[Show abstract][Hide abstract] ABSTRACT: An 83-year-old man was admitted with renal dysfunction, anemia, and peripheral leukocytosis. His peripheral leukocyte count was 41000/µl. A computed tomography scan revealed a solid cystic mass in the liver, mural thickening in the ascending colon and nodules in the right lower lung field. Colonoscopy revealed ascending colon cancer, and analysis of the biopsy specimens revealed well-differentiated adenocarcinoma. However, although a liver abscess was suspected, pus and bacteria were not found in the cystic lesion of the liver mass, the solid lesion of the mass was diagnosed as carcinoma. The serum concentration of granulocyte colony-stimulating factor (G-CSF) was elevated to 256 pg/ml. Because his general condition worsened, we could not treat these tumors, but he died 38 days after admission. Autopsy revealed adenosquamous carcinoma of the liver, well-differentiated adenocarcinoma of the ascending colon, urothelial carcinoma of the urinary bladder, and metastatic squamous cell carcinoma of the lung. Immunohistochemical analysis revealed positive staining for G-CSF in the liver tumor sample.
No preview · Article · Feb 2011 · Nippon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology
[Show abstract][Hide abstract] ABSTRACT: A 35-year-old Japanese female was admitted for remarkable hepatic dysfunction. She had traveled abroad frequently and had a history of sexual partnership with multiple foreigners. Examinations revealed that she was infected with hepatitis B virus (HBV) of genotype E, a very rare genotype in Japan. Since her hepatitis was deteriorating after admission, we started administration of entecavir on 18th hospital day. It took about 6 months until HBsAg was replaced by anti-HBs, and HBV DNA decreased to undetectable level. Here we report this case in detail because HBV genotype E infection is rarely experienced in Japan.