S. Topcu

Cumhuriyet University, Sivas, Sivas, Turkey

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Publications (5)1.13 Total impact

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    ABSTRACT: In this study the effect of hypoxia on thrombocytes was investigated in patients with a chronic obstructive pulmonary disease (COPD). 15 Hypoxic (group 1), 15 nonhypoxic (group 2) patients with COPD and 10 healthy persons (group 3) were included in the study. The differences in haemoglobin, hematocrit and PaCO2 values of group 1 and group 2 were insignificant, but there was a significant difference between group 3 and the other two groups. The differences in blood pH values in the above groups were insignificant, but the differences in FEV1, FVC and PaO2 values were significant. We found that thrombocyte aggregation increased significantly in group 1 and group 2. Also the platelet count decreased and mean platelet volume increased significantly in group 1. As a result, we think that in hypoxic patients with COPD, thrombocyte count decreases, volume and aggregation formation increases and oxygen plus antiaggregation therapy may have positive effects on the survival and life quality of these patients.
    No preview · Article · Jan 1997 · Materia medica Polona. Polish journal of medicine and pharmacy
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    ABSTRACT: From March 1992 to July 1992, 30 uremic patients (15 dialysed, 15 non-dialysed) and 15 non-uremic patients who had dyspeptic complaints were compared in terms of gastric and duodenal diseases. Gastritis and duodenitis graded as I, II and III were not found different in three groups (p > 0.05). Although the incidence of peptic ulcer disease is very high in both groups of uremic patients in comparison with the controls, there was no significant difference between two uremic groups (p > 0.05). Also the prevalence of gastritis determined histologically was not different in dialysed and non-dialysed uremic patients (p > 0.05). The incidence of the histologically proven gastritis was found higher in uremic patients than in non-uremic patients (p < 0.05). But, there were no significant differences among the three groups with regard to the rate of histologically proved duodenitis (p > 0.05). Gastrin levels, urea positivity, the incidence of gastritis and duodenitis and peptic ulcers did not differ in both uremic groups. However, these values were found significantly high in the uremic patients when compared to non-uremics. These findings showed serum gastrin levels, H.-pylori-infection, gastritis and duodenal disease in the uremic patients to be higher than those of the control group. Moreover, no effect of hemodialysis treatment on these results was observed.
    No preview · Article · May 1996 · Clinical nephrology
  • F. Candan · S. Topcu · L. Hocaoglu
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    ABSTRACT: It has been reported that thyroid function tests change during calorie-restricted diet treatment. However, the results are often conflicting. The present study was carried out to evaluate the effect of dexfenfluramine on thyroid function in 40 obese women. Patients were divided into two groups: the first group (group 1) (n = 20) received dexfenfluramine 15 mg twice a day plus calorie-restricted diet and the second group (group 2) (n = 20) had only calorie-restricted diet. Both groups were similar in respect to age. The study period lasted three months. Mean basal levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) revealed no significant differences between the two groups (p > 0.05). Patients receiving dexfenfluramine had low FT3 levels when compared with group 2 (p < 0.01). Thyroid hormone levels showed no significant changes in group 2 (p > 0.05). However, the levels of FT3 were decreased significantly in group 1 (p < 0.05). In conclusion, our study suggested that dexfenfluramine with its anorexigenic feature and other unknown effects causes reduction in FT3 levels in obese patients.
    No preview · Article · Jan 1995
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    ABSTRACT: We planned to investigate the natriuretic and diuretic effects of nitrendipine which is an agent frequently used in the treatment of hypertension. Twenty healthy men aged between 23 to 36 (mean age: 29.65±0.87) were examined. The study was done in three study periods intervals. In each period, the first day no treatment, the second day placebo, and the third day 10 mg or 20 mg of nitrendipine or a placebo was given. A double-blind controlled study was performed. In the first 6-hour period, after 10 or 20 mg nitrendipine administration, the increase in glomerular filtration rate (GFR) and sodium (Na+) excretion was significant (p<0.01), but the increase in potassium (K+) excretion was not significant (p>0.05). In the next 18-hour period after the initial 6 hours, we observed that nitrendipine did not significantly affect the excretion of K+ nor the GFR (p>0.05), but did significantly increase the excretion of Na+ (p<0.05). As a result, we may conclude that single-dose, oral administration of nitrendipine has natriuretic and diuretic effects without significantly affecting GFR and K+ excretion.
    No preview · Article · Jan 1994
  • N. Demirtas · Z. Seyfikli · S. Topcu

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