parameters in 307 cases with LDH and in 307 control subjects. Multiple linear regression analysis was conducted to assess the significant factors for whole blood viscosity (WBV) at low shear rate. Results: LDH patients had markedly lower physical activity and significantly higher WBV 3 s-1 compared with non-LDH subjects (p < 0.001). Moreover, WBV (3 s-1) tended to increase as physical activity decreased. Multiple linear regression analysis revealed that reduced physical activity was a significant factor contributing to elevated WBV (3 s-1). Conclusions: WBV (3 s-1) is elevated in patients with LDH. In addition, reduced physical activity is a significant factor for WBV (3 s-1). Further studies are warranted to determine the role of WBV (3 s-1) in LDH.
    No preview · Article · Oct 2015 · Clinical hemorheology and microcirculation
  • Xin-Yang Yu · Ying Li · Tiemin Liu · Rui-Tao Wang
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    ABSTRACT: Background: Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for increased cardiovascular disease. Altered hemorheological parameters have also been shown to play a crucial role in atherogenesis. Moreover, increased viscosity is observed in insulin resistance, metabolic syndrome, hypertension, diabetes, ischemic heart disease, and stroke. A recent study confirmed that whole blood viscosity (WBV) is a predictor of cardiovascular events. Aims: This study aimed to investigate the association of WBV with NAFLD. Methods: In this cross-sectional study, we investigated the relationship between WBV and NAFLD in 1329 subjects (962 men and 367 women) in a general health examination. Results: WBV at low shear stress was elevated in patients with NAFLD. In addition, the prevalence of metabolic syndrome and NAFLD increased as WBV quartiles increased both in men and in women. Multiple regression analysis further identified WBV as an independent and significant determinant for NAFLD. Conclusions: The findings showed that WBV at low shear stress is increased in NAFLD. Moreover, WBV at low shear stress is independently associated with NAFLD even after adjusting other cardiovascular risk factors.
    No preview · Article · Oct 2015 · Clinical hemorheology and microcirculation
  • Wen-Xue Sun · Ji-Rong Zhang · Ying Li · Rui-tao Wang

    No preview · Article · May 2015 · Respiratory Medicine
  • Xin-Yang Yu · Xue-Song Li · Ying Li · Tiemin Liu · Rui-Tao Wang
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    ABSTRACT: Systemic inflammation may be a common mechanism for the development of osteoporosis (OP) and atherosclerosis. Elevated arterial stiffness is an index of subclinical atherosclerosis. Recent studies found that neutrophil/lymphocyte ratio (NLR), is a useful marker of cardiovascular disease and a more powerful predictor than any other leukocyte subtypes. However, little research has been conducted to investigate the relationship between NLR and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). In this cross-sectional study, we examined the relationship between NLR and baPWV in 512 subjects. Compared to the control subjects, NLR and baPWV increased in patients with OP. Partial correlation analysis revealed that there was a significant correlation between NLR and baPWV after adjusting for confounding factors in OP. Multivariate linear regression analysis showed that NLR was a significant factor for increased baPWV in patients with OP (β=0.249, p<0.001). However, there was no association between NLR and baPWV in control subjects. NLR and baPWV are elevated in OP. Moreover, NLR is independently associated with baPWV. Further studies are warranted to investigate whether anti-inflammatory treatment could improve arterial stiffness in postmenopausal women with OP. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    No preview · Article · Apr 2015 · Archives of gerontology and geriatrics
  • Rui-Tao Wang · Ji-Rong Zhang · Ying Li · Tiemin Liu · Kai-Jiang Yu
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    ABSTRACT: Diabetic retinopathy (DR) is the most common complication of type 2 diabetes mellitus (T2DM). Inflammation plays a considerable role in the pathogenesis of T2DM and DR. Emerging evidence revealed that the neutrophil-lymphocyte ratio (NLR) may be a useful marker of cardiovascular disease. The brachial-ankle pulse wave velocity (baPWV) is an indicator for early atherosclerotic changes. Therefore, this study aimed to investigate the association of NLR with baPWV in patients with DR. In this cross-sectional study, we investigated the relationship between NLR and baPWV in 402 participants. Participants were divided into the following three groups: 133 control subjects without T2DM; 138 diabetic subjects without DR; and 131 patients with DR. NLR and baPWV were elevated both in T2DM and in DR. Moreover, compared to T2DM, NLR and baPWV were higher in DR. There was a positive correlation between NLR and baPWV in patients with T2DM and DR after adjusting confounding factors. Multiple linear regression analysis further revealed that NLR was an independent and significant determinant for elevated baPWV (for T2DM, β=0.170; p=0.041; for DR, β=0.188; p=0.022, respectively). The findings showed that NLR and baPWV are elevated both in T2DM and in DR. In addition, NLR is independently associated with baPWV. Early detection of abnormal NLR levels may be helpful for the search of subclinical atherosclerosis in patients with T2DM and DR. Copyright © 2014 Elsevier Inc. All rights reserved.
