Jong Won Park

Korea Institute of Machinery and Materials, Sŏul, Seoul, South Korea

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Publications (109)192.08 Total impact

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    ABSTRACT: Background: Proper monitoring for volume overload is important to improve prognosis in peritoneal dialysis (PD) patients. The association between volume status and residual renal function (RRF) remains an unresolved issue. The aim of the present study was to evaluate the association between the edema index and survival or RRF in incident PD patients. Patients and methods: We identified all adults who underwent PD. The edema index was defined as the ratio of extracellular fluid to total body fluid. Participants with available data regarding survivorship or non-survivorship during the first year after PD initiation were included in the area under the receiver operating characteristic curve analysis. The cutoff value of the edema index for 1-year mortality was >0.371 in men and >0.372 in women. Participants were divided into two groups according to the cutoff value of their baseline edema indices: High (>cutoff value) and Low (≤cutoff value). Survivors during the first year after PD initiation were divided into two groups according to the initial and 1-year edema index: Non-improvement (maintenance of criteria in the initial Low group during the year) and Other (all participants except those in the Non-improvement group). Results: In total, 631 patients were enrolled in the present study. The cutoff value of the edema index for 1-year mortality was >0.371 in men and >0.372 in women. The respective mean initial RRF values (mL·min-1·1.73 m-2) in the Low and High groups, respectively, were 4.88 ± 4.09 and 4.21 ± 3.28 in men (P = 0.108), and 3.19 ± 2.57 and 2.98 ± 2.70 in women (P = 0.531). There were no significant differences between groups in either sex. The respective mean RRF values at 1 year after PD initiation in the Low and High groups, respectively, were 3.56 ± 4.35 and 2.73 ± 2.53 in men, and 2.80 ± 2.36 and 1.85 ± 1.51 in women. RRF at 1 year after PD initiation was higher in the Low group than in the High group (men: P = 0.027; women: P = 0.001). In men, the cumulative 5-year survival rates were 78.7% and 46.2% in the Low and High groups, respectively, whereas in women, rates were 77.2% and 58.8% in the Low and High groups, respectively. For survivors during the first year after PD initiation, the Non-improvement group was associated with a poor survival rate compared with the Other group for both sexes. Conclusion: A high edema index was associated with mortality in incident PD patients at baseline and follow-up. The edema index may be used as a new marker for predicting mortality in PD patients.
    No preview · Article · Jan 2016 · PLoS ONE
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    ABSTRACT: Background: The aim of this study was to investigate whether glycosylated hemoglobin (HbA1c) level in nondiabetic patients is associated with hearing impairment in the general Korean population. Patients and methods: Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded from this study for the following reasons: they could not provide data regarding pure tone audiometry, they had ear disease, they had brain disorders, asymmetric sensory neural hearing loss (HL), or they were younger than 40 years or had diabetes mellitus. Finally, 7449 participants were included in this study. Results: The mean HbA1c levels in the low, middle, and high tertiles were 5.3% ± 0.2%, 5.7% ± 0.1%, and 6.1% ± 0.2%, respectively. The numbers of participants in the low, middle, and high tertiles were 2808, 2509, and 2132, respectively. The low-frequency, mid-frequency, high-frequency, and average hearing thresholds were significantly increased with increasing HbA1c tertile. Linear regression analyses showed that HbA1c level in the nondiabetic participants was associated with components of metabolic syndrome. The mean numbers of metabolic syndrome components in the low, middle, and high HbA1c tertiles were 1.22, 1.53, and 2.02, respectively. The participants in the middle and high HbA1c tertiles had a 1.239- and 1.253-fold increased risk of HL, respectively, compared with those in the low HbA1c tertile. Conclusion: HbA1c level was associated with hearing impairment in the nondiabetic participants of this study. Therefore, the participants with high HbA1c levels should be closely monitored for hearing impairment.
