[Show abstract][Hide abstract] ABSTRACT: The formation equilibria of the [Pt(SMC)(H2O)2]+ complex with some biologically relevant ligands such as L-methionine (L-met) and glutathione (GSH) were studied. The stoichiometry
and stability constants of the formed complexes are reported, and the concentration distribution of the various complex species
has been evaluated as a function of pH. The reaction between [PtCl2(SMC)] and guanosine-5′-monophosphate (5′-GMP) was studied by 1H NMR spectroscopy. The NMR spectra indicated that first step is the hydrolysis of the [PtCl2(SMC)] complex and second step is the substitution of an aqua ligand, either in the cis or trans position with guanosine-5′-monophosphate in molar ratio 1:1. The values of rate constant showed faster substitution of coordinated
H2O in the trans position to the S donor atom of S-methyl-L-cysteine, whereas the slower reaction was assigned to the displacement of the
cis coordinated aqua molecule. This is due to the strong trans labilization effect of coordinated sulfur.
Full-text · Article · Dec 2008 · Journal of Solution Chemistry