    No preview · Article · Nov 2014 · Journal of Diabetes and its Complications
  • Ying Li · Xiu-Xia Tian · Tiemin Liu · Rui-Tao Wang
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    ABSTRACT: Type 2 diabetes mellitus (DM) carries an increased risk for cardiovascular complications. The brachial-ankle pulse wave velocity (baPWV) is an index for early atherosclerotic changes. Recently, the effect of altered blood rheology on atherosclerosis has received attention. Therefore, this study aimed to examine the association of hemorheological parameters with baPWV in patients with DM. In this cross-sectional study, we investigated the relationship between rheological parameters and baPWV in 323 control subjects (160 men and 163 women) and 382 patients with DM (170 men and 212 women). The participants with DM had higher whole blood viscosity (WBV) levels both at low shear rate (3 s(-1)) and at high shear rate (200 s(-1)) than those without DM. Different metabolic parameters were compared across WBV (3 s(-1)) quartiles. The mean values of baPWV gradually increased with WBV (3 s(-1)) quartiles. In addition, there was a positive correlation between baPWV and WBV 3 s(-1) in patients with DM after adjusting confounding factors (r = 0.285, p = 0.039). Stepwise multiple linear regression analysis further revealed that WBV (3 s(-1)) is a significant determinant for increased baPWV in DM (β = 0.184; p < 0.001). However, there were no association between WBV (3 s(-1)) and baPWV in control subjects. The findings showed that baPWV increased as WBV (3 s(-1)) elevated in DM. Moreover, WBV (3 s(-1)) is independently associated with baPWV even after adjusting other cardiovascular risk factors. Early detection of abnormal WBV levels at low shear rate should warrant for early search of undetected arterial stiffness in patients with DM.
    No preview · Article · Oct 2014 · Endocrine
  • Ning Li · Guo-wei Zhang · Ji-rong Zhang · Di Jin · Ying Li · Tiemin Liu · Rui-tao Wang
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    ABSTRACT: Background and aims NAFLD is an independent risk factor for increased cardiovascular disease. Arterial stiffness is an index of subclinical atherosclerosis. The aims of this study were to examine prospectively the relationship between Non-alcoholic fatty liver disease (NAFLD) and the progression of arterial stiffness. Methods and results A prospective study of 728 men and 497 women free of hypertension, and diabetes at the baseline were conducted. The subjects were followed for 5 years. The progression rate of arterial stiffness was measured by calculating the increase in brachial-ankle pulse wave velocity (baPWV). Results The changes of the baPWV (adjusted for age) during the study period was significantly greater in the patients with NAFLD (172.4± 42.1 cm/s for men, 95.8 ± 36.7 cm/s for women) than in the subjects without NAFLD (70.3 ± 56.5 cm/s for men, 55.4 ± 42.2 cm/s for women). For the subjects with metabolic syndrome, after adjusting for multiple risk factors, NAFLD was a significant predictor of baPWV progression (for male, β = 0.843; P < 0.001; for female, β = 0.575; P < 0.001, respectively). In addition, results were unmodified in subjects without metabolic syndrome. Conclusions NAFLD was found to be an independent predictor of faster progression of baPWV even after adjusting other cardiovascular risk factors. These prospective data support a pathogenic role for NAFLD in the development of arterial stiffness.