    No preview · Article · Jan 2016 · Metabolic syndrome and related disorders
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    ABSTRACT: Background: Many studies have reported an association between glycated hemoglobin A1c (HbA1c) and metabolic syndrome (MetS) in non-diabetes patients. Each component of MetS is in fact related to chronic kidney disease (CKD) incidence and progression. Therefore, HbA1c in non-diabetic mellitus (DM) may be intrinsically associated with the prevalence of CKD. The hypothesis of the present study was that high HbA1c in non-DM patients is associated with CKD. Patients and methods: The total number of participants in this study was 24,594. The participants were divided into three groups according to their HbA1c levels: a Low group (<5.7% or <39 mmol/mol), a Middle group (5.7-6.0% or 39-42 mmol/mol), and a High group (>6.0% or >42 mmol/mol). The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Results: The number of participants allocated to the Low, Middle, and High groups was 8,651, 4,634, and 1,387, respectively. Linear regression analyses were performed to evaluate the association between variables. Standardized β ± standard error was 0.25 ± 0.22 for waist circumference, 0.44 ± 0.20 for fasting glucose, -0.14 ± 0.30 for high-density lipoprotein cholesterol levels, 0.15 ± 2.31 for triglyceride levels, 0.21 ± 0.00 for systolic blood pressure, 0.10 ± 0.00 for diastolic blood pressure, and -0.22 ± 0.42 for eGFR (P < 0.001 for all variables). eGFR in non-diabetes participants was inversely associated with the HbA1c level, where eGFR decreased as HbA1c levels increased. Standardized βs were -0.04 ± 0.42 in multivariable analysis (P < 0.001). The proportion of participants with only MetS, only CKD, or both MetS and CKD was higher in the High group than in the Low and Middle groups. Conclusion: High HbA1c in non-DM patients may be associated with CKD. Renal function in patients with high HbA1c levels may need to be monitored.
    Preview · Article · Dec 2015 · PLoS ONE
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    ABSTRACT: Background: Visceral fat area (VFA) using bioimpedance analysis (BIA) as a simple analyzer can be used to assess VFA, which may be associated with HL. The aim of the present study was to evaluate the clinical relevance and usefulness of VFA using BIA as a predictor of HL. Patients and Methods: In total, 18,415 patients were recruited into our study. VFAs were measured using multi-frequency BIA. VFAs were normalized by body mass index (BMI). Participants were divided into 3 tertiles based on their VFA/BMI for both sexes. For both ears of each participant, the low-frequency (Low-Freq), mid-frequency (Mid-Freq), and high-frequency (High-Freq) values were obtained calculating the pure tone averages at 0.5 and 1 kHz, 2 and 3 kHz, and 4 and 6 kHz, respectively. The average hearing threshold (AHT) was calculated as the pure tone average at the 4 frequencies (i.e., 0.5, 1, 2, and 3 kHz). HL was defined as AHT >40 dB. Results: The VFA/BMI had the greatest AUROC among VFA, BMI, and VFA/BMI in both sexes in this study. In both univariate and multivariate analyses, VFA/BMI tertiles were associated with all 4 hearing thresholds (i.e., Low-Freq, Mid-Freq, High-Freq, and AHT). The 4 hearing thresholds were positively correlated with VFA/BMI as a continuous variable. The odds ratio for HL increased as the VFA/BMI tertile increased. Conclusion: VFA/BMI was associated with hearing impairment in the Asian population. The participants with high VFA/BMI should be closely monitored for hearing impairment.
    No preview · Article · Dec 2015 · International journal of medical sciences
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    ABSTRACT: Supercapacitors provide high-power energy storage for electrical systems. The expected useful life of a supercapacitor is related to the oxidation of functional groups on the graphite electrode surface during usage, and it is highly dependent on operational voltage and temperature. In this paper, a life model is developed for commercial supercapacitors. The model incorporates a new voltage multiplier to describe the combined effects of temperature and voltage on supercapacitor life. Accelerated testing was conducted to obtain the time to failure of supercapacitors over a range of voltage and temperature conditions, validate the life model, and compare the model with two previously established capacitor life models. Failure was defined by a 30% decrease in capacitance or a 100% increase in equivalent series resistance.
