[Show abstract][Hide abstract]ABSTRACT: The aim of this study was to determine type 2 diabetes, impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) prevalence in Sivas, Turkey.
This cross-sectional study was conducted in the city center of Sivas. The study population of 771 subjects was selected by the cluster sampling method from 115,998 individuals aged > or =30 years. Participants with fasting venous plasma glucose concentrations <100 mg/dl were classified as "normal." Diabetes was diagnosed in participants if they had fasting blood glucose levels > or =126 mg/dl. An oral glucose tolerance test (OGTT) was performed in subjects with fasting blood glucose levels > or =100 mg/dl and <126 mg/dl.
According to the fasting blood glucose levels of the 771 subjects, 44 (5.7%) had diabetes. OGTTs were performed in 80 (10.4%) subjects. According to OGTT results, there were 5 subjects with diabetes, 20 subjects with IGT (2.6%), and 55 subjects with IFG (7.1%). The combined prevalence of IFG and IGT was 9.7%. After OGTT, the total number of diabetic subjects was determined to be 49 (6.4%). Twenty-four (3.1%) of the subjects had a previous diagnosis of diabetes. Multivariate analyses showed that age, sex, hypertension, cigarette smoking, obesity, and family history of diabetes were risk factors for type 2 diabetes (P < 0.05).
Diabetes incidence increases with changes in dietary habits and lifestyle. Education is particularly important for public health, as the community may then have required knowledge about the disease and its risk factors.
[Show abstract][Hide abstract]ABSTRACT: The aim of the present study was to evaluate whether there is a relationship between bone mineral density (BMD) and insulin resistance and hyperinsulinemia in women with polycystic ovary syndrome (PCOS). The study consisted of 28 amenorrheic women with PCOS and 11 amenorrheic women without PCOS. Fifteen healthy women with normal ovulatory function, matched for age and body mass index (BMI), served as controls. BMD was measured at the lumbar spine and left femoral neck with dual-energy X-ray absorptiometry. Blood samples were obtained to measure serum levels of insulin, follicle-stimulating hormone, luteinizing hormone, sex hormone-binding globulin (SHBG), total and free testosterone, androstenedione and estradiol by radioimmunassay. Insulin resistance was estimated by the in sulin tolerance test (ITT), and K(ITT) was taken as the insulin sensitivity index. In the PCOS group, K(ITT) was significantly lower and insulin levels were higher than in either of the control groups (P < 0.001). BMD in the PCOS group was lower than in the healthy group and higher than in the amenorrheic control group (P < 0.05). In the PCOS group, there were positive correlations of BMD of the lumbar spine with insulin (r = 0.42: P < 0.05) and negative correlations of BMD with K(ITT) (r = -0.58; P < 0.001) and SHBG (r = -0.38; P < 0.05). The inverse association of BMD and K(ITT) was independent of BMI, insulin, SHBG, androstenedione, and free testosterone. In conclusion, insulin resistance and hyperinsulinemia in women with PCOS may be a relative protective factor against bone mineral loss.
No preview · Article · Feb 2001 · Journal of Bone and Mineral Metabolism
[Show abstract][Hide abstract]ABSTRACT: In this study the effect of hypoxia on thrombocytes was investigated in patients with a chronic obstructive pulmonary disease (COPD). 15 Hypoxic (group 1), 15 nonhypoxic (group 2) patients with COPD and 10 healthy persons (group 3) were included in the study. The differences in haemoglobin, hematocrit and PaCO2 values of group 1 and group 2 were insignificant, but there was a significant difference between group 3 and the other two groups. The differences in blood pH values in the above groups were insignificant, but the differences in FEV1, FVC and PaO2 values were significant. We found that thrombocyte aggregation increased significantly in group 1 and group 2. Also the platelet count decreased and mean platelet volume increased significantly in group 1. As a result, we think that in hypoxic patients with COPD, thrombocyte count decreases, volume and aggregation formation increases and oxygen plus antiaggregation therapy may have positive effects on the survival and life quality of these patients.