    No preview · Article · Oct 2014 · Nutrition Metabolism and Cardiovascular Diseases
  • Wen-Xue Sun · Ji-Rong Zhang · Zhi-Gang Cao · Ying Li · Rui-Tao Wang
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    ABSTRACT: Background: Systemic inflammation is related to disease progression in asthma. Activated platelets play a critical role in atherogenesis, inflammation, and atherothrombosis. The mean platelet volume (MPV) is an early marker of platelet activation. Objectives: The aim of this study is to clarify the relevance of MPV levels in patients with stable and exacerbated asthma. Methods: We investigated the peripheral blood cell count parameters, C-reactive protein (CRP), lung function parameters, and arterial blood gas in patients with asthma and control subjects. Eighty-five stable asthma patients and 85 asthmatics with exacerbations were investigated. Eighty-five controls matched for age, gender, body mass index (BMI), and smoking status were recruited. Results: Patients with exacerbated asthma had lower MPV and higher CRP levels and white blood cell (WBC) counts compared to patients with stable asthma and control subjects. Furthermore, the MPV was reduced in patients with stable asthma compared to control subjects. Negative correlations between MPV and CRP were present in stable and exacerbated asthma. Although there was no relationship between MPV and WBC count in stable asthma, there was an inverse relationship between MPV and WBC count in exacerbated asthma. Conclusions: These findings show that patients with stable asthma had a lower MPV compared to controls and the MPV levels in asthmatic patients with exacerbations were lower compared to those in patients with stable asthma. Further investigations regarding the role of MPV in asthma may be beneficial in the search for therapeutic targets. © 2014 S. Karger AG, Basel.
    No preview · Article · May 2014 · Respiration
  • Bing Li · Xin Liu · Zhi-Gang Cao · Ying Li · Tie-Min Liu · Rui-Tao Wang
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    ABSTRACT: The presence of silent cerebral infarction (SCI) increases the risk of transient ischemia attack, symptomatic stroke, cardiovascular disease and dementia. Mean platelet volume (MPV) is a surrogate marker of activated platelets and is considered a link between inflammation and thrombosis. In addition, MPV is a risk predictor for cardiovascular disease, stroke, and overall vascular mortality. The purpose of the study was to assess the MPV levels in SCI patients. A cross-sectional study was conducted to evaluate the association between MPV and SCI in 2215 subjects (1385 men and 830 women). The participants with SCI had higher MPV levels than those without SCI (10.4 ± 1.3 fL vs. 9.2 ± 1.2 fL; P < 0.001). Moreover, the subjects with a high MPV had a higher prevalence of SCI. Multivariate logistic regression analyses revealed that the odds ratios (ORs) and 95% confidence intervals (CIs) for SCI according to MPV quartiles were 1.000, 2.131 (1.319-3.444), 3.015 (1.896-4.794), 7.822 (4.874-12.554), respectively (P < 0.001). MPV is a novel index for SCI regardless of classical cardiovascular risk factors.
    No preview · Article · Apr 2014 · Internal Medicine Journal
  • Rui-Tao Wang · Wen-Xue Sun · Di Jin · Ying Li

    No preview · Article · Mar 2014 · Respiratory medicine
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    Jia-Ying Li · Ying Li · Zheng Jiang · Rui-Tao Wang · Xi-Shan Wang
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    ABSTRACT: Colon cancer is the second most common cancer in developed countries. Activated platelets play a key role in inflammation and atherothrombosis, with mean platelet volume (MPV) is an early marker of platelet activation. The aim of the study was to clarify the relevance of MPV in patients with colon cancer. We measured MPV levels in 128 patients with colon cancer before and after surgery, and 128 controls matched for age, gender, body mass index (BMI) and smoking status. The odds ratios (ORs) and 95% confidence intervals (CIs) for colon cancer were calculated using multivariate logistic regression analyses across MPV quartiles. Patients with colon cancer had higher MPV compared with controls. Surgical tumor resection resulted in a significant decrease in MPV levels (11.4 fL vs 10.7 fL; p<0.001). A positive correlation between MPV and tumor-nodule-metastases (TNM) stage was found. Furthermore, after adjusting for other risk factors, the ORs (95%CIs) for colon cancer according to MPV quartiles were 1.000, 2.238 (1.014-4.943), 3.410 (1.528-7.613), and 5.379 (2.372-12.198), respectively. The findings show that patients with colon cancer have higher MPV levels compared with controls, and these are reduced after surgery. In addition, MPV was found to be independently associated with the presence of colon cancer. Further studies are warranted to assess the utility of MPV as a novel diagnostic screening tool for colon cancer.
