Masanori Nakamura

Kokura Memorial Hospital, Kitakyūshū, Fukuoka, Japan

Are you Masanori Nakamura?

Claim your profile

Publications (24)4.17 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: We report a rare case of cytomegalovirus (CMV) colitis followed by severe ischemic colitis in a non-immunocompromised patient. An 86-year-old woman was admitted after experiencing episodes of vomiting and diarrhea. The next day, hematochezia was detected without abdominal pain. The initial diagnosis of ischemic colitis was based on colonoscopy and histological findings. The follow-up colonoscopy revealed a prolonged colitis. Immunohistochemical staining detected CMV-positive cells following conservative therapy. Intravenous ganciclovir therapy led to successful healing of ulcers and disappearance of CMV-positive cells. The prevalence of CMV infection is common in adults. CMV colitis is relatively common in immunocompromised patients; however, it is rare in immunocompetent patients. In our case, CMV infection was allowed to be established due to the disruption of the colonic mucosa by the prior severe ischemic colitis. Our experience suggests that biopsies may be necessary to detect CMV and the prompt management of CMV colitis should be instituted when intractable ischemic colitis is observed.
    No preview · Article · Mar 2015
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We previously demonstrated the efficacy of gefitinib, a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR), on an anaplastic thyroid cancer (ATC) cell line. We also observed that gefitinib was not effective in regulating cell growth in a different ATC cell line that exhibited an altered EGFR-initiated signal transduction pathway. In the present study, we attempted to regulate the downstream effector of EGFR-Akt-mammalian target of rapamycin (mTOR) pathway by an mTOR inhibitor, everolimus. A total of 8 ATC cell lines were employed, 7 of which were established in our institute. OCUT-2 was known to carry a mutation in the phosphoinositide-3-kinase, catalytic, α polypeptide gene (PI3KCA) and to be gefitinib-resistant, whereas ACT-1 exhibited a remarkable growth arrest by gefitinib. All the cell lines were tested for the cytotoxic effect of everolimus. The mechanisms of cellular toxicity were investigated by EGFR stimulation, cell cycle and concurrent exposure to paclitaxel. In OCUT-2, but not in any of the other cell lines, everolimus achieved a significant growth inhibition (inhibition of 30 and 50% was achieved by concentrations of 0.8 and 5 nM, respectively). The growth in OCUT-2 was inhibited by everolimus, even with concordant EGFR stimulation. This effect was demonstrated by a G2M cell cycle arrest. An additive effect of everolimus onto the cytotoxic effect of paclitaxel was demonstrated at a dose of 1-2 nM. A significant growth inhibitory effect of everolimus on the gefitinib-resistant ATC cell line was demonstrated, suggesting a possible correlation between the efficacy of everolimus and PI3KCA gene mutation and the significance of molecular-targeted therapy in the management of ATC.
    Preview · Article · Jan 2015 · Molecular and Clinical Oncology
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report a case of laparoscopic surgery for a rectal carcinoid after aluminum potassium and tannic acid(ALTA)therapy for an internal hemorrhoid. A 66-year-old man was admitted to our hospital because of bleeding during defecation. He was diagnosed via anoscopy with Goligher grade II internal hemorrhoids. Examination via colonoscopy revealed 2 yellowish submucosal tumors in the lower rectum that were 5mm and 10mm in diameter. A rectal carcinoid tumor was diagnosed based on histopathology. Abdominal computed tomography demonstrated no metastases to the liver or lymph nodes. First, we performed ALTA therapy for the internal hemorrhoids. Two weeks later, we performed laparoscopic-assisted low anterior resection(D2)for the rectal carcinoid. The patient was discharged without complications and has not experienced recurrence during the 2 years of follow-upcare.
    No preview · Article · Nov 2014 · Gan to kagaku ryoho. Cancer & chemotherapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: Although papillary thyroid microcarcinoma (PTMC) has an excellent prognosis, certain cases exhibit aggressive clinical manifestations. In this study, we assessed the expression of E-cadherin and Ki-67 in primary PTMC tumors and metastatic lymph nodes, in order to investigate the mechanism underlying the mainly indolent but potentially malignant nature of PTMC. A total of 93 PTMC patients treated in our institute were included in this study. All primary tumors and 57 metastatic lymph nodes were immunohistochemically stained and a total of 73 tumors (78.5%) were positive for E-cadherin. E-cadherin expression was significantly less common at the invasive front (58.1%, P<0.01) compared to that at the center of the tumor. Tumors that had lost E-cadherin expression at the invasive front frequently presented with lymph node metastasis (70.6%). Small tumors (≤5 mm diameter) expressed E-cadherin significantly more frequently compared with larger tumors (P=0.04); however, no other particular characteristic was found to correlate with the status of E-cadherin expression in the primary tumors. E-cadherin expression was detected in 49 (86.0%) of the 57 metastatic foci and correlated significantly with the expression status at the invasive front of the tumor (P=0.02). The Ki-67 index was universally low and was not correlated with the clinicopathological characteristics or the E-cadherin expression of the tumors. These results suggested that cancer cells in the metastatic lymph nodes exhibit indolent characteristics, similar to those of the primary PTMC. However, the metastatic cancer cells may have already completed the process of epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET), suggesting an innate malignant potential.
