Renata Cristinny de Farias Campina

Federal University of Pernambuco, Arrecife, Pernambuco, Brazil

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Publications (3)4.85 Total impact

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    ABSTRACT: During the early periods of development, i.e., gestation and lactation, the influences of stimulus such as undernutrition can lead to several behavioural and morphofunctional damages to organs and systems in general, including pathways and structures that control energy balance and feeding behaviour. Although a large body of evidences have shown the effects of this stimulus on structures such as hypothalamus, only few studies have directed their attention to the long-term effects of undernutrition on the nucleus of the solitary tract (NTS). The aim of this study was to investigate the effects of early undernutrition on the NTS and control of food intake in adulthood. Male Wistar rats were divided into two groups according to the diet offered to the dams during gestation and lactation: control group (C, diet containing 17% casein) or isocaloric low-protein group (LP, diet containing 8% casein). On 35 or 180 days, we evaluated the rats’ body weight, food intake, behavioural satiety sequence and c-Fos protein expression in the NTS in response to food stimulus. Based on these assessments, it was found that perinatal undernutrition promoted an increase in food intake and the number of activated cells in rostral and, mainly, medial NTS in response to food stimulation in adulthood. These results indicated that the NTS is a structure particularly vulnerable to the influences of nutritional manipulation in the early stages of development with effects on food control in adulthood.
    No preview · Article · Nov 2014 · International Journal of Developmental Neuroscience
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    ABSTRACT: Standard formalin embalming is the most important of all work with cadavers in anatomy laboratories, as it keeps the tissue strict, insoluble and protected against deterioration. The most commonly used substance for preservation of cadavers and tissues is formaldehyde, a preservative because it is inexpensive, easy penetration and fast action on the parts. Another substance used is glycerin with rapid action and dehydrating fixative, used also for the preservation of anatomical specimens. This study aimed to compare two techniques that use glycerin in conserving parts of the central nervous system of animals. We evaluated the properties and fixing of conservative solutions applied. The two techniques chosen for this work were: the Giacomini and Torres method. In the Torres method, the tissue was more flexible and easy to visualize the structures. In the Giacomini method, the tissues were dark colored, rigid, with little flexibility. This technique requires a shorter time of immersion, compared to Torres. We conclude that the most appropriate method for application in laboratories of anatomy and applicability in practical lessons is technique was Torres.
    No preview · Article · Jan 2011 · Journal of Morphological Sciences
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    ABSTRACT: The appearance, the odor, and the flavor of foods, all send messages to the encephalic area of the brain. The hypothalamus, in particular, plays a key role in the mechanisms that control the feeding behavior. These signals modulate the expression and the action of anorexigenic or orexigenic substances that influence feeding behavior. The serotonergic system of neurotransmission consists of neurons that produce and liberate serotonin as well as the serotonin-specific receptor. It has been proven that some serotonergic drugs are effective in modulating the mechanisms of control of feeding behavior. Obesity and its associated illnesses have become significant public health problems. Some drugs that manipulate the serotonergic systems have been demonstrated to be effective interventions in the treatment of obesity. The complex interplay between serotonin and its receptors, and the resultant effects on feeding behavior have become of great interest in the scientific community.
    No preview · Article · Dec 2010 · Nutritional Neuroscience