    Full-text · Article · Jan 2014 · Asian Pacific journal of cancer prevention: APJCP
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    Rui-Yan Li · Zhi-Gang Cao · Ji-Rong Zhang · Ying Li · Rui-Tao Wang
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    ABSTRACT: The presence of silent cerebral infarction (SCI) increases the risk of transient ischemia attack, symptomatic stroke, cardiovascular disease, and dementia. Total bilirubin (TB) levels were demonstrated to be decreased in carotid intima-media thickness, cardiovascular disease, stroke, and peripheral arterial disease. However, little information is available concerning the correlation between TB and SCI. A cross-sectional study was conducted to evaluate the association between TB and SCI in 2865 subjects (1831 men and 1034 women) undergoing medical checkup. The participants with SCI had lower TB levels than those without SCI. The subjects with a low TB had a higher prevalence of SCI. Moreover, partial correlation showed that TB levels were tightly correlated with brachial-ankle pulse wave velocity after adjusting for confounding covariates (r=-0.149; P<0.001). Multivariate logistic regression analysis revealed that higher TB was associated with a lower risk of SCI (odds ratio, 0.925; 95% confidence interval, 0.897-0.954; P<0.001). TB is a novel biochemical indicator for SCI regardless of classical cardiovascular risk factors. Early measurement of TB may be useful to assess the risk of SCI.
    Preview · Article · Dec 2013 · Arteriosclerosis Thrombosis and Vascular Biology
  • Wen-Xue Sun · Di Jin · Ying Li · Rui-Tao Wang
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    ABSTRACT: Systemic inflammation is related to disease progression in asthma. The brachial-ankle pulse wave velocity (baPWV) is a marker for early atherosclerotic changes. The aim of this study is to evaluate the baPWV levels in patients with stable and severe asthma. We examined baPWV, high sensitivity C-reactive protein (CRP), lung function parameters, and arterial blood gas analysis in patients with asthma and control subjects. 85 stable asthma patients and 85 severe asthmatics were investigated. 85 control subjects matched for age, gender, body mass index (BMI) and smoking status were recruited. The patients with severe asthma had increased baPWV and CRP compared with the patients with stable asthma and control subjects. Furthermore, baPWV was elevated in stable asthma compared with control subjects. There was a negative correlation between baPWV and forced expiratory volume in 1 s (FEV1), after adjusting age, gender, BMI and smoking status (r = -0.414, p < 0.001). Similarly, baPWV was negatively correlated with FEV1/forced vital capacity (FVC) (r = -0.431, p < 0.001). Although there was no correlation between CRP and baPWV in patients with stable asthma, CRP was positively correlated with baPWV in patients with severe asthma (r = 0.229, p = 0.039). baPWV tends to increase as pathogenic condition aggravated in asthma. In addition, elevated baPWV correlates with impaired lung function. Our observation suggests that baPWV is useful for early detection of subclinical atherosclerosis in asthma.