    No preview · Article · Mar 2014 · Molecular and Clinical Oncology
  • Naoki Aomatsu · Masanori Nakamura · Tsuyoshi Hasegawa · Keiho Aomatsu
    [Show abstract] [Hide abstract]
    ABSTRACT: We report a case of hyperplastic polyp prolapsing into the duodenum, which caused the ball valve syndrome. A 65-year-old woman was admitted because of epigastric pain and vomiting after eating. CT of the upper abdomen showed a tumor within the duodenal bulb. Endoscopic examination revealed transpyloric prolapse caused by the typeIV gastric polyp. The polyp was pushed back into the stomach. Polypectomy was performed. The tumor was 25×20 mm in size. Histological findings were consistent with a hyperplastic gastric foveolar polyp. After treatment, the patient’s symptoms resolved. She has not shown any recurrence of the symptoms until now.
    No preview · Article · Jan 2014
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A 42 year-old woman visited our hospital with severe abdominal pain at night. The patient had severe abdominal pain, rebound tenderness and a slight muscular defense. A slight swollen appendix was detected on an abdominal CT scan, but ascites was not detected. Laboratory tests showed an elevated white blood cell count (46,600/mm3). The patient was hospitalized as pelvic peritonitis. A morning of the next day, the patient was diagnosed appendicitis because abdominal pain was limited in right lower abdomen. So an appendectomy was performed. The resected appendix was red and swollen slightly, but not perforation. There was ascites like a pus in the abdominal cavity. Postoperative progress was good. The patient was diagnosed as having colitis caused by amoebasis after the operation and was treated with metronidazole from the 10th day after the operation. We report a rare case of amoebic colitis presenting as acute appendicitis at the HIV-antibody negative woman who has not been abroad.
    Preview · Article · Jan 2014 · Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons)
  • [Show abstract] [Hide abstract]
    ABSTRACT: Anaplastic thyroid cancer (ATC) is thought to often be transformed from pre-existing differentiated thyroid cancer. It is one of the most aggressive malignancies and has a dismal prognosis due to its resistance to multimodal therapies. Basic exploratory studies using authentic ATC cell lines that retain its clinical features are necessary. We investigated the characteristics of seven ATC cell lines newly established at our institute to confirm their possible utility for basic studies. Seven distinct cell lines from six patients were established. Their molecular characteristics and sensitivities to cytotoxic anti-cancer drugs were investigated and compared with each other, and with the clinical features of the original tumors. All cells showed extensive chromosomal abnormality and Pax8 expression, indicating human thyroid follicular cell origin. Vascular endothelial growth factor was secreted from all cells, suggesting possible candidacy for targeted therapy. Vimentin was expressed, but E-cadherin expression was lost in all cells but OCUT-1C, which showed different features from those of OCUT-1F derived from the same tumor, suggesting a mixture of cancer cell clones with various degrees of differentiation within a single ATC tumor. Cells were likely to show sensitivity for taxanes, indicating the usefulness of taxanes as the first-line chemotherapy. OCUT-2, a cell line with both B-Raf and PI3 KCA mutation, demonstrated the importance of molecular target-oriented therapy. Basic studies using authentic ATC cell lines retaining the clinical features of the original tumor are useful models for investigating the mechanism of anaplastic transformation and exploring novel therapeutic strategies.
    No preview · Article · Dec 2013 · World Journal of Surgery
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report a case of emergency resection of a giant gastrointestinal stromal tumor of the stomach associated with hemorrhagic shock. A 79-year-old woman was admitted to our hospital because of massive hematemesis. Laboratory analysis revealed a hemoglobin level of 6.5 g/dL. Abdominal computed tomography (CT) and upper gastrointestinal endoscopy revealed a submucosal tumor, 12 cm in diameter, in the fornix of the stomach. As a Dieulafoy-like lesion was present, we attempted coagulation hemostasis in the exposed blood vessels. Endoscopic hemostasis was not successful. The patient went into hemorrhagic shock. Emergency surgery was performed: total gastrectomy with distal pancreatosplenectomy. The resected specimen measured 10×12×7 cm and was hard. Immunohistologically, the tumor was positive for c-kit and CD34 and negative for alpha smooth muscle actin (αSMA), desmin, and S-100. Histological examination revealed that the patient had a high-risk gastrointestinal stromal tumor of the stomach with no nodal metastasis. The postoperative course was uneventful and the patient has remained alive without recurrence for 4 years.
    No preview · Article · Nov 2013 · Gan to kagaku ryoho. Cancer & chemotherapy

