A. Melhouf

Université Sidi Mohamed Ben Abdellah, Fezna, Meknès-Tafilalet, Morocco

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Publications (10)2.36 Total impact

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    Preview · Article · Apr 2013 · Pan African Medical Journal
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    Full-text · Article · Jan 2013 · Pan African Medical Journal
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    ABSTRACT: It is known that most cases of Ovarian Hyperstimulation Syndrome (OHSS) are associated with the therapies for ovulation induction. However, OHSS may rarely be associated with a spontaneous ovulatory cycle, usually in the case of multiple gestations, hypothyroidism or polycystic ovary syndrome. We report a case of severe OHSS in spontaneous pregnancy with invasive mole in a 34 years old woman. The clinical picture showed abdominal pain, massive ascites, nausea, dyspnea and amenorrhea. After imaging examinations and laboratory tests, the diagnosis was established. The patient was managed expectantly with no complications. Although spontaneous ovarian hyperstimulation is a rare entity, it is important that the physician recognizes this condition. Prompt diagnosis and successful management is likely to avoid serious complications, which may develop rapidly.
    Preview · Article · Oct 2011 · Pan African Medical Journal
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    ABSTRACT: Malignant ovarian germ cell tumours (MOGCTs) are rare but curable at all stages of the disease. We report the case of a 25-year-old patient who consulted for pelvic pain in her 4th day of post-partum. The gynaecological examination revealed a firm mass independent of the uterus. A pelvic ultrasound and abdomino-pelvic tomography revealed a heterogeneous mass probably linked to the ovary, with ascetic fluid. A laparotomy was indicated. It showed an ovarian tumour localized in the left ovary with ascetic fluid. The patient underwent a left salpingo-oophorectomy with biopsies of the right ovary, peritoneum and the omentum. The histological study showed a dysgerminoma and yolk sac tumor. The level of human chorionic gonadotropin and fetoprotein was normal. Sixmonthly abdomino-pelvic tomography and marker measurements revealed no abnormalities. The patient did not experience any recurrence. MOGCTs are rare neoplasms that affect girls and young women and have good prognosis at all stages of disease with optimal therapy and the majority of MOGCT patients retain their reproductive function.
    No preview · Article · Dec 2009 · Oncologie

