Monique Trabelsi

Hôpital Charles-Nicolle, Tunis-Ville, Tūnis, Tunisia

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Publications (4)0 Total impact

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    ABSTRACT: Background Diagnosis of urolithiasis in infancy is uncommon. It imposes rational exploration resting on medical history, clinical features, radiologic assessment, metabolic investigation and stone analysis. Aim The aim of this study is to evaluate epidemiologic and etiologic features of the urolithiasis in infancy. Methods It's a retrospective study including 14 cases of urolithiasis in infants, enrolled in pediatric department of Charles-Nicolle Hospital during fourteen years (1995–2008). Results The median age was 13 months. Thirty five percent of the patients had a positive family history of urolithiasis. The main presenting symptoms were urinary tract infection (four cases) and macroscopic hematuria (three cases). Radio-opaque urolithiasis were diagnosed in nine patients (64%), multiple stones in four patients (28%). Six of patients were diagnosed as having metabolic urolithiasis, four anatomic, two infectious and two idiopathic. Conclusion In our study, metabolic causes remain the first cause of urolithiasis in infancy.
    No preview · Article · Oct 2011 · Journal de Pédiatrie et de Puériculture
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    ABSTRACT: Primary hyperoxaliuria type 1 is an autosomal recessive disorder characterized by increasing urinary excretion of calcium oxalate, recurrent urolithiasis, nephrocalcinosis, and accumulation of insoluble oxalate throughout the body. This inborn error of metabolism appears to be a common cause of end stage renal disease in Tunisia. To review the clinical, biological and radiological futures of primary hyperoxaluria type 1 and to correlate these aspects with the development of end-stage renal disease. we retrospectively reviewed 44 children with Primary hyperoxaliuria type I who were treated in our department during a period of 15 years between 1995 and 2009. The diagnosis was established by quantitative urinary oxalate excretion. In patient with renal impairment, the diagnosis was made by infrared spectroscopy of stone or by renal biopsy. Male to female ratio was 1.2. The median age at diagnosis was 5.75 years. About 43 % of those were diagnosed before the age of 5 years. Initial symptoms were dominated by uraemia. Four patients were asymptomatic and diagnosed by sibling screening of known patients. Nephrocalcinosis was present in all patients. It is cortical in 34%, medullary in 32% and global in 34%. At diagnosis, twelve children were in end-stage renal disease (27%). Pyridoxine response, which is defined by a reduction in urine oxalate excretion of 60% or more, was found in 27%. In the majority of patients, the clinical expression of Primary hyperoxaliuria type 1 is characterized by nephrocalcinosis, urolithiasis and renal failure. Pyridoxine sensitivity is associated with better outcome.
    No preview · Article · Feb 2011 · La Tunisie médicale
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    ABSTRACT: Infections following renal transplantation in children are a major cause of severe morbidity and mortality. Surgery is complex and performed in a subject whose immunological mechanisms are impaired by end stage renal failure and immunosuppressive drugs. To evaluate the incidence and the risk factors of early infectious following renal transplantation in children. Methods: Infectious complications were retrospectively monitored in 37 children receiving renal transplantation at our center from 1992 to 2008. Infectious complications identified were dominated by urinary tract infections occurred in 12 patients. The clinical symptomatology is dominated by fever and decrease in health. In 4 patients the urinary infection was asymptomatic. Three patients had pneumonia; the diagnosis was suspected clinically and confirmed by the chest radiography. Three other patients developed sepsis. In one of them, the etiology was a peritonitis related to dialysis catheter. Two transplant showed a herpetic cheilitis and one patient developed a parvovirus infection that evolved well after two transfusions. In all cases, the outcome was favourable with no deaths or impact on graft function. After renal transplantation, the disturbance of inflammatory reactions explains the often latent or delayed infectious process making early diagnosis difficult. It is imperative to monitor infectious to minimize morbidity and mortality.
    No preview · Article · Jan 2011 · La Tunisie médicale
  • O. Naija · M. Trabelsi · I.B. Massoud · M.R. Lakhoua
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    ABSTRACT: We report a case of post-yersinial reactive arthritis in a 4-year-old child. Three weeks after the onset of diarrhea, he developed tenderness of joints and bilateral conjunctivitis. Serological tests revealed antibodies to Yersinia pseudotuberculosis type IV. After a follow-up of 4~months, he has no complaints. Our recent case illustrates the typical features and highlights the need to look for the diagnosis.
    No preview · Article · Jan 2010