No preview · Article · Jan 1997 · Materia medica Polona. Polish journal of medicine and pharmacy
[Show abstract][Hide abstract]ABSTRACT: From March 1992 to July 1992, 30 uremic patients (15 dialysed, 15 non-dialysed) and 15 non-uremic patients who had dyspeptic complaints were compared in terms of gastric and duodenal diseases. Gastritis and duodenitis graded as I, II and III were not found different in three groups (p > 0.05). Although the incidence of peptic ulcer disease is very high in both groups of uremic patients in comparison with the controls, there was no significant difference between two uremic groups (p > 0.05). Also the prevalence of gastritis determined histologically was not different in dialysed and non-dialysed uremic patients (p > 0.05). The incidence of the histologically proven gastritis was found higher in uremic patients than in non-uremic patients (p < 0.05). But, there were no significant differences among the three groups with regard to the rate of histologically proved duodenitis (p > 0.05). Gastrin levels, urea positivity, the incidence of gastritis and duodenitis and peptic ulcers did not differ in both uremic groups. However, these values were found significantly high in the uremic patients when compared to non-uremics. These findings showed serum gastrin levels, H.-pylori-infection, gastritis and duodenal disease in the uremic patients to be higher than those of the control group. Moreover, no effect of hemodialysis treatment on these results was observed.
No preview · Article · May 1996 · Clinical nephrology
[Show abstract][Hide abstract]ABSTRACT: It has been reported that thyroid function tests change during calorie-restricted diet treatment. However, the results are often conflicting. The present study was carried out to evaluate the effect of dexfenfluramine on thyroid function in 40 obese women. Patients were divided into two groups: the first group (group 1) (n = 20) received dexfenfluramine 15 mg twice a day plus calorie-restricted diet and the second group (group 2) (n = 20) had only calorie-restricted diet. Both groups were similar in respect to age. The study period lasted three months. Mean basal levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) revealed no significant differences between the two groups (p > 0.05). Patients receiving dexfenfluramine had low FT3 levels when compared with group 2 (p < 0.01). Thyroid hormone levels showed no significant changes in group 2 (p > 0.05). However, the levels of FT3 were decreased significantly in group 1 (p < 0.05). In conclusion, our study suggested that dexfenfluramine with its anorexigenic feature and other unknown effects causes reduction in FT3 levels in obese patients.
[Show abstract][Hide abstract]ABSTRACT: The effects of nitrendipine (dihydropyridine) and verapamil (phenalalkylamin), which are structurally dissimilar in the calcium channel blockers, on rat model gentamicin-induced nephrotoxicity were investigated. Both drugs showed no beneficial effects on gentamicin nephrotoxicity according to biochemical parameters, and caused no changes on renal histopathology. These results indicated that calcium channel blockage with nitrendipine or verapamil has no protective effect on aminoglycoside nephrotoxicity.
[Show abstract][Hide abstract]ABSTRACT: We planned to investigate the natriuretic and diuretic effects of nitrendipine which is an agent frequently used in the treatment of hypertension. Twenty healthy men aged between 23 to 36 (mean age: 29.65±0.87) were examined. The study was done in three study periods intervals. In each period, the first day no treatment, the second day placebo, and the third day 10 mg or 20 mg of nitrendipine or a placebo was given. A double-blind controlled study was performed. In the first 6-hour period, after 10 or 20 mg nitrendipine administration, the increase in glomerular filtration rate (GFR) and sodium (Na+) excretion was significant (p<0.01), but the increase in potassium (K+) excretion was not significant (p>0.05). In the next 18-hour period after the initial 6 hours, we observed that nitrendipine did not significantly affect the excretion of K+ nor the GFR (p>0.05), but did significantly increase the excretion of Na+ (p<0.05). As a result, we may conclude that single-dose, oral administration of nitrendipine has natriuretic and diuretic effects without significantly affecting GFR and K+ excretion.
[Show abstract][Hide abstract]ABSTRACT: SUMMARY Lots of factors like hyperlipidemia, hypertension, platelet and coagulation disorders are responsible for the development of the atherosclerosis event in diabetes. In this study we investigated the effect of fluvastatin given for 2 months; on lipid levels, fibrinogen and platelet aggregation. In this study a total of 20 patients received 40 mg/day fluvastatin. The values at the initial and at 2 months after treatment for lipid levels, fibrinogen and platelet aggregation were investigated. While there were significant decreases in triglyceride, total cholesterol, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) measurements, no significant changes in high-density lipoprotein (HDL) and fibrinogen were observed in the fluvastatin receiving patients. We found that platelet aggregation decreased with fluvastatin treatment.