  • No preview · Article · Jan 2013 · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
  • [Show abstract] [Hide abstract]
    ABSTRACT: In the early stages of breast cancer when axillary lymph node dissection is avoidable, we performed same day surgery with a breast-conserving operation following sentinel lymph node navigation biopsy under local anesthesia. Initial sentinel lymph node biopsy under local anesthesia is performed to avoid false-negative sentinel lymph node metastasis. Resected sentinel lymph nodes were examined in fixed sections by hematoxylin-eosin staining and immunohistochemistry. The enrolled subjects were 20 patients with breast cancer whose diagnoses were confirmed before treatment. Two (10.0%) patients had metastasis.
    No preview · Article · Nov 2012 · Gan to kagaku ryoho. Cancer & chemotherapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: Case: A 104-year-old female patient with a left breast mass was admitted to our hospital. Ultrasonography showed an irregular and low-echoic mass of about 2.4×2.4×1.4 cm size in the left breast EAC area. Core needle biopsy examination indicated invasive ductal carcinoma of the breast: ER (+), PR (+), and HER2 (-). An overall examination did not show a distant metastasis. We diagnosed her with left breast cancer(luminal A type) T2N0M0, stage IIA. We administered anastrozole at a dose of 1 mg/day. After 6 months, the primary tumor diameter was reduced to 2.1 cm, and the effect of anastrozole was considered a clinical partial response. The patient did not experience any adverse events during treatment. The partial response was maintained for about 2 years. We experienced a successful case of a super-elderly breast cancer patient treated with anastrozole. We conclude that hormone therapy is a useful treatment for super-elderly postmenopausal women with estrogen receptor-positive breast cancer.
    No preview · Article · Nov 2012 · Gan to kagaku ryoho. Cancer & chemotherapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: Aspiration biopsy cytology (ABC) is commonly performed for the diagnosis of thyroid tumor. Because ABC may not provide sufficient tissue for pathological diagnosis, we performed needle biopsy using a Monopty Biopsy Instrument for the accurate diagnosis of thyroid cancer. Furthermore, it is difficult to safely perform a core needle biopsy (CNB) for the diagnosis of breast cancer in the thyroid gland region. In this study, we evaluated the feasibility of using a Monopty Biopsy Instrument as an alternative to conventional ABC or CNB for the biopsy-based diagnosis of thyroid cancer. Twenty patients with clinically suspected thyroid cancer were enrolled, and all patients were thoroughly examined. Seven cases of thyroid cancer were diagnosed, of which 5 cases were papillary carcinoma and 2 were undifferentiated carcinoma.
    No preview · Article · Nov 2012 · Gan to kagaku ryoho. Cancer & chemotherapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: Case: The patient was an 82-year-old woman. Three years ago, she was aware of a tumor in her left breast that was gradually increasing in size and bleeding, prompting her to visit our hospital. Ultrasonography showed an irregular and low- echoic mass with a skin ulcer of about 2×2 cm in size in the left breast A area. Skin biopsy examination indicated adenocarcinoma, estrogen receptor-positive, progesterone receptor-positive, and human epidermal growth factor receptor type 2-negative. An overall examination did not show a distant metastasis. We diagnosed left breast cancer (luminal A type) with T4bN0M0, stage IIIB. We administered tamoxifen at a dose of 20 mg/day. After 8 months of tamoxifen treatment, no signs of an apparent mass were observed by palpation and ultrasonography. The effect of tamoxifen was considered a clinical complete response (CR). The patient did not experience any adverse events during treatment. Although CR was maintained for nearly 6 years by continuation of hormone therapy, tumor growth was observed after 6 years and 9 months. We performed partial resection of the left breast under local anesthesia. At present, 3 months after the operation, our patient is alive with no recurrence. We conclude that hormone (tamoxifen) therapy is a useful treatment for elderly postmenopausal woman with estrogen receptor-positive advanced breast cancer.
    No preview · Article · Nov 2012 · Gan to kagaku ryoho. Cancer & chemotherapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: Carcinomatous meningitis due to breast cancer is comparatively rare in Japan. Here, we report 4 cases of carcinomatous meningitis due to breast cancer. Meningeal metastasis was present in only 1 of the 4 cases, and the other 3 cases were associated with brain metastasis. Meningeal metastasis frequently causes symptoms associated with intracranial hypertension. Gadolinium-enhanced magnetic resonance imaging and cerebrospinal fluid cytology were useful for the diagnosis of meningeal metastasis. Multidisciplinary therapy, such as radiation and chemotherapy, was performed. Two of the 4 patients were treated with combined intrathecal administration of methotrexate and whole brain radiation. The quality of life was improved by multidisciplinary therapy.
    No preview · Article · Nov 2012 · Gan to kagaku ryoho. Cancer & chemotherapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: Standardized therapeutic strategies have not been established yet to manage poorly to undifferentiated thyroid cancer. We experienced a 74-year-old female patient with advanced papillary thyroid cancer that recurred in the cervical skin with a de-differentiation profile after the initial extended surgical therapy. The patient was treated with weekly administration of docetaxel. A rapid regression of the lesion was observed clinically, and complete eradication of the lesion was confirmed pathologically after 14 courses of the treatment. The residual well-differentiated papillary thyroid carcinoma compartment was pathologically confirmed in two cervical lymph nodes after chemotherapy. Although no further treatment was conducted, the patient had no sign of recurrent disease until an accident caused her death 45 weeks after the initial operation. Systemic chemotherapy with weekly administration of docetaxel might be one of the strategies worth implementing to manage patients with de- or poorly differentiated papillary thyroid carcinoma.
    No preview · Article · Apr 2012