    No preview · Article · Dec 2015 · IEEE Transactions on Device and Materials Reliability
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    Seok Hui Kang · Kyu Hyang Cho · Jong Won Park · Jun Young Do
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    ABSTRACT: Background The aim of the present study of the general population was to identify the best predictor of metabolic risk among the body index variables evaluated with dual-energy X-ray absorptiometry (DEXA) or anthropometric indices including the waist to height ratio (WHtR). Patients and Methods Data from the Korean National Health and Nutrition Examination Survey 2008–2011 were used for the analyses. As a result, 15,965 participants were included in this study. The body mass (BM) index was calculated as the body weight divided by the height squared. The WHtR was calculated as the waist circumference divided by height. Body composition indices such as lean mass (LM), fat mass (FM), trunk fat mass (TFM), and bone mineral content (BMC) were determined by using DEXA. Skeletal muscle mass (SM) was defined as the sum of the lean soft masses of both extremities. The LM, FM, BMC, TFM, and SM indices were calculated by dividing the total LM, total FM, total BMC, TFM, or SM by the height squared. Results The WHtR had the highest area under the curve (AUC) and was the best predictor of metabolic syndrome for both sexes. In addition, the WHtR had the highest AUCs for components of metabolic syndrome (male: AUC 0.823, 95 % confidence interval [CI] 0.814–0.832; female: AUC 0.870, 95 % CI 0.863–0.877). There was a small statistically significant difference in AUC between WHtR and the other indices. Multivariate logistic regression showed that male participants in the second, third, and fourth quartiles had a 4.0 (95 % CI, 3.1–5.2), 9.6 (95 % CI, 7.5–12.3), and 36.1 (95 % CI, 28.0–46.4) times increased risk of metabolic syndrome compared with patients in the first quartile and female participants in the second, third, and fourth quartiles had a 4.3 (95 % CI, 3.1–6.0), 18.0 (95 % CI, 13.3–24.5), and 58.5 (95 % CI, 42.9–79.9) times increased risk of metabolic syndrome compared with patients in the first quartile. Conclusion Among the BM, FM, LM, SM, TFM, and WHtR indices, WHtR is most useful to predict the presence of metabolic syndrome and insulin resistance in the Korean population. Electronic supplementary material The online version of this article (doi:10.1186/s12902-015-0075-5) contains supplementary material, which is available to authorized users.
    Preview · Article · Dec 2015 · BMC Endocrine Disorders
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    ABSTRACT: Introduction The objective of the present study was to examine the association between low-grade albuminuria and hearing impairment in the non-diabetic population. Materials and methods Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded from this study if they were younger than 19 years old, or had urine albumin/creatinine ratio (UACR) >= 30 mg/g or diabetes mellitus. There were 10 608 participants included in this study. The participants were divided into three groups according to their UACR tertiles. Results There were 1560; 1561; and 1552 male and 1982; 1975; and 1978, female participants in the low, middle, and high tertile groups, respectively. The results indicated the association between low-grade albuminuria and the numbers of metabolic syndrome (MetS) components or Framingham risk score, and the presence of MetS or the proportions of participants at high cardiovascular risk. Univariate and multivariate linear regression analyses demonstrated an association between the UACR and average hearing threshold (AHT) that was observed in both sexes. Multivariate analyses showed that mean AHTs in the low, middle, and high tertile groups were, respectively, 16.127 dB, 17.139 dB, and 18.604 dB for men, and 14.842 dB, 15.100 dB, and 16.353 dB, respectively, for women. Low-frequency, mid-frequency, and high-frequency hearing thresholds according to UACR tertiles showed similar trends. In both sexes, multivariate logistic regression analyses revealed that participants in the low and middle tertile groups had a decreased risk for hearing loss compared to participants in the high tertile group. Conclusion Low-grade albuminuria was associated with hearing impairment in the non-diabetic participants of this study.
    No preview · Article · Nov 2015 · Annals of Medicine

