Ya-Li Zhang

Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Shi, China

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Publications (7)4.3 Total impact

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    ABSTRACT: Objective: Complementary and alternative medicine, particularly herbal therapy, is widely used by patients with ulcerative colitis (UC), but controlled data are limited. To describe the clinical presentation and treatment strategies for UC in inpatients from Shanghai, China and to improve the therapeutic outcomes for patients with UC. Methods: Medical records from 247 patients with UC who were admitted to Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between January 2008 and June 2013 were analyzed for gender, age, course of the disease, clinical type, extent and severity of the disease, treatment strategies, and therapeutic outcomes. Results: Gender ratios and disease onset of inpatients with UC in the Shanghai area were consistent with other reports in the literature. In contrast to previous studies, most patients exhibited disease of the left colon, over half of the patients had problems of the rectum or sigmoid colon, and most patients had either mild or moderate UC. Comparison of Sutherland Disease Actirity Index scores for patients treated with Chinese medicine (CM) and those treated with integrated CM and Western medicine revealed significant reductions in scores for both groups after treatment (P <0.01), with no significant difference in therapeutic effects between groups (P =0.938). Conclusions: Herbal medicine has been widely used in patients with mild to moderate disease and as adjunct therapy in patients with moderate to severe disease. Therefore, the strategy was proposed for the treatment of UC with CM therapy based on 2 steps according to the stage of the disease, even in the clinical setting.
    No preview · Article · Oct 2015 · Chinese Journal of Integrative Medicine
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    ABSTRACT: Objective: To explore the relationship between ulcerative colitis (UC) and lung injuries by assessing their clinical manifestations and characteristics. Methods: From July 2009 to April 2012, 91 UC patients presenting to Longhua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study. According to the scores of disease activity index, the patients were divided into the mild, moderate, and severe groups. Meanwhile, the records of pulmonary symptoms, chest X-ray image, and pulmonary function were reviewed. Results: Sixty-eight (74.7%) patients had at least 1 pulmonary symptom, such as cough (38.5%), shortness of breath (27.5%), and expectoration (17.6%). And 77 (84.6%) had at least 1 ventilation abnormality. Vital capacity value was significantly lower in the severe group than that in the mild group (91.82%±10.38% vs. 98.92%±12.12%, P<0.05). Conclusions: Lung injury is a common extraintestinal complication of UC. According to the theory in Traditional Chinese Medicine that the lung and large intestine are related, both the lungs and large intestine should be treated simultaneously.
    No preview · Article · Jul 2015 · Chinese Medical Sciences Journal
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    Yan-Cheng Dai · Zhi-Peng Tang · Ya-Li Zhang
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    ABSTRACT: Atrophic gastritis, is the main consequence of long-standing Helicobacter pylori infection, and is linked to the development of gastric cancer. The severity of atrophic gastritis is related to the lifetime risk of gastric cancer development, especially in terms of its degree and extent of mucosal damage. Therefore, it is important for clinicians to assess the severity of atrophic gastritis, interfere with the disease progress, and reverse gastric mucosal atrophy. In the article, we demonstrated some methods (conventional endoscopy, modern endoscopic technology and noninvasive methods) that may help assess the severity of atrophic gastritis and select the reasonable treatment protocols.
    Preview · Article · Apr 2011 · World Journal of Gastroenterology
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    ABSTRACT: To observe the influence of Shenqing Recipe (SQR), a kind of Traditional Chinese Medicine, on the morphology and quantity of colonic interstitial cells of Cajal (ICC) in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis, and to investigate the possible mechanism of SQR in regulating intestinal dynamics. Sixty rats were randomly divided into normal control, model 1, model 2, mesalazine, and high-dose, and low-dose SQR groups with 10 rats in each group. TNBS (10 mg) dissolved in 50% ethanol was instilled into the lumen of the rat colon of the latter five groups to induce colitis. On the 4th day after administration of TNBS, each treatment group was administered one of the following formulations by enteroclysis gavage once a day for 7 days: 600 mg•kg⁻¹•d⁻¹ mesalazine, 2.4 g•kg⁻¹•d⁻¹ SQR, and 1.2 g•kg⁻¹•d⁻¹ SQR. Model 2 rats received normal saline solution. After 7 days colonic samples were collected. While the colonic samples of model 1 group were collected on the 3rd day after TNBS administered. Ultrastructure of ICC in the damaged colonic tissues was observed with transmission electron microscope. Expression of c-kit protein in colonic tissue was determined by immunohistochemical staining and Western blot. The ultrastructure of colonic ICC in the rat model of TNBS-induced colitis showed a severe injury, and administration of SQR or mesalazine reduced the severity of injury. Similarly, the expression of c-kit protein of TNBS-induced colitis rat model was significantly decreased compared with the normal control group (P < 0.05). Treatment with SQR or mesalazine significantly increased the expression of c-kit protein compared with the administration of control formulations (P < 0.05), especially the high-dose SQR group. SQR could alleviate and repair the injured ICC, and improve its quantity, which might be involved in regulating intestinal motility.
    No preview · Article · Mar 2011 · Chinese Medical Sciences Journal

  • No preview · Article · Sep 2010 · Journal of Traditional Chinese Medicine

  • No preview · Article · Dec 2009 · Chinese Medical Sciences Journal
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    Ya-Li Zhang · Zhi-Peng Tang
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    ABSTRACT: Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an adhesion molecule that is preferentially expressed on the surface of vas- cular endothelial cells in intestinal tract and associated lymphoid tissues, and it is a major determinant of lymphocyte trafficking to the gut mucosa. The expression of MAdCAM-1 is dramatically increased in the inflammatory sites of ulcerative colitis (UC). This article reviews the molecular structure, distribution, biologi- cal function of MAdCAM-1 and its role in the pathogenesis of UC. It is also emphasized that MAdCAM-1 is a potential therapeutic target in UC.
    Preview · Article · Apr 2007 · World Chinese Journal of Digestology