  • No preview · Article · Jan 2012 · Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

  • No preview · Article · Jan 2012 · Journal of Cancer Therapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: We report a case of advanced follicular thyroid carcinoma with massive involvement of the great veins of the cervix and mediastinum, and extensive tumor thrombus growing intraluminally into the superior vena cava. The patient, a 70-year-old Japanese woman, was treated successfully by a cooperative surgical team of endocrine and cardiovascular surgeons. Total thyroidectomy with thrombectomy was performed via a minimum phlebotomy in the right brachiocephalic vein, sacrificing only the right internal jugular vein, achieving complete primary tumor resection. She recovered quickly without any complications, and received (131)I radioisotope ablation for her multiple lung metastases. At the time of writing, more than 12 months after surgery, she was well. These treatments thus achieved progression-free survival without impairing her quality of life. Following the case report, we discuss the surgical indications for locally advanced thyroid carcinoma involving the great veins of the mediastinum by reviewing previous reports.
    No preview · Article · Nov 2011 · Surgery Today
  • [Show abstract] [Hide abstract]
    ABSTRACT: We studied and analyzed therapeutic outcomes of a radical surgery under local anesthesia for breast cancer in our department. Subjects were 42 patients with breast cancer whose diagnoses were definitely made before surgery. Indications were: localized DCIS diagnosed preoperatively; invasive carcinoma less than 3 cm in tumor diameter on ultrasound; and clinically tumors with negative axillary lymph nodes. Operative procedures included lumpectomy associated with sentinel lymph node navigation biopsy. We could perform the operation under local anesthesia in all of the 42 patients, and were not demanded to shift from local to general anesthesia. Two patients had sentinel lymph nodes metastasis. Surgical stumps were positive in 14 patients( 33.3%). None of serious complications were encountered. Today's radical operation under local anesthesia for breast cancer is a useful procedure as minimally invasive surgery as for the indications employed in this study.
    No preview · Article · Nov 2011 · Gan to kagaku ryoho. Cancer & chemotherapy
  • [Show abstract] [Hide abstract]
    ABSTRACT: CASE 1: A 59-year-old female patient with left inflammatory breast cancer (HER2 type) T4N1M0, stage III B. Although a partial response (PR) was observed after chemotherapy, an increase of the tumor was confirmed, and thus she underwent pectoralis-conserving mastectomy and immediate reconstruction with a rectus abdominis flap. After the surgery, the patient continued to undergo radiotherapy and administration of trastuzumab. At present, after 1 year and 3 months, she is alive with no recurrence. CASE 2: A 67-year-old female patient with left inflammatory breast cancer (triple negative) T4N2M0, stage III B. Since a variety of chemotherapeutics were ineffective, she underwent mastectomy with pectoralis resection and immediate reconstruction with a rectus abdominis flap to control pain/bleeding caused by the increased tumor. Although radiotherapy and chemotherapy were performed after the surgery, lung and hepatic metastases were developed 6 months after the surgery, and she died in the 10th month after the surgery. CONCLUSION: In mastectomy for inflammatory breast cancer, an immediate reconstruction with a muscle cutaneous flap enabled unhesitating mastectomy in a wide area, and thus we consider this will be a useful technique.
    No preview · Article · Nov 2011 · Gan to kagaku ryoho. Cancer & chemotherapy