[Show abstract][Hide abstract] ABSTRACT: Calcium (Ca) plays an important role in the pathogenesis of ischemic cell damage. Intracellular Ca accumulation leads neuronal damage by triggering the cycle of cytotoxic events, however the relationship of serum Ca levels and the pathways involved in ischemic injury is unclear. To investigate the effect of serum Ca on clinical features of ischemic stroke; the association of serum Ca levels measured in the first 24 hours with the severity of clinical symptoms on admission and short-term prognosis is evaluated.
158 consecutive patients who admitted to the hospital with ischemic stroke in the first 24 hours after the onset of symptoms were enrolled to the study. Serum total Ca levels, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores on admission and mRS scores at discharge were recorded. Patients were classified according to serum total Ca levels into three groups and compared in terms of stroke risk factors, etiology, severity of clinical symptoms on admission and short term prognosis.
A total of 158 patients with acute ischemic stroke including 84 women and 74 men were enrolled in the study prospectively. NIHSS scores were higher in the groupl which consist of lower Ca levels compared with others (p < 0.05, p < 0.001 respectively), and they were found to be higher in group 2 than group 3 (p = 0.029). mRS scores at discharge showed no differences between groups. Except for coronary artery disease was more common in group 2, no statistically significant differences were determined in terms of stroke risk factors and etiology of stroke.
The results of our study reveal that lower Ca levels may be associated with more severe clinical symptoms on admission in acute stroke patients.
Preview · Article · Mar 2011 · Acta neurologica Belgica
[Show abstract][Hide abstract] ABSTRACT: Objectives: Inflammatory mechanisms play an important role in the pathogenesis of cerebral ischemia and in the risk of stroke. In several studies, elevated leukocyte count has been associated with cardiovascular and cerebrovascular events. The aim of this study is to investigate the relationship between the leukocyte and neutrophil counts and stroke severity, short term prognosis and stroke subtypes of the patients with acute ischemic stroke.Materials/Methods: Leukocyte and neutrophil counts were measured in 166 consecutive acute ischemic stroke patients in the first 24 hour of admission. Clinical findings, stroke risk factors and brain imagings were evaluated. According to their etiology, patients were classified by using the TOAST criteria. Stroke severity was assessed by the modified Rankin Scale(mRS) on admission and discharge, National Institutes of Health Stroke Scale (NIHSS) was used on admission.Results: While 51(%30.72) patients had leukocyte ≥10000/µl and 115(%69.28) patients had leukocyte <10000/ µl, 70(%42.17) patients had neutrophil ≥6100/µl and 96(%57.83) patients had neutrophil<6100/µl. leukocyte and neutrophil counts were significantly higher in severe stroke (p<0.001) hence short term prognosis was significantly poor in these patients. (p<0.001) We found a strong correlation between large vessel disease and high leukocyte count (p<0.05) and also between small vessel disease and normal leukocyte count. (p<0.05) Results were similar for neutrophil levels of patients according to stroke subtypes.Conclusıon: According to our study; high leukocyte and neutrophil levels on admission correlate with large vessel disease and therefore could be a predictor of stroke severity and unfavourable outcome.
Preview · Article · Jan 2010 · Journal of Neurological Sciences