Hannah Mahan

Iowa State University, Ames, Iowa, United States

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Publications (2)0 Total impact

  • Di Wu · Stephen Smith · Hannah Mahan · Robert L Jernigan
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    ABSTRACT: Flexibility and dynamics of protein structures are reflected in the B-factors and order parameters obtained experimentally with X-ray crystallography and Nuclear Magnetic Resonance (NMR). Methods such as Normal Mode Analysis (NMA) and Elastic Network Models (ENM) can be used to predict the fluctuations of protein structures for either atomic level or coarse-grained structures. Here, we introduce the Local-Distance Matrix Error (DME), an efficient and simple analytic method to study the fluctuations of protein structures, especially for the ensembles of NMR-determined protein structures. Comparisons with the fluctuations obtained by experiments and other by computations show strong correlations.
    No preview · Article · Jan 2011 · International Journal of Bioinformatics Research and Applications
  • Di Wu · Stephen Smith · Hannah Mahan · Robert L. Jernigan · Zhijun Wu
    [Show abstract] [Hide abstract]
    ABSTRACT: Flexibility and dynamics of protein structures are reflected in the B-factors and order parameters obtained experimentally with X-ray crystallography and Nuclear Magnetic Resonance (NMR). Methods such as Normal Mode Analysis (NMA) and Elastic Network Models (ENM) can be used to predict the fluctuations of protein structures for either atomic level or coarse-grained structures. Here, we introduce the Local-Distance Matrix Error (DME), an efficient and simple analytic method to study the fluctuations of protein structures, especially for the ensembles of NMR-determined protein structures. Comparisons with the fluctuations obtained by experiments and other by computations show strong correlations.
    No preview · Article · Jan 2011 · International Journal of Bioinformatics Research and Applications