  • No preview · Article · Oct 2015
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    ABSTRACT: Advances in bioimpedance analysis (BIA) technologies now enable visceral fat area (VFA) to be assessed using this method. The aim of this study was to evaluate the clinical relevance and usefulness of VFA as a predictor of chronic kidney disease (CKD) and metabolic syndrome (MS), using BIA. We identified 24,791 adults who underwent voluntary routine health checkups at Yeungnam University Hospital. In total 22,480 patients were recruited into our study. Participants were divided into 3 tertiles based on their VFA: low, middle, and high tertiles. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m(2). The higher tertile of VFA was associated with a higher prevalence of diabetes mellitus, hypertension, and male sex. Waist-to-hip ratio, body mass index, blood pressure, lean mass, body fat %, and fasting glucose, total cholesterol, triglyceride, GGT, AST, ALT, and uric acid levels all increased as the VFA tertile increased (P < 0.001 for all variables). The prevalence of CKD was 6.9% in the low tertile, 13.9% in the middle tertile, and 25.2% in the high tertile (P < 0.001). The prevalence of MS was 2.2% in the low tertile, 12.8% in the middle tertile, and 36.7% in the high tertile (P < 0.001). The AUROC values for VFA were higher than those for BMI and WHR. For VFA, the sensitivity and specificity for predicting CKD were 62.66% (95% CI, 61.0-64.3) and 64.22% (95% CI, 63.5-64.9), respectively, and 77.65% (95% CI, 76.3-79.0), and 68.81% (95% CI, 68.1-69.5), respectively for predicting MS. Our results demonstrated that the VFA, measured by BIA, is a simple method for predicting the risk of CKD and MS. © 2015 S. Karger AG, Basel.
    No preview · Article · Apr 2015 · Kidney and Blood Pressure Research
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    Ki-Sung Son · Hyeong-Seop Jeon · Jin-Ho Park · Jong Won Park
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    ABSTRACT: Acceleration sensors are usually used to measure the vibration of a structure. Although this is the most accurate method, it cannot be used remotely because these are contact-type sensors. This makes measurement difficult in areas that cannot be easily approached by surveyors, such as structures located in high or dangerous areas. Therefore, a method that can measure the vibration without installing sensors is required for the vibration measurement of structures located in these areas. Many conventional studies have been carried out on non-contact-type vibration measurement methods using cameras. However, they have been applied to structures with relatively large vibration displacements such as buildings or bridges, and since most of them use targets, people still have to approach the structure to install the targets. Therefore, a new method is required to supplement the weaknesses of the conventional methods. In this paper, a method is proposed to measure vibration displacements remotely using a camera without having to approach the structure. Furthermore, an estimation method for the measurement resolution and measurement error is proposed for the vibration displacement of a cylindrical structure measured using the proposed measurement method. The proposed methods are described, along with experimental results that verified their accuracy.
    Preview · Article · Mar 2015 · Nuclear Engineering and Technology
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    ABSTRACT: Background: The aim of this study was to determine whether metabolic syndrome (MetS) or chronic kidney disease (CKD) is associated with hearing thresholds in the general Korean population. Patients and methods: A total of 16,554 participants were included in this study. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III guidelines, and CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 or a dipstick proteinuria result of ≥1+. The hearing thresholds were measured at 0.5, 1, 2, 3, 4, and 6 kHz. Low-frequency (Freq) was defined as pure-tone averages at 0.5 and 1 kHz, while Mid-Freq and High-Freq were defined as the average thresholds at mid-frequency (2 and 3 kHz) and high frequency (4 and 6 kHz), respectively. Results: In men, the hearing thresholds were 15.1 ± 14.5 dB, 22.2 ± 21.3 dB, and 37.3 ± 26.5 dB for Low-, Mid-, and High-Freq, respectively. In women, the hearing thresholds were 14.9 ± 15.3 dB, 16.6 ± 18.0 dB, and 26.1 ± 21.5 dB for Low-, Mid-, and High-Freq, respectively. The hearing thresholds for men were significantly higher than the hearing thresholds for women in all 3 threshold categories. Male and female subjects with MetS or CKD had higher hearing thresholds than the subjects that did not have these disorders. In the multivariate analysis, MetS was associated with increased hearing thresholds in women, and CKD was associated with increased hearing thresholds in men and women. Conclusion: MetS is associated with hearing thresholds in women, and CKD is associated with hearing thresholds in men and women. Therefore, patients with MetS or CKD should be closely monitored for hearing impairment.