    No preview · Article · Nov 2013 · Respiratory medicine
  • Qing-Cheng Liang · Di Jin · Ying Li · Rui-Tao Wang
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    ABSTRACT: Abstract Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascular dementia (VaD) and AD. In this cross-sectional study, we investigated the levels of platelet count, MPV, and platelet distribution width (PDW) in 150 VaD patients, 110 AD patients, and 150 non-demented controls. MPV and PDW were significantly lower in patients with VaD and AD as compared with controls. The decrease in PDW for AD patients as compared with VaD patients was also significant (p < 0.001). In addition, there was a positive correlation between Mini-Mental State Examination (MMSE) and MPV and PDW, after adjusting confounding factors (r = 0.532 for MPV and r = 0.425 for PDW, p < 0.001 for both). Multivariate regression analysis showed that MPV and PDW were significantly associated with MMSE (β = 0.366 for MPV and β = 0.273 for PDW, p < 0.001 for both). In conclusion, MPV and PDW were both decreased in VaD and AD. PDW levels were significantly lower in AD as compared to those in VaD. Our findings suggest that PDW in combination with MMSE scores could be potential indicators for distinguishing VaD from AD.
    No preview · Article · Oct 2013 · Platelets
  • Rui-Yan Li · Zhi-Gang Cao · Ying Li · Rui-Tao Wang
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    ABSTRACT: The presence of silent cerebral infarction (SCI) increases the risk of transient ischemia attack, symptomatic stroke, cardiovascular disease and dementia. Increased viscosity is associated with aging, obesity, carotid intima-media thickness, metabolic syndrome, hypertension, diabetes, ischemic heart disease, and stroke. The purpose of the study was to assess the hemorheological parameters levels in SCI patients. A cross-sectional study was conducted to evaluate the association between hemorheological parameters and SCI in 1487 subjects (868 men and 619 women) undergoing medical check-up. The participants with SCI had higher whole blood viscosity (WBV) levels at low shear rate than those without SCI (10.34 ± 1.77 mPa.s vs. 8.98 ± 0.88 mPa.s; P < 0.001). Moreover, the subjects with a high WBV had a higher prevalence of SCI. Logistic regression analysis revealed that a significant association of WBV levels with the risk of SCI after adjustment for confounding factors (OR: 2.025; 95% CI: 1.750-2.343; P < 0.001). Whole blood viscosity at low shear rate is a novel indicator for SCI regardless of classical cardiovascular risk factors. Early measurement of whole blood viscosity may be helpful to assess the risk of stroke.
    No preview · Article · Aug 2013 · Clinical hemorheology and microcirculation
  • Kai-Jiang Yu · Mei-Jie Zhang · Ying Li · Rui-Tao Wang
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    ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for increased cardiovascular disease. The brachial-ankle pulse wave velocity (baPWV) is a marker for early atherosclerotic changes. Recently, the effect of changed blood rheology on atherosclerosis has received attention. A study confirmed that whole blood viscosity (WBV) is a predictor of cardiovascular events. Therefore, this study aimed to investigate the association of WBV with baPWV in patients with NAFLD. In this cross-sectional study, we investigated the relationship between WBV and baPWV in 2032 participants (1035 men and 997 women) with NAFLD in a general health examination. Different metabolic parameters were compared across WBV (3 s(-1) ) quartiles. The mean values of baPWV gradually increased with WBV (3 s(-1) ) quartiles. Stepwise multiple linear regression analysis revealed that WBV (3 s(-1) ) is a significant determinant for increased baPWV both in men and in women (for male, β = 0.229; P < 0.001; for female, β = 0.672; P < 0.001). The findings showed that baPWV elevated as WBV (3 s(-1) ) increased in NAFLD. Moreover, WBV (3 s(-1) ) is independently associated with baPWV even after adjusting other cardiovascular risk factors. Early detection of abnormal WBV levels at low shear rate should warrant for early search of undetected arterial stiffness in patients with NAFLD.
