Publications (3)12.01 Total impact
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ABSTRACT: Background: Otitis media with effusion is one of the leading causes of hearing loss in children. Effective treatment of effusion in the middle ear requires appropriate empirical treatment and characterization of responsible pathogens. Objective of the present study was to detect pathogens in clinical samples from patients with otitis media with effusion in our area and to determine the sensitivity profile of isolated organisms to commonly used antibiotics. Methods: Sixty three samples of middle ear effusion were aseptically obtained from 36 children, who had been treated up to at least two weeks before sampling. They were analyzed using standard bacteriological and multiplex polymerase chain reaction (PCR) assays. Antibiotic susceptibility tests were also performed. Results: PCR analysis showed that DNA of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were present in 60 (95.2%) of the samples. The culture-positive effusion for Streptococcus Pneumoniae, HaemophilusInfluenzae and Moraxella catarrhalis was 34.9%. Almost all isolates of Streptococcus pneumoniaee were sensitive to ciprofloxacin and erythromycin, and none of them was sensitive to co-trimoxazole. None of H. Influenzae isolates was sensitive to erythromycin, cefixim, co-trimoxazole, ampicillin and amoxicillin. None of M. Catarrhalis isolates was sensitive to ceftriaxone, co-trimoxazole, ampicillin and amoxicillin. Conclusion: Compared with other studies using PCR method, the number of H. influenza isolates was in higher in the present study (95.2%). Antibiotic sensitivity profiles of pathogens isolated in this study were different from others. Thus, we can determine empirical antibiotic therapy based on sensitivity profile in our geographic area.
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ABSTRACT: Objective: To describe the clinical and cytopathologic findings in 15 cases of salivary gland myoepithelial neoplasms and to assess the value of fine needle aspiration in the diagnosis of these tumors. Study Design: Between 2000 and 2007, 15 consecutive patients were diagnosed with benign and malignant myoepithelioma of the head and neck region. A literature review of PubMed using the search terms myoepithelioma, myoepithelial carcinoma and salivary gland was performed. Results: There were 8 men and 7 women. The age at presentation was 12-79 years (mean, 44.5). Parotid gland consisted of 73% of all primary sites. There were 10 benign and 5 malignant myoepitheliomas. In the benign group, only in 1 case did fine needle aspiration (FNA) revealed benign spindle cell variant, and in others, FNA diagnosis was mixed tumor. Similarly, in the malignant group, FNA diagnosis was malignant in only 1 case. The predominant cell morphology in the benign group was plasmacytoid cells, followed by a spindle and clear cell population. The cell morphology in the malignant lesions was epithelioid cell, clear cell and spindle cell. Scant fibrillary myxoid material was observed in both benign and malignant specimens. In the literature review and by analyzing the pooled data from 24 major reported series including 601 patients, the mean age at diagnosis was 51 years, and the mean male/female ratio was 1/.01. In addition, 39% of all tumors were malignant, and parotid gland consisted of 45% of all primary sites. Conclusion: According to the findings of the present study and review of the literature, the cytologic criteria for preoperative diagnosis of salivary gland myoepithelial neoplasms remain unsatisfactory and need to be clarified.
Shiraz University of Medical Sciences
Shīrāz, Fars, Iran
- Department of Otolaryngology