[Show abstract][Hide abstract] ABSTRACT: Posterior capsule opacification (PCO) compromises vision development in infants after cataract surgery and lead to amblyopia. To observe the effects of curcumin on PCO in infant rabbits, curcumin was injected under the capaule and into the anterior chamber during phacoemulsification.
Seventy-five 1-month-old healthy New Zealand white rabbits were randomized into 3 groups, one eye of each rabbit was randomly selected to be operated. The operation involved continuous circular capsulorhexis, followed by hydrodissection with 0.6 ml each of balanced salt solution (BSS, group A), hydroxypropyl-β-dodextrin (HP-β-CD, 90 µg/ml, group B) or CUR-HP-β-CD (123 µg/ml, group C), respectively. After phacoemulsification, 0.4 ml of each drug solution was injected into the anterior chamber via an incision. The extent of corneal edema and the inflammatory response within the anterior chamber were considered as measures PCO and observed postoperatively. All eyes were examined 1 and 2 months postoperative by slit lamp microscopy and photography after pupil dilation. On the third day postoperative, 6 rabbits from each group were executed. Paraffin-embedded sections were stained with hematoxylin-eosin (HE) or terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL, indicative of apoptosis). Stained sections were observed under light microscopy. Proliferation of lens epithelial cells (LECs) was observed microscopically on day 3, day 7, month 1 and month 2 after the operation with HE staining.
The remission of cornea edema occurred earlier in group C than in groups A and B (P < 0.05); there were no significant differences between groups A and B. The remission of anterior chamber exudation in group C was earlier than those in groups A and B (P < 0.05). No significant difference in the times when PCO occurred, was observed among groups. Compared to groups A and B, the extent of PCO was less severe (P < 0.05). Three days after the operation, LECs aggregated at the orbit. Meanwhile, minor apoptosis was observed in all groups. One month after the operation transparent, cortex and proliferating LECs were observed near the orbit in groups A and B. Two months postoperative, heavy cortex proliferation was observed in all groups: epithelial cells migrated and aggregated at the posterior capsule and rearranged under the anterior capsule in the control group. Proliferation was also observed in group C, but to a less severe extent than in the other two groups.
CUR-HP-β-CD exerts an inhibitory effect on PCO.
No preview · Article · Nov 2011 · Chinese medical journal
[Show abstract][Hide abstract] ABSTRACT: To evaluate the visual quality in patients implanted with aspheric diffractive multifocal intraocular lens.
Prospective nonrandomized controlled study. One hundred cataract eyes in 50 patients were included. Patients received AcrySof IQ ReSTOR IOL (SN6AD3) or AcrySof IQ IOL (SN60WF) implantation. The follow up period was 6 months. The mean of uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA), uncorrected near visual acuity (UCNVA), best distance-corrected near visual acuity (BCNVA) and intermediate uncorrected visual acuity in patients with SN6AD3 and SN60WF was compared preoperatively and postoperatively in all patients. Photopic and mesopic contrast sensitivity function with and without glare were tested at 6 months after operation. Aberrations were recorded postoperatively. Subjective outcomes were assessed by VF-14 questionnaire. The chi-square test was applied to compare categorical variables and the paired-samples t test was used to compare the measure data.
Postoperatively, there were no significant differences between groups in spherical equivalent (SE) (t = 0.233, P = 0.876), UCDVA (t = 1.018, P = 0.265) or BCNVA (t = 0.679, P = 0.501). The BCDVA in the monofocal IOL group was better than that in the multifocal IOL group (t = 2.388, P = 0.021). UCNVA improved remarkably after the implantation of multifocal IOL (t = 11.311, P = 0.000). The intermediate UCVA in the monofocal IOL eyes was butter than that in the multifocal IOL at 60 cm (t = 2.414, P = 0.020). The total aberration (F = 5.169, P = 0.041), total low grade (F = 4.973, P = 0.036) and total high grade total aberrations (F = 4.640, P = 0.048) were higher in the multifocal IOL group. There was no difference between these two groups in the defocus (F = 0.862, P = 0.358), astigmatism (F = 3.893, P = 0.052), spherical aberration (F = 1.743, P = 0.055), coma (F = 2.724, P = 0.105) and trefoil (F = 3.014, P = 0.109). Contrast sensitivity in eyes with multifocal IOL was lower than that in eyes with monofocal IOL, especially under mesopic conditions without glare at 6 c/d (t = 2.16, P = 0.041) at 3 c/d (t = 2.329, P = 0.029) and 6 c/d under mesopic conditions with glare (t = 2.087, P = 0.048). Most patients were satisfied with their IOL implantation. Percentage of patients wearing spectacle for distance vision were less than 4% in all groups. Percentage in patients wearing spectacle for near vision in SN60WF and SN6AD3 groups was 60% and 16%, respectively. Percentage of overall spectacle wear was 64% and 24% in patients wearing SN60WF and SN6AD3, respectively. On the questionnaire, patients in multifocal IOL group complained with double vision, trouble in night vision and halo; while patients in monofocal IOL group noted more about near blur.
Compared with monofocal lenses, multifocal IOL provide greater depth of focus so that better near vision, higher percentage of spectacle independence and satisfactory visual function, are obtained but the contrast sensitivity decreases slightly.
No preview · Article · Aug 2010 · [Zhonghua yan ke za zhi] Chinese journal of ophthalmology