    No preview · Article · Aug 2013 · Journal of Gastroenterology and Hepatology
  • Zong-Yan Teng · Li-Chun Pei · Ying Zhang · Ying Li · Rui-Tao Wang
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    ABSTRACT: Osteoporosis (OP) is associated with cardiovascular disease. Moreover, osteoporosis has been shown to be an independent predictor of cardiovascular mortality. Recent studies revealed that altered blood rheology plays a critical role in atherosclerosis. A study confirmed that whole blood viscosity (WBV) is a predictor of cardiovascular events. However, little research has been conducted to investigate the relationship between blood viscosity and osteoporosis. In this cross-sectional study, we investigated the relationship between the rheological parameters and bone mineral density (BMD) in 481 subjects in the International Physical Examination and Healthy Center of the Second Affiliated Hospital, Harbin, China. Different biochemical parameters and rheological parameters were determined and BMD was measured in osteoporosis, osteopenia, and normal BMD group. WBV and plasma viscosity increased as BMD decreased. Partial correlation analysis showed there are significant correlations between WBV in low shear stress, plasma viscosity and BMD at the spine L2-4 and femoral neck after adjusting for confounding factors. Furthermore, WBV in high shear stress and physical activity are correlated to lumbar spine BMD. Stepwise multivariate linear regression analysis revealed that WBV was a significant factor for decreased BMD (β = -0.513; P < 0.001 for lumbar spine L2-4 BMD; β = -0.157; P = 0.003 for femoral neck BMD). In conclusion, The findings show that WBV is elevated in osteoporosis and negatively correlated with BMD. Further studies are warranted to investigate whether antiosteoporosis medication could normalize whole blood vicosity in postmenopausal women with osteoporosis.
    No preview · Article · Jul 2013 · Bone
  • Rui-Tao Wang · Jia-Ying Li · Zhi-Gang Cao · Ying Li
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    ABSTRACT: An increased mean platelet volume (MPV) is an early marker of platelet activation. Activated platelets play a role in atherogenesis, inflammation, and atherothrombosis. Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular disease-related mortality. The aim of the study is to measure the MPVs in patients with stable and exacerbated COPD. We investigated the peripheral blood cell count parameters, C-reactive protein (CRP), fibrinogen, lung function parameters, and arterial blood gas analysis in patients with COPD and in controls. Seventy participants were investigated at admission for an acute exacerbation of COPD and reassessed when stable . Seventy controls were matched for age, gender, body mass index (BMI), medication use and smoking . Participants with an exacerbation of COPD had lower MPV and higher CRP, white blood cells (WBC) and fibrinogen compared with when in stable phase of COPD and controls. MPV was also lower in patients in stable phase COPD compared with controls. Negative correlations between MPV and CRP and between MPV and platelet count were present in patients in stable and exacerbation of COPD. The findings show that COPD patients, during acute exacerbation and in stable phase, have lower MPVs compared to healthy controls; the MPVs increase once patients have recovered from their exacerbation of COPD.
    No preview · Article · Jun 2013 · Respirology
  • Rui-Tao Wang · Di Jin · Ying Li · Qing-Cheng Liang
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    ABSTRACT: Neuroinflammation is a critical driving force underlying mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathologies. Activated platelets play an important role in neuroinflammation and have been implicated in AD pathogenic mechanisms. Mean platelet volume (MPV), a marker of platelet activation, is involved in the pathophysiology of a variety of pro-inflammatory diseases. However, little research has been conducted to investigate the relationship between platelet indices and MCI and AD pathogenesis. In this cross-sectional study, we investigated the levels of platelet count, MPV and platelet distribution width (PDW) in 120 AD patients, 120 MCI patients, and 120 non-demented controls. Our study showed that MPV and PDW were significantly lower in patients with AD as compared with either MCI or controls. Moreover, MCI patients had lower MPV and PDW values compared with the controls (P < 0.001). In addition, there is a positive correlation between mini-mental state examination (MMSE) and MPV and PDW, after adjusting age, gender, and body mass index (r = 0.576, P < 0.001 for MPV; r = 0.465, P < 0.001 for PDW, respectively). Multivariate analysis showed that MPV and PDW were significantly associated with MMSE (β = 0.462; P < 0.001 for MPV; β = 0.245; P < 0.001 for PDW; respectively). In conclusion, MPV and PDW were decreased in MCI and AD patients. Further prospective research is warranted to determine the potential clinical application of MPV and PDW as biomarkers in the early diagnosis of AD.
    No preview · Article · Feb 2013 · Journal of Psychiatric Research