    Preview · Article · Mar 2015 · PLoS ONE
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    ABSTRACT: Arrhythmias are complications of tunneled cuffed hemodialysis catheter insertion. Most complications associated with arrhythmias occur during guide-wire access, where the guide wire can cause traumatic damage to the conduction system of the heart. Conducting system injury in tunneled cuffed hemodialysis catheter insertion often involves the right bundle, causing right bundle branch block (RBBB). Transient RBBB with sinus rhythm is not usually accompanied by abnormal vital signs. However if patients already have left bundle branch block (LBBB), new onset RBBB can cause complete atrioventricular block (AVB), which can lead to fatal complications requiring invasive treatment. We report on a patient with LBBB who developed complete AVB during hemodialysis catheter insertion.
    Preview · Article · Jan 2015
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    ABSTRACT: The presence of peritoneal dialysate when performing bioimpedance analysis may affect body composition measurements. The aim of this study was to evaluate the impact of dialysate on body composition measurements in Asians. Forty-one patients undergoing maintenance peritoneal dialysis in our hospital peritoneal dialysis unit were included in this study. Dialysate was drained from the abdomen prior to measurement, and bioimpedance analysis was performed using multi-frequency bioimpedance analysis, with each subject in a standing position (D-). Dialysate was then administered and the measurement was repeated (D+). The presence of peritoneal dialysate led to an increase in intracellular water (ICW), extracellular water (ECW), and total body water (D-: 20.33 ± 3.72 L for ICW and 13.53 ± 2.54 L for ECW; D+: 20.96 ± 3.78 L for ICW and 14.10 ± 2.59 L for ECW; P < 0.001 for both variables). Total and trunk oedema indices were higher in the presence of peritoneal dialysate. In addition, the presence of peritoneal dialysate led to an overestimation of mineral content and free fat mass (FFM) for the total body; but led to an underestimation of body fat (D-: 45.80 ± 8.26 kg for FFM and 19.30 ± 6.27 kg for body fat; D+: 47.51 ± 8.38 kg for FFM and 17.59 ± 6.47 kg for body fat; P < 0.001 for both variables). Our results demonstrate that the presence of peritoneal dialysate leads to an overestimation of FFM and an underestimation of fat mass. An empty abdomen is recommended when evaluating body composition using bioimpedance analysis.
    No preview · Article · Nov 2014 · Nephrology
  • Jong Won Park · Kyoung-Jin Min · Dong Eun Kim · Taeg Kyu Kwon
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    ABSTRACT: Withaferin A is a steroidal lactone purified from the Indian medicinal plant, Withania somnifera. Withaferin A has been shown to inhibit the proliferation, metastasis, invasion and angiogenesis of cancer cells. In the present study, we investigated whether withaferin A induces apoptosis in the human head and neck cancer cells, AMC-HN4. Withaferin A markedly increased the sub-G1 cell population and the cleavage of poly(ADP-ribose) polymerase (PARP), which are markers of apoptosis. Pan-caspase inhibitor, z-VAD-fmk (z-VAD), markedly inhibited the withaferin A-induced apoptosis. However, the withaferin A-induced increase in the expression of COX-2 was not affected by treatment with z-VAD. Furthermore, withaferin A upregulated cyclooxygenase-2 (COX-2) expression. The COX-2 inhibitor, NS-398, reduced the withaferin A-induced production of prostaglandin E2. However, treatment with NS-398 did not affect the sub-G1 population and the cleavage of PARP. In addition, the withaferin A-induced apoptosis was independent of reactive oxygen species production. Thiol donors [N-acetylcysteine (NAC) and dithiothreitol (DTT)] reversed withaferin A-induced apoptosis. Therefore, our data suggest that withaferin A induces apoptosis through the mechanism of thiol oxidation in head and neck carcinoma cells.
    No preview · Article · Oct 2014 · International Journal of Molecular Medicine