  • No preview · Article · Dec 2009 · La Revue de Médecine Interne
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    ABSTRACT: Post-partum pituitary necrosis (Sheehan's syndrome) is a rare complication of post-partum hemorrhage. The diagnosis can be erratic and often delayed. In this case report of Sheehan's syndrome in the post-partum period, the signs were characterized by agalactia, severe hypoglycemia, and low serum levels of thyroid hormones, cortico-adrenal hormones, and gonadotrophin (FSH, LH). The hypophyseal magnetic resonance imaging confirmed the diagnosis of hypopituitarism secondary to pituitary necrosis.
    Preview · Article · Jun 2009 · Libyan Journal of Medicine
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    ABSTRACT: Le lymphome malin non hodgkinien primitif de l’ovaire chez l’enfant est une entité rare. Nous rapportons l’observation d’une fillette de 13 ans, qui a consulté pour une tumeur abdominopelvienne. L’exploration radiologique était en faveur d’une tumeur ovarienne. Le diagnostic différentiel fut posé avec les tumeurs germinales, mais les marqueurs biologiques étaient normaux. Devant la suspicion des tumeurs malignes solides, la laparotomie a été indiquée et a pu mettre en évidence une tumeur ovarienne unilatérale. La patiente a bénéficié d’une annexectomie. L’étude histologique a révélé un lymphoma malin primitif non hodgkinien de l’ovaire. Le bilan d’extension fut normal et la patiente a recçu une chimiothérapie adjuvante. Nous soulignerons la difficulté du diagnostic préopératoire, les caractéristiques thérapeutiques et pronostiques de cette entité. The malign, primitive and non-Hodgkin’s lymphoma of the ovary in young child is a rare entity. Therefore, we report the observation of a 13-years-old girl who consulted for an abdominopelvic tumour. The radiological exploration suggested an ovarian tumor. The differential diagnosis was put with the germinal tumors but the biological markers were normal. The laparotomy was indicated and highlighted an unilateral ovarian tumor, and the patient benefited of an annexectomy. The histological study revealed a primary malignant and non-Hodgkin’s lymphoma of the ovary. The assessment of extension was normal and the patient received adjuvant chemotherapy. In this case report, we are underlining the difficulty of the preoperative diagnosis, the therapeutic and the prognosis of this rare entity.
    No preview · Article · Apr 2009 · Oncologie
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    ABSTRACT: Les auteurs rapportent deux observations d’un syndrome de Demons-Meigs survenant chez deux femmes colligées au service de gynécologie et d’obstétrique, CHU Hassan-II, Fès. II s’agit d’une ascite, d’une pleurésie et d’une tumeur ovarienne bénigne fibrothécome. L’évolution est favorable après l’ablation de la tumeur. Les auteurs soulignent les caractéristiques cliniques, thérapeutiques, évolutives et pronostiques de ce syndrome. The authors report a case of Demons-Meigs syndrome associated in two women. This syndrome associates ascitic effusion, pleural effusion and benign ovarian fibrothecoma. The evolution is favourable after total excision of the tumor. The authors underline the clinical, therapeutic and pronosis features of the syndrome.
    No preview · Article · Jul 2007 · Oncologie
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    ABSTRACT: Les auteurs rapportent l’observation d’une patiente de 30 ans présentant une tumeur de la granulosa juvénile de l’ovaire. Le tableau clinique associe une ascite à une masse pelvienne. La tumeur était strictement localisée à l’ovaire. Un traitement chirurgical conservateur a été jugé suffisant pour enlever la totalité du tissu tumoral. Une ’etude histologique erronée a montré un aspect en faveur d’un fibrothé come ovarien. Au cours de la surveillance, la patiente a présenté une ascite de grande abondance nécessitant une reprise de la laparotomie avec découverte d’une carcinose péritoné ale et réalisation de multiples biopsies péritonéales. Les résultats anatomopathologiques étaient en faveur d’une tumeur de la granulosa juvénile de l’ovaire (TGJO). Une chimiothérapie est faite et la patiente est décédée quatre mois plus tard. À travers cette observation et une revue de la littérature, nous allons insister sur la difficulté du diagnostic histologique de ces tumeurs. The authors describe a juvenile granulosa cell tumour occurring in a 30-year-old woman. Clinically, the presence of ascites was associated with a pelvic mass. The tumour was localized strictly to the ovary, so conservative surgery was performed, proving sufficient to remove all the tumour tissue. Erroneous histological results revealed microscopic signs of an ovarian fibrothecoma. The patient, who presented with ascites, underwent laparotomy and excision was found to be impossible. A second histological examination showed microscopic signs of an ovarian juvenile granulosa cell tumour. Adjuvant chemotherapy was administered. After four months of treatment, however, the patient died. The purpose of this study is to assess the difficulty in using histological examinations to evaluate these tumours.
    No preview · Article · May 2007 · Oncologie
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    ABSTRACT: Purpose: Cavernous haemangiomas of the uterine cer-vix are very rare and usually harmless. It is a benign tumor that may cause gynecological obstetrical com-plications. Although it is a benign condition but it can have serious consequences for the mother as well as for the baby. The treatment is often surgical and dia-gnosis is histological. Methods and Result: we repor-ted a case of cavernous haemangioma of the cervix in a 25-year old multiparous patient, referred to our Centre in the 33 -34 gestational weeks for premature labor with membranes rupture. A 3 cm × 6 cm soft regular purplish red mass is found in the uterine cer-vix. Tocolosys, prophylactic antibiotic therapy and corticotherapy for fetus pulmonary maturation were then decided after elimination of chorioamniotite si-gns. Caesarean has been made during labor, a week later, for tumor previa. The tumor excision has been made through the vagina after fetus extraction. The histological examination confirmed diagnosis of the cavernous haemangioma. Discussion: Further to this observation, the clinical, histological and therapeutic characteristics of the cavernous haemangioma unu-sual presentation were drawn up and literature enri-ched since this pathology is rare. Most previous repor-ts in the literature consist of single-case histories, and the experience of individual institutions is limited. The patients dramatically present dilemmas in the disease management. This can result in uncontrolled bleeding especially during operative delivery and may require hysterectomy. To avoid unexpected bleeding from hae-mangioma, patients should be repeatedly examined for haemangioma of the birth canal, and special care shou-ld be taken in choosing the delivery mode.
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