Philip Murphy

Trinity College Dublin, Dublin, Leinster, Ireland

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Publications (4)10.32 Total impact

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    ABSTRACT: This study examined whether acceptance and commitment therapy (ACT) enhances treatment as usual (TAU) in improving treatment outcomes in patients with alcohol use disorder (AUD) and comorbid affective disorder.Fifty-two participants were included in the study, of whom 26 were patients with AUD and either depression or bipolar disorder treated with ACT group therapy in parallel with TAU (inpatient integrated treatment) and 26 were matched controls who had received TAU alone. Drinking and craving outcomes were total alcohol abstinence, cumulative abstinence duration (CAD) and Obsessive Compulsive Drinking Scale (OCDS) scores at 3 and 6. months postintervention. Affective and anxiety outcomes were Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Young Mania Rating Scale (YMRS) scores at these follow-ups.Baseline demographic and clinical characteristics were similar in both groups. Retention rates were high: 100% of the ACT group were followed up at 3 and 6. months; 92.3% and 84.6% of the TAU alone group were followed up at 3 and 6. months, respectively. Patients in the ACT group reported significantly higher CAD at 3 and 6. months, significantly lower BDI and BAI scores at 3 and 6. months, and significantly lower OCDS scores at 3. months, than those who received only TAU. No other significant differences in treatment outcomes were found between the groups.ACT provides added benefit to TAU in improving drinking, craving, depression and anxiety outcomes in patients with AUD and comorbid affective disorder. Most treatment improvements were sustained over a 6-month follow-up period.
    No preview · Article · May 2015 · Behavior Therapy
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    Conor K Farren · Philip Murphy · Sharon McElroy
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    ABSTRACT: Alcohol use disorders (AUDs) and affective disorders commonly co-occur, and this co-occurrence is mutually detrimental. To date, few long-term outcome studies exist involving patients with these comorbid disorders. We wished to determine treatment outcomes 5 years after inpatient integrated treatment in patients with these co-occurring disorders, and identify prognostic factors associated with long-term outcome. Two hundred and five depressed and bipolar patients with AUD who completed an inpatient integrated treatment program for dual diagnosis were assessed at baseline, posttreatment discharge, and at 3 months, 6 months, 2 years, and 5 years after treatment. The retention rate at 3 months postdischarge was 95.6%, 75.6% at 6 months, 70.2% at 2 years, and 55.6% at 5 years. Depression, elation, anxiety, and craving scores all fell over the 5-year period, as did the drinking outcome measures in both the depressed and bipolar alcoholics. Each of the primary drinking outcome measures had independent prognostic factors: abstinence at 2 years predicted abstinence at 5 years; number of drinking days at 6 months and 2 years predicted number of drinking days at 5 years; number of drinks per drinking day at 6 months and 2 years predicted number of drinks per drinking day at 5 years. Moreover, the majority of nonabstinent light drinkers at 3 months, who had significantly reduced their mean weekly alcohol consumption since baseline, remained light drinkers at 5 years and very few went on to be heavy drinkers. Indeed, if they did alter category by 5 years, they tended to become abstinent. Dual diagnosis of AUD and depression or bipolar disorder may be treated successfully together with intensive intervention and follow-up, and various prognostic factors emerge. Early abstinence predicts later abstinence, and the vast majority of those who achieve light drinking early in recovery remain light drinkers or become abstinent at 5 years.
    Full-text · Article · Jan 2014 · Alcoholism Clinical and Experimental Research
  • Philip Murphy · Lisa Murphy · Hugh Garavan
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    ABSTRACT: This study investigated the predictive value of two alternative and most widely used measures of Behavioural Activation System (BAS) sensitivity on problematic alcohol use. Participants were 84 college students who completed a measure of alcohol problem severity (Alcohol Use Disorders Identification Test, AUDIT) and two different measures of BAS sensitivity [the BAS and Sensitivity to Reward (SR) scales]. They were divided into 42 problem drinkers and 42 non-problem drinkers based on the AUDIT scores. In a logistic regression controlling for gender and age, BAS and SR scale scores uniquely predicted problem from non-problem drinking. Similarly, multiple regression of the entire sample revealed that, after gender and age had been controlled, BAS and SR scale scores predicted unique variance in AUDIT scores. Moreover, both regressions showed that the SR scale was superior in terms of predictive power. The findings indicate the advantage of including both scales when predicting problematic drinking, but that, if choosing between the two, the SR scale is the better predictor of problem drinking.
    No preview · Article · Apr 2013 · Irish Journal of Psychology
  • Philip Murphy · Hugh Garavan
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    ABSTRACT: Evidence from a number of substance abuse populations suggests that substance abuse is associated with a cluster of differences in cognitive processes. However, investigations of this kind in non-clinical samples are relatively few. The present study examined the ability of alcohol-attentional bias (an alcohol Stroop task), impulsive decision-making (a delay discounting task), and impaired inhibitory control (a GO-NOGO task) to: (a) discriminate problem from non-problem drinkers among a sample of college students; (b) predict scores on the Alcohol Use Disorders Identification Test (AUDIT; a measure of alcohol consumption, drinking behaviour, and alcohol-related problems) across all of the student drinkers; (c) predict AUDIT scores within the subgroups of problem and non-problem student drinkers. In logistic regression controlling for gender and age, student drinkers with elevated alcohol-attentional bias and impulsive decision-making were over twice as likely to be a problem than a non-problem drinker. Multiple regression analysis of the entire sample revealed that all three cognitive measures were significant predictors of AUDIT scores after gender and age had been controlled; the cognitive variables together accounted for 48% of the variance. Moreover, subsequent multiple regressions revealed that impaired inhibitory control was the only significant predictor of AUDIT scores for the group of non-problem drinkers, and alcohol-attentional bias and impulsive decision-making were the only significant predictors of AUDIT scores for the group of problem drinkers. Finally, both impulsive decision-making and impaired inhibitory control were significantly correlated with alcohol-attentional bias across the whole sample. Implications are discussed relating to the development of problematic drinking.
    No preview · Article · Dec 2010 · Drug and alcohol dependence