  • No preview · Article · Oct 2014
  • Hyeong-Seop Jeon · Ki-Sung Son · Soon Woo Han · Jong Won Park

    No preview · Article · Oct 2014
  • Ki-Sung Son · Hyeong-Seop Jeon · Soon Woo Han · Jong Won Park

    No preview · Article · Sep 2014
  • Steven J. Jordan · Woo‐Baik Lee · Jong Won Park
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    ABSTRACT: Program trading has been identified as a mechanism that links the futures and spot markets. It has also been identified as a potential cause of market instability leading to regulations on program trading during volatile markets. Program trading halts provide a natural experiment to test the hypothesis that program trading is an important mechanism that maintains relative market pricing. This study is the first to analyze the effect of removing all program trades on the connectedness of the spot and futures markets during large market moves. The Korean regulatory environment has several unique properties that lend itself to such a study. Overall, we provide evidence that (i) the basis is unaffected when program trading is eliminated during large market moves, (ii) arbitrage exists and appears to be able to identify uninformed price moves, (iii) the data do not support the argument that halts provide a time-out period in order for markets to reevaluate information, and (iv) there are costs associated with imposing trading halt regulations on financial markets. © 2014 Wiley Periodicals, Inc. Jrl Fut Mark
    No preview · Article · Aug 2014 · Journal of Futures Markets
  • Hak Geon Lee · Chang Ho Yun · Jong Won Park · Yong Woo Lee

    No preview · Article · Jun 2014
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    ABSTRACT: The aim of this study is to measure the difference of ionized calcium between heparinized whole blood and serum. We recruited 107 maintenance hemodialysis (HD) patients from our hospital HD unit. The clinical and laboratory data included ionized calcium in serum and in whole blood (reference, 4.07 to 5.17 mg/dL). The level of ionized calcium in serum was higher than that in whole blood (p < 0.001). Bland-Altman analysis showed that difference for ionized calcium was 0.5027. For the difference, the nonstandardized β was -0.4389 (p < 0.001) and the intercept was 2.2418 (p < 0.001). There was a significant difference in the distribution of categories of ionized calcium level between two methods (κ, 0.279; p < 0.001). This study demonstrates that whole blood ionized calcium is underestimated compared with serum ionized calcium. Positive difference increases as whole blood ionized calcium decreases. Therefore, significant hypocalcemia in whole blood ionized calcium should be verified by serum ionized calcium.
    Preview · Article · Mar 2014 · The Korean Journal of Internal Medicine

Publication Stats

811 Citations
192.08 Total Impact Points

Institutions

  • 2015
    • Korea Institute of Machinery and Materials
      Sŏul, Seoul, South Korea
  • 2005-2015
    • Chungnam National University
      • Department of Information and Communication Engineering
      Daiden, Daejeon, South Korea
  • 1997-2015
    • Yeungnam University
      • Division of Internal Medicine
      경산시, Gyeongsangbuk-do, South Korea
  • 2014
    • Keimyung University
      • Department of Microbiology
      Sŏul, Seoul, South Korea
  • 2009-2014
    • University of Seoul
      • • College of Business Administration
      • • Department of Business Administration
      Sŏul, Seoul, South Korea
    • Ajou University
      • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
    • Korea Institute of Science and Technology
      • Clean Energy Research Center
      Sŏul, Seoul, South Korea
  • 2010-2012
    • National Fisheries Research and Development Institution
      Sŏul, Seoul, South Korea
    • Loughborough University
      Loughborough, England, United Kingdom
    • Good Samsun Hospital
      Tsau-liang-hai, Busan, South Korea
  • 2008-2012
    • Gyeongsang National University
      • School of Materials Science and Engineering
      Shinshū, South Gyeongsang, South Korea
  • 2010-2011
    • Hallym University Medical Center
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 1995-2011
    • Catholic University of Korea
      • • Department of Internal Medicine
      • • College of Medicine
      • • Department of Dermatology
      Seoul, Seoul, South Korea
  • 2007
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
    • Seoul Veterans Hospital
      Sŏul, Seoul, South Korea
  • 2004
    • Cheju Halla University
      Tse-tsiu, Jeju, South Korea
  • 2000
    • Inha University
      • Department of Electronic and Electrical Engineering
      Chemulpo, Incheon, South Korea
  • 1996
    • Semyung University
      Seishō-gun, North Gyeongsang, South Korea