Yegang Chen

Tianjin Medical University, T’ien-ching-shih, Tianjin Shi, China

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Publications (2)2.85 Total impact

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    ABSTRACT: Objective: To investigate the relationship between the expression of tumor suppressor in lung cancer-1 (TSLC1) and clinicopathological characteristics of patients with non-muscle-invasive bladder cancer (NMIBC) and evaluate the prognostic significance of TSLC1. Methods: TSLC1 expression in 241 specimens of NMIBC was examined by immunohistochemistry. The correlation between TSLC1 expression and clinicopathological characteristics was evaluated using the chi-square test. The prognostic significance of TSLC1 was analyzed by univariate, multivariate analysis and Kaplan-Meier survival curves. Results: The total negative rate of TSLC1 expression was 47.3% in NMIBC. Decreased expression of TSLC1 was correlated with a higher clinical stage, higher pathological grade, the number of tumors, lager tumor size, tumor recurrence and progression. TSLC1 expression was an independent risk factor for predicting tumor recurrence (p = 0.005) and progression (p Conclusion: Decreased expression of TSLC1 is correlated with the malignancy of NMIBC tissues and low TSLC1 expression may serve as a predictor for bladder cancer recurrence and progression.
    No preview · Article · Aug 2015 · Urologia Internationalis
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    ABSTRACT: To investigate the clinical significance of T-cadherin (T-cad) tissue expression in patients with bladder transitional cell carcinoma (TCC). T-cad expression in 113 bladder TCC specimens and 37 normal controls were examined by immunohistochemical staining, and the results were correlated with clinicopathologic parameters. The χ(2) test, Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazard model were used for statistical analysis. T-cad expression in bladder TCC samples was lower than in the controls. Decreased T-cad expression was correlated with advanced stage (p = 0.0027), high grade (p = 0.0078), large tumor size (p = 0.0262), and tumor relapse (p = 0.0293), but no association was found among T-cad expression and age (p = 0.1265), gender (p = 0.4236), tumor number (p = 0.0595) or tumor shape (p = 0.1779). Moreover, decreased T-cad expression was significantly associated with poor overall survival (p = 0.0168), even though it is not an independent prognostic marker (p = 0.2005). Decreased T-cad expression in tumor tissues is closely associated with malignancy in bladder TCC.
    No preview · Article · Apr 2011 · Urologia Internationalis

Publication Stats

7 Citations
2.85 Total Impact Points

